[Ocular sarcoidosis].

Abstract:

:Ocular manifestation of sarcoidosis occurs in up to 60% of patients with confirmed systemic sarcoidosis and represents one of the most common forms of noninfectious uveitis. In known pulmonary sarcoidosis, ocular involvement can occur in up to 80% of cases. Sarcoidosis can also present only in the eye, without a systemic manifestation (ocular sarcoidosis). Typically, ocular sarcoidosis shows bilateral granulomatous uveitis and can involve all parts of the eye. Apart from an acute anterior uveitis, chronic intermediate or posterior uveitis can be found. In order to prevent a severe reduction of visual acuity leading to blindness, early diagnosis and treatment is essential. For diagnosis, specific clinical signs involving the eye (bilateral granulomatous changes in all parts of the eye) and typical laboratory investigations (angiotensin-converting enzyme, ACE; lysozyme; soluble interleukin 2 receptor, sIL2R; chest X‑ray; chest CT) have to be taken into account, since biopsy to prove noncaseating granulomas is not performed with changes restricted to the eye due to the high risk of vision loss. Ocular sarcoidosis mostly responds well to local or systemic steroid treatment. If the therapeutic effect is insufficient, immunosuppressive agents and biologics can be applied.

journal_name

Z Rheumatol

authors

Springer-Wanner C,Brauns T

doi

10.1007/s00393-017-0303-7

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

391-397

issue

5

eissn

0340-1855

issn

1435-1250

pii

10.1007/s00393-017-0303-7

journal_volume

76

pub_type

杂志文章,评审
  • [Off-label therapy from the perspective of the medical insurance service].

    abstract::The assessment of off-label medications is one of the most common reasons for assessment of drugs for individual patients in the German medical services. Tension is not uncommon because of great expectations of patients and doctors on the one hand and the requirements of the law on the other. They often do not match. ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-011-0900-9

    authors: Grell L,Rieger M

    更新日期:2012-02-01 00:00:00

  • Prolactin levels and autoantibodies in female patients with systemic lupus erythematosus.

    abstract::We investigated the relationships between prolactin (PRL) levels and antibody occurrence in systemic lupus erythematosus (SLE). No significant association between PRL levels and the majority of the autoantibodies studied (anti-U1 RNP, anti-rRNP, anti-Sm, anti-dsDNA, anti-DNP, auto-LCA, anti-EACA) could be confirmed (P...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s003930070024

    authors: Kozáková D,Rovenský J,Cebecauer L,Bosák V,Jahnová E,Vigas M

    更新日期:2000-01-01 00:00:00

  • [Novel autoantibodies for the diagnosis of rheumatoid arthritis].

    abstract::The diagnosis of rheumatoid arthritis has been hampered by the lack of a truly disease-specific serologic marker. Thus, despite its moderate specificity rheumatoid factor (RF) is still the only established marker antibody for RA and among the diagnostic criteria of the American College of Rheumatology the only serolog...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-002-0470-y

    authors: Steiner G,Smolen JS

    更新日期:2002-12-01 00:00:00

  • [Interstitial nephritis in rheumatic diseases].

    abstract::Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-014-1482-0

    authors: Korsten P,Müller GA

    更新日期:2015-05-01 00:00:00

  • [Why rheumatoid arthritis needs cardiologists].

    abstract::Rheumatoid arthritis (RA) is associated with a shortened life expectancy. Most premature deaths are caused by cardiovascular (CV) events; therefore it is of importance to consider the increased CV risk when treating RA patients. Traditional CV risk factors cannot fully explain the increased risk but the common underst...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-013-1198-6

    authors: Pieringer H,Hoppe UC

    更新日期:2013-05-01 00:00:00

  • [Interactions of oral anti-diabetic agents and non-steroid anti-rheumatic agents].

    abstract::Due to the relative increase of age-diabetes and to the different forms of rheumatic diseases, long-term medicament therapy and the question of possible interactions between oral antidiabetic drugs ( OAD ) and nonsteroidal anti-inflammatory drugs (NSAID) become more important. Unfortunately there exist studies on most...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Knüsel O

