Abstract：
:The prognosis for patients with rheumatoid arthritis or spondyloarthritides has improved dramatically due to earlier diagnosis, recognition of the need to treat early with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), alone or in combinations, the establishment of treatment targets, and the development of biological DMARDs (bDMARDs). Many patients are now able to achieve clinical remission or low disease activity with therapy, and reduce or eliminate systemic corticosteroid use. Guidelines recommend methotrexate as a first-line agent for the initial treatment of rheumatoid arthritis; however, a majority of patients will require a change of csDMARD or step up to combination therapy with the addition of another csDMARD or a bDMARD. However, treatment failure is common and switching to a different therapy may be required. The large number of available treatment options, combined with a lack of comparative data, makes the choice of a new therapy complex and often not evidence based. We summarize and discuss evidence to inform treatment decisions in patients who require a change in therapy, including baseline factors that may predict response to therapy.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Govoni M,Bortoluzzi A,Lo Monaco A,Adami S,Addimanda O,Caimmi C,De Vita S,Ferri C,Manfredi A,Orsolini G,Possemato N,Quartuccio L,Salvarani C,Zabotti A,Rossini Mdoi
10.1007/s12325-014-0142-8subject
Has Abstractpub_date
2014-08-01 00:00:00pages
780-802issue
8eissn
0741-238Xissn
1865-8652journal_volume
31pub_type
杂志文章,评审abstract：INTRODUCTION:Data regarding the prevalence of immune thrombocytopenia (ITP) is limited, and is derived from North American population-based analyses. Therefore, the authors conducted the first study outside the United States (US) using the United Kingdom (UK) General Practice Research Database (GPRD) to estimate the ad...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-011-0084-3
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have an increased risk of comorbid conditions, including cardiovascular disease (CVD). Anemia is prevalent in the CKD population and worsens as kidney function declines, resulting in a diminished quality of life and increased morbidity/mortality. The purpose of th...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0566-z
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:Examine outcomes and costs of patients with persistent asthma who initiated treatment with beclomethasone dipropionate hydrofluoroalkane (BDP-HFA) or fluticasone propionate (FP). METHODS:MedStat's Commercial Claims and Encounters database (July 1, 2002-June 30, 2007) was utilized. Patients (n=13,968) were in...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0056-z
更新日期：2009-08-01 00:00:00
abstract：:Designed to provide information about patients with schizophrenia who switch from depot neuroleptics to the oral, atypical antipsychotic risperidone, this multicenter observational study enrolled patients who wished to stop the depot, had an unsatisfactory response, or experienced unacceptable side effects. Individual...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1999-03-01 00:00:00
abstract：:The lipid triad is the association of small, dense (sd) low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and hypertriglyceridemia, all of which play a role in coronary artery disease in patients with type 2 diabetes. Although statins have demonstrated clear positive effects on cardiovascular morbidit...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/BF02849947
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to investigate whether the efficacy of liraglutide observed in randomized controlled trials translates into therapeutic benefits in the French population during routine clinical practice. METHODS:This observational, prospective, multicenter study included 3152 adults with type 2 ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0245-x
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVES:Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS:The IMS LifeLink Health Plan Claims database was use...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-014-0110-3
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:Although chronic opioid therapy is usually initiated using short-acting opioids, many patients with chronic pain are subsequently converted to long-acting and extended-release preparations. In clinical practice, optimal management requires careful individualization of dosage in order to achieve an appropri...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0051-7
更新日期：2012-10-01 00:00:00
abstract：INTRODUCTION:Alcohol dependence represents a severe pathological disorder associated with a significant rate of morbidity and mortality. To date, limited pharmacological agents exist to treat this disorder, and there is a growing interest for new therapies. In this context, pregabalin represents a promising strategy. P...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-012-0061-5
更新日期：2012-11-01 00:00:00
abstract：:The origin of chronic periodontal disease is strongly related to the nature and physiology of the subgingival bacterial biofilm, of which Porphyromonas gingivalis is a main protagonist. This study was conducted in vitro, to test the susceptibility of the W83 strain of P gingivalis to several oral antiseptics, bearing ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02877764
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Ivabradine has opened up new possibilities for treating stable angina and chronic heart failure by lowering heart rate. Ivabradine lowers heart rate by selectively inhibiting the I f current in the sinoatrial node. This study aimed to determine whether the decrease in heart rate achieved with ivabradine wa...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：10.1007/s12325-015-0253-x
更新日期：2015-10-01 00:00:00
abstract：:The corneal toxicity of 2 intraocular pressure-lowering agents was compared in a rabbit cornea model with New Zealand White rabbits. Corneal epithelial morphology and cell size were assessed by in vivo confocal microscopy. Baseline microscopic examinations were performed on 1 eye of each animal. Two weeks later, the e...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850305
更新日期：2006-09-01 00:00:00
abstract：:Diabetic foot ulcers (DFUs) are one of the most common and serious complications of diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a dynamic and complex biological process that can be divided into four partly overlapping phases: hemostasis, inflammation, proliferative and remode...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-014-0140-x
更新日期：2014-08-01 00:00:00
abstract：:Fibroids, the most common tumor in women of reproductive age, impact negatively on women's health and quality of life, and have significant cost implications for their management. The current mainstay treatments are surgical (myomectomy and hysterectomy) and more recently radiological (UAE and focused ultrasound surge...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0042-8
更新日期：2012-08-01 00:00:00
abstract：:Despite the results from clinical trials in patients with hypertension and the development of a long list of guidelines for the management of hypertension, many physicians and other healthcare professionals still manage hypertension using approaches that clearly diverge at least partially from the recommendations of t...
