当前位置： SCI文献检索 > ADVANCES IN THERAPY期刊下所有文献 > Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride.

Assessment of corneal epithelial integrity after acute exposure to ocular hypotensive agents preserved with and without benzalkonium chloride.

Abstract：

:The corneal toxicity of 2 intraocular pressure-lowering agents was compared in a rabbit cornea model with New Zealand White rabbits. Corneal epithelial morphology and cell size were assessed by in vivo confocal microscopy. Baseline microscopic examinations were performed on 1 eye of each animal. Two weeks later, the eyes were bathed for 3 min in travoprost 0.004% preserved without benzalkonium chloride (BAK( or latanoprost 0.005% preserved with 0.02% BAK; the eyes were then rinsed with balanced salt solution, and the corneas were again examined by confocal microscopy (n=4/group). A second group of animals was exposed to the medications through a dosing regimen of 1 drop/min (lpar3 drops total) (n=4/group). In eyes treated with travoprost without BAK (3-min bath), superficial epithelial cells were similar to baseline, as indicated by their visible cell borders and bright nuclei. In contrast, the surface cells in eyes treated with latanoprost were significantly smaller and brighter and had less distinct borders. Surface cell size was significantly smaller as compared with baseline size and as compared with rabbits treated with travoprost without BAK for 3 min. Similar effects on corneal epithelial cell morphology were observed with the 1-drop/min dosing regimen. In this rabbit model, travoprost 0.004% preserved without BAK did not cause corneal epithelial toxicity; latanoprost 0.005% induced superficial cell loss, most likely caused by the presence of a relatively high concentration of BAK (0.02%).

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Whitson JT,Cavanagh HD,Lakshman N,Petroll WM

doi

10.1007/BF02850305

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

663-71

issue

5

eissn

0741-238X

issn

1865-8652

pii

529

journal_volume

23

pub_type

杂志文章

相关文献

ADVANCES IN THERAPY文献大全
  • Population-based screening with the Coronary Heart Disease Risk Factor Calculator.

    abstract：:Data from the Framingham Heart Study and risk-appraisal models were used to develop a Coronary Heart Disease (CHD) Risk Factor Calculator for early identification of high-risk individuals. The Calculator was tested at an employee health fair for a large northeastern US corporation. Of the 590 employees who registered ...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02850248

    authors： Day D

    更新日期：2001-01-01 00:00:00

  • The Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Depressive Symptoms in Major Depressive Disorder and Bipolar Disorder.

    abstract：INTRODUCTION:Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive diso...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-017-0482-2

    authors： Mandelli L,Wang SM,Han C,Lee SJ,Patkar AA,Masand PS,Pae CU,Serretti A

    更新日期：2017-03-01 00:00:00

  • Efficacy and safety of ketorolac tromethamine 0.5% and levocabastine 0.05%: a multicenter comparison in patients with seasonal allergic conjunctivitis.

    abstract：:This multicenter, double-masked, randomized, parallel-group study compared the efficacy and safety of ketorolac tromethamine 0.5% ophthalmic solution with levocabastine 0.05% and ketorolac tromethamine vehicle in patients with seasonal allergic conjunctivitis. One drop of ketorolac, levocabastine, or vehicle was insti...

    journal_title：Advances in therapy

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF02854842

    authors： Donshik PC,Pearlman D,Pinnas J,Raizman MB,Tauber J,Tinkelman D,Walters TR

    更新日期：2000-03-01 00:00:00

  • Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related diabetic nephropathy: case report.

    abstract：:Nonketotic hyperosmolar coma (NHC) is characterized by severe hyperglycemia; absence of, or only slight ketosis; nonketotic acidosis; severe dehydration; depressed sensorium or frank coma; and various neurologic signs. This condition is uncommon in type 1 diabetes. Because of little or no osmotic diuresis in patients ...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02849861

    authors： Dogan E,Erkoc R,Sayarlioglu H,Buyukbese A

    更新日期：2005-09-01 00:00:00

  • Anterior Chamber Inflammation After Cataract Surgery: A Randomized Clinical Trial Comparing Bromfenac 0.09% to Dexamethasone 0.1.

    abstract：PURPOSE:To compare the efficacy of bromfenac 0.09% and dexamethasone 0.1% in the treatment of anterior chamber inflammation after uncomplicated cataract surgery. METHODS:Seventy-six patients with senile cataracts and no other ocular comorbidities who underwent uneventful phacoemulsification were randomized 1:1 to rece...

