Hormone replacement therapy: what is the evidence today?

Abstract:

:Based on the most recent studies, it clearly appears that long-term hormone replacement therapy (HRT) prevents fractures but does not improve established coronary artery disease. In addition, HRT leads to a small increase in breast cancer incidence and to a decrease in colorectal cancer incidence. HRT increases the incidence of venous thrombosis, pulmonary embolisms and strokes. As a consequence, HRT can no longer be recommended for primary or secondary prevention of cardiovascular diseases. In addition, it was also demonstrated that HRT was not able to improve cognitive functions and prevent dementia. Therefore regarding daily clinical practice, HRT certainly remains useful to control the symptoms of oestrogen deficiency in recently menopausal patients, but it should definitively no longer be recommended for long-term treatment.

journal_name

Z Rheumatol

authors

Uebelhart B,Frey D,Uebelhart D

doi

10.1007/s00393-003-0559-y

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

508-11

issue

6

eissn

0340-1855

issn

1435-1250

journal_volume

62

pub_type

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