    更新日期:1984-03-01 00:00:00

  • [Health economic aspects of a stratified medicine for rheumatoid arthritis].

    abstract::Up to now stratified therapy concepts have not played an important role in the treatment of patients with rheumatoid arthritis; however, a high heterogeneity regarding the effectiveness of therapies and occurrence of side effects in patients with the same indications provokes research efforts aiming at identifying and...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-011-0883-6

    authors: Frank M,Mittendorf T

    更新日期:2013-02-01 00:00:00

  • [Pharmacokinetic studies following 2 and 4-week Felbinac gel administration to the knee joint].

    abstract::Twelve patients with osteoarthrosis were locally treated with Felbinac Gel (biphenyl acetic acid (BPAA) 3%) three times daily for 14 days (five patients), 28 days (six patients) or 42 days (one patient) before elective knee joint surgery. BPAA plasma concentrations as of the seventh day of treatment were steady at bet...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Bolten W,Waldorf-Bolten E,Sarfert D,Lehmann W,Miehlke W

    更新日期:1990-11-01 00:00:00

  • [History of the German Society of Rheumatology 1947-2007].

    abstract::The "German Society of Rheumatology" was founded in Bad Neuenahr in the Federal Republic of Germany In 1947. The society perceived itself as the successor to the "German Society for the Abatement of Rheumatism". The primary aim of the society was close cooperation with other German-speaking rheumatological societies i...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 历史文章,杂志文章

    doi:10.1007/s00393-010-0674-5

    authors: Hewelt T

    更新日期:2011-01-01 00:00:00

  • [Stage oriented surgical cartilage therapy. Current situation].

    abstract::Chondral or osteochondral lesions are typical injuries in orthopaedics and traumatology. Since there is no regeneration of damaged articular cartilage, these lesions can lead to premature osteoarthritis. Therefore, an adequate therapy for these injuries is an important goal. Nowadays, common methods in cartilage thera...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-007-0213-1

    authors: Vogt S,Braun S,Imhoff AB

    更新日期:2007-10-01 00:00:00

  • [Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score].

    abstract::The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synoviti...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-017-0308-2

    authors: Krenn V,Perino G,Rüther W,Krenn VT,Huber M,Hügle T,Najm A,Müller S,Boettner F,Pessler F,Waldstein W,Kriegsmann J,Häupl T,Wienert S,Krukemeyer MG,Sesselmann S,Tikhilov R,Morawietz L

    更新日期:2017-08-01 00:00:00

  • [Evidence-based medicine and therapeutic ultrasound of the musculoskeletal system].

    abstract::The aim of this review is to critically analyze the evidence of therapeutic ultrasound between 0.8 and 3 MHz for treating musculoskeletal diseases. Relevant randomized, controlled, clinical trials and systematic reviews published on this topic have been taken into consideration.There was evidence of effectiveness for ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-009-0457-z

    authors: Ebenbichler G

    更新日期:2009-09-01 00:00:00

  • [Oxaprozin versus diclofenac retard in treated of activated arthrosis].

    abstract:AIM:The present study should elucidate the efficacy, patient acceptability, and side effect profiles of Oxaprozin and Diclofenac retard when given to patients with active primary osteoarthrosis. METHODS:80 outpatients with active primary osteoarthrosis with a radiological grade of II or III in the hip or knee joint (m...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s003930050068

    authors: Karbowski A,Schwitalle M,Eckardt A

    更新日期:1998-04-01 00:00:00

  • [Low back pain in rheumatoid arthritis].

    abstract::Low back pain (LBP) in patients with rheumatoid arthritis (RA) has so far been of little concern in clinical investigations. The main focus of scientific publications on spinal problems in RA was the cervical spine. In a recent study, we could demonstrate that LBP in RA patients leads to a significantly higher degree ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-017-0363-8

    authors: Kothe R

    更新日期:2017-12-01 00:00:00

  • [ECG changes in chronic polyarthritis compared to a healthy control group].

