当前位置： SCI文献检索 > ADVANCES IN THERAPY期刊下所有文献 > The Challenges of Switching Therapies in an Evolving Multiple Biosimilars Landscape: A Narrative Review of Current Evidence.

The Challenges of Switching Therapies in an Evolving Multiple Biosimilars Landscape: A Narrative Review of Current Evidence.

Abstract：

:With the increasing availability of biosimilars, the practice of switching therapies for non-medical reasons between an originator biologic and an analogous biosimilar has become more common. The evidence to support this practice mostly comes from single-switch randomized controlled trials (RCTs) and real-world (RW) evidence studies. However, as more biosimilars of the same originator enter the market, multiple switching events between originators and biosimilars is becoming a reality, despite limited evidence to support the efficacy and safety of such practice. Some countries have established guidelines, policies, or laws related to interchangeability and/or automatic substitution, whereas others have left these practices unregulated or controlled by other components of the healthcare system. Collectively, guidelines on single non-medical switching are often vague, with even less focus given to multiple non-medical switching, leaving this practice mostly unregulated. This narrative review will first discuss the current regulatory perspectives on non-medical switching and challenges associated with switching therapies, particularly with the availability of multiple biosimilars. We will then review the current evidence from RCTs and RW studies in the light of three different multiple-switch scenarios currently taking place in clinical practice: switching between an originator and a single biosimilar, switching between biosimilars of the same originator, and the clinical practice of switching back to the originator (i.e., switchbacks) after a failure of the initial non-medical switch to the analogous biosimilar.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Feagan BG,Marabani M,Wu JJ,Faccin F,Spronk C,Castañeda-Hernández G

doi

10.1007/s12325-020-01472-1

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

4491-4518

issue

11

eissn

0741-238X

issn

1865-8652

pii

10.1007/s12325-020-01472-1

journal_volume

37

pub_type

杂志文章,评审

相关文献

ADVANCES IN THERAPY文献大全
  • Therapeutic options after treatment failure in rheumatoid arthritis or spondyloarthritides.

    abstract：:The prognosis for patients with rheumatoid arthritis or spondyloarthritides has improved dramatically due to earlier diagnosis, recognition of the need to treat early with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), alone or in combinations, the establishment of treatment targets, and the ...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-014-0142-8

    authors： Govoni M,Bortoluzzi A,Lo Monaco A,Adami S,Addimanda O,Caimmi C,De Vita S,Ferri C,Manfredi A,Orsolini G,Possemato N,Quartuccio L,Salvarani C,Zabotti A,Rossini M

    更新日期：2014-08-01 00:00:00

  • Pharmacokinetics and Safety of Posaconazole Tablet Formulation in Chinese Participants at High Risk for Invasive Fungal Infection.

    abstract：INTRODUCTION:This study characterized the multidose pharmacokinetic (PK) characteristics of posaconazole tablets used as prophylactic antifungal therapy in Chinese patients with acute myelogenous leukemia (AML) at risk for invasive fungal infection (IFI). METHODS:Participants in this open-label, single-arm, phase 1b s...

    journal_title：Advances in therapy

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12325-020-01341-x

    authors： Liu K,Wu D,Li J,Chen H,Ning H,Zhao T,Dai H,Chen L,Mangin E,Winchell GA,Waskin H,Jiang J,Qiu Y,Zhao XM

    更新日期：2020-05-01 00:00:00

  • Effect of Ivabradine on Endothelial Function in Patients with Stable Angina Pectoris: Assessment with the Endo-PAT 2000 Device.

    abstract：INTRODUCTION:Ivabradine has opened up new possibilities for treating stable angina and chronic heart failure by lowering heart rate. Ivabradine lowers heart rate by selectively inhibiting the I f current in the sinoatrial node. This study aimed to determine whether the decrease in heart rate achieved with ivabradine wa...

    journal_title：Advances in therapy

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12325-015-0253-x

    authors： Jedlickova L,Merkovska L,Jackova L,Janicko M,Fedacko J,Novakova B,Chmelarova A,Majernik J,Pella D

    更新日期：2015-10-01 00:00:00

  • Angio-immunoblastic T-cell lymphoma in evolution: a case report.

    abstract：:Angio-immunoblastic T-cell lymphoma (AITL), a rare disease that constitutes 1% to 2% of non-Hodgkin's lymphomas, presents in middle-aged and elderly individuals. This report describes a patient with high-grade fever and lymphadenopathy. An extensive in-hospital work-up that included lymph node biopsy yielded negative ...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02849974

    authors： Usmani SZ,Sahay T,Eisenberg L

    更新日期：2007-07-01 00:00:00

  • Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights.

