Abstract：
:Nateglinide is an oral antidiabetic medication that acts through rapid, short-term stimulation of insulin production. This study was undertaken to identify the incidence and nature of adverse effects of nateglinide and to assess its efficacy in clinical practice. Patients (n = 3254) were recruited from 606 centers in Japan with a 12-week observation period. Pretreatment and posttreatment values were obtained for fasting blood glucose, postprandial blood glucose, hemoglobin A1c (HbA1c), triglycerides, cholesterol, and body mass index. All adverse events were reported, along with standard laboratory blood variables. The incidence of adverse events was 7.40%; hypoglycemia, including hypoglycemic symptoms, was reported as the most prevalent (1.62%). Adverse events were observed more frequently in patients with hepatic or renal dysfunction; no significant findings were noted in the remaining patient population. The efficacy rating determined by the treating physicians was 76.40%. HbA1c decreased by 0.81% from 7.70+/-1.53% to 6.89+/-1.22%, postprandial glucose decreased by 54.05 mg/dL from 228.91+/-73.69 mg/dL to 174.86+/-62.86 mg/dL, and fasting glucose decreased by 23.73 mg/dL from 164.15+/-51.42 mg/dL to 140.43+/-42.63 mg/dL. These effects were most marked in patients who were previously medication naïve or who had been diagnosed with diabetes for a short period. Mean body mass index decreased, and nateglinide was equally effective in obese patients. Nateglinide showed good therapeutic effect when used as the first choice in patients with a short duration of diabetes, and in those with no history of previous treatment. Moreover, nateglinide seemed to be useful for the treatment of elderly patients and obese patients.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Taki H,Maki T,Iso T,Iwamoto K,Kajiura Tdoi
10.1007/BF02849871subject
Has Abstractpub_date
2005-09-01 00:00:00pages
513-26issue
5eissn
0741-238Xissn
1865-8652pii
426journal_volume
22pub_type
杂志文章,多中心研究abstract：INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01352-8
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:To evaluate the short-term efficacy and safety of intravitreal dexamethasone implant (IDI) in patients with macular oedema associated with diabetic retinopathy (DR) and retinal vein occlusion (RVO) using enhanced-depth image optical coherence tomography (EDI-OCT) and to estimate the effect of dexamethasone...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0848-0
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Real-world data are sparse on longitudinal associations of opioid use with pain interference with activities (PIA) and daily function with osteoarthritis (OA) in the USA. METHODS:Data from the 2010-2015 Medical Expenditure Panel Surveys were analyzed for community-dwelling adults with OA. Opioid use patte...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01200-4
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Diuretic responsiveness in patients with chronic heart failure (CHF) is better assessed by urine production per unit diuretic dose than by the absolute urine output or diuretic dose. Diuretic resistance arises over time when the plateau rate of sodium and water excretion is reached prior to optimal fluid e...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-015-0254-9
更新日期：2015-10-01 00:00:00
abstract：:The prevalence of chronic airways diseases such as chronic obstructive pulmonary disease and asthma is increasing. They lead to symptoms such as a cough and shortness of breath, partially through bronchoconstriction. Inhaled anticholinergics are one of a number of treatments designed to treat bronchoconstriction in ai...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-009-0074-x
更新日期：2009-10-01 00:00:00
abstract：:Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-013-0020-9
更新日期：2013-04-01 00:00:00
abstract：:In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients, with favorable toxicity profiles of immunotherapeutic agents relati...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-019-01051-z
更新日期：2019-10-01 00:00:00
abstract：:This study was performed to investigate the relationships between markers of inflammation in serum (interleukin-6 [IL-6], interleukin-10 [IL-10], and granulocyte elastase [GE]), severity of injury, and clinical outcomes, and to evaluate the predictive value of these markers for major complications and mortality. This ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02877699
更新日期：2007-09-01 00:00:00
abstract：:In the past 15 years, improvements in the treatment of HIV infection have dramatically reduced morbidity and mortality. Nucleoside reverse transcriptase inhibitors are the backbone of combination antiretroviral therapy for the treatment of HIV. One of the recommended and commonly used therapies in this class is the on...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-010-0006-9
更新日期：2010-01-01 00:00:00
abstract：:The article "A Relative Cost of Control Analysis of Once-Weekly Semaglutide Versus Exenatide Extended-Release and Dulaglutide for Bringing Patients to HbA1c and Weight Loss Treatment Targets in the USA", written by Pierre Johansen, Barnaby Hunt, Neeraj N. Iyer, Tam Dang-Tan, Richard F. Pollock was originally published...
