Efficacy and tolerability of Hypericum extract STW 3-VI in patients with moderate depression: a double-blind, randomized, placebo-controlled clinical trial.

abstract：:Knee osteoarthritis (KOA) is the most common musculoskeletal disorder, especially in middle up to old age. KOA also results in many complications like changes in gait. Nowadays, changes in lifestyle and the reduced physical activity make people more vulnerable to KOA. Therefore, considering the increasing prevalence o...

journal_title：Advances in therapy

authors： Ganjeh S,Rezaeian ZS,Mostamand J

更新日期：2020-08-01 00:00:00

abstract：:The aims of this study were to determine whether the nursing costs of functional disability could be assessed retrospectively and, if so, whether this method was sensitive enough to show the influence of a treatment on economic costs. Four studies were available for this purpose: three randomized, double-blind, place...

journal_title：Advances in therapy

authors： Vlietinck R,Van Loon H,Van de Broele H,Tormans G

更新日期：1993-09-01 00:00:00

abstract：INTRODUCTION:Clinical guidelines recommend levothyroxine as the standard of care for hypothyroidism and that patients should be treated with a consistent preparation of synthetic levothyroxine without switching among formulations. This study examines the likelihoods of negative clinical outcomes between continuous user...

journal_title：Advances in therapy

authors： Hennessey JV,Espaillat R,Duan Y,Soni-Brahmbhatt S,Lage MJ,Singer P

更新日期：2020-10-28 00:00:00

abstract：INTRODUCTION:It is unclear whether patients and their loved ones appreciate that cardiovascular disease (CVD) is the major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). The purpose of this survey was to evaluate the degree of awareness regarding the link between T2DM and CVD. METHODS:An online s...

journal_title：Advances in therapy

authors： Perreault L,Boardman MK,Pak J

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Endometriosis symptoms are nonspecific and overlap with other gynecologic and gastrointestinal diseases, leading to long diagnostic delays. The burden of endometriosis has been documented; however, little is known about the impact of diagnostic delays on healthcare costs leading up to diagnoses. The purpos...

journal_title：Advances in therapy

authors： Surrey E,Soliman AM,Trenz H,Blauer-Peterson C,Sluis A

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

journal_title：Advances in therapy

authors： Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Most cases of small cell lung cancer (SCLC) are diagnosed at an advanced stage. The objective of this study was to investigate patient characteristics, survival, chemotherapy treatments, and health care use after a diagnosis of advanced SCLC in subjects enrolled in a health system network. METHODS:This wa...

journal_title：Advances in therapy

authors： He J,Shao C,Hui SL,Zhang Z,Baker J,Dexter PR,Kachroo S,Jin F

更新日期：2020-01-01 00:00:00

abstract：:This double-blind, randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department. Seventy consecutive adult patients with fractures or dislocations suitable for re...

journal_title：Advances in therapy

authors： Soysal S,Karcioglu O,Demircan A,Topacoglu H,Serinken M,Ozucelik N,Tirpan K,Gunerli A

更新日期：2004-09-01 00:00:00

abstract：:Bacterial translocation is the passage of bacteria or endotoxins from the gastrointestinal tract to extraintestinal sites, such as mesenteric lymph nodes, liver, spleen, and bloodstream. In this study, the investigators examined the effects of various enteral nutrients on bacterial translocation and intestinal morphol...

journal_title：Advances in therapy

authors： Aydogan A,Kismet K,Kilicoglu B,Erel S,Ozcan AH,Gollu A,Yildiz E,Akkus MA

更新日期：2007-01-01 00:00:00

abstract：:Alpha-mannosidosis is a rare lysosomal storage disorder that generally presents in early childhood. It is a progressive, highly heterogeneous disease that is difficult to recognize, and a diagnosis is usually reached after referrals to multiple specialists. It is important to understand the challenges faced by patient...

journal_title：Advances in therapy

authors： Verrecchia E,Sicignano LL,Massaro MG,Rocco R,Silvestri G,Rossi S,Manna R