    abstract：:Diabetic foot ulcers (DFUs) are one of the most common and serious complications of diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a dynamic and complex biological process that can be divided into four partly overlapping phases: hemostasis, inflammation, proliferative and remode...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-014-0140-x

    authors： Baltzis D,Eleftheriadou I,Veves A

    更新日期：2014-08-01 00:00:00

  • Structured weight-loss programs: meta-analysis of weight loss at 24 weeks and assessment of effects of intervention intensity.

    abstract：:Obesity is increasing in epidemic proportions globally while current therapies continue to be suboptimal. In this investigation, weight loss in obese individuals after 24 weeks with different nutrition interventions was compared. The impact of intervention intensity was assessed. Inclusion criteria were established an...

    journal_title：Advances in therapy

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/BF02850334

    authors： Anderson JW,Luan J,Høie LH

    更新日期：2004-03-01 00:00:00

  • Randomized trial of brinzolamide/brimonidine versus brinzolamide plus brimonidine for open-angle glaucoma or ocular hypertension.

    abstract：INTRODUCTION:Fixed-combination intraocular pressure (IOP)-lowering medications simplify treatment regimens for patients requiring 2 ocular hypotensive agents to maintain sufficiently low IOP. The aim of this study was to evaluate the safety and efficacy of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) versu...

    journal_title：Advances in therapy

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s12325-014-0168-y

    authors： Gandolfi SA,Lim J,Sanseau AC,Parra Restrepo JC,Hamacher T

    更新日期：2014-12-01 00:00:00

  • Secukinumab Use in Patients with Moderate to Severe Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis in Real-World Setting in Europe: Baseline Data from SERENA Study.

    abstract：INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-020-01352-8

    authors： Kiltz U,Sfikakis PP,Gaffney K,Sator PG,von Kiedrowski R,Bounas A,Gullick N,Conrad C,Rigopoulos D,Lespessailles E,Romanelli M,Ghislain PD,Brandt-Jürgens J,Rashkov R,Aassi M,Orsenigo R,Perella C,Pournara E,Gathmann S,

    更新日期：2020-06-01 00:00:00

  • Angiotensin-Converting Enzyme Inhibition: Beyond Blood Pressure Control-The Role of Zofenopril.

    abstract：:The extensive use of angiotensin-converting enzyme inhibitors (ACEIs) as antihypertensive agents and the huge amount of data collected in clinical trials and post-marketing studies has allowed the extending of the indication of ACEIs beyond blood pressure control. Current guidelines recommend ACEIs in symptomatic pati...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-020-01455-2

    authors： Borghi C,Omboni S

    更新日期：2020-10-01 00:00:00

  • Impulse magnetic-field therapy for insomnia: a double-blind, placebo-controlled study.

    abstract：:This 4-week double-blind, placebo-controlled study assessed the efficacy of impulse magnetic-field therapy for insomnia. One hundred one patients were randomly assigned to either active treatment (n = 50) or placebo (n = 51) and allocated to one of three diagnostic groups: (1) sleep latency; (2) interrupted sleep; or ...

    journal_title：Advances in therapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02850111

    authors： Pelka RB,Jaenicke C,Gruenwald J

    更新日期：2001-07-01 00:00:00

  • Enhanced Safety Surveillance of Seasonal Quadrivalent Influenza Vaccines in English Primary Care: Interim Analysis.

    abstract：INTRODUCTION:The European Medicines Agency (EMA) requires vaccine manufacturers to conduct enhanced safety surveillance (ESS) of seasonal influenza vaccines including a near real-time evaluation of collected data. The objective was to identify whether the use of passive surveillance or active surveillance provides diff...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-018-0747-4

    authors： de Lusignan S,Dos Santos G,Byford R,Schuind A,Damaso S,Shende V,McGee C,Yonova I,Ferreira F

    更新日期：2018-08-01 00:00:00

  • Ocular trauma in Turkey: a 2-year prospective study.

    abstract：:This 2-year prospective study was conducted to identify those at risk for ophthalmologic emergencies, to define the risk factors and reasons for eye injuries, to analyze treatment options, and to compare findings with those of previous studies. A total of 203 patients (74% male, mean age 27.3+/-13.9 y, 51% right eye i...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02850133

    authors： Oner A,Kekec Z,Karakucuk S,Ikizceli I,Sözüer EM

    更新日期：2006-03-01 00:00:00

  • Reduction of infectious morbidity with uterine stapling device.

    abstract：:Available data from comparative trials involving 483 patients were analyzed to determine the rate of infectious morbidity following the use of absorbable staples versus traditional incision and suturing of the vaginal cuff in abdominal hysterectomy. Infections occurred in 24 of 268 (9%) patients who received absorbab...

    journal_title：Advances in therapy

    pub_type： 杂志文章,meta分析

    doi：

    authors： Martens MG,Shailer LD

    更新日期：1991-05-01 00:00:00

  • Acceptance of Intanza® 9 μg intradermal influenza vaccine in routine clinical practice in Australia and Argentina.

