Abstract:
INTRODUCTION:There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. AFFIRM (Aranesp Efficiency Relative to Mircera) was a retrospective, multi-site, observational study designed to estimate the population mean maintenance dose conversion ratio [DCR; dose ratio achieving comparable hemoglobin level (Hb) between two evaluation periods] in European hemodialysis patients whose treatment was switched from DA to PEG-Epo. METHODS:Eligible patients had received hemodialysis for ≥ 12 months and DA for ≥ 7 months. Data were collected from 7 months before until 7 months after switching treatment. DCR was calculated for patients with Hb and ESA data available in both evaluation periods (EP; Months 1 and 2 were defined as the pre-switch EP, and Months 6 and 7 as the post-switch EP). Red blood cell transfusions pre- and post-switch were quantified. RESULTS:Of 302 patients enrolled, 206 had data available for DCR analysis. The geometric mean DCR was 1.17 (95% CI 1.05, 1.29). Regression analysis indicated a non-linear relationship between pre- and post-switch ESA doses; DCR decreased with increasing pre-switch DA dose. The geometric mean weekly ESA doses were 24.1 μg DA in the pre-switch EP and 28.6 μg PEG-Epo in the post-switch EP. Mean Hb was 11.5 g/dL in the pre-switch EP and 11.4 g/dL in the post-switch EP. There were 16 transfusions and 34 units transfused in the pre-switch period, versus 48 transfusions and 95 units transfused post-switch. Excluding patients receiving a transfusion within 90 days of or during either EP, the DCR was 1.21 (95% CI 1.09, 1.35). CONCLUSION:In these hemodialysis patients switched from DA to PEG-Epo the DCR was 1.17 and 1.21 after accounting for the effect of transfusions. The number of transfusions and units transfused increased approximately threefold from the pre-switch to the post-switch period.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Choi P,Farouk M,Manamley N,Addison Jdoi
10.1007/s12325-013-0063-ysubject
Has Abstractpub_date
2013-11-01 00:00:00pages
1007-17issue
11eissn
0741-238Xissn
1865-8652journal_volume
30pub_type
杂志文章,多中心研究abstract::Resistance to first- and second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and development and progression of central nervous system metastases remain significant issues in the treatment of ALK-positive non-small-cell lung cancer. Lorlatinib is a novel third-generation ALK TKI that i...
journal_title:Advances in therapy
pub_type: 杂志文章
doi:10.1007/s12325-020-01365-3
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abstract:BACKGROUND:It is hypothesized that diabetes mellitus (DM) and mood disorders share points of pathophysiological commonality in the central nervous system. METHODS:A PubMed search of all English-language articles published between 1966 and March 2009 was performed with the following search terms: depression, mood disor...
journal_title:Advances in therapy
pub_type: 杂志文章,评审
doi:10.1007/s12325-010-0011-z
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abstract:INTRODUCTION:Rivastigmine is a cholinesterase inhibitor, approved for the treatment of mild-to-moderate dementia of Alzheimer's type. This study assessed the short- and long-term effectiveness and safety of rivastigmine in patients with mild-to-moderate Alzheimer's disease (AD) in a real-world clinical setting in Taiwa...
journal_title:Advances in therapy
pub_type: 杂志文章,多中心研究
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journal_title:Advances in therapy
pub_type: 杂志文章
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章
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journal_title:Advances in therapy
pub_type: 杂志文章
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journal_title:Advances in therapy
pub_type: 杂志文章
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journal_title:Advances in therapy
pub_type: 杂志文章,meta分析
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章,多中心研究
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abstract::Pregnancy in adolescence has been and continues to be a problem in public health. The purpose of this study was to investigate obstetric outcomes of adolescent pregnancies in Samsun, Turkey. A cross-sectional study was conducted between January 1 and December 31, 2004, at 3 hospitals in Samsun, Turkey. Of the 10,100 w...
journal_title:Advances in therapy
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journal_title:Advances in therapy
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Advances in therapy
pub_type: 杂志文章,评审
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journal_title:Advances in therapy
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journal_title:Advances in therapy
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00
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journal_title:Advances in therapy
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章
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journal_title:Advances in therapy
pub_type: 杂志文章,评审
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