How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?

Abstract:

:Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. The index of suspicion for a non-squamous cell carcinoma entity should be high when a submucosal mass is present. An accurate diagnosis is mandatory due to the impact each biologic entity has on treatment and outcome. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. The role of adjuvant radiotherapy has not been well defined, although there is an agreement that it should be considered in advanced-stage or high-grade disease. This review considers only the most common malignant salivary neoplasms of the larynx with a focus on clinical management of these tumors.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

López F,Williams MD,Skálová A,Hellquist H,Suárez C,Nixon IJ,Rodrigo JP,Cardesa A,Strojan P,Quer M,Hunt JL,Rinaldo A,Ferlito A

doi

10.1007/s12325-017-0494-y

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

813-825

issue

4

eissn

0741-238X

issn

1865-8652

pii

10.1007/s12325-017-0494-y

journal_volume

34

pub_type

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