Comparative efficacy of valsartan and olmesartan in mild-to-moderate hypertension: results of 24-hour ambulatory blood pressure monitoring.

Abstract:

:The aim of this prospective, randomized, open-label, blinded endpoint (PROBE) study was to compare the antihypertensive efficacy of 2 angiotensin II (AII) receptor antagonists with different pharmacologic profiles, valsartan and olmesartan, in patients with mild-to-moderate essential hypertension. After an initial 2-week washout period, 114 patients (64 men, 50 women; aged 35-70 years) were randomly assigned to receive valsartan 160 mg or olmesartan 20 mg once daily for 8 weeks. After the washout period and after 2 and 8 weeks of treatment, 24-hour ambulatory blood pressure monitoring (ABPM) was performed using a noninvasive device, and casual blood pressure (BP) and heart rate were measured. Both olmesartan and valsartan had a clear-cut antihypertensive effect. However, significantly earlier and more pronounced antihypertensive activity was achieved with valsartan than with olmesartan, as demonstrated by (1) significantly lower 24-hour, daytime, and nighttime ABPM values after 2 weeks with valsartan (P<.01); (2) significantly lower percentage of abnormal BP readings with valsartan; (3) significantly higher trough-peak ratio and smoothness index with valsartan, suggesting a more prolonged and homogeneous antihypertensive effect; and (4) lower 24-hour postdose clinic systolic and diastolic BP values versus olmesartan. These findings show that pharmacodynamic and pharmacokinetic differences between AII receptor antagonists, at clinically comparable dosages, may be associated with differences in antihypertensive efficacy.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Destro M,Scabrosetti R,Vanasia A,Mugellini A

doi

10.1007/BF02850182

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

32-43

issue

1

eissn

0741-238X

issn

1865-8652

pii

374

journal_volume

22

pub_type

临床试验,杂志文章,随机对照试验
  • Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study.

    abstract:INTRODUCTION:To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG). METHODS:Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pres...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-0897-z

    authors: Parisi V,Oddone F,Roberti G,Tanga L,Carnevale C,Ziccardi L,Manni G

    更新日期:2019-04-01 00:00:00

  • Retrospective estimate of the nursing cost of autonomy impairment and cost benefit in clinical trials: feasibility and application of piracetam in demented elderly patients.

    abstract::The aims of this study were to determine whether the nursing costs of functional disability could be assessed retrospectively and, if so, whether this method was sensitive enough to show the influence of a treatment on economic costs. Four studies were available for this purpose: three randomized, double-blind, place...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:

    authors: Vlietinck R,Van Loon H,Van de Broele H,Tormans G

    更新日期:1993-09-01 00:00:00

  • Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review.

    abstract::Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell c...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01287-0

    authors: Amaya-Montoya M,Pérez-Londoño A,Guatibonza-García V,Vargas-Villanueva A,Mendivil CO

    更新日期:2020-04-01 00:00:00

  • Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related diabetic nephropathy: case report.

    abstract::Nonketotic hyperosmolar coma (NHC) is characterized by severe hyperglycemia; absence of, or only slight ketosis; nonketotic acidosis; severe dehydration; depressed sensorium or frank coma; and various neurologic signs. This condition is uncommon in type 1 diabetes. Because of little or no osmotic diuresis in patients ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02849861

    authors: Dogan E,Erkoc R,Sayarlioglu H,Buyukbese A

    更新日期:2005-09-01 00:00:00

  • The Association Between Switching from Synthroid® and Clinical Outcomes: US Evidence from a Retrospective Database Analysis.

    abstract:INTRODUCTION:Clinical guidelines recommend levothyroxine as the standard of care for hypothyroidism and that patients should be treated with a consistent preparation of synthetic levothyroxine without switching among formulations. This study examines the likelihoods of negative clinical outcomes between continuous user...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01537-1

    authors: Hennessey JV,Espaillat R,Duan Y,Soni-Brahmbhatt S,Lage MJ,Singer P

    更新日期:2020-10-28 00:00:00

  • Long-Term Efficacy of Tumor Necrosis Factor Inhibitors for the Treatment of Methotrexate-Naïve Rheumatoid Arthritis: Systematic Literature Review and Meta-Analysis.