journal_title：Advances in therapy
pub_type： 共识发展会议,杂志文章,评审
doi：10.1007/BF02849881
更新日期：2005-03-01 00:00:00
abstract：:The aims of this study were to determine whether the nursing costs of functional disability could be assessed retrospectively and, if so, whether this method was sensitive enough to show the influence of a treatment on economic costs. Four studies were available for this purpose: three randomized, double-blind, place...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:The article "Sleep Quality and Congestion with Breathe Right Nasal Strips: Two Randomized Controlled Trials", written by Michael J. Noss, Renee Ciesla, and Gilbert Shanga, was originally published electronically on the publisher's internet portal (currently SpringerLink) on June 17, 2019 without Open Access. The artic...
journal_title：Advances in therapy
pub_type： 已发布勘误
doi：10.1007/s12325-019-01069-3
更新日期：2019-11-01 00:00:00
abstract：:The aim of this prospective, randomized, open-label, blinded endpoint (PROBE) study was to compare the antihypertensive efficacy of 2 angiotensin II (AII) receptor antagonists with different pharmacologic profiles, valsartan and olmesartan, in patients with mild-to-moderate essential hypertension. After an initial 2-w...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850182
更新日期：2005-01-01 00:00:00
abstract：INTRODUCTION:Diabetes-related healthcare costs are increasing in the United States, with inpatient hospitalization the largest component of medical expenditures. The aims of this study were to characterize hospitalized type 2 diabetes mellitus (T2DM) patients, understand the relationship between hospitalization and hea...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0223-3
更新日期：2015-07-01 00:00:00
abstract：:As head and neck squamous cell carcinoma (HNSCC) patients with distant metastases (DM) were generally treated only palliatively, the value of screening for DM was usually limited to attempts to avoid extensive locoregional treatment when DM were present pretreatment. Recently, the concept of treating oligometastases, ...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-018-0662-8
更新日期：2018-02-01 00:00:00
abstract：INTRODUCTION:Healthy eating is a critical aspect of the prevention and management of type 2 diabetes (T2DM). Disrupted eating patterns can result in poor glucose control and increase the likelihood of diabetic complications. Teneligliptin inhibits dipeptidyl peptidase-4 activity for 24 h and suppresses postprandial hyp...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0704-2
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHO...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0030-7
更新日期：2013-05-01 00:00:00
abstract：:The purpose of this study was to evaluate risk pattern and mortality in a general population epidemiologic study performed by a staff of hypertension specialists working as the "good father of a family," with lifestyle and therapeutic advice and instrumental measurements. Mortality among the study population (n=856) d...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850213
更新日期：2006-11-01 00:00:00
abstract：INTRODUCTION:Accumulating studies indicate that melatonin is a natural oncostatic agent capable of mediating the influence of the psychoneuroendocrine system on cancer growth. Although there is increasing evidence to show that the pineal gland may play a role in human non-small cell lung cancer (NSCLC), there is uncert...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0068-8
更新日期：2009-09-01 00:00:00
abstract：INTRODUCTION:One method of treatment for allergic diseases is allergen-specific immunotherapy (SIT). The clinical efficacy of SIT in pollen-induced allergic rhinitis has been demonstrated in several controlled clinical trials. There is no consensus about the protective effect of SIT. In this study, we evaluated the cor...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0004-3
更新日期：2008-01-01 00:00:00
abstract：:Tumor necrosis factor (TNF) inhibitors are widely used biologics for the treatment of several chronic inflammatory diseases. The launch of anti-TNF biosimilars has introduced the possibility of non-medical switching between originator biologics and their biosimilars. However, the potential clinical and patient-reporte...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0742-9
更新日期：2018-09-01 00:00:00
abstract：INTRODUCTION:In budesonide/formoterol (Symbicort(R) Turbuhaler(R), AstraZeneca, Lund, Sweden) maintenance and reliever therapy (SMART), patients with asthma take a daily maintenance dose of budesonide/formoterol, with the option of taking additional doses for symptom relief instead of a short-acting beta(2)-agonist (SA...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0063-0
更新日期：2009-09-01 00:00:00
abstract：:Despite more than a century of evolving federal legislation, there remain many unapproved drugs on the United States (US) market. This article reviews the history of drug approval in the US, beginning with the landmark Pure Food and Drug Act of 1906, through to the development of the US Food and Drug Administration (F...
journal_title：Advances in therapy
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s12325-011-0059-4
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION:This trial was conducted to assess the long-term safety, efficacy, and benefit of early add-on of linagliptin to insulin in patients with type 2 diabetes mellitus (T2DM). METHODS:This trial enrolled 246 subjects. The subjects were randomized to the linagliptin group or the control group and were observed ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-021-01631-y
更新日期：2021-01-28 00:00:00
abstract：INTRODUCTION:Our objective was to determine the effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in a broad range of patient profiles, including subgroups with varying hypertension severity, age and cardiovascular risk profiles. METHODS:Patient data from four large prospective observat...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01527-3
更新日期：2020-11-05 00:00:00