    abstract::ECG from 200 patients with radiologically and clinically definite rheumatoid arthritis were compared with those from a healthy group with the same age and sex distribution. The frequency of pathological changes of the ECG was found to be the same in both groups. Therefore doubt remains whether the pathological changes...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Droste U,Zimmermann H

    更新日期:1979-07-01 00:00:00

  • [Initial results of the clinical use of the immunostimulant bestatin (3-amino-2-hydroxy-4-phenylbutyryl leucine) in patients with chronic polyarthritis].

    abstract::We tested the efficacy of the immunomodulator Bestatin, which has been successfully applied in Japan, in a preliminary open study in ten patients with classical or definite rheumatoid arthritis. Patients whose arthritis was characterized by a low humoral activity showed a partial remission of the disease after six mon...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Meske S,Vogt P,Maly FE,Seitz M,Müller W

    更新日期:1985-09-01 00:00:00

  • [Methotrexate toxicity. Myths and facts].

    abstract::Methotrexate (MTX) is a safe and well-tolerated drug for the treatment of rheumatic diseases, even if the strictest safety standards are considered. Initial apprehension as to severe pulmonary or hepatic side-effects has not been confirmed. The risk of infection is not elevated compared with other disease-modifying an...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-010-0687-0

    authors: Keysser G

    更新日期:2011-02-01 00:00:00

  • [Inflammation-related cardiovascular morbidity : Pathophysiology and therapy].

    abstract::Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased mortality, largely as a consequence of cardiovascular (CV) disease. Studies found relative risk ratios of 2 for myocardial infarction in RA and up to 7 for myocardial infarction in SLE patients.Beyond the traditional CV risk...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-009-0585-5

    authors: Fischer-Betz R,Halle M,Schneider M

    更新日期:2010-10-01 00:00:00

  • [Chronic widespread pain and tender points in low back pain: a population-based study].

    abstract:BACKGROUND:Clinical observation suggests a frequent coincidence of back pain (BP) and fibromyalgia (FMA). Based on data from a population survey on back pain we studied the hypothesis of FMA being a frequent underlying condition of BP. We additionally studied the association of the severity of back pain and both chroni...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-004-0531-5

    authors: Hüppe A,Brockow T,Raspe H

    更新日期:2004-02-01 00:00:00

  • [Imaging procedures in rheumatology: imaging in vasculitis].

    abstract::In small vessel vasculitides, imaging studies aid in determining disease extent and activity, localization for biopsy, and for disease monitoring. They do not directly delineate the vasculitic lesion. Imaging studies focus on the upper and lower respiratory tract. Cranial magnetic resonance imaging (MRI) shows upper r...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:10.1007/s00393-006-0107-7

    authors: Schmidt WA,Both M,Reinhold-Keller E

    更新日期:2006-11-01 00:00:00

  • Influence of anti-rheumatic drugs on human lymphocytes in vitro.

    abstract:UNLABELLED:Influence of anti-rheumatic drugs on human lymphocytes, especially T and B cell membranes, was studies with D-penicillamine, aurothiomalate, dexamethasone, cyclophosphamide, mitomycin C and aspirin. METHOD:Peripheral blood obtained from five healthy individuals and lymphocytes were separated by centrifugati...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Yoshino S,Ishiyama I

    更新日期:1977-01-01 00:00:00

  • [Immunoablation followed by autologous stem cell transplantation in lupus: a clinical update].

    abstract::Systemic lupus erythematosus (SLE) is a classic systemic autoimmune disease. Standard treatment consists of chronic therapy with antimalarials, glucocorticoids and immunosuppressive/cytotoxic drugs, which is associated with considerable side effects. In contrast, immunoablation of autoreactive immunologic memory follo...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-008-0391-5

    authors: Alexander T,Arnold R,Hiepe F

    更新日期:2009-05-01 00:00:00

  • [Gold treatment of progressive chronic polyarthritis--a clinical study].

