[Novel revision of the training regulations for German physicians-Consequences for trainees and trainers in rheumatology].

abstract：:The difference between mofebutazone and phenylbutazone is shown by means of toxicological, pharmacological and pharmacokinetic studies as well as by the protein binding. In spite of a certain chemical similarity both substances differ distinctly. Mofebutazone is approx. 5-6 times less toxic than phenylbutazone but its...

journal_title：Zeitschrift fur Rheumatologie

authors： Loew D,Schuster O,Knoell HE,Graul EH

更新日期：1985-07-01 00:00:00

abstract：:In order to measure therapeutic effects or assess disease course, outcomes measurement parameters are commonly used in patients with rheumatoid arthritis. From the patient's perspective, possibly the most important outcome measurement parameter is quality of life (QoL). QoL may be defined in terms of "health status" a...

journal_title：Zeitschrift fur Rheumatologie

authors： Stamm T

更新日期：2010-05-01 00:00:00

abstract：:Autoimmune hemolysis is a rare complication of systemic rheumatic diseases. We report on a 68-year-old female patient with established, long-standing rheumatoid arthritis, who complained of progressive weakness and worsening of her arthralgia under therapy with leflunomide. Physical and laboratory examination revealed...

journal_title：Zeitschrift fur Rheumatologie

authors： Lehmann P,Hartung W,Ehrenstein B,Schölmerich J,Fleck M

更新日期：2010-08-01 00:00:00

abstract：:Activated monocytes/macrophages secrete monokines, regulatory proteins which are capable of initiating and maintaining immune processes as well as having an effect on other non immunocompetent cells. In rheumatoid arthritis the monokine Interleukin-1 (IL-1) was detected in the synovial fluid. IL-1 activates immunocomp...

journal_title：Zeitschrift fur Rheumatologie

authors： Hermann E,Müller W

更新日期：1985-09-01 00:00:00

abstract：:The sulfhydryl groups are chemically active parts of the protein molecule and participate in many important biochemical and metabolic processes. The present material comprised 132 patients with rheumatoid arthritis, 104 patients with other diseases and 44 controls. The patients with rheumatoid arthritis had decreased ...

journal_title：Zeitschrift fur Rheumatologie

authors： Haataja M,Kalliomäki JL

更新日期：1977-03-01 00:00:00

abstract：:A 74-year-old female patient with rheumatoid arthritis was diagnosed with Pneumocystis jiroveci pneumonia (PcP) following therapy with methotrexate and prednisone. Although bactrim treatment was initiated and PcP was not detected by a control bronchoalveolar lavage, the patient died. The precise cause of death remains...

journal_title：Zeitschrift fur Rheumatologie

authors： Bertisch B,Ruef C

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Leukotrienes and prostaglandines are important mediators of inflammation. While prostaglandine synthesis can be influenced by NSAIDs therapeutical approaches to the 5-lipoxygenase pathway are rare. Resinous extracts of Boswellia serrata (H15, indish incense), known from traditional ayurvedic medicine, decrea...

journal_title：Zeitschrift fur Rheumatologie

authors： Sander O,Herborn G,Rau R

更新日期：1998-02-01 00:00:00

abstract：:Up to now stratified therapy concepts have not played an important role in the treatment of patients with rheumatoid arthritis; however, a high heterogeneity regarding the effectiveness of therapies and occurrence of side effects in patients with the same indications provokes research efforts aiming at identifying and...

journal_title：Zeitschrift fur Rheumatologie

authors： Frank M,Mittendorf T

更新日期：2013-02-01 00:00:00

abstract：:Health services research in rheumatology investigates the healthcare needs, the quality of care and trends in healthcare for patients with musculoskeletal disorders. Using rheumatoid arthritis (RA) as an example, key results of health services research during the last 25 years are summarized. There are currently appro...

journal_title：Zeitschrift fur Rheumatologie

authors： Zink A

更新日期：2014-03-01 00:00:00

abstract：:An attempt is made to compile the pharmacological data on the leading non-steroidal anti-inflammatory drugs. They concern the pharmacodynamics, the pharmacokinetics and the unwanted effects of these compounds. From these data a few suggestions for rational use are made: Ibuprofen and diclofenac present as drugs with s...