    abstract:INTRODUCTION:Synthesis of evidence on the long-term use of first-line biologic therapy in patients with early rheumatoid arthritis (RA) is required. We compared the efficacy of up to 5 years' treatment with first-line tumor necrosis factor inhibitors (TNFis) versus other treatment strategies in this population. METHOD...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-018-0869-8

    authors: Gulácsi L,Zrubka Z,Brodszky V,Rencz F,Alten R,Szekanecz Z,Péntek M

    更新日期:2019-03-01 00:00:00

  • Anterior Chamber Inflammation After Cataract Surgery: A Randomized Clinical Trial Comparing Bromfenac 0.09% to Dexamethasone 0.1.

    abstract:PURPOSE:To compare the efficacy of bromfenac 0.09% and dexamethasone 0.1% in the treatment of anterior chamber inflammation after uncomplicated cataract surgery. METHODS:Seventy-six patients with senile cataracts and no other ocular comorbidities who underwent uneventful phacoemulsification were randomized 1:1 to rece...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12325-019-01076-4

    authors: Coassin M,De Maria M,Mastrofilippo V,Braglia L,Cimino L,Sartori A,Fontana L

    更新日期:2019-10-01 00:00:00

  • A Comparison of Analgesia After a Thoracoscopic Lung Cancer Operation with a Sustained Epidural Block and a Sustained Paravertebral Block: A Randomized Controlled Study.

    abstract:INTRODUCTION:This study aimed to compare the challenge of puncture and catheterization and the effect of postoperative analgesia of ultrasound-guided continuous thoracic paravertebral block and the continuous epidural analgesia in patients receiving thoracoscopic surgery for lung cancer. METHODS:One-hundred and fifty ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01446-3

    authors: Huang QW,Li JB,Huang Y,Zhang WQ,Lu ZW

    更新日期:2020-09-01 00:00:00

  • Multislice Computed Tomographic Manifestation of Transient Hepatic Attenuation Difference in the Left Lobe of the Liver: A Retrospective Study.

    abstract:INTRODUCTION:Transient hepatic attenuation differences (THAD) are areas of high parenchymal enhancement observed during the hepatic arterial phase on computed tomography (CT). THAD in the left lobe of the liver can lead to surgical complications. METHODS:A retrospective study was conducted on patients who underwent mu...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01428-5

    authors: Yang B,Si G,He Q,Liu S,Wang S,Xian R,Zhang J,Yu F,Guan J

    更新日期:2020-09-01 00:00:00

  • Echinacea reduces the risk of recurrent respiratory tract infections and complications: a meta-analysis of randomized controlled trials.

    abstract:INTRODUCTION:Respiratory tract infections are common, and these infections occur frequently in children, susceptible adults, and older persons. The risk for recurrences and complications relates not only to the presence of viruses but also to immune function. Therefore, modulation of the immune system and antiviral int...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12325-015-0194-4

    authors: Schapowal A,Klein P,Johnston SL

    更新日期:2015-03-01 00:00:00

  • Metabonomics and diabetes mellitus.

    abstract::Diabetes mellitus is one of the most serious heterogeneous endocrinologic diseases; more than 90% of those given this diagnosis have type 2 diabetes mellitus, usually accompanied by macrovascular and microvascular complications. Because most cases include a 7- to 10-y latency period before disease onset, however, it i...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/BF02877709

    authors: Chen P,Liu J

    更新日期:2007-09-01 00:00:00

  • How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?

    abstract::Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific sympt...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-017-0494-y

    authors: López F,Williams MD,Skálová A,Hellquist H,Suárez C,Nixon IJ,Rodrigo JP,Cardesa A,Strojan P,Quer M,Hunt JL,Rinaldo A,Ferlito A

    更新日期:2017-04-01 00:00:00

  • Safety and tolerability of tapentadol extended release in moderate to severe chronic osteoarthritis or low back pain management: pooled analysis of randomized controlled trials.

    abstract:INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-014-0128-6

    authors: Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

    更新日期:2014-06-01 00:00:00

  • Secukinumab Use in Patients with Moderate to Severe Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis in Real-World Setting in Europe: Baseline Data from SERENA Study.

    abstract:INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01352-8

    authors: Kiltz U,Sfikakis PP,Gaffney K,Sator PG,von Kiedrowski R,Bounas A,Gullick N,Conrad C,Rigopoulos D,Lespessailles E,Romanelli M,Ghislain PD,Brandt-Jürgens J,Rashkov R,Aassi M,Orsenigo R,Perella C,Pournara E,Gathmann S,