    abstract：INTRODUCTION:Intanza® 9 μg (Sanofi Pasteur SA, Lyon, France), a split virion trivalent influenza vaccine delivered by intradermal injection with a microinjection system, became available as a vaccination for adults aged 18 to 59 years old, as of the 2010 southern hemisphere influenza season. METHODS:This study was des...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-011-0042-0

    authors： Eizenberg P,Booy R,Naser N,Mason G,Stamboulian D,Weber F

    更新日期：2011-08-01 00:00:00

  • Two innovative pharmaceutical forms of leuprorelin: results from 818 patients with advanced prostate cancer.

    abstract：OBJECTIVES:This study set out to examine the efficacy and tolerability of two innovative implant forms of leuprorelin acetate in men with advanced hormone-dependent prostate cancer in everyday clinical practice. METHODS:Data were collected from 818 patients (from 273 centers across Germany) who were pretreated with sl...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-013-0010-y

    authors： Gravel P,Samland D,Löffler M,Maier S,Panozzo M,Muenzberg M

    更新日期：2013-03-01 00:00:00

  • Effects of various enteral nutrition solutions on bacterial translocation and intestinal morphology during the postoperative period.

    abstract：:Bacterial translocation is the passage of bacteria or endotoxins from the gastrointestinal tract to extraintestinal sites, such as mesenteric lymph nodes, liver, spleen, and bloodstream. In this study, the investigators examined the effects of various enteral nutrients on bacterial translocation and intestinal morphol...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02849991

    authors： Aydogan A,Kismet K,Kilicoglu B,Erel S,Ozcan AH,Gollu A,Yildiz E,Akkus MA

    更新日期：2007-01-01 00:00:00

  • A Narrative Review of the Patient Journey Through the Lens of Non-communicable Diseases in Low- and Middle-Income Countries.

    abstract：:Low- and middle-income countries (LMICs) are challenged with a disproportionately high burden of noncommunicable diseases (NCDs) and limited healthcare resources at their disposal to tackle the NCD epidemic. Understanding the patient journey for NCDs from the patients' perspective can help healthcare systems in these ...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-020-01519-3

    authors： Devi R,Kanitkar K,Narendhar R,Sehmi K,Subramaniam K

    更新日期：2020-12-01 00:00:00

  • The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes in Asia.

    abstract：:The improvement of glycemic control in patients with type 2 diabetes (T2D) is an urgent need in Asia. East Asian T2D patients have distinct characteristics, including relatively low body weight, early impairment of islet beta cell function with reduced insulin secretion and a marked increase in postprandial blood gluc...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-019-00914-9

    authors： Lu JM

    更新日期：2019-04-01 00:00:00

  • Current Perspectives of Prophylaxis and Management of Acute Infective Endophthalmitis.

    abstract：:Endophthalmitis is an intraocular inflammatory condition which may or may not be caused by infective agents. Noninfectious (sterile) endophthalmitis may be attributable to various causes including postoperative retained soft lens matter or toxicity following introduction of other agents into the eye. Infectious endoph...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-016-0307-8

    authors： Tranos P,Dervenis N,Vakalis AN,Asteriadis S,Stavrakas P,Konstas AG

    更新日期：2016-05-01 00:00:00

  • Consequences of Supraphysiological Dialysate Magnesium on Arterial Stiffness, Hemodynamic Profile, and Endothelial Function in Hemodialysis: A Randomized Crossover Study Followed by a Non-Controlled Follow-Up Phase.

    abstract：INTRODUCTION:Increasing dialysate magnesium (D-Mg2+) appears to be an intriguing strategy to obtain cardiovascular benefits in subjects with end-stage kidney disease (ESKD) on hemodialysis. To date, however, hemodialysis guidelines do not suggest to increase D-Mg2+ routinely set at 0.50 mmol/L. METHODS:A randomized 4-...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-020-01505-9

    authors： Del Giorno R,Lavorato Hadjeres S,Stefanelli K,Allegra G,Zapparoli C,Predrag L,Berwert L,Gabutti L

    更新日期：2020-12-01 00:00:00

  • Moxifloxacin in complicated skin and skin structure infections (cSSSIs): A prospective, international, non-interventional, observational study.

    abstract：INTRODUCTION:ARTOS was an international, prospective, non-interventional, non-controlled observational study designed to determine the effectiveness, safety, and tolerability of moxifloxacin under daily-life conditions in patients with complicated skin and skin structure infections (cSSSIs) treated in Europe, the Middl...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-013-0038-z

    authors： Bogner JR,Kutaiman A,Esguerra-Alcalen M,Heldner S,Arvis P

    更新日期：2013-06-01 00:00:00

  • Indirect Treatment Comparison of Nivolumab Versus Observation or Ipilimumab as Adjuvant Therapy in Resected Melanoma Using Pooled Clinical Trial Data.

