abstract：INTRODUCTION:This trial was conducted to assess the long-term safety, efficacy, and benefit of early add-on of linagliptin to insulin in patients with type 2 diabetes mellitus (T2DM). METHODS:This trial enrolled 246 subjects. The subjects were randomized to the linagliptin group or the control group and were observed ...

journal_title：Advances in therapy

authors： Katsuno T,Shiraiwa T,Iwasaki S,Park H,Watanabe N,Kaneko S,Terasaki J,Hanafusa T,Imagawa A,Shimomura I,Ikegami H,Koyama H,Namba M,Miyagawa JI,TRUST2 study group.

更新日期：2021-01-28 00:00:00

abstract：INTRODUCTION:Phase IV post-marketing surveillance studies are needed to evaluate the real-world safety and effectiveness of drug products. This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (...

journal_title：Advances in therapy

authors： Gharibdoost F,Salari AH,Salesi M,Ebrahimi Chaharom F,Mottaghi P,Hosseini M,Sahebari M,Nazarinia M,Mirfeizi Z,Shakibi M,Moussavi H,Karimifar M,Mowla K,Karimzadeh H,Anjidani N,Jamshidi A

更新日期：2021-01-11 00:00:00

abstract：:Some patients with interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis exhibit a progressive clinical phenotype. These chronic progressive fibrosing ILDs have a variety of underlying diseases, and their prevalence is currently unknown. Here we carry out the first systematic review of literature ...

journal_title：Advances in therapy

authors： Olson A,Hartmann N,Patnaik P,Wallace L,Schlenker-Herceg R,Nasser M,Richeldi L,Hoffmann-Vold AM,Cottin V

更新日期：2020-12-14 00:00:00

abstract：INTRODUCTION:Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic changes; however, the metabolic side effects produced by aripiprazole are more benign. The aim of the study was to evaluate if aripiprazole and olanzapine alter prolactin levels, lipid and glucose metabolism and hepati...

journal_title：Advances in therapy

authors： Koller D,Almenara S,Mejía G,Saiz-Rodríguez M,Zubiaur P,Román M,Ochoa D,Navares-Gómez M,Santos-Molina E,Pintos-Sánchez E,Abad-Santos F

更新日期：2020-12-05 00:00:00

abstract：INTRODUCTION:Partial nephrectomy (PN) has evolved into the surgical standard of care for localized renal lesions. Hemostatic agents (HA) support the surgeon in achieving local hemostasis during PN. We previously reported initial results with the HA Hemopatch® in PN. We now report our experiences with Hemopatch® in a la...

journal_title：Advances in therapy

authors： Hupe MC,Büttner M,Tabrizi PF,Merseburger AS,Kuczyk MA,Imkamp F

更新日期：2020-12-04 00:00:00

abstract：:Low- and middle-income countries (LMICs) are challenged with a disproportionately high burden of noncommunicable diseases (NCDs) and limited healthcare resources at their disposal to tackle the NCD epidemic. Understanding the patient journey for NCDs from the patients' perspective can help healthcare systems in these ...

journal_title：Advances in therapy

authors： Devi R,Kanitkar K,Narendhar R,Sehmi K,Subramaniam K

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Increasing dialysate magnesium (D-Mg2+) appears to be an intriguing strategy to obtain cardiovascular benefits in subjects with end-stage kidney disease (ESKD) on hemodialysis. To date, however, hemodialysis guidelines do not suggest to increase D-Mg2+ routinely set at 0.50 mmol/L. METHODS:A randomized 4-...

journal_title：Advances in therapy

authors： Del Giorno R,Lavorato Hadjeres S,Stefanelli K,Allegra G,Zapparoli C,Predrag L,Berwert L,Gabutti L

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) approved to date are administered by injection; therefore, patient perceptions of an oral GLP-1 RA are unknown. This discrete choice experiment explored preferences for (unbranded) oral and injectable GLP-1 RA profiles among Japanese patients with typ...

journal_title：Advances in therapy

authors： Igarashi A,Bekker Hansen B,Langer J,Tavella F,Collings H,Davies N,Wyn R

更新日期：2020-11-27 00:00:00

abstract：:Alpha-mannosidosis is a rare lysosomal storage disorder that generally presents in early childhood. It is a progressive, highly heterogeneous disease that is difficult to recognize, and a diagnosis is usually reached after referrals to multiple specialists. It is important to understand the challenges faced by patient...