journal_title：Advances in therapy
pub_type： 已发布勘误
doi：10.1007/s12325-019-00945-2
更新日期：2019-05-01 00:00:00
abstract：:Recently, high levels of neurotrophic factors have been found in bronchial asthma; these factors include nerve growth factor, brain-derived neurotrophic factor, and leukemia inhibitory factor, among others. Neurotrophic factors are first synthesized in bronchial epithelial cells, immune cells, and other cells in the a...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02848784
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to investigate whether the efficacy of liraglutide observed in randomized controlled trials translates into therapeutic benefits in the French population during routine clinical practice. METHODS:This observational, prospective, multicenter study included 3152 adults with type 2 ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0245-x
更新日期：2015-09-01 00:00:00
abstract：:This multicenter, double-masked, randomized, parallel-group study compared the efficacy and safety of ketorolac tromethamine 0.5% ophthalmic solution with levocabastine 0.05% and ketorolac tromethamine vehicle in patients with seasonal allergic conjunctivitis. One drop of ketorolac, levocabastine, or vehicle was insti...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02854842
更新日期：2000-03-01 00:00:00
abstract：:Fibroids, the most common tumor in women of reproductive age, impact negatively on women's health and quality of life, and have significant cost implications for their management. The current mainstay treatments are surgical (myomectomy and hysterectomy) and more recently radiological (UAE and focused ultrasound surge...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0042-8
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:This trial was conducted to assess the long-term safety, efficacy, and benefit of early add-on of linagliptin to insulin in patients with type 2 diabetes mellitus (T2DM). METHODS:This trial enrolled 246 subjects. The subjects were randomized to the linagliptin group or the control group and were observed ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-021-01631-y
更新日期：2021-01-28 00:00:00
abstract：:The aim of this prospective, randomized, open-label, blinded endpoint (PROBE) study was to compare the antihypertensive efficacy of 2 angiotensin II (AII) receptor antagonists with different pharmacologic profiles, valsartan and olmesartan, in patients with mild-to-moderate essential hypertension. After an initial 2-w...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850182
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:The objective of this study was to report outcome measures with third-generation pre-attached scrotal port adjustable transobturator male system (ATOMS) for male stress urinary incontinence (SUI) after radical prostatectomy. METHODS:A prospective open study was conducted on consecutive patients. Evaluatio...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0528-5
更新日期：2017-05-01 00:00:00
abstract：INTRODUCTION:The aim of this analysis was to characterize the safety and tolerability of empagliflozin in patients with type 2 diabetes mellitus (T2DM) who were randomized to empagliflozin (10/25 mg) or placebo in clinical trials. METHODS:Pooled data from 20 trials were analyzed for patients with T2DM treated with emp...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01329-7
更新日期：2020-08-01 00:00:00
abstract：:The tolerability of brimonidine tartrate 0.15%--referred to as bromonidine-Purite 0.15% in this study--was compared with brimonidine tartrate 0.2% in irritated eyes of healthy volunteers as well as patients with glaucoma or ocular hypertension (N=20) in a 2-week, single-center, randomized, double-masked, crossover stu...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02849799
更新日期：2003-11-01 00:00:00
abstract：:Hyperthyroidism is associated with increased bone turnover. Besides the hormones of calcium metabolism, locally produced factors are important in maintaining normal bone metabolism. Interleukin-6 (IL-6), in particular, has a major influence on bone turnover. In this study, serum IL-6 and tumor necrosis factor-alpha (T...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850169
更新日期：2006-05-01 00:00:00
abstract：:Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific sympt...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-017-0494-y
更新日期：2017-04-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s12325-008-0071-5
更新日期：2008-06-01 00:00:00
abstract：INTRODUCTION:New biosimilars of monoclonal antibodies are anticipated to bring significant cost savings and increase access to treatment. The rituximab biosimilar CT-P10 has recently been approved in Europe in all indications held by reference rituximab (RTX), including rheumatoid arthritis, non-Hodgkin's lymphoma, and...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-017-0522-y
更新日期：2017-05-01 00:00:00
abstract：:Combination therapies are a widely accepted approach to type 2 diabetes treatment, considering that monotherapies fail to provide adequate glycemic control in the majority of cases. The combination of oral antidiabetic agents into a single tablet would significantly simplify the therapeutic regimen and maximize patien...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0067-z
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:It is unclear whether patients and their loved ones appreciate that cardiovascular disease (CVD) is the major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). The purpose of this survey was to evaluate the degree of awareness regarding the link between T2DM and CVD. METHODS:An online s...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-0871-9
更新日期：2019-03-01 00:00:00
abstract：:Two patients with thalassemia minor and end-stage renal failure on hemodialysis were treated with epoetin zeta (Silapo, Retacrit; STADA, Germany), a medicinal product that was developed and registered as biosimilar to epoetin alfa. Dosing was titrated individually for two patients to achieve a stable hemoglobin (Hb) c...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0119-6
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:Sevelamer hydrochloride (SH) and lanthanum carbonate (LC) are calcium-free phosphate binders used for the management of hyperphosphatemia in patients with end-stage renal disease (ESRD). The objective of this analysis was to evaluate the real-world dose-relativity between SH and LC monotherapy in US patien...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-013-0077-5
更新日期：2013-12-01 00:00:00
abstract：INTRODUCTION:This retrospective study used data from a primary care database to compare two insulin products in routine clinical practice for the treatment of type 2 diabetes in the UK. PATIENTS AND METHODS:Records were analyzed for patients with type 2 diabetes who had been initiated on biphasic insulin aspart 30 (BI...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-010-0079-5
更新日期：2010-11-01 00:00:00
abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is associated with poor prognosis despite significant recent advances in its treatment. An intravenous formulation of epoprostenol sodium containing glycine and mannitol (epoprostenol GM; GlaxoSmithKline, London, UK) is widely used to treat PAH. A new formulation of ep...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-013-0029-0
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:The 1100delC CHEK2 allele has been associated with a 1.4-to 4.7-fold increased risk of breast cancer in women carrying this mutation. Our study investigated the frequency of this allele in a Chinese population. METHODS:Using touchdown polymerase chain reaction, we sequenced the CHEK2.1100delC mutation in ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0057-3
更新日期：2008-05-01 00:00:00