journal_title：Zeitschrift fur Rheumatologie

authors： Brune K

更新日期：1987-01-01 00:00:00

abstract：:New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent d...

journal_title：Zeitschrift fur Rheumatologie

authors： Feist E,Burmester GR,Dörner T

更新日期：2003-08-01 00:00:00

abstract：:Patients with rheumatic diseases need a comprehensive and interdisciplinary treatment. In this context patient education takes the part to lead patients to a better self-management. The goals of patient education are the increase of knowledge and introspection, the positive influencing of attitudes and self-efficacy a...

journal_title：Zeitschrift fur Rheumatologie

authors： Ehlebracht-König I

更新日期：2003-01-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) represents the most common clinically relevant form of primary immunodeficiency. This heterogeneous antibody deficiency syndrome is characterized not only by susceptibility to bacterial respiratory tract infections but displays additional signs of immune dysregulation, such as a...

journal_title：Zeitschrift fur Rheumatologie

authors： Warnatz K,Goldacker S

更新日期：2013-09-01 00:00:00

abstract：:A 28-year-old female patient had load-dependent pain of the left knee. MRI showed an osteochondral defect of the medial condyle based on extensive osteonecrosis of the femoral and tibial bone. An association with a prior steroid treatment after cervical injury is most likely. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Steinhagen J,Rüther W

更新日期：2004-06-01 00:00:00

abstract：:Among all laboratory parameters used today in the assessment of activity and progression of rheumatoid arthritis erythrocyte sedimentation rate (ESR) can only be recommended reservedly. ESR is influenced by anemia, reduction of plasma fibrinogen, dysproteinemia and by the concentration of acute phase proteins. Quantif...

journal_title：Zeitschrift fur Rheumatologie

authors： Chlud K

更新日期：1985-01-01 00:00:00

abstract：:Recent Deutsche Gesellschaft für Rheumatologie (DGRh, German Society of Rheumatology) guidelines emphasized the significance of coordinated multidisciplinary care and rehabilitation of patients with inflammatory rheumatic diseases. Nationwide data from the German pension insurance funds showed that inpatient rehabilit...

journal_title：Zeitschrift fur Rheumatologie

authors： Mau W,Beyer W,Ehlebracht-König I,Engel JM,Genth E,Jäckel WH,Lange U,Thiele K

更新日期：2014-03-01 00:00:00

abstract：:Three days after cholecystectomy, seven patients received a single dose of auranofin (5 tablets Ridaura = 4.35 mg gold). At defined time points thereafter the gold content in samples of blood, plasma, urine, bile, and feces was determined by instrumental neutron activation analysis (INAA). Maxima of the mean gold conc...

journal_title：Zeitschrift fur Rheumatologie

authors： Benn HP,Schnier C,Bauer E,Seiler KU,Elhöft H,Löffler H

更新日期：1991-01-01 00:00:00

abstract：:The pressure load is critical for vascular wall alteration. Systolic blood pressure was measured by Doppler sonography in the finger and arm arteries of 24 patients with rheumatoid arthritis and compared to a control group (n = 22) of nearly the same age. The transmitter frequency of the ultrasound probe was 9.6 MHz. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Beste KW

更新日期：1985-05-01 00:00:00

abstract：:Light microscopic examination of histological sections of synovial membrane from patients with rheumatoid arthritis revealed that prolonged administration of corticosteroids had an inhibiting effect on the participation of lymphocytes and histiocytes in inflammatory infiltrates, as well as on the hypertrophy of synovi...

journal_title：Zeitschrift fur Rheumatologie

authors： Soren A,Cooper NS,Rosenberger JL,Waugh TR

更新日期：1983-05-01 00:00:00

abstract：:30 patients with hepatitis, 50 patients with gynecological diseases, and 100 with urological diseases were investigated with regards to lumbago to find out whether there is a correlation between the internal disease and the signs of low back pain. The patients were compared with a control group of 33 healthy people. T...

