[Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score].


:The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synovitis, meniscopathy-related synovitis and synovitis in hemochromatosis). Synovitis scores of between ≥ 5 and 9 are classified as high-grade synovitis (rheumatoid arthritis, psoriatic arthritis, Lyme's arthritis, post-infection/reactive arthritis and peripheral arthritis in Bechterew disease); sensitivity is 61.7% and sensitivity 96.1%. According to receiver operating characteristic (ROC) analysis (AUC: 0.8-0.9), diagnostic value is good. National and international acceptance of the synovitis score has grown since the first publication in 2002 and a related follow-up publication in 2006. PubMed data analysis (as of 11.01.2017) yielded the following citation values according to "cited by PubMed Central articles" for two publications relating to the synovitis score: there were 29 cited-by-PubMed articles for DOI: 10.1078/0344-0338-5710261 , and 44 cited-in-PubMed articles for the second publication, DOI: 10.1111/j.1365-2559.2006.02508 . This makes a total of 73 PubMed citations over a period of 15 years, thereby evidencing the score's international acceptance. Immunohistochemical determination of a number of CD antigens relevant to inflammation has been proposed to further specify the synovitis score for the purposes of risk stratification of high-grade synovitis (e.g., risk of progression and sensitivity to biological agents).


Z Rheumatol


Krenn V,Perino G,Rüther W,Krenn VT,Huber M,Hügle T,Najm A,Müller S,Boettner F,Pessler F,Waldstein W,Kriegsmann J,Häupl T,Wienert S,Krukemeyer MG,Sesselmann S,Tikhilov R,Morawietz L




Has Abstract


2017-08-01 00:00:00














  • [B-cell depletion in the treatment of rheumatoid arthritis].

    abstract::New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent d...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Feist E,Burmester GR,Dörner T

    更新日期:2003-08-01 00:00:00

  • [Cytokines].

    abstract::Cytokine driven inflammation is a common feature in autoimmune diseases. Cytokines are needed under physiological conditions within the innate and adaptive immune systems to control infectious diseases and neoplastic disorders by regulation of the cell cycle and apoptosis. Cytokines can also be found in persistently i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Feuchtenberger M,Kneitz C,Tony HP

    更新日期:2007-07-01 00:00:00

  • [Safety of antirheumatic drug treatment in the elderly].

    abstract::Mainly due to the general demographic changes and decreasing mortality in rheumatic diseases based on therapeutic progress, the proportion of older patients treated by rheumatologists is growing. Drug treatment in the elderly, however, harbors certain risks including age-specific pharmacokinetic features and high rate...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Krüger K,Strangfeld A,Kneitz C

    更新日期:2014-04-01 00:00:00

  • [Glycosaminoglycanpolysulfate (GAGPS, Arteparon) for basic therapy of arthrosis. II. Comparative studies, Arteparon forte and physical therapy vs. physical therapy alone; late results].

    abstract::Five to 9 months after a comparative study of 2 groups of patients with coxarthrosis and gonarthrosis, 69 individuals (group 1) receiving Arteparon forte injections and physical therapy and 46 persons (group 2) with physical therapy only, questioneer with specific questions was sent out. From 72 questioneers mailed 55...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Rau E,Schmid C,Bach GL

    更新日期:1977-07-01 00:00:00

  • [Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts].

    abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease, which is mainly characterized by synovial hyperplasia, pathological immune phenomena and progressive destruction of the affected joints. Various cell types are involved in the pathogenesis of RA including T cells, antigen presenting cells, and endothelial ce...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Seemayer CA,Distler O,Kuchen S,Müller-Ladner U,Michel BA,Neidhart M,Gay RE,Gay S

    更新日期:2001-10-01 00:00:00

  • [§ 116b SGB V (social insurance code, book five) for rheumatology patients. An empirical assessment on the basis of administrative data].

    abstract:BACKGROUND:The choice between outpatient and inpatient care is currently undergoing major changes within the German health care system with the amendment of § 116b SGB V. This study investigates what proportion of hitherto inpatient rheumatologic care could potentially be given on an outpatient basis. METHODS:The anal...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Rath T,Bokern E,Sefo-Bukow E,Büscher G,Lüngen M,Rubbert-Roth A

    更新日期:2011-01-01 00:00:00

  • Association of HLA-G polymorphisms with systemic lupus erythematosus and correlation between soluble HLA‑G levels and the disease: a meta-analysis.

    abstract:OBJECTIVE:To investigate the association between HLA‑G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA‑G (sHLA‑G) levels and SLE. METHODS:A meta-analysis was performed to investigate the relationships between HLA‑G 14-bp insertion (I)/dele...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Bae SC,Lee YH

    更新日期:2020-04-09 00:00:00

  • [Prospective study of JCR-Oligo I of the Child and Adolescence Rheumatology Working Group].

    abstract::Intra-articular injection of corticosteroids is a powerful anti-inflammatory treatment with relatively few side effects. To date no prospective RCT exists on its use in children with oligoarthritis type I. Thus, in January 2000 the Arbeitsgemeinschaft started a multicenter RCT to compare in children with this diagnosi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Forster J