    journal_title：Advances in therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12325-019-01076-4

    authors： Coassin M,De Maria M,Mastrofilippo V,Braglia L,Cimino L,Sartori A,Fontana L

    更新日期：2019-10-01 00:00:00

  • Survival, Chemotherapy Treatments, and Health Care Utilization Among Patients with Advanced Small Cell Lung Cancer: An Observational Study.

    abstract：INTRODUCTION:Most cases of small cell lung cancer (SCLC) are diagnosed at an advanced stage. The objective of this study was to investigate patient characteristics, survival, chemotherapy treatments, and health care use after a diagnosis of advanced SCLC in subjects enrolled in a health system network. METHODS:This wa...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-019-01161-8

    authors： He J,Shao C,Hui SL,Zhang Z,Baker J,Dexter PR,Kachroo S,Jin F

    更新日期：2020-01-01 00:00:00

  • Ocular trauma in Turkey: a 2-year prospective study.

    abstract：:This 2-year prospective study was conducted to identify those at risk for ophthalmologic emergencies, to define the risk factors and reasons for eye injuries, to analyze treatment options, and to compare findings with those of previous studies. A total of 203 patients (74% male, mean age 27.3+/-13.9 y, 51% right eye i...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02850133

    authors： Oner A,Kekec Z,Karakucuk S,Ikizceli I,Sözüer EM

    更新日期：2006-03-01 00:00:00

  • Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?

    abstract：INTRODUCTION:Oral supplementation of chondroitin sulfate (CS) and glucosamine (GlcN), symptomatic slow-acting molecules, is recommended by European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and Musculoskeletal Diseases (ESCEO) and other European Union (EU) guidelines for the restorati...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-019-01064-8

    authors： Stellavato A,Restaino OF,Vassallo V,Finamore R,Ruosi C,Cassese E,De Rosa M,Schiraldi C

    更新日期：2019-11-01 00:00:00

  • Genital infection with human papillomavirus in adolescents.

    abstract：:Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in adolescents. Such infection is associated with substantial health risks and is unpredictable in its resolution. Genital warts are the most common clinical manifestations of genital HPV infections. Most genital warts are c...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF02849928

    authors： Leung AK,Kellner JD,Davies HD

    更新日期：2005-05-01 00:00:00

  • Treatment patterns following discontinuation of adalimumab, etanercept, and infliximab in a US managed care sample.

    abstract：OBJECTIVES:Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS:The IMS LifeLink Health Plan Claims database was use...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-014-0110-3

    authors： Yeaw J,Watson C,Fox KM,Schabert VF,Goodman S,Gandra SR

    更新日期：2014-04-01 00:00:00

  • Clinical outcomes of patients with anterior segment neovascularization treated with or without intraocular bevacizumab.

    abstract：INTRODUCTION:The purpose of this study was to evaluate the clinical outcomes of patients with anterior segment neovascularization treated with or without intravitreal bevacizumab. METHODS:This was a retrospective, comparative case series of 60 patients with anterior segment neovascularization: 30 consecutive patients ...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-009-0001-1

    authors： Lupinacci AP,Calzada JI,Rafieetery M,Charles S,Netland PA

    更新日期：2009-02-01 00:00:00

  • Pitfalls in radiologic and histopathologic diagnosis of urologic disease--report of 4 cases.

    abstract：:Cases are presented to illustrate pitfalls in radiologic and histopathologic diagnosis in urology. In a 73-year-old woman, ultrasound revealed calcification in an irregular mass arising from the left wall of the bladder. Bladder biopsy reported the mass as papillary transitional cell carcinoma. Histologically, the spe...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02850223

    authors： Vaidyanathan S,Soni BM,Hughes PL,Mansour P,Singh G

    更新日期：2006-11-01 00:00:00

  • The Association Between Switching from Synthroid® and Clinical Outcomes: US Evidence from a Retrospective Database Analysis.

    abstract：INTRODUCTION:Clinical guidelines recommend levothyroxine as the standard of care for hypothyroidism and that patients should be treated with a consistent preparation of synthetic levothyroxine without switching among formulations. This study examines the likelihoods of negative clinical outcomes between continuous user...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-020-01537-1

    authors： Hennessey JV,Espaillat R,Duan Y,Soni-Brahmbhatt S,Lage MJ,Singer P

    更新日期：2020-10-28 00:00:00

  • Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells.

    abstract：INTRODUCTION:This clinical study aimed to investigate the effect of brinzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelial cells (CECs) in patients with glaucoma using a follow-up clinical study design. METHODS:Patients with primary open-angle glaucoma or ocular hypertension were administrated an...

