Abstract：
:The single-tablet combination of vildagliptin and metformin addresses key defects of type 2 diabetes for improved glycemic control. By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, vildagliptin raises the levels of the active incretin hormones, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide. This leads to increased synthesis and release of insulin from the pancreatic beta cells and decreased release of glucagon from the pancreatic alpha cells. The combination tablet also contains metformin, which addresses insulin resistance. The complementary mechanisms of action of the two agents in combination have been shown to provide additive and sustained reductions in hemoglobin A(1c) compared with metformin monotherapy. In active-controlled trials, the vildagliptin-metformin combination has been shown to produce equivalent reductions in hemoglobin A(1c) to pioglitazone-metformin and glimepiride-metformin combinations, without significant risk of hypoglycemia and without causing weight gain. In clinical trials, the overall incidence of any adverse event was similar in patients randomized to vildagliptin plus metformin and placebo plus metformin. Available data support the use of vildagliptin in combination with metformin as a promising second-line treatment for the management of type 2 diabetes and this is reflected in the latest UK National Institute for Health and Clinical Excellence draft guideline for consultation on new agents for blood glucose control in type 2 diabetes.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Tahrani AA,Piya MK,Barnett AHdoi
10.1007/s12325-009-0010-0subject
Has Abstractpub_date
2009-02-01 00:00:00pages
138-54issue
2eissn
0741-238Xissn
1865-8652journal_volume
26pub_type
杂志文章,评审abstract：INTRODUCTION:Extraintestinal manifestations (EIMs) in patients with Crohn's disease (CD) are common and associated with additional morbidity. This study aimed to evaluate the effect of adalimumab therapy on EIM resolution and identify potential predictors of EIM resolution in adult and pediatric patients with moderate ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0678-0
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have an increased risk of comorbid conditions, including cardiovascular disease (CVD). Anemia is prevalent in the CKD population and worsens as kidney function declines, resulting in a diminished quality of life and increased morbidity/mortality. The purpose of th...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0566-z
更新日期：2017-07-01 00:00:00
abstract：INTRODUCTION:New inhalers propelled by hydrofluoroalkanes (HFAs) have improved plume characteristics: higher fine particle fraction, and warmer plumes with reduced force and velocity. Together, this may avoid reflex interruption of inhalation and improve lung deposition of the inhaled drugs. However, even with HFA-prop...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0219-z
更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION:Little has been published on respiratory syncytial virus (RSV) among Medicare patients at high risk (HR) of RSV complications due to age or comorbidity. METHODS:Adult patients (at least 18 years of age) with at least 1 diagnostic code for RSV were identified using the 5% US Medicare database from 2011 thr...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01230-3
更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:Antipsychotic medications are associated with significant weight gain, type 2 diabetes mellitus, dyslipidemia, and increased cardiovascular risk. Suggested mechanisms of weight gain from antipsychotic medication include antagonism of histamine and serotonin receptors, and effects on the hypothalamic-pituit...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-009-0070-1
更新日期：2009-10-01 00:00:00
abstract：:In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients, with favorable toxicity profiles of immunotherapeutic agents relati...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-019-01051-z
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s12325-008-0071-5
更新日期：2008-06-01 00:00:00
abstract：:The analgesic properties of 2 antiemetic agents--metoclopramide and ondansetron--were investigated in studies which showed that metoclopramide may decrease postoperative opioid requirements, but the analgesic effect of ondansetron is controversial. The postoperative effects of metoclopramide and ondansetron on pain in...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/BF02850080
更新日期：2005-07-01 00:00:00
abstract：:Combination therapies are a widely accepted approach to type 2 diabetes treatment, considering that monotherapies fail to provide adequate glycemic control in the majority of cases. The combination of oral antidiabetic agents into a single tablet would significantly simplify the therapeutic regimen and maximize patien...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0067-z
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:This trial was conducted to assess the long-term safety, efficacy, and benefit of early add-on of linagliptin to insulin in patients with type 2 diabetes mellitus (T2DM). METHODS:This trial enrolled 246 subjects. The subjects were randomized to the linagliptin group or the control group and were observed ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-021-01631-y
更新日期：2021-01-28 00:00:00
abstract：:The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850143
更新日期：2006-03-01 00:00:00
abstract：:The original article can be found online. ...
