Short-Term Assessment of Intravitreal Dexamethasone Implant Using Enhanced-Depth Image Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients with Retinal Vascular Diseases.


INTRODUCTION:To evaluate the short-term efficacy and safety of intravitreal dexamethasone implant (IDI) in patients with macular oedema associated with diabetic retinopathy (DR) and retinal vein occlusion (RVO) using enhanced-depth image optical coherence tomography (EDI-OCT) and to estimate the effect of dexamethasone on the choroid and the retinal vascular network using OCT angiography (OCTA). METHODS:Fifteen eyes in 15 patients with macular oedema secondary to diabetes (DR, n = 8) or retinal vein occlusion (RVO, n = 7) were treated with intravitreal injection of sustained-release IDI. Primary efficacy end points were changes in best corrected visual acuity and central macular thickness (CMT). Secondary end points were changes in choroidal thickness and choroidal and retinal vascular networks as determined by OCTA. RESULTS:CMT was significantly reduced from baseline by 3 h after injection (p < 0.01) and improved further during the 3-month follow-up. Visual acuity improvement was consistent with CMT reduction. No alterations in IOP or systemic side effects were observed. OCTA showed improvement from baseline in terms of decreased number and size of cysts and restoration of the retinal vascular network; flow choroidal thickness did not change significantly. CMT and visual acuity variations were similar in the two groups. CONCLUSIONS:CMT reduced as early as 3 h after the injection of IDI, with further reduction during follow-up. Choroidal thickness was unchanged, whereas the vascular retinal network improved from baseline to the end of study. Both EDI-OCT and OCTA were useful in demonstrating the early beneficial effects of IDI on the macula and the perifoveal vascular network. FUNDING:The article processing charges, the open access fee and the medical writing and editorial assistance was funded by Allergan.


Adv Ther


Advances in therapy


Minnella AM,Federici M,Pagliei V,Lanza A,Gambini G,Caputo CG,Falsini B,Caporossi A




Has Abstract


2019-02-01 00:00:00














  • Drug evaluation: vildagliptin-metformin single-tablet combination.

    abstract::The single-tablet combination of vildagliptin and metformin addresses key defects of type 2 diabetes for improved glycemic control. By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, vildagliptin raises the levels of the active incretin hormones, glucagon-like peptide 1 and glucose-dependent insulinotropic pepti...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Tahrani AA,Piya MK,Barnett AH

    更新日期:2009-02-01 00:00:00

  • The Challenges of Switching Therapies in an Evolving Multiple Biosimilars Landscape: A Narrative Review of Current Evidence.

    abstract::With the increasing availability of biosimilars, the practice of switching therapies for non-medical reasons between an originator biologic and an analogous biosimilar has become more common. The evidence to support this practice mostly comes from single-switch randomized controlled trials (RCTs) and real-world (RW) e...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Feagan BG,Marabani M,Wu JJ,Faccin F,Spronk C,Castañeda-Hernández G

    更新日期:2020-11-01 00:00:00

  • Caregivers' and Physicians' Perspectives on Alpha-Mannosidosis: A Report from Italy.

    abstract::Alpha-mannosidosis is a rare lysosomal storage disorder that generally presents in early childhood. It is a progressive, highly heterogeneous disease that is difficult to recognize, and a diagnosis is usually reached after referrals to multiple specialists. It is important to understand the challenges faced by patient...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Verrecchia E,Sicignano LL,Massaro MG,Rocco R,Silvestri G,Rossi S,Manna R

    更新日期:2020-11-24 00:00:00

  • Treatment of hypertension and adherence to treatment guidelines in clinical practice: an Italian study.

    abstract::Despite the results from clinical trials in patients with hypertension and the development of a long list of guidelines for the management of hypertension, many physicians and other healthcare professionals still manage hypertension using approaches that clearly diverge at least partially from the recommendations of t...

