Effect of acute and long-term administration of ramipril on circadian rhythm of blood pressure in essential hypertension.

Abstract:

:Ambulatory monitoring was used to evaluate the antihypertensive efficacy and effect on circadian rhythms of blood pressure and heart rate of a single dose and long-term administration of ramipril in 20 patients with mild to moderate essential hypertension. Patients initially were randomized to receive either placebo or a single 5-mg dose of ramipril, followed 1 week later by 5 mg of ramipril daily for 6 months. Systolic (SBP) and diastolic blood pressure (DBP) and heart rate were measured every 20 minutes for 24 hours. Single-dose ramipril reduced both SBP and DBP (P < .001) without affecting heart rate. Long-term treatment produced a small additional antihypertensive effect, again without modifying heart rate. Cosinor analysis demonstrated that both administrations of ramipril effectively lowered SBP and DBP mesors (P < .001), compared to placebo; circadian rhythms remained undisturbed. Heart rate also was not modified on any circadian parameter. A significant reduction (P < .001) of blood pressure amplitude, however, occurred after long-term treatment and may have importance in terms of preventing cardiac damage.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Cavazzini D,Amadei G,Manfredini R,Musacci G,Mele D,Longhini C

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

11-21

issue

1

eissn

0741-238X

issn

1865-8652

pii

2

journal_volume

12

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF02850056

    authors: Tauber J,Alocril Community Allergy Trial Study Group.

    更新日期:2002-03-01 00:00:00

  • Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review.

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    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

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    authors: Amaya-Montoya M,Pérez-Londoño A,Guatibonza-García V,Vargas-Villanueva A,Mendivil CO

    更新日期:2020-04-01 00:00:00

  • 12-Month Retrospective Comparison of Kahook Dual Blade Excisional Goniotomy with Istent Trabecular Bypass Device Implantation in Glaucomatous Eyes at the Time of Cataract Surgery.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01025-1

    authors: ElMallah MK,Seibold LK,Kahook MY,Williamson BK,Singh IP,Dorairaj SK,KDB Goniotomy Study Group.

    更新日期:2019-09-01 00:00:00

  • Successful treatment of acute subretinal hemorrhage in age-related macular degeneration by combined intravitreal injection of recombinant tissue plasminogen activator and gas.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:

    authors: Hesse L,Kroll P

    更新日期:1997-09-01 00:00:00

  • Self-expandable metallic stents for malignant gastric outlet obstruction.

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    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-010-0061-2

    authors: Boškoski I,Tringali A,Familiari P,Mutignani M,Costamagna G

    更新日期:2010-10-01 00:00:00

  • Mental Health Status in Patients Undergoing Intracoronary Acetylcholine Provocation Test.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01424-9

    authors: Saito Y,Shoji T,Tateishi K,Kitahara H,Fujimoto Y,Kobayashi Y

    更新日期:2020-09-01 00:00:00

  • Brain volume abnormalities and neurocognitive deficits in diabetes mellitus: points of pathophysiological commonality with mood disorders?

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    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-010-0011-z

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    更新日期:2010-02-01 00:00:00

  • The Role of the Pharmacist in the Treatment of Patients with Infantile Hemangioma Using Propranolol.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-016-0391-9

    authors: Castaneda S,Melendez-Lopez S,Garcia E,De la Cruz H,Sanchez-Palacio J

    更新日期:2016-10-01 00:00:00

  • The Cost-Effectiveness of Ranibizumab Treat and Extend Regimen Versus Aflibercept in the UK.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-016-0367-9

    authors: Ghosh W,Wickstead R,Claxton L,Kusel J,Taylor M,Fleetwood K,Pulikottil-Jacob R

    更新日期:2016-09-01 00:00:00

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0119-6

    authors: Kumchev E,Koytchev R,Dimitrakov D,Stavrev P,Tsochev G,Siebert-Weigel M

    更新日期:2008-12-01 00:00:00

  • Cannabis Use in Hospitalized Patients with Chronic Pain.