更新日期：2020-11-24 00:00:00

abstract：INTRODUCTION:The healthcare sector contributes 5-8% of the global greenhouse gas emissions. Global and regional organizations and governments have started to design and implement measures to reduce global greenhouse gas emissions in the healthcare sector, e.g. by green public procurement policies and inclusion of ecolo...

journal_title：Advances in therapy

authors： Ortsäter G,Borgström F,Soulard S,Miltenburger C

更新日期：2019-12-01 00:00:00

abstract：:Some patients with interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis exhibit a progressive clinical phenotype. These chronic progressive fibrosing ILDs have a variety of underlying diseases, and their prevalence is currently unknown. Here we carry out the first systematic review of literature ...

journal_title：Advances in therapy

authors： Olson A,Hartmann N,Patnaik P,Wallace L,Schlenker-Herceg R,Nasser M,Richeldi L,Hoffmann-Vold AM,Cottin V

更新日期：2020-12-14 00:00:00

abstract：INTRODUCTION:The long-term safety of dimethyl fumarate (DMF) in patients with relapsing-remitting multiple sclerosis (RRMS) has been studied in mainly Caucasian patients. The present interim analysis aimed to evaluate the 72-week safety of DMF in Japanese patients with RRMS. METHODS:Safety data of Japanese subjects en...

journal_title：Advances in therapy

authors： Ochi H,Niino M,Onizuka Y,Hiramatsu K,Hase M,Yun J,Matta A,Torii S

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:To evaluate the short-term efficacy and safety of intravitreal dexamethasone implant (IDI) in patients with macular oedema associated with diabetic retinopathy (DR) and retinal vein occlusion (RVO) using enhanced-depth image optical coherence tomography (EDI-OCT) and to estimate the effect of dexamethasone...

journal_title：Advances in therapy

authors： Minnella AM,Federici M,Pagliei V,Lanza A,Gambini G,Caputo CG,Falsini B,Caporossi A

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Video-assisted thoracic surgery (VATS) lung resections are complex procedures with a critical role played by endoscopic staplers in the transection of vessels, bronchi, and lung tissue. This retrospective, observational study compared hospital resource use, costs, and complications of VATS lobectomy proced...

journal_title：Advances in therapy

authors： Miller DL,Roy S,Kassis ES,Yadalam S,Ramisetti S,Johnston SS

更新日期：2018-05-01 00:00:00

abstract：:Nateglinide is an oral antidiabetic medication that acts through rapid, short-term stimulation of insulin production. This study was undertaken to identify the incidence and nature of adverse effects of nateglinide and to assess its efficacy in clinical practice. Patients (n = 3254) were recruited from 606 centers in ...

journal_title：Advances in therapy

authors： Taki H,Maki T,Iso T,Iwamoto K,Kajiura T

更新日期：2005-09-01 00:00:00

abstract：:Many doubts surround the numerous forms of nonsurgical treatment of nonresectable hepatocellular carcinoma (HCC). Our study aimed to reach reliable conclusions on the actual efficacy of these treatments. We examined 85 studies involving a total of 6746 patients: 6113 were treated; the remaining 633 were not. We applie...

journal_title：Advances in therapy

authors： Malaguarnera M,Trovato G,Restuccia S,Giugno I,Franzé CM,Receputo G,Siciliano R,Motta M,Trovato BA

更新日期：1994-11-01 00:00:00

abstract：INTRODUCTION:Little has been published on respiratory syncytial virus (RSV) among Medicare patients at high risk (HR) of RSV complications due to age or comorbidity. METHODS:Adult patients (at least 18 years of age) with at least 1 diagnostic code for RSV were identified using the 5% US Medicare database from 2011 thr...

journal_title：Advances in therapy

authors： Wyffels V,Kariburyo F,Gavart S,Fleischhackl R,Yuce H

更新日期：2020-03-01 00:00:00

abstract：:The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...

journal_title：Advances in therapy

authors： Käufeler R,Polasek W,Brattström A,Koetter U

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...