journal_title：Zeitschrift fur Rheumatologie

authors： Tilscher H,Bogner G,Landsiedl F

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting a broad range of different organ systems and, hence, presenting with multiple symptomatic domains, which considerably reduces the quality of life of patients. Within the last decade the prognosis of the disease has been...

journal_title：Zeitschrift fur Rheumatologie

authors： Schneider M,Haupt M

更新日期：2015-09-01 00:00:00

abstract：:An appropriate treatment of elderly rheumatic patients implements comprehensive diagnostics and exclusion diagnostics of e.g. coronary heart disease, osteoporosis, renal failure, diabetes mellitus type 2 and thyroid gland dysfunction. Furthermore, the complex disease situation might require the integration of other fa...

journal_title：Zeitschrift fur Rheumatologie

authors： Lakomek HJ,Brabant T,Lakomek M,Lüttje D

更新日期：2013-08-01 00:00:00

abstract：:Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium size arteries that may affect various organs. The clinical appearance is very variable. The most common manifestations are of the skin, the peripheral nervous system presenting as mononeuritis multiplex and the mesenteric and renal blood vessels due to t...

journal_title：Zeitschrift fur Rheumatologie

authors： Schirmer JH,Holl-Ulrich K,Moosig F

更新日期：2014-12-01 00:00:00

abstract：AIM:To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS:CIA rat models were immunized with bovine type II collagen. Serum IL-6 levels in normal and C...

journal_title：Zeitschrift fur Rheumatologie

authors： Wang X,Yan X,Wang F,Ge F,Li Z

更新日期：2018-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease of still unknown etiology that results in characteristic destructive changes of the joints. Research of the past years has demonstrated that synovial fibroblasts play a central role in the initiation and perpetuation of these destructive changes. Stimulation of...

journal_title：Zeitschrift fur Rheumatologie

authors： Korb A,Peters M,Meinecke I,Pap T

更新日期：2007-07-01 00:00:00

abstract：:In general, the risk of serious infections increases with age, mainly explained by immunosenescence and accumulation of comorbidities. Those patients with rheumatoid arthritis who are of advanced age and require treatment with immunosuppressive agents are at particular risk to develop an infectious disease. Actual req...

journal_title：Zeitschrift fur Rheumatologie

authors： Kneitz C,Strangfeld A,Krüger K

更新日期：2014-04-01 00:00:00

abstract：:In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclid...

journal_title：Zeitschrift fur Rheumatologie

authors： Klett R,Puille M,Matter HP,Steiner D,Stürz H,Bauer R

更新日期：1999-08-01 00:00:00

abstract：:The revised S2 guidelines for treatment of giant cell arteritis have recently been published. Glucocorticosteroids remain the standard first line treatment. For severe or relapsing courses of the disease, the IL‑6 antagonist tocilizumab, a potent antibody, is now available as a therapeutic option; however, how long th...

journal_title：Zeitschrift fur Rheumatologie

authors： Henes J

更新日期：2020-12-22 00:00:00

abstract：:Following the EULAR recommendations published in 2010 German guidelines for the medical treatment of rheumatoid arthritis were developed based on an update of the systematic literature search and expert consensus. Methotrexate is the standard treatment option at the time of diagnosis, preferably in combination with lo...

journal_title：Zeitschrift fur Rheumatologie

authors： Krüger K,Wollenhaupt J,Albrecht K,Alten R,Backhaus M,Baerwald C,Bolten W,Braun J,Burkhardt H,Burmester G,Gaubitz M,Gause A,Gromnica-Ihle E,Kellner H,Kuipers J,Krause A,Lorenz HM,Manger B,Nüßlein H,Pott HG,Rubbert-

更新日期：2012-09-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is a mainstay in musculoskeletal imaging. The term"bone marrow edema" is frequently used for describing the radiological findings, especially with respect to rheumatic diseases. The referring physician should be aware that this term has a purely descriptive character and the pathophysi...

journal_title：Zeitschrift fur Rheumatologie

authors： Hamer OW,Kriegsmann J

更新日期：2012-01-01 00:00:00