    更新日期:2000-04-01 00:00:00

  • [Diagnosis, therapy and current research aspects of selected chronic inflammatory diseases with head and neck involvement].

    abstract::Wegener's granulomatosis, Churg-Strauss syndrome and analgesics intolerance syndrome with polyps demonstrate non-specific manifestations in the head and neck region. These symptoms can often lead to early diagnosis and initiation of the correct therapy. However, symptoms are often ambiguous and many rare differential ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Laudien M,Ambrosch P,Till A,Podschun R,Lamprecht P

    更新日期:2008-09-01 00:00:00

  • [Translational aspects on the role of B-cells in autoimmune diseases. "From bench to bedside" and "from bed to benchside"].

    abstract::In recent years, new findings in immunology have been successfully converted to therapeutic principles, in particular for rheumatoid arthritis (RA) and spondylarthritides. The introduction of cytokine blockers in RA using tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 inhibitors presented the first original ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Mei H,Dörner T

    更新日期:2009-07-01 00:00:00

  • [Pharmacologic characteristics as the basis for differential therapy using non-steroidal anti-inflammatory agents].

    abstract::An attempt is made to compile the pharmacological data on the leading non-steroidal anti-inflammatory drugs. They concern the pharmacodynamics, the pharmacokinetics and the unwanted effects of these compounds. From these data a few suggestions for rational use are made: Ibuprofen and diclofenac present as drugs with s...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Brune K

    更新日期:1987-01-01 00:00:00

  • [Detection of dsDNA antibodies in diagnosis of systemic lupus erythematosus--comparative studies of diagnostic effectiveness of 3 ELISA methods with different antigens and a Crithidia luciliae immunofluorescence test].

    abstract::Antibodies to double-stranded DNA (anti-dsDNA, dsDNA-Ab) are frequently found in systemic lupus erythematosus (SLE), especially during active disease and differ with respect to immunoglobulin class and avidity. The detection of anti-dsDNA is one of the diagnostic criteria for SLE according to the American College of R...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Wigand R,Gottschalk R,Falkenbach A,Matthias T,Kaltwasser JP,Hoelzer D

    更新日期:1997-03-01 00:00:00

  • [Activity leakage and radiation exposure in radiation synovectomy of the knee: influence of different therapeutic modalities].

    abstract::In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclid...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Klett R,Puille M,Matter HP,Steiner D,Stürz H,Bauer R

    更新日期:1999-08-01 00:00:00

  • [Therapy of juvenile chronic arthritis with sulfasalazine].

    abstract::Sulfasalazine was used as second line agent in 15 children with different forms of rheumatoid arthritis. In 9 cases amelioration could be achieved with respect to clinical symptoms as well as laboratory parameters. Thus, sulfasalazine can be recommended as basic medication also in juvenile rheumatoid arthritis. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 临床试验,杂志文章


    authors: Suschke HJ

    更新日期:1987-03-01 00:00:00

  • Chronic synovitis with marked infiltration of granulocytes in a patient with an unusual development of systemic lupus erythematosus.

    abstract::The case described concerns a patient initially presenting the clinical symptoms of rheumatoid arthritis, including the presence of nodules, and slowly developing into systemic lupus erythematosus (SLE). Besides the signs of chronic inflammation in the synovial tissue, many granulocytes and PAS-positive macrophages we...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Meijers KA,Eulderink F,van de Putte LB,Wiersema-van Gogh H,de Vries E,Cats A

    更新日期:1979-07-01 00:00:00

  • [Ulcerative colitis caused by oral gold therapy in rheumatoid arthritis].

    abstract::We report on a 39-year-old male patient suffering from seropositive rheumatoid arthritis who developed severe colitis during oral gold (Auranofin) therapy. So far, two further cases of colitis during oral, and 28 cases of enterocolitis during parenteral chrysotherapy have been described. The pathomechanism has not bee...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Bross-Bach U,Saal JG,Hartmann F,Müller CA,Waller HD

    更新日期:1987-07-01 00:00:00

  • [The knee joint in rheumatoid arthritis-current orthopaedic surgical treatment options].

    abstract::The knee joint is often involved in rheumatoid arthritis. Despite ever-improving medical antirheumatic therapies, surgical treatment continues to play an important role in optimal multidisciplinary care. The aim of the present work is to process current orthopedic surgical therapy procedures on the knee joint accordin...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Maderbacher G,Greimel F,Schaumburger J,Grifka J,Baier C

    更新日期:2018-12-01 00:00:00

  • [Systemic sclerosis - diagnosis and classification].

    abstract::Systemic sclerosis (SSc) is a polymorphic and heterogenic systemic disorder with inflammation, fibrosis and vascular damage. Early diagnosis and classification may be difficult if disease expression is oligosymptomatic (undifferentiated), presenting with only Raynaud's phenomenon or limited scleroderma. Scleroderma sp...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Genth E,Krieg T

    更新日期:2006-07-01 00:00:00

  • [Ophthalmological diagnosis in systemic vasculitis].