    abstract::In an intraindividual series of investigation consisting of 30 patients with rheumatoid arthritis the effect of gold therapy (Aurothioglucose) has been proved controlling biochemical and clinical parameters. Controls of the function-index by Steinbrocker et al. have shown a significant improvement in comparison with t...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Knoche U,Wagner H,Hauss WH

    更新日期:1975-05-01 00:00:00

  • The synovial changes in rheumatoid arthritis under corticosteroid treatment.

    abstract::Light microscopic examination of histological sections of synovial membrane from patients with rheumatoid arthritis revealed that prolonged administration of corticosteroids had an inhibiting effect on the participation of lymphocytes and histiocytes in inflammatory infiltrates, as well as on the hypertrophy of synovi...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Soren A,Cooper NS,Rosenberger JL,Waugh TR

    更新日期:1983-05-01 00:00:00

  • [Liberation of the oxygen radical from peripheral human phagocytes (granulocytes and monocytes) in patients with chronic polyarthritis].

    abstract::Monocytes from patients with definite or classical rheumatoid arthritis show a significantly higher release of O2-radicals in the chemiluminescence assay (2925 X 10(3) cpm) than those of healthy volunteers (267 X 10(3) cpm) (p = 0.01). This difference does not appear in a similar test with granulocytes, which in both ...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Meske S,Maly FE,Estefan M,Müller W

    更新日期:1985-01-01 00:00:00

  • [Imaging procedures in rheumatology. Differential diagnosis using various imaging procedures in rheumatoid arthritis (RA)].

    abstract::Conventional radiography, ultrasonography (US), magnetic resonance imaging (MRI), computed tomography, and scintigraphy are imaging techniques in use for rheumatoid arthritis (RA). Conventional radiography of the hands and the forefeet should be performed every 6 to 12 months in the first two years, and every 12 to 24...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-005-0720-x

    authors: Kellner H,Schmidt W,Rau R

    更新日期:2005-11-01 00:00:00

  • [Variability of the clinical picture and the classification of progressive systemic scleroderma].

    abstract::Fiftythree patients with progressive systemic sclerosis were studied. Four of them (3 males) had the diffuse form of the disease. The skin manifestation of this clinical picture is characterized by diffuse progression of the cutaneous sclerosis over almost the whole body surface, except for the hands where it eventual...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章

    doi:

    authors: Giordano M,Ara M,Capelli L,Tirri G,Vatti M

    更新日期:1976-07-01 00:00:00

  • [Relevance of big data for molecular diagnostics].

    abstract::Big data analysis raises the expectation that computerized algorithms may extract new knowledge from otherwise unmanageable vast data sets. What are the algorithms behind the big data discussion? In principle, high throughput technologies in molecular research already introduced big data and the development and applic...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-018-0436-3

    authors: Bonin-Andresen M,Smiljanovic B,Stuhlmüller B,Sörensen T,Grützkau A,Häupl T

    更新日期:2018-04-01 00:00:00

  • [Paradigm shift in ANCA diagnostics : New international consensus recommendations].

    abstract:BACKGROUND:Up to now indirect immunofluorescence (IIF) followed by an antigen-specific assay specific for proteinase 3 (PR3) or myeloperoxidase (MPO) has been the standard method for the detection of antineutrophil cytoplasmic antibodies (ANCA). The development of more sensitive and highly specific PR3-ANCA and MPO-ANC...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-016-0240-x

    authors: Csernok E,Kempiners N,Hellmich B

    更新日期:2017-03-01 00:00:00

  • [Magnetic resonance tomography and hybrid imaging in rheumatology].

    abstract::In rheumatologic diseases magnet resonance imaging (MRI) is capable of depicting early inflammatory changes which are frequently missed by other imaging modalities. New MRI protocols and hardware, primarily whole-body MRI and low-field extremity MRI facilitate the use of MRI in rheumatology patients. The increasing nu...

    journal_title:Zeitschrift fur Rheumatologie

    pub_type: 杂志文章,评审

    doi:10.1007/s00393-012-1068-7

    authors: Buchbender C,Schneider M,Ostendorf B

    更新日期:2013-03-01 00:00:00