journal_title：Advances in therapy

authors： Verrecchia E,Sicignano LL,Massaro MG,Rocco R,Silvestri G,Rossi S,Manna R

更新日期：2020-11-24 00:00:00

abstract：:Endocrine therapy (ET) is integral to the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC). Aromatase inhibitors (AIs; e.g., anastrozole, letrozole, exemestane), selective estrogen receptor modulators (e.g., tamoxifen), and the selec...

journal_title：Advances in therapy

authors： Nagaraj G,Ma CX

更新日期：2020-11-15 00:00:00

abstract：INTRODUCTION:Benefit and risk of anticoagulation in cirrhotic patients with portal vein thrombosis (PVT) remain controversial, especially in those with asymptomatic PVT and in non-liver transplant candidates. Furthermore, the predictors of portal vein recanalization and bleeding events after anticoagulation are critica...

journal_title：Advances in therapy

authors： Wang L,Guo X,Xu X,De Stefano V,Plessier A,Noronha Ferreira C,Qi X

更新日期：2020-11-05 00:00:00

abstract：INTRODUCTION:Our objective was to determine the effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in a broad range of patient profiles, including subgroups with varying hypertension severity, age and cardiovascular risk profiles. METHODS:Patient data from four large prospective observat...

journal_title：Advances in therapy

authors： Dézsi CA,Glezer M,Karpov Y,Brzozowska-Villatte R,Farsang C

更新日期：2020-11-05 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of premature deaths globally and in Ukraine. Dyslipidemia is a recognized risk factor for the development of CVD. Therefore, early detection and appropriate management of dyslipidemia are essential for the primary prevention of CVDs. However, currently, there is a l...

journal_title：Advances in therapy

authors： Dolzhenko MM,Barnett OY,Grassos C,Dragomiretska NV,Goloborodko BI,Ilashchuk TO,Zuiev KO,Karpenko OV,Kolesnikova OV,Kolesnyk TV,Talaieva TV,Vakaliuk IP,Tiabut TD,Mesnikova IL,Zinych OV

更新日期：2020-11-01 00:00:00

abstract：:In the original article, under the "Access to treatment" heading. ...

journal_title：Advances in therapy

authors： Rezk MF,Pieper B

更新日期：2020-11-01 00:00:00

abstract：:With the increasing availability of biosimilars, the practice of switching therapies for non-medical reasons between an originator biologic and an analogous biosimilar has become more common. The evidence to support this practice mostly comes from single-switch randomized controlled trials (RCTs) and real-world (RW) e...

journal_title：Advances in therapy

authors： Feagan BG,Marabani M,Wu JJ,Faccin F,Spronk C,Castañeda-Hernández G

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:In FRESCO (Fruquintinib Efficacy and Safety in 3+ Line Colorectal Cancer Patients) trial, fruquintinib demonstrated a statistically significant and clinically meaningful overall survival benefit in Chinese patients with metastatic colorectal cancer (mCRC). However, its safety profile, including adverse eve...

journal_title：Advances in therapy

authors： Li J,Guo W,Bai Y,Deng Y,Yang L,Chen Z,Zhong H,Xu R,Pan H,Shu Y,Yuan Y,Zhou J,Xu N,Liu T,Ma D,Wu C,Cheng Y,Xu J,Chen D,Li W,Sun S,Yu Z,Cao P,Shen L,Chen H,Wang S,Wang H,Fan S,Guo X,Wang N,Han R

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Clinical guidelines recommend levothyroxine as the standard of care for hypothyroidism and that patients should be treated with a consistent preparation of synthetic levothyroxine without switching among formulations. This study examines the likelihoods of negative clinical outcomes between continuous user...

journal_title：Advances in therapy

authors： Hennessey JV,Espaillat R,Duan Y,Soni-Brahmbhatt S,Lage MJ,Singer P

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a serious health concern. Repurposing of existing drugs indicated for other conditions seems to be the first choice for immediate therapeutic management. The quality of early evidence favoring the different treatment options needs t...

journal_title：Advances in therapy

authors： Subramanian K,Nalli A,Senthil V,Jain S,Nayak A,Bhat A

更新日期：2020-10-01 00:00:00

abstract：:The extensive use of angiotensin-converting enzyme inhibitors (ACEIs) as antihypertensive agents and the huge amount of data collected in clinical trials and post-marketing studies has allowed the extending of the indication of ACEIs beyond blood pressure control. Current guidelines recommend ACEIs in symptomatic pati...