    abstract::Ocular manifestations of systemic vasculitides are extraordinarily pleomorph and have been described for many decades. In the introduction the special interaction of the immune system and the eye is outlined. Thereafter diagnostic procedures of patients suffering from systemic vasculitides are shown from an ophthalmol...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Nölle B

    更新日期:2001-08-01 00:00:00

  • [Inflammatory muscle diseases].

    abstract::Inflammatory myopathies are as a rule rare diseases of skeletal muscle. In the majority of cases noninfective autoimmunological reactions are assumed. Only few diseases have an infectious origin. From a myopathological point of view, polymyositis must be selected from interstitial nodular myositis. The most important ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Pongratz D

    更新日期:1986-07-01 00:00:00

  • [Identification of patients with axial spondylarthritis in primary care (AWARE study)].

    abstract:BACKGROUND:Early detection of patients with axial spondylarthritis (axSpA) in primary care is difficult. The combination of various parameters indicative of inflammatory back pain (AWARE criteria) was found to be beneficial in an initial study. OBJECTIVE:Review of the criteria for the identification of young patients ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Braun J,Mosch T,Fischer I,Kiltz U

    更新日期:2019-08-01 00:00:00

  • Enumeration of T cell subsets and functional suppressor cell assays in patients with rheumatoid arthritis and HLA-B27-associated arthritis.

    abstract::Seronegative rheumatoid arthritis (RA) patients have increased proportions of OKT-4+ (helper) T cells and diminished proportions of OKT-8+ (suppressor/cytotoxic) T cells in the peripheral blood. This phenomenon corresponds to diminished inhibition of B cell activation by peripheral blood lymphocytes (PBL). Seropositiv...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Lemm G,Warnatz H

    更新日期:1984-05-01 00:00:00

  • [Interstitial nephritis in rheumatic diseases].

    abstract::Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Korsten P,Müller GA

    更新日期:2015-05-01 00:00:00

  • [Patient-centered assessment of functional health in systemic sclerosis -- where are we now?].

    abstract::Self-administered patient-centered questionnaires have been shown to be practical, reliable and valid in terms of evaluating functional limitations in rheumatic diseases. In systemic sclerosis a modified version of the HAQ and condition-specific questionnaires have been used. The Health Assessment Questionnaire (HAQ) ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Sigl T,Ewert T,Stucki G

    更新日期:2004-12-01 00:00:00

  • [Ocular sarcoidosis].

    abstract::Ocular manifestation of sarcoidosis occurs in up to 60% of patients with confirmed systemic sarcoidosis and represents one of the most common forms of noninfectious uveitis. In known pulmonary sarcoidosis, ocular involvement can occur in up to 80% of cases. Sarcoidosis can also present only in the eye, without a syste...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审


    authors: Springer-Wanner C,Brauns T

    更新日期:2017-06-01 00:00:00

  • [Spontaneous pneumoperitoneum in progressive systemic sclerosis (generalized scleroderma)].

    abstract::In a twenty-nine year old female patient with progressive systemic sclerosis (scleroderma) (PSS) and an impressing involvement of the intestine (disturbance of the oesophageal motility, pseudo-obstruction, malabsorption) a spontaneous, asymptomatic pneumoperitoneum is observed. Perforation or pneumatosis cystoides int...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Lang B,Meske S,Billmann P,Vaith P,Peter HH

    更新日期:1986-03-01 00:00:00

  • [Biomarkers and personalized medicine].

    abstract::Biomarkers form the basis for patient stratification and the development of individualized treatment strategies. As the understanding of the pathophysiological processes underlying rheumatic diseases increases, novel biomarkers will become available and established markers can be used more efficiently. Autoantibodies ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Scherer HU,Burmester GR,Häupl T

    更新日期:2013-02-01 00:00:00

  • Hormone replacement therapy: what is the evidence today?

    abstract::Based on the most recent studies, it clearly appears that long-term hormone replacement therapy (HRT) prevents fractures but does not improve established coronary artery disease. In addition, HRT leads to a small increase in breast cancer incidence and to a decrease in colorectal cancer incidence. HRT increases the in...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Uebelhart B,Frey D,Uebelhart D

    更新日期:2003-12-01 00:00:00

  • An overwhelming pulmonary fungus ball in a systemic lupus erythematosus patient.

    abstract::Impaired host immunity has been regarded as a predisposing factor in post-primary tuberculosis in adults. Patients with systemic lupus erythematosus (SLE) are usually exposed to high doses of corticosteroids and eventually develop defective cellular immunity that increases the risk for active tuberculosis. SLE-associa...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: Kocakoc E,Ozgocmen S,Kiris A,Ozcakar L,Boztosun Y,Yildirim N

    更新日期:2003-12-01 00:00:00

  • [Insufficiency fractures of the ileum and sacrum].

    abstract::Insufficiency fractures are fractures in bones with nontumorous disease (e.g., osteoporosis, rheumatoid arthritis or following radiation) at normal load. Two cases of insufficiency fracture of the ilium and sacrum are presented. Predisposing factors, clinical picture, imaging procedure and therapy are outlined. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章


    authors: König A

    更新日期:2000-10-01 00:00:00