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    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01416-9

    authors: Orhurhu V,Urits I,Olusunmade M,Olayinka A,Salisu Orhurhu M,Uwandu C,Aner M,Ogunsola S,Akpala L,Hirji S,Viswanath O,Karri J,Simopoulos T,Gill J

    更新日期:2020-08-01 00:00:00

  • Self-Care in the Twenty First Century: A Vital Role for the Pharmacist.

    abstract::In order for the global healthcare system to remain sustainable, healthcare spending needs to be reduced, and self-treating certain conditions under the guidance of a pharmacist provides a means of accomplishing this goal. This article was developed to describe global healthcare trends affecting self-care with a speci...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

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    更新日期:2016-10-01 00:00:00

  • Enhanced Safety Surveillance of Seasonal Quadrivalent Influenza Vaccines in English Primary Care: Interim Analysis.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0747-4

    authors: de Lusignan S,Dos Santos G,Byford R,Schuind A,Damaso S,Shende V,McGee C,Yonova I,Ferreira F

    更新日期:2018-08-01 00:00:00

  • Comparative Effectiveness of nab-Paclitaxel Plus Gemcitabine vs FOLFIRINOX in Metastatic Pancreatic Cancer: A Retrospective Nationwide Chart Review in the United States.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0784-z

    authors: Kim S,Signorovitch JE,Yang H,Patterson-Lomba O,Xiang CQ,Ung B,Parisi M,Marshall JL

    更新日期:2018-10-01 00:00:00

  • Non-Small Cell Lung Cancer Patients Harboring HER2 Mutations: Clinical Characteristics and Management in a Real-Life Setting. Cohort HER2 EXPLORE GFPC 02-14.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01001-9

    authors: Auliac JB,Dô P,Bayle S,Doubre H,Vinas F,Letreut J,Falchero L,Hauss PA,Thomas P,Chouaid C

    更新日期:2019-08-01 00:00:00

  • Efficacy and safety of butterbur herbal extract Ze 339 in seasonal allergic rhinitis: postmarketing surveillance study.

    abstract::The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850143

    authors: Käufeler R,Polasek W,Brattström A,Koetter U

    更新日期:2006-03-01 00:00:00

  • Clarithromycin suspension vs penicillin V suspension in children with streptococcal pharyngitis.

    abstract::Clarithromycin, an advanced-generation macrolide antibiotic, has demonstrated excellent in vitro activity against group A beta-hemolytic streptococcus (GABHS). Potent activity against Streptococcus pyogenes and a favorable pharmacokinetic profile have made it a reasonable alternative for treatment of patients with str...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1007/BF02868027

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    更新日期:2000-01-01 00:00:00

  • Ginkgo biloba (EGb 761) in the treatment of equilibrium disorders.

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    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章

    doi:

    authors: Cesarani A,Meloni F,Alpini D,Barozzi S,Verderio L,Boscani PF

    更新日期:1998-09-01 00:00:00

  • Evaluation of MRI-US Fusion Technology in Sports-Related Musculoskeletal Injuries.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-015-0217-1

    authors: Wong-On M,Til-Pérez L,Balius R

    更新日期:2015-06-01 00:00:00

  • An economic evaluation of budesonide/formoterol for maintenance and reliever treatment in asthma in general practice.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

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    更新日期:2009-09-01 00:00:00

  • Improvement of glycemic control by re-education in insulin injection technique in patients with diabetes mellitus.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-013-0066-8

    authors: Nakatani Y,Matsumura M,Monden T,Aso Y,Nakamoto T

    更新日期:2013-10-01 00:00:00

  • Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells.

    abstract:INTRODUCTION:This clinical study aimed to investigate the effect of brinzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelial cells (CECs) in patients with glaucoma using a follow-up clinical study design. METHODS:Patients with primary open-angle glaucoma or ocular hypertension were administrated an...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12325-016-0373-y

    authors: Nakano T,Inoue R,Kimura T,Suzumura H,Tanino T,Yamazaki Y,Yoshikawa K,Tatemichi M

    更新日期:2016-08-01 00:00:00

  • Two innovative pharmaceutical forms of leuprorelin: results from 818 patients with advanced prostate cancer.

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    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-013-0010-y

    authors: Gravel P,Samland D,Löffler M,Maier S,Panozzo M,Muenzberg M

    更新日期:2013-03-01 00:00:00

  • Dose conversion ratio in hemodialysis patients switched from darbepoetin alfa to PEG-epoetin beta: AFFIRM study.

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    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

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    更新日期:2013-11-01 00:00:00

  • Second-Generation Trabecular Micro-Bypass Stents as Standalone Treatment for Glaucoma: A 36-Month Prospective Study.

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  • Attitudes of physiotherapists and physiotherapy students toward euthanasia: a comparative study.

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    journal_title:Advances in therapy

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    更新日期:2007-01-01 00:00:00

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    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究,随机对照试验

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    更新日期:2014-12-01 00:00:00

  • The Association Between Switching from Synthroid® and Clinical Outcomes: US Evidence from a Retrospective Database Analysis.

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    pub_type: 杂志文章

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