Abstract：
:The extensive use of angiotensin-converting enzyme inhibitors (ACEIs) as antihypertensive agents and the huge amount of data collected in clinical trials and post-marketing studies has allowed the extending of the indication of ACEIs beyond blood pressure control. Current guidelines recommend ACEIs in symptomatic patients with heart failure with reduced ejection fraction to decrease the risk of heart failure hospitalization, and also in patients after acute myocardial infarction (AMI) with ST-elevation with or without post-AMI ventricular dysfunction. Analyzing the association between the choice of an ACEI after AMI with the risk of mortality and re-infarction, a class effect, rather than the superiority of some agents, has been described. The focus of this review is centered on the role of ACEIs in addition to and beyond blood pressure control. It summarizes clinical evidence on the use of these agents in cardiovascular diseases, with a specific interest in the experience with zofenopril, which presents a peculiar pharmacological profile that may contribute to additional clinical benefits in some identifiable populations of patients. Indeed, the presence of a sulfhydryl group in its structure confers on zofenopril high anti-oxidant and anti-ischemic properties involving the activation of the H2S system, resulting in a cardioprotective effect. The efficacy and safety of zofenopril have been extensively evaluated and proved in the Survival of Myocardial Infarction Long-Term Evaluation (SMILE) program in numerous clinical settings. The pharmacological features and ancillary characteristics of zofenopril with potent cardioprotective effects seem to differentiate it from other ACEIs and to confer further benefits to patients.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Borghi C,Omboni Sdoi
10.1007/s12325-020-01455-2subject
Has Abstractpub_date
2020-10-01 00:00:00pages
4068-4085issue
10eissn
0741-238Xissn
1865-8652pii
10.1007/s12325-020-01455-2journal_volume
37pub_type
杂志文章,评审abstract：:Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell c...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01287-0
更新日期：2020-04-01 00:00:00
abstract：:Despite the results from clinical trials in patients with hypertension and the development of a long list of guidelines for the management of hypertension, many physicians and other healthcare professionals still manage hypertension using approaches that clearly diverge at least partially from the recommendations of t...
journal_title：Advances in therapy
pub_type： 共识发展会议,杂志文章,评审
doi：10.1007/BF02849881
更新日期：2005-03-01 00:00:00
abstract：:In this 2-week, randomized, crossover study, ophthalmic solutions of nedocromil sodium 2% and olopatadine hydrochloride 0.1% were compared for effectiveness and acceptability in 28 patients with perennial allergic conjunctivitis and previous olopatadine experience. Patients received nedocromil twice daily or olopatadi...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02853155
更新日期：2000-05-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to evaluate the clinical outcomes of patients with anterior segment neovascularization treated with or without intravitreal bevacizumab. METHODS:This was a retrospective, comparative case series of 60 patients with anterior segment neovascularization: 30 consecutive patients ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0001-1
更新日期：2009-02-01 00:00:00
abstract：:This study was undertaken to evaluate the ocular hypotensive efficacy of brimonidine Purite 0.15% (Alphagan P 0.15%; Allergan, Inc., Irvine, Calif) given as adjunctive therapy with latanoprost 0.005% (Xalatan; Pfizer Inc., New York, NY( to patients with open-angle glaucoma or ocular hypertension. In this multicenter, ...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02849898
更新日期：2007-03-01 00:00:00
abstract：:In an open, controlled study, 44 patients complaining of vertigo, dizziness, or both, caused by vascular vestibular disorders were randomly treated with extract of Ginkgo biloba (EGb 761) 80 mg twice daily or with betahistine dihydrochloride (BI) 16 mg twice daily for 3 months. A complete neuro-otologic and equilibrim...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：INTRODUCTION:The pharmacokinetics, safety, and tolerability of DS-8500a (a G protein receptor 119 agonist) up to 100 mg have been investigated in healthy Japanese adults. The objective of this study was to evaluate the effects of hepatic or renal impairment on the pharmacokinetics of a single 25-mg oral dose of DS-8500...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0739-4
更新日期：2018-08-01 00:00:00
abstract：:Complicated urinary tract infection (UTI), which often requires hospitalization or prolongs a hospital stay, presents numerous diagnostic and therapeutic challenges. Implementation of effective antimicrobial treatment is vital because of the risk of adverse sequelae due to persistence of infection, relapse, or reinfec...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：:This 6-month randomized study evaluated the safety and efficacy of sibutramine in 57 overweight Hispanic patients with hypertension. Following a 2-week washout to confirm the diagnosis of hypertension, antihypertensive medication was adjusted to achieve a blood pressure less than 140/90 mm Hg before institution of eit...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850257
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:The incidence of inflammatory bowel disease (IBD) in Denmark is among the highest in the world, with Crohn's disease and ulcerative colitis occurring at rates of 9.1 and 18.6 per 100,000 person-years respectively in 2010-2013. Anemia is the most prevalent extraintestinal complication of IBD, most commonly ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0827-5
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. This real-world study evaluated persistence, dose titration, health care resource utilization (HCRU) and associated costs, and medication use among CD patients treated with ustekinumab (UST) in several pooled US commercia...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01276-3
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:Spinal muscular atrophy (SMA) is a neurodegenerative disease of the motor neurons that results in progressive muscle weakness. It is also the leading hereditary cause of infant mortality. Homozygous loss of the survival motor neuron (SMN1) gene causes SMA, and the number of copies of the SMN2 gene modulate...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0030-1
更新日期：2008-03-01 00:00:00
abstract：:In the original article. The third author name is incorrect. The correct name is Nicholas J. Leeper. ...