    journal_title:Advances in therapy

    pub_type: 共识发展会议,杂志文章,评审


    authors: Malacco E,Ferri C,Grandi AM,Kilama MO,Soglian AG,Vigna L

    更新日期:2005-03-01 00:00:00

  • SkQ1 Ophthalmic Solution for Dry Eye Treatment: Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Model.

    abstract:INTRODUCTION:This Phase 2 clinical trial assessed the efficacy and safety of the novel antioxidative, renewable compound SkQ1 for topical treatment of dry eye signs and symptoms. METHODS:In a single-center, randomized, double-masked, placebo-controlled, 29-day study, 91 subjects with mild to moderate dry eye instilled...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验


    authors: Petrov A,Perekhvatova N,Skulachev M,Stein L,Ousler G

    更新日期:2016-01-01 00:00:00

  • Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related diabetic nephropathy: case report.

    abstract::Nonketotic hyperosmolar coma (NHC) is characterized by severe hyperglycemia; absence of, or only slight ketosis; nonketotic acidosis; severe dehydration; depressed sensorium or frank coma; and various neurologic signs. This condition is uncommon in type 1 diabetes. Because of little or no osmotic diuresis in patients ...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Dogan E,Erkoc R,Sayarlioglu H,Buyukbese A

    更新日期:2005-09-01 00:00:00

  • Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.

    abstract:INTRODUCTION:The 1100delC CHEK2 allele has been associated with a 1.4-to 4.7-fold increased risk of breast cancer in women carrying this mutation. Our study investigated the frequency of this allele in a Chinese population. METHODS:Using touchdown polymerase chain reaction, we sequenced the CHEK2.1100delC mutation in ...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Chen W,Yurong S,Liansheng N

    更新日期:2008-05-01 00:00:00

  • Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.

    abstract:INTRODUCTION:Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic changes; however, the metabolic side effects produced by aripiprazole are more benign. The aim of the study was to evaluate if aripiprazole and olanzapine alter prolactin levels, lipid and glucose metabolism and hepati...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Koller D,Almenara S,Mejía G,Saiz-Rodríguez M,Zubiaur P,Román M,Ochoa D,Navares-Gómez M,Santos-Molina E,Pintos-Sánchez E,Abad-Santos F

    更新日期:2020-12-05 00:00:00

  • Correction to: Unlocking the Value of Anti-TNF Biosimilars: Reducing Disease Burden and Improving Outcomes in Chronic Immune-Mediated Inflammatory Diseases: A Narrative Review.

    abstract::In the original article, under the "Access to treatment" heading. ...

    journal_title:Advances in therapy

    pub_type: 已发布勘误


    authors: Rezk MF,Pieper B

    更新日期:2020-11-01 00:00:00

  • The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes in Asia.

    abstract::The improvement of glycemic control in patients with type 2 diabetes (T2D) is an urgent need in Asia. East Asian T2D patients have distinct characteristics, including relatively low body weight, early impairment of islet beta cell function with reduced insulin secretion and a marked increase in postprandial blood gluc...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Lu JM

    更新日期:2019-04-01 00:00:00

  • Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors.

    abstract::In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients, with favorable toxicity profiles of immunotherapeutic agents relati...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Arora S,Velichinskii R,Lesh RW,Ali U,Kubiak M,Bansal P,Borghaei H,Edelman MJ,Boumber Y

    更新日期:2019-10-01 00:00:00

  • Current Perspectives of Prophylaxis and Management of Acute Infective Endophthalmitis.

    abstract::Endophthalmitis is an intraocular inflammatory condition which may or may not be caused by infective agents. Noninfectious (sterile) endophthalmitis may be attributable to various causes including postoperative retained soft lens matter or toxicity following introduction of other agents into the eye. Infectious endoph...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Tranos P,Dervenis N,Vakalis AN,Asteriadis S,Stavrakas P,Konstas AG

    更新日期:2016-05-01 00:00:00

  • Dyspnea in COPD: New Mechanistic Insights and Management Implications.