journal_title：Advances in therapy

authors： Kiltz U,Sfikakis PP,Gaffney K,Sator PG,von Kiedrowski R,Bounas A,Gullick N,Conrad C,Rigopoulos D,Lespessailles E,Romanelli M,Ghislain PD,Brandt-Jürgens J,Rashkov R,Aassi M,Orsenigo R,Perella C,Pournara E,Gathmann S,

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Adherence to disease-modifying therapies (DMTs) is essential for the reduction of multiple sclerosis (MS) progression and relapse. However, only limited data currently exist on the impact of treatment adherence on MS-related clinical and economic outcomes in the real world setting. OBJECTIVE:To assess the i...

journal_title：Advances in therapy

authors： Tan H,Cai Q,Agarwal S,Stephenson JJ,Kamat S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:High-dose intravenous esomeprazole is the only approved pharmacological treatment for the prevention of peptic ulcer rebleeding (currently approved in over 100 countries worldwide), but has not yet been approved in China. This study aimed to evaluate a high-dose esomeprazole intravenous regimen vs. an acti...

journal_title：Advances in therapy

authors： Bai Y,Chen DF,Wang RQ,Chen YX,Shi RH,Tian DA,Chen H,Eklund S,Li ZS,Chinese Peptic Ulcer Bleeding Research Group.

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Subsequent lines of subcutaneous tumor necrosis factor alpha inhibitor (SC-TNFi) treatment may be well motivated in the management of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)-collectively named inflammatory arthritis (IA). However, the costs associated with swit...

journal_title：Advances in therapy

authors： Dalén J,Luttropp K,Svedbom A,Black CM,Kachroo S

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Repository corticotropin injection (RCI; H.P. Acthar® Gel; Mallinckrodt Pharmaceuticals Inc., Hampton, NJ) is a highly purified, prolonged-release porcine preparation of adrenocorticotropic hormone (ACTH) analogue that is FDA-approved for treatment of 19 autoimmune and inflammatory disorders. The diverse p...

journal_title：Advances in therapy

authors： Philbin M,Niewoehner J,Wan GJ

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive diso...

journal_title：Advances in therapy

authors： Mandelli L,Wang SM,Han C,Lee SJ,Patkar AA,Masand PS,Pae CU,Serretti A

更新日期：2017-03-01 00:00:00

abstract：:Real-world studies have become increasingly important in providing evidence of treatment effectiveness in clinical practice. While randomized clinical trials (RCTs) are the "gold standard" for evaluating the safety and efficacy of new therapeutic agents, necessarily strict inclusion and exclusion criteria mean that tr...

journal_title：Advances in therapy

authors： Blonde L,Khunti K,Harris SB,Meizinger C,Skolnik NS

更新日期：2018-11-01 00:00:00

abstract：:The lipid triad is the association of small, dense (sd) low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and hypertriglyceridemia, all of which play a role in coronary artery disease in patients with type 2 diabetes. Although statins have demonstrated clear positive effects on cardiovascular morbidit...

journal_title：Advances in therapy

authors： Bevilacqua M,Righini V,Barrella M,Vago T,Chebat E,Dominguez LJ

更新日期：2005-11-01 00:00:00

abstract：:The single-tablet combination of vildagliptin and metformin addresses key defects of type 2 diabetes for improved glycemic control. By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, vildagliptin raises the levels of the active incretin hormones, glucagon-like peptide 1 and glucose-dependent insulinotropic pepti...

journal_title：Advances in therapy

authors： Tahrani AA,Piya MK,Barnett AH

更新日期：2009-02-01 00:00:00

abstract：:A 54-y-old patient with rheumatoid arthritis (RA) and bilateral lower-limb lymphoedema is presented. Complete decongestive physical therapy (CDP) is the cornerstone of the management programme in all patients suffering from lymphoedema associated with RA, but it is not clear which therapy is the most effective in decr...

journal_title：Advances in therapy

authors： Eyigor S,Karapolat H,Kirazli Y

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG). METHODS:Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pres...

journal_title：Advances in therapy

authors： Parisi V,Oddone F,Roberti G,Tanga L,Carnevale C,Ziccardi L,Manni G

更新日期：2019-04-01 00:00:00