    journal_title：Advances in therapy

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12325-016-0373-y

    authors： Nakano T,Inoue R,Kimura T,Suzumura H,Tanino T,Yamazaki Y,Yoshikawa K,Tatemichi M

    更新日期：2016-08-01 00:00:00

  • Self-Care in the Twenty First Century: A Vital Role for the Pharmacist.

    abstract：:In order for the global healthcare system to remain sustainable, healthcare spending needs to be reduced, and self-treating certain conditions under the guidance of a pharmacist provides a means of accomplishing this goal. This article was developed to describe global healthcare trends affecting self-care with a speci...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-016-0395-5

    authors： Bell J,Dziekan G,Pollack C,Mahachai V

    更新日期：2016-10-01 00:00:00

  • Assessing thrombosis risk in patients with idiopathic, diabetic, and postsurgical gastroparesis.

    abstract：:Patients with severe gastrointestinal motility disorders are often found to have intravenous access clots or deep venous thrombosis. It has previously been reported that many patients who have intravenous access thrombosis have concomitant thrombotic risk factors. In this study, the goal was to determine the underlyin...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02850315

    authors： Lobrano A,Blanchard K,Rock W,Johnson W,Schmieg B,Borman K,Araghizadeh F,Minocha A,Abell TL

    更新日期：2006-09-01 00:00:00

  • Management of macular edema secondary to central retinal vein occlusion: an evidence-based.

    abstract：:Retinal vein occlusions are common retinal vascular disorders with the potential for significant vision-related morbidity. Retinal vein occlusions are classified as either branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), or hemiretinal vein occlusion (HRVO) based on the specific occlusion s...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-010-0088-4

    authors： Aref AA,Scott IU

    更新日期：2011-01-01 00:00:00

  • Consensus Recommendations for Management and Counseling of Adverse Events Associated With Lorlatinib: A Guide for Healthcare Practitioners.

    abstract：:Resistance to first- and second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and development and progression of central nervous system metastases remain significant issues in the treatment of ALK-positive non-small-cell lung cancer. Lorlatinib is a novel third-generation ALK TKI that i...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-020-01365-3

    authors： Reed M,Rosales AS,Chioda MD,Parker L,Devgan G,Kettle J

    更新日期：2020-06-01 00:00:00

  • Effect of acute and long-term administration of ramipril on circadian rhythm of blood pressure in essential hypertension.

    abstract：:Ambulatory monitoring was used to evaluate the antihypertensive efficacy and effect on circadian rhythms of blood pressure and heart rate of a single dose and long-term administration of ramipril in 20 patients with mild to moderate essential hypertension. Patients initially were randomized to receive either placebo o...

    journal_title：Advances in therapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Cavazzini D,Amadei G,Manfredini R,Musacci G,Mele D,Longhini C

    更新日期：1995-01-01 00:00:00

  • A review of uric acid, crystal deposition disease, and gout.

    abstract：:There has been increased interest in gout in both academic and clinical practice settings. Several reasons may explain this. The prevalence of both hyperuricemia and gout has risen in the last decades in developed countries and therefore the burden of gout has increased. The association of hyperuricemia and gout with ...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-014-0175-z

    authors： Perez-Ruiz F,Dalbeth N,Bardin T

    更新日期：2015-01-01 00:00:00

  • Anticoagulation Favors Thrombus Recanalization and Survival in Patients With Liver Cirrhosis and Portal Vein Thrombosis: Results of a Meta-Analysis.

    abstract：INTRODUCTION:Benefit and risk of anticoagulation in cirrhotic patients with portal vein thrombosis (PVT) remain controversial, especially in those with asymptomatic PVT and in non-liver transplant candidates. Furthermore, the predictors of portal vein recanalization and bleeding events after anticoagulation are critica...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-020-01550-4

    authors： Wang L,Guo X,Xu X,De Stefano V,Plessier A,Noronha Ferreira C,Qi X

    更新日期：2020-11-05 00:00:00

  • Anticholinergic treatment in airways diseases.

    abstract：:The prevalence of chronic airways diseases such as chronic obstructive pulmonary disease and asthma is increasing. They lead to symptoms such as a cough and shortness of breath, partially through bronchoconstriction. Inhaled anticholinergics are one of a number of treatments designed to treat bronchoconstriction in ai...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-009-0074-x

    authors： Flynn RA,Glynn DA,Kennedy MP

    更新日期：2009-10-01 00:00:00

  • Intravenous Esomeprazole for Prevention of Peptic Ulcer Rebleeding: A Randomized Trial in Chinese Patients.

    abstract：INTRODUCTION:High-dose intravenous esomeprazole is the only approved pharmacological treatment for the prevention of peptic ulcer rebleeding (currently approved in over 100 countries worldwide), but has not yet been approved in China. This study aimed to evaluate a high-dose esomeprazole intravenous regimen vs. an acti...

    journal_title：Advances in therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12325-015-0265-6

    authors： Bai Y,Chen DF,Wang RQ,Chen YX,Shi RH,Tian DA,Chen H,Eklund S,Li ZS,Chinese Peptic Ulcer Bleeding Research Group.