    abstract::Dyspnea is the most common symptom experienced by patients with chronic obstructive pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt a sedentary lifestyle which predictably leads to extensive skeletal muscle deconditioning, social isolation, and its negative psychological sequalae. This "dysp...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: O'Donnell DE,Milne KM,James MD,de Torres JP,Neder JA

    更新日期:2020-01-01 00:00:00

  • Effectiveness and Safety of High Dose Tigecycline for the Treatment of Severe Infections: A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Studies assessing the effect of high dose tigecycline on severe infections are limited and remain controversial. OBJECTIVES:To assess systematically the effectiveness and safety of high dose tigecycline in the treatment of severe infections. METHODS:Pubmed, Web of Science, Embase, MEDLINE, Cochrane Library...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析


    authors: Zha L,Pan L,Guo J,French N,Villanueva EV,Tefsen B

    更新日期:2020-03-01 00:00:00

  • Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review.

    abstract::Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell c...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Amaya-Montoya M,Pérez-Londoño A,Guatibonza-García V,Vargas-Villanueva A,Mendivil CO

    更新日期:2020-04-01 00:00:00

  • A preliminary report on spinal muscular atrophy lymphoblastoid cell lines: are they an appropriate tool for drug screening?

    abstract:INTRODUCTION:Spinal muscular atrophy (SMA) is a neurodegenerative disease of the motor neurons that results in progressive muscle weakness. It is also the leading hereditary cause of infant mortality. Homozygous loss of the survival motor neuron (SMN1) gene causes SMA, and the number of copies of the SMN2 gene modulate...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Dayangaç-Erden D,Topaloğlu H,Erdem-Yurter H

    更新日期:2008-03-01 00:00:00

  • Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights.

    abstract::Diabetic foot ulcers (DFUs) are one of the most common and serious complications of diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a dynamic and complex biological process that can be divided into four partly overlapping phases: hemostasis, inflammation, proliferative and remode...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Baltzis D,Eleftheriadou I,Veves A

    更新日期:2014-08-01 00:00:00

  • Pitfalls in radiologic and histopathologic diagnosis of urologic disease--report of 4 cases.

    abstract::Cases are presented to illustrate pitfalls in radiologic and histopathologic diagnosis in urology. In a 73-year-old woman, ultrasound revealed calcification in an irregular mass arising from the left wall of the bladder. Bladder biopsy reported the mass as papillary transitional cell carcinoma. Histologically, the spe...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Vaidyanathan S,Soni BM,Hughes PL,Mansour P,Singh G

    更新日期:2006-11-01 00:00:00

  • Real-life dosage and clinical efficacy of biphasic insulin preparations in patients with type 2 diabetes.

    abstract:INTRODUCTION:This retrospective study used data from a primary care database to compare two insulin products in routine clinical practice for the treatment of type 2 diabetes in the UK. PATIENTS AND METHODS:Records were analyzed for patients with type 2 diabetes who had been initiated on biphasic insulin aspart 30 (BI...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Fakhoury WK,Richter H,Christensen TE

    更新日期:2010-11-01 00:00:00

  • Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells.

    abstract:INTRODUCTION:This clinical study aimed to investigate the effect of brinzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelial cells (CECs) in patients with glaucoma using a follow-up clinical study design. METHODS:Patients with primary open-angle glaucoma or ocular hypertension were administrated an...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章


    authors: Nakano T,Inoue R,Kimura T,Suzumura H,Tanino T,Yamazaki Y,Yoshikawa K,Tatemichi M

    更新日期:2016-08-01 00:00:00

  • Cutaneous manifestations in brucellosis: a prospective study.

    abstract::Brucellosis remains an important public health problem in Turkey, just as it is in other regions of the world. This study was conducted to determine the types and rates of cutaneous lesions that occur in patients with brucellosis. Brucellosis was diagnosed by standard tube agglutination testing for Brucella antibodies...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Akcali C,Savas L,Baba M,Turunc T,Seckin D

    更新日期:2007-07-01 00:00:00

  • Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.