    更新日期:2020-06-01 00:00:00

  • Reduction of cardiovascular risk and mortality: a population-based approach.

    abstract::The purpose of this study was to evaluate risk pattern and mortality in a general population epidemiologic study performed by a staff of hypertension specialists working as the "good father of a family," with lifestyle and therapeutic advice and instrumental measurements. Mortality among the study population (n=856) d...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850213

    authors: Casiglia E,Saugo M,Schiavon L,Tikhonoff V,Rigoni G,Basso G,Mazza A,Rizzato E,Guglielmi F,Martini B,Bascelli A,Caffi S,Pessina AC

    更新日期:2006-11-01 00:00:00

  • Assessing thrombosis risk in patients with idiopathic, diabetic, and postsurgical gastroparesis.

    abstract::Patients with severe gastrointestinal motility disorders are often found to have intravenous access clots or deep venous thrombosis. It has previously been reported that many patients who have intravenous access thrombosis have concomitant thrombotic risk factors. In this study, the goal was to determine the underlyin...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850315

    authors: Lobrano A,Blanchard K,Rock W,Johnson W,Schmieg B,Borman K,Araghizadeh F,Minocha A,Abell TL

    更新日期:2006-09-01 00:00:00

  • Cutaneous manifestations in brucellosis: a prospective study.

    abstract::Brucellosis remains an important public health problem in Turkey, just as it is in other regions of the world. This study was conducted to determine the types and rates of cutaneous lesions that occur in patients with brucellosis. Brucellosis was diagnosed by standard tube agglutination testing for Brucella antibodies...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02849964

    authors: Akcali C,Savas L,Baba M,Turunc T,Seckin D

    更新日期:2007-07-01 00:00:00

  • Anticholinergic treatment in airways diseases.

    abstract::The prevalence of chronic airways diseases such as chronic obstructive pulmonary disease and asthma is increasing. They lead to symptoms such as a cough and shortness of breath, partially through bronchoconstriction. Inhaled anticholinergics are one of a number of treatments designed to treat bronchoconstriction in ai...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-009-0074-x

    authors: Flynn RA,Glynn DA,Kennedy MP

    更新日期:2009-10-01 00:00:00

  • Clinical Challenges in the Management of Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: A Literature Review.

    abstract::Endocrine therapy (ET) is integral to the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC). Aromatase inhibitors (AIs; e.g., anastrozole, letrozole, exemestane), selective estrogen receptor modulators (e.g., tamoxifen), and the selec...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01552-2

    authors: Nagaraj G,Ma CX

    更新日期:2020-11-15 00:00:00

  • Outcomes and costs of patients with persistent asthma treated with beclomethasone dipropionate hydrofluoroalkane or fluticasone propionate.

    abstract:OBJECTIVE:Examine outcomes and costs of patients with persistent asthma who initiated treatment with beclomethasone dipropionate hydrofluoroalkane (BDP-HFA) or fluticasone propionate (FP). METHODS:MedStat's Commercial Claims and Encounters database (July 1, 2002-June 30, 2007) was utilized. Patients (n=13,968) were in...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-009-0056-z

    authors: Lage MJ,Gross GN,Brewster C,Spalitto A

    更新日期:2009-08-01 00:00:00

  • Impact of adherence to disease-modifying therapies on clinical and economic outcomes among patients with multiple sclerosis.

    abstract:BACKGROUND:Adherence to disease-modifying therapies (DMTs) is essential for the reduction of multiple sclerosis (MS) progression and relapse. However, only limited data currently exist on the impact of treatment adherence on MS-related clinical and economic outcomes in the real world setting. OBJECTIVE:To assess the i...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12325-010-0093-7

    authors: Tan H,Cai Q,Agarwal S,Stephenson JJ,Kamat S

    更新日期:2011-01-01 00:00:00

  • Iron chelation therapy: clinical effectiveness, economic burden and quality of life in patients with iron overload.

    abstract:INTRODUCTION:This study of UK patients examines clinical, health-related quality of life (HRQOL) and economic outcomes associated with iron chelation therapy (ICT). Desferrioxamine (DFO) (Desferal; Novartis, Switzerland) and Deferiprone (Ferriprox; Apotex, Canada) are ICTs used to treat iron overload. DFO requires 8-to...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0085-z

    authors: Payne KA,Rofail D,Baladi JF,Viala M,Abetz L,Desrosiers MP,Lordan N,Ishak K,Proskorovsky I