journal_title：Advances in therapy
pub_type： 已发布勘误
doi：10.1007/s12325-020-01220-5
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:To evaluate, from the patient's perspective, the burden of pain associated with hip/knee osteoarthritis (OA) in the USA and selected European Union (EU) countries. METHODS:Data were drawn from the 2017 global Adelphi OA Disease Specific Programme™ (DSP). Patients with hip/knee OA were stratified based on ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01445-4
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:This study characterized the multidose pharmacokinetic (PK) characteristics of posaconazole tablets used as prophylactic antifungal therapy in Chinese patients with acute myelogenous leukemia (AML) at risk for invasive fungal infection (IFI). METHODS:Participants in this open-label, single-arm, phase 1b s...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-020-01341-x
更新日期：2020-05-01 00:00:00
abstract：:In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients, with favorable toxicity profiles of immunotherapeutic agents relati...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-019-01051-z
更新日期：2019-10-01 00:00:00
abstract：:Cardiovascular diseases (CVDs) are the leading cause of premature deaths globally and in Ukraine. Dyslipidemia is a recognized risk factor for the development of CVD. Therefore, early detection and appropriate management of dyslipidemia are essential for the primary prevention of CVDs. However, currently, there is a l...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01490-z
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS:A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general inf...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-0889-z
更新日期：2019-03-01 00:00:00
abstract：INTRODUCTION:The European Medicines Agency (EMA) requires vaccine manufacturers to conduct enhanced safety surveillance (ESS) of seasonal influenza vaccines including a near real-time evaluation of collected data. The objective was to identify whether the use of passive surveillance or active surveillance provides diff...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0747-4
更新日期：2018-08-01 00:00:00
abstract：INTRODUCTION:Oral supplementation of chondroitin sulfate (CS) and glucosamine (GlcN), symptomatic slow-acting molecules, is recommended by European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and Musculoskeletal Diseases (ESCEO) and other European Union (EU) guidelines for the restorati...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01064-8
更新日期：2019-11-01 00:00:00
abstract：INTRODUCTION:Sevelamer hydrochloride (SH) and lanthanum carbonate (LC) are calcium-free phosphate binders used for the management of hyperphosphatemia in patients with end-stage renal disease (ESRD). The objective of this analysis was to evaluate the real-world dose-relativity between SH and LC monotherapy in US patien...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-013-0077-5
更新日期：2013-12-01 00:00:00
abstract：:X-linked hypophosphataemia (XLH) is the most prevalent form of hereditary rickets characterized by an alteration of phosphate metabolism which frequently leads to the appearance of fractures, bone deformities and growth delay. Although the mechanism of growth impairment in patients with XLH still needs to be clarified...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-019-01178-z
更新日期：2020-05-01 00:00:00
abstract：:Eupatorium laevigatum Lam. is a plant common to the central region of Brazil, where it is a widely used remedy for lesions such as buccal aphthae. These painful inflammatory ulcers affect 50% of the general population. For the first part of this two-part study, a phytotherapeutic preparation from E. laevigatum extract...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850010
更新日期：2000-11-01 00:00:00
abstract：:This multicenter, double-masked, randomized, parallel-group study compared the efficacy and safety of ketorolac tromethamine 0.5% ophthalmic solution with levocabastine 0.05% and ketorolac tromethamine vehicle in patients with seasonal allergic conjunctivitis. One drop of ketorolac, levocabastine, or vehicle was insti...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02854842
更新日期：2000-03-01 00:00:00
abstract：:Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-013-0020-9
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVES:This study set out to examine the efficacy and tolerability of two innovative implant forms of leuprorelin acetate in men with advanced hormone-dependent prostate cancer in everyday clinical practice. METHODS:Data were collected from 818 patients (from 273 centers across Germany) who were pretreated with sl...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0010-y
更新日期：2013-03-01 00:00:00
abstract：:Alpha-mannosidosis is a rare lysosomal storage disorder that generally presents in early childhood. It is a progressive, highly heterogeneous disease that is difficult to recognize, and a diagnosis is usually reached after referrals to multiple specialists. It is important to understand the challenges faced by patient...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01574-w
更新日期：2020-11-24 00:00:00
abstract：:Nateglinide is an oral antidiabetic medication that acts through rapid, short-term stimulation of insulin production. This study was undertaken to identify the incidence and nature of adverse effects of nateglinide and to assess its efficacy in clinical practice. Patients (n = 3254) were recruited from 606 centers in ...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/BF02849871
更新日期：2005-09-01 00:00:00
abstract：:The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850143
更新日期：2006-03-01 00:00:00
abstract：:This 2-year prospective study was conducted to identify those at risk for ophthalmologic emergencies, to define the risk factors and reasons for eye injuries, to analyze treatment options, and to compare findings with those of previous studies. A total of 203 patients (74% male, mean age 27.3+/-13.9 y, 51% right eye i...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850133
更新日期：2006-03-01 00:00:00