    abstract：INTRODUCTION:Nivolumab has been approved in patients with melanoma with lymph node involvement or metastatic disease who have undergone complete resection, in the adjuvant setting. A pivotal trial compared nivolumab with ipilimumab; however, no head-to-head trial exists comparing nivolumab to observation, a common comp...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-019-01060-y

    authors： Freeman M,Betts KA,Jiang S,Du EX,Gupte-Singh K,Lu Y,Rao S,Shoushtari AN

    更新日期：2019-10-01 00:00:00

  • Genital infection with human papillomavirus in adolescents.

    abstract：:Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in adolescents. Such infection is associated with substantial health risks and is unpredictable in its resolution. Genital warts are the most common clinical manifestations of genital HPV infections. Most genital warts are c...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF02849928

    authors： Leung AK,Kellner JD,Davies HD

    更新日期：2005-05-01 00:00:00

  • National assessment of Medicare prescription plan coverage gaps among patients with atrial fibrillation in the US.

    abstract：INTRODUCTION:The Medicare Part D prescription plan has a coverage gap from $2250 to $5100 per year (2006 thresholds) in which patients pay full drug costs (the "donut hole"). We examined prescription costs in patients aged >or=65 years with atrial fibrillation (AF), and the proportions entering/exiting the donut hole i...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-009-0054-1

    authors： Kim MH,Lin J,Kreilick C

    更新日期：2009-08-01 00:00:00

  • A review of uric acid, crystal deposition disease, and gout.

    abstract：:There has been increased interest in gout in both academic and clinical practice settings. Several reasons may explain this. The prevalence of both hyperuricemia and gout has risen in the last decades in developed countries and therefore the burden of gout has increased. The association of hyperuricemia and gout with ...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-014-0175-z

    authors： Perez-Ruiz F,Dalbeth N,Bardin T

    更新日期：2015-01-01 00:00:00

  • Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients.

    abstract：INTRODUCTION:Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHO...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-013-0030-7

    authors： Arai T

    更新日期：2013-05-01 00:00:00

  • 72-Week Safety and Tolerability of Dimethyl Fumarate in Japanese Patients with Relapsing-remitting Multiple Sclerosis: Analysis of the Randomised, Double Blind, Placebo-Controlled, Phase III APEX Study and its Open-Label Extension.

    abstract：INTRODUCTION:The long-term safety of dimethyl fumarate (DMF) in patients with relapsing-remitting multiple sclerosis (RRMS) has been studied in mainly Caucasian patients. The present interim analysis aimed to evaluate the 72-week safety of DMF in Japanese patients with RRMS. METHODS:Safety data of Japanese subjects en...

    journal_title：Advances in therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12325-018-0788-8

    authors： Ochi H,Niino M,Onizuka Y,Hiramatsu K,Hase M,Yun J,Matta A,Torii S

    更新日期：2018-10-01 00:00:00

  • Non-Small Cell Lung Cancer Patients Harboring HER2 Mutations: Clinical Characteristics and Management in a Real-Life Setting. Cohort HER2 EXPLORE GFPC 02-14.

    abstract：BACKGROUND:Mutation of human receptor tyrosine kinase epidermal growth factor receptor-2 (HER2) is a rare event, found in approximately 1% non-small cell lung cancers (NSCLC). The objective was to investigate the clinical characteristics and management of HER2-mutated NSCLCs in a real-life setting. METHODS:This multic...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-019-01001-9

    authors： Auliac JB,Dô P,Bayle S,Doubre H,Vinas F,Letreut J,Falchero L,Hauss PA,Thomas P,Chouaid C

    更新日期：2019-08-01 00:00:00

  • Prognosis and treatment outcome in patients with acute myeloid leukemia with t(8;21)(q22;q22).

    abstract：:Patients with acute myeloid leukemia (AML) with the t(8;21) karyotype generally have a favorable clinical course, but key prognostic factors remain poorly defined. This study was conducted to determine the prognoses and treatment outcomes of patients with AML with this unique cytogenetic change. A total of 22 patients...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02849984

    authors： Chen CC,Gau JP,Yu YB,Lu CH,Lee KD,You JY

    更新日期：2007-07-01 00:00:00

  • Angiotensin Receptor Blockers Versus Angiotensin Converting Enzyme Inhibitors for the Treatment of Arterial Hypertension and the Role of Olmesartan.

    abstract：:Blood pressure lowering by all classes of antihypertensive drugs is accompanied by significant reductions of stroke and major cardiovascular (CV) events. Drugs acting on the renin-angiotensin-aldosterone system, such as angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), showed s...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-018-0859-x

    authors： Omboni S,Volpe M

    更新日期：2019-02-01 00:00:00