    更新日期:2008-08-01 00:00:00

  • An economic evaluation of budesonide/formoterol for maintenance and reliever treatment in asthma in general practice.

    abstract:INTRODUCTION:In budesonide/formoterol (Symbicort(R) Turbuhaler(R), AstraZeneca, Lund, Sweden) maintenance and reliever therapy (SMART), patients with asthma take a daily maintenance dose of budesonide/formoterol, with the option of taking additional doses for symptom relief instead of a short-acting beta(2)-agonist (SA...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-009-0063-0

    authors: Goossens LM,Riemersma RA,Postma DS,van der Molen T,Rutten-van Mölken MP

    更新日期:2009-09-01 00:00:00

  • Dorsal root ganglion: the target of acupuncture in the treatment of asthma.

    abstract::Recently, high levels of neurotrophic factors have been found in bronchial asthma; these factors include nerve growth factor, brain-derived neurotrophic factor, and leukemia inhibitory factor, among others. Neurotrophic factors are first synthesized in bronchial epithelial cells, immune cells, and other cells in the a...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/BF02848784

    authors: Feng JT,Hu CP,Li XZ

    更新日期:2007-05-01 00:00:00

  • The Proteolytic Fraction from Latex of Vasconcellea cundinamarcensis (P1G10) Enhances Wound Healing of Diabetic Foot Ulcers: A Double-Blind Randomized Pilot Study.

    abstract:INTRODUCTION:The aim of the study was to investigate the role of the proteolytic fraction from Vasconcellea cundinamarcensis, designated as P1G10, on the healing of chronic foot ulcers in neuropathic patients with diabetes 2. METHODS:Fifty patients were enrolled in a prospective, randomized, double-blind trial, to ver...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12325-018-0684-2

    authors: Tonaco LAB,Gomes FL,Velasquez-Melendez G,Lopes MTP,Salas CE

    更新日期:2018-04-01 00:00:00

  • Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study.

    abstract:INTRODUCTION:Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in p...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-016-0399-1

    authors: Baltzis D,Roustit M,Grammatikopoulou MG,Katsaboukas D,Athanasiou V,Iakovou I,Veves A,Manes C,Trakatelli MC

    更新日期:2016-10-01 00:00:00

  • Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride.

    abstract::The corneal toxicity of 2 intraocular pressure-lowering agents was compared in a rabbit cornea model with New Zealand White rabbits. Corneal epithelial morphology and cell size were assessed by in vivo confocal microscopy. Baseline microscopic examinations were performed on 1 eye of each animal. Two weeks later, the e...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850305

    authors: Whitson JT,Cavanagh HD,Lakshman N,Petroll WM

    更新日期:2006-09-01 00:00:00

  • Prophylactic intranasal mupirocin ointment in the treatment of peritonitis in continuous ambulatory peritoneal dialysis patients.

    abstract::This study was undertaken to evaluate the effectiveness of prophylactic intranasal mupirocin for peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD). A total of 49 patients undergoing CAPD for at least 6 mo were followed for 1 year. A nasal smear was obtained from each patient at the beginning ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/BF02849908

    authors: Sit D,Kadiroglu AK,Kayabasi H,Yilmaz ME

    更新日期:2007-03-01 00:00:00

  • Impact of medication adherence and persistence on clinical and economic outcomes in patients with type 2 diabetes treated with liraglutide: a retrospective cohort study.

    abstract:INTRODUCTION:Adherence to diabetes medication has been linked to improved glycemic levels and lower costs, but previous research on adherence has typically involved oral antidiabetic medication or insulin. This study examines how adherence and persistence to once-daily liraglutide impact glycemic control and economic o...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-015-0199-z

    authors: Buysman EK,Liu F,Hammer M,Langer J

    更新日期:2015-04-01 00:00:00

  • Intensive postremission chemotherapy in Taiwanese adults with acute myelogenous leukemia.

    abstract::Intensive postremission chemotherapy has produced disease-free survival comparable to that of bone marrow transplantation in patients with acute myelogenous leukemia (AML), but its efficacy was unknown in Taiwan. We assessed the efficacy of intensive postremission chemotherapy, consisting of high-dose arabinoside-C (H...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02852390

    authors: Hsu HC,Gau JP,Liu JM,Chau WK,Ho CH

    更新日期:2001-03-01 00:00:00