journal_title：Advances in therapy
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12325-018-0767-0
更新日期：2018-09-01 00:00:00
abstract：INTRODUCTION:Healthy eating is a critical aspect of the prevention and management of type 2 diabetes (T2DM). Disrupted eating patterns can result in poor glucose control and increase the likelihood of diabetic complications. Teneligliptin inhibits dipeptidyl peptidase-4 activity for 24 h and suppresses postprandial hyp...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0704-2
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:Comparisons between brand and biosimilar basal insulin in hospitalized patients are lacking. We aimed to compare the efficacy and safety of brand insulin glargine vs. biosimilar insulin glargine in non-critical hospitalized patients with type 2 diabetes mellitus (T2DM). METHODS:This retrospective study wa...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-00922-9
更新日期：2019-05-01 00:00:00
abstract：:Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in adolescents. Such infection is associated with substantial health risks and is unpredictable in its resolution. Genital warts are the most common clinical manifestations of genital HPV infections. Most genital warts are c...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02849928
更新日期：2005-05-01 00:00:00
abstract：:Clarithromycin, an advanced-generation macrolide antibiotic, has demonstrated excellent in vitro activity against group A beta-hemolytic streptococcus (GABHS). Potent activity against Streptococcus pyogenes and a favorable pharmacokinetic profile have made it a reasonable alternative for treatment of patients with str...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02868027
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:Intanza® 9 μg (Sanofi Pasteur SA, Lyon, France), a split virion trivalent influenza vaccine delivered by intradermal injection with a microinjection system, became available as a vaccination for adults aged 18 to 59 years old, as of the 2010 southern hemisphere influenza season. METHODS:This study was des...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-011-0042-0
更新日期：2011-08-01 00:00:00
abstract：:Fibroids, the most common tumor in women of reproductive age, impact negatively on women's health and quality of life, and have significant cost implications for their management. The current mainstay treatments are surgical (myomectomy and hysterectomy) and more recently radiological (UAE and focused ultrasound surge...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0042-8
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:To compare the efficacy and safety of combined cataract extraction and either excisional goniotomy performed with the Kahook Dual Blade (KDB; phaco-KDB group) or single iStent trabecular bypass implantation (phaco-iStent group) in eyes with mild to moderate glaucoma and visually significant cataract. METHODS:T...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01025-1
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:Endometriosis symptoms are nonspecific and overlap with other gynecologic and gastrointestinal diseases, leading to long diagnostic delays. The burden of endometriosis has been documented; however, little is known about the impact of diagnostic delays on healthcare costs leading up to diagnoses. The purpos...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01215-x
更新日期：2020-03-01 00:00:00
abstract：:Retinal vein occlusions are common retinal vascular disorders with the potential for significant vision-related morbidity. Retinal vein occlusions are classified as either branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), or hemiretinal vein occlusion (HRVO) based on the specific occlusion s...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-010-0088-4
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Subsequent lines of subcutaneous tumor necrosis factor alpha inhibitor (SC-TNFi) treatment may be well motivated in the management of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)-collectively named inflammatory arthritis (IA). However, the costs associated with swit...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01425-8
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS:A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general inf...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-0889-z
更新日期：2019-03-01 00:00:00
abstract：:Complicated urinary tract infection (UTI), which often requires hospitalization or prolongs a hospital stay, presents numerous diagnostic and therapeutic challenges. Implementation of effective antimicrobial treatment is vital because of the risk of adverse sequelae due to persistence of infection, relapse, or reinfec...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：INTRODUCTION:The long-term safety of dimethyl fumarate (DMF) in patients with relapsing-remitting multiple sclerosis (RRMS) has been studied in mainly Caucasian patients. The present interim analysis aimed to evaluate the 72-week safety of DMF in Japanese patients with RRMS. METHODS:Safety data of Japanese subjects en...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-018-0788-8
更新日期：2018-10-01 00:00:00
abstract：INTRODUCTION:Partial nephrectomy (PN) has evolved into the surgical standard of care for localized renal lesions. Hemostatic agents (HA) support the surgeon in achieving local hemostasis during PN. We previously reported initial results with the HA Hemopatch® in PN. We now report our experiences with Hemopatch® in a la...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01584-8
更新日期：2020-12-04 00:00:00
abstract：INTRODUCTION:This study aimed to demonstrate the clinical utility of non-invasive multigene Cxbladder urine tests in reducing the overall number of diagnostic tests and invasive procedures used in the clinical evaluation of patients presenting with microhematuria, a key symptom of urothelial carcinoma (UC). There is a ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0518-7
更新日期：2017-05-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to determine prescribing trends in a specialist glaucoma clinic in the UK. Specifically, the aims were to determine which drugs were prescribed as first-, second-, and third-line treatment, the persistence of first-, second-, and third-line treatment regimens, and the proporti...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0593-9
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:Accumulating studies indicate that melatonin is a natural oncostatic agent capable of mediating the influence of the psychoneuroendocrine system on cancer growth. Although there is increasing evidence to show that the pineal gland may play a role in human non-small cell lung cancer (NSCLC), there is uncert...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0068-8
更新日期：2009-09-01 00:00:00
abstract：:Brucellosis remains an important public health problem in Turkey, just as it is in other regions of the world. This study was conducted to determine the types and rates of cutaneous lesions that occur in patients with brucellosis. Brucellosis was diagnosed by standard tube agglutination testing for Brucella antibodies...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849964
更新日期：2007-07-01 00:00:00