    更新日期：2015-11-01 00:00:00

  • Healthcare-Related Costs Associated with Switching Subcutaneous Tumor Necrosis Factor-α Inhibitor in the Treatment of Inflammatory Arthritis: a Retrospective Study.

    abstract：INTRODUCTION:Subsequent lines of subcutaneous tumor necrosis factor alpha inhibitor (SC-TNFi) treatment may be well motivated in the management of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)-collectively named inflammatory arthritis (IA). However, the costs associated with swit...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-020-01425-8

    authors： Dalén J,Luttropp K,Svedbom A,Black CM,Kachroo S

    更新日期：2020-09-01 00:00:00

  • The Case for the Use of Patient and Caregiver Perception of Change Assessments in Rare Disease Clinical Trials: A Methodologic Overview.

    abstract：INTRODUCTION:The traditional model of evaluating treatments based primarily on primary outcome measures has stumbled in its application to rare disease. Rare disease clinical trials face the methodological challenges of small, heterogeneous patient populations and relatively few validated, disease-specific outcome meas...

    journal_title：Advances in therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s12325-019-00920-x

    authors： Contesse MG,Valentine JE,Wall TE,Leffler MG

    更新日期：2019-05-01 00:00:00

  • Reduction of infectious morbidity with uterine stapling device.

    abstract：:Available data from comparative trials involving 483 patients were analyzed to determine the rate of infectious morbidity following the use of absorbable staples versus traditional incision and suturing of the vaginal cuff in abdominal hysterectomy. Infections occurred in 24 of 268 (9%) patients who received absorbab...

    journal_title：Advances in therapy

    pub_type： 杂志文章,meta分析

    doi：

    authors： Martens MG,Shailer LD

    更新日期：1991-05-01 00:00:00

  • Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer.

    abstract：INTRODUCTION:Recent research has suggested that serum tumor markers can give valuable prognostic information in gastric cancer. In this study, we examined the relationship between preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA 72-4, and alfa fetoprotein (AFP) levels on clinicopath...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-008-0100-4

    authors： Ucar E,Semerci E,Ustun H,Yetim T,Huzmeli C,Gullu M

    更新日期：2008-10-01 00:00:00

  • Prognosis and treatment outcome in patients with acute myeloid leukemia with t(8;21)(q22;q22).

    abstract：:Patients with acute myeloid leukemia (AML) with the t(8;21) karyotype generally have a favorable clinical course, but key prognostic factors remain poorly defined. This study was conducted to determine the prognoses and treatment outcomes of patients with AML with this unique cytogenetic change. A total of 22 patients...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/BF02849984

    authors： Chen CC,Gau JP,Yu YB,Lu CH,Lee KD,You JY

    更新日期：2007-07-01 00:00:00

  • Denosumab Versus Zoledronic Acid in Bone Disease Treatment of Newly Diagnosed Multiple Myeloma: An International, Double-Blind, Randomized Controlled Phase 3 Study-Asian Subgroup Analysis.

    abstract：INTRODUCTION:The primary analysis of a global phase 3 study that evaluated the efficacy and safety of denosumab versus zoledronic acid for preventing skeletal-related events (SREs) in adults with newly diagnosed multiple myeloma (MM) indicated that denosumab was noninferior to zoledronic acid for time to first on-study...

    journal_title：Advances in therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s12325-020-01395-x

    authors： Huang SY,Yoon SS,Shimizu K,Chng WJ,Chang CS,Wong RS,Gao S,Wang Y,Gordon SW,Glennane A,Min CK

    更新日期：2020-07-01 00:00:00

  • Improvement of glycemic control by re-education in insulin injection technique in patients with diabetes mellitus.

    abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control. METHODS:A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All pat...

    journal_title：Advances in therapy

    pub_type： 杂志文章

    doi：10.1007/s12325-013-0066-8

    authors： Nakatani Y,Matsumura M,Monden T,Aso Y,Nakamoto T

    更新日期：2013-10-01 00:00:00