journal_title：Advances in therapy

authors： Borghi C,Omboni S

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:This study aimed to compare the challenge of puncture and catheterization and the effect of postoperative analgesia of ultrasound-guided continuous thoracic paravertebral block and the continuous epidural analgesia in patients receiving thoracoscopic surgery for lung cancer. METHODS:One-hundred and fifty ...

journal_title：Advances in therapy

authors： Huang QW,Li JB,Huang Y,Zhang WQ,Lu ZW

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:To evaluate, from the patient's perspective, the burden of pain associated with hip/knee osteoarthritis (OA) in the USA and selected European Union (EU) countries. METHODS:Data were drawn from the 2017 global Adelphi OA Disease Specific Programme™ (DSP). Patients with hip/knee OA were stratified based on ...

journal_title：Advances in therapy

authors： Jackson J,Iyer R,Mellor J,Wei W

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Transient hepatic attenuation differences (THAD) are areas of high parenchymal enhancement observed during the hepatic arterial phase on computed tomography (CT). THAD in the left lobe of the liver can lead to surgical complications. METHODS:A retrospective study was conducted on patients who underwent mu...

journal_title：Advances in therapy

authors： Yang B,Si G,He Q,Liu S,Wang S,Xian R,Zhang J,Yu F,Guan J

更新日期：2020-09-01 00:00:00

abstract：:Shock is a serious acute circulatory failure leading to inadequate oxygen delivery to the cells. Its treatment is mainly based on circulating fluid optimization, and vasopressors to provide an adequate mean arterial pressure and microcirculatory flow. Norepinephrine is the drug of choice, but high dosages may be respo...

journal_title：Advances in therapy

authors： Puntillo F,Giglio M,Pasqualucci A,Brienza N,Paladini A,Varrassi G

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Randomized controlled trials and real-world data from the USA have shown similar glycemic control with insulin glargine 300 U/ml (Gla-300) and insulin glargine 100 U/ml (Gla-100) and reduced hypoglycemia risk with Gla-300. This real-world study describes the efficacy and safety of Gla-300 and Gla-100 in pa...

journal_title：Advances in therapy

authors： Escalada J,Bonnet F,Wu J,Bonnemaire M,Gupta S,Cambron-Mellott JM,Nicholls C,Müller-Wieland D

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Previous studies showed the relation of mental distress such as anxiety and depression to coronary vasoconstriction and myocardial ischemia. However, the mental health status of patients suspected to have vasospastic angina is unclear. METHODS:A total of 99 patients underwent intracoronary acetylcholine (AC...

journal_title：Advances in therapy

authors： Saito Y,Shoji T,Tateishi K,Kitahara H,Fujimoto Y,Kobayashi Y

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Subsequent lines of subcutaneous tumor necrosis factor alpha inhibitor (SC-TNFi) treatment may be well motivated in the management of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)-collectively named inflammatory arthritis (IA). However, the costs associated with swit...

journal_title：Advances in therapy

authors： Dalén J,Luttropp K,Svedbom A,Black CM,Kachroo S

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:To date, no study has reported the prevalence of cannabis use in chronic pain patients. The aim of this study is to investigate the trends in cannabis use among chronic pain in-patients from 2011 to 2015 in the USA. METHODS:Patients were identified from the National Inpatient Sample (NIS) database using t...

journal_title：Advances in therapy

authors： Orhurhu V,Urits I,Olusunmade M,Olayinka A,Salisu Orhurhu M,Uwandu C,Aner M,Ogunsola S,Akpala L,Hirji S,Viswanath O,Karri J,Simopoulos T,Gill J

更新日期：2020-08-01 00:00:00

abstract：:Knee osteoarthritis (KOA) is the most common musculoskeletal disorder, especially in middle up to old age. KOA also results in many complications like changes in gait. Nowadays, changes in lifestyle and the reduced physical activity make people more vulnerable to KOA. Therefore, considering the increasing prevalence o...

journal_title：Advances in therapy

authors： Ganjeh S,Rezaeian ZS,Mostamand J

更新日期：2020-08-01 00:00:00

abstract：:In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina. ...

journal_title：Advances in therapy

authors： Oddone F,Tanga L,Kóthy P,Holló G,VISIONARY Study Group.