    abstract::Neuroinflammation is a process involved in the pathogenesis of different disorders, both autoimmune, such as neuropsychiatric systemic lupus erythematosus, and degenerative, such as Alzheimer's and Parkinson's disease. In the central nervous system, the local milieu is tightly regulated by different mediators, among w...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Gualtierotti R,Guarnaccia L,Beretta M,Navone SE,Campanella R,Riboni L,Rampini P,Marfia G

    更新日期:2017-02-01 00:00:00

  • SOFA Score Can Effectively Predict the Incidence of Sepsis and 30-Day Mortality in Liver Transplant Patients: A Retrospective Study.

    abstract:INTRODUCTION:This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS:A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general inf...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Wang XW,Niu XG,Li JX,Zhang SS,Jiao XF

    更新日期:2019-03-01 00:00:00

  • Combination therapy in hypertension.

    abstract::Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Gorostidi M,de la Sierra A

    更新日期:2013-04-01 00:00:00

  • Prediction of Perioperative Death Following Surgery for Renal Cell Carcinoma with Vein Involvement: A Retrospective Study.

    abstract:INTRODUCTION:Advanced renal cell carcinoma (RCC) shows a propensity for extending into the tributaries of the renal veins, which poses a notable surgical challenge. In this study we addressed the question as to whether patients with RCC and vein involvement can be identified as having a significant risk of immediate de...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Akkoyun M,Merseburger AS,Kramer MW,Herrmann TR,Kuczyk MA,von Klot CA

    更新日期:2015-08-01 00:00:00

  • Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride.

    abstract::The corneal toxicity of 2 intraocular pressure-lowering agents was compared in a rabbit cornea model with New Zealand White rabbits. Corneal epithelial morphology and cell size were assessed by in vivo confocal microscopy. Baseline microscopic examinations were performed on 1 eye of each animal. Two weeks later, the e...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Whitson JT,Cavanagh HD,Lakshman N,Petroll WM

    更新日期:2006-09-01 00:00:00

  • Outcome Measures of Adjustable Transobturator Male System with Pre-attached Scrotal Port for Male Stress Urinary Incontinence After Radical Prostatectomy: A Prospective Study.

    abstract:INTRODUCTION:The objective of this study was to report outcome measures with third-generation pre-attached scrotal port adjustable transobturator male system (ATOMS) for male stress urinary incontinence (SUI) after radical prostatectomy. METHODS:A prospective open study was conducted on consecutive patients. Evaluatio...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Angulo JC,Arance I,Esquinas C,Dorado JF,Marcelino JP,Martins FE

    更新日期:2017-05-01 00:00:00

  • Physical Activity in Liver Transplantation: A Patient's and Physicians' Experience.

    abstract::Liver transplantation has become a highly standardized, acceptable option for selected patients with end-stage liver disease and/or hepatocellular carcinoma in the setting of cirrhosis. Both conditions are associated with loss of skeletal muscle mass (sarcopenia) and physical deconditioning. Both conditions result in ...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Beekman L,Berzigotti A,Banz V

    更新日期:2018-11-01 00:00:00

  • Liraglutide for the treatment of type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials.

    abstract:INTRODUCTION:Liraglutide has been widely used in the treatment of type 2 diabetes mellitus (T2DM), however, the results of a number of randomized placebo-controlled trials on the effects of liraglutide for the treatment of T2DM have varied. The purpose of this study was to assess the effects of liraglutide versus place...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析


    authors: Du Q,Wang YJ,Yang S,Zhao YY,Han P

    更新日期:2014-11-01 00:00:00

  • Randomized trial of brinzolamide/brimonidine versus brinzolamide plus brimonidine for open-angle glaucoma or ocular hypertension.

    abstract:INTRODUCTION:Fixed-combination intraocular pressure (IOP)-lowering medications simplify treatment regimens for patients requiring 2 ocular hypotensive agents to maintain sufficiently low IOP. The aim of this study was to evaluate the safety and efficacy of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) versu...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gandolfi SA,Lim J,Sanseau AC,Parra Restrepo JC,Hamacher T

    更新日期:2014-12-01 00:00:00