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:The aim of this analysis was to characterize the safety and tolerability of empagliflozin in patients with type 2 diabetes mellitus (T2DM) who were randomized to empagliflozin (10/25 mg) or placebo in clinical trials. METHODS:Pooled data from 20 trials were analyzed for patients with T2DM treated with emp...

journal_title：Advances in therapy

authors： Kinduryte Schorling O,Clark D,Zwiener I,Kaspers S,Lee J,Iliev H

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:The primary analysis of a global phase 3 study that evaluated the efficacy and safety of denosumab versus zoledronic acid for preventing skeletal-related events (SREs) in adults with newly diagnosed multiple myeloma (MM) indicated that denosumab was noninferior to zoledronic acid for time to first on-study...

journal_title：Advances in therapy

authors： Huang SY,Yoon SS,Shimizu K,Chng WJ,Chang CS,Wong RS,Gao S,Wang Y,Gordon SW,Glennane A,Min CK

更新日期：2020-07-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which can induce multisystem disease. Human angiotensin-converting enzyme 2 (ACE2) widely expressing in arterial and venous endothelial cells and arterial smooth muscle cells has been identified as a functional rec...

journal_title：Advances in therapy

authors： Wang J,Saguner AM,An J,Ning Y,Yan Y,Li G

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:The anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) alectinib was approved in Japan in 2014 for the treatment of ALK fusion gene-positive advanced non-small cell lung cancer (NSCLC). With the approvals of crizotinib in 2012 and ceritinib in 2017, Japan became the first country with multipl...

journal_title：Advances in therapy

authors： Goto Y,Yamamoto N,Masters ET,Kikkawa H,Mardekian J,Wiltshire R,Togo K,Ohe Y

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is the classic progressive fibrosing interstitial lung disease (ILD), but some patients with ILDs other than IPF also develop a progressive fibrosing phenotype (PF-ILD). Information on use and cost of healthcare resources in patients with PF-ILD is limited. METHODS:We u...

journal_title：Advances in therapy

authors： Olson AL,Maher TM,Acciai V,Mounir B,Quaresma M,Zouad-Lejour L,Wells CD,De Loureiro L

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To evaluate the impact on cost, time, resource use, and clinic workflow of converting the route of drug administration from a neurokinin-1 receptor antagonist (NK-1 RA) 30-min intravenous (IV) infusion to aprepitant IV, and more specifically to IV push, within a multicenter community oncology practice. METHODS...

journal_title：Advances in therapy

authors： Burns D,Kula J,Marshall S,Ashworth E,Ornelas M

更新日期：2020-07-01 00:00:00

abstract：:Resistance to first- and second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and development and progression of central nervous system metastases remain significant issues in the treatment of ALK-positive non-small-cell lung cancer. Lorlatinib is a novel third-generation ALK TKI that i...

journal_title：Advances in therapy

authors： Reed M,Rosales AS,Chioda MD,Parker L,Devgan G,Kettle J

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Pigmented villonodular synovitis (PVNS), also known as giant-cell tumour of the tendon sheath (GCTT), is a rare, benign proliferative tumour affecting the inner lining of synovial joints and tendon sheets. Information on treatment needs of PVNS patients to inform drug development is currently scarce. We co...

journal_title：Advances in therapy

authors： Cook NS,Landskroner K,Shah B,Walda S,Weiss O,Pallapotu V

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...

journal_title：Advances in therapy

authors： Kiltz U,Sfikakis PP,Gaffney K,Sator PG,von Kiedrowski R,Bounas A,Gullick N,Conrad C,Rigopoulos D,Lespessailles E,Romanelli M,Ghislain PD,Brandt-Jürgens J,Rashkov R,Aassi M,Orsenigo R,Perella C,Pournara E,Gathmann S,

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Asthma is associated with significant economic burden. Inhaled corticosteroid and long-acting beta2-agonist (ICS/LABA) combination therapies are considered mainstays of treatment. We describe real-world use of ICS/LABAs by comparing treatment persistence and adherence among patients with asthma in the Unit...

journal_title：Advances in therapy

authors： Parimi M,Svedsater H,Ann Q,Gokhale M,Gray CM,Hinds D,Nixon M,Boxall N

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:This study characterized the multidose pharmacokinetic (PK) characteristics of posaconazole tablets used as prophylactic antifungal therapy in Chinese patients with acute myelogenous leukemia (AML) at risk for invasive fungal infection (IFI). METHODS:Participants in this open-label, single-arm, phase 1b s...

journal_title：Advances in therapy

authors： Liu K,Wu D,Li J,Chen H,Ning H,Zhao T,Dai H,Chen L,Mangin E,Winchell GA,Waskin H,Jiang J,Qiu Y,Zhao XM

更新日期：2020-05-01 00:00:00