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Comparison of meperidine plus midazolam and fentanyl plus midazolam in procedural sedation: a double-blind, randomized controlled trial.

Abstract：

:This double-blind, randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department. Seventy consecutive adult patients with fractures or dislocations suitable for reduction were randomized to receive fentanyl (1 mcg/kg; n = 36) or meperidine (0.5 mg/kg; n = 34) in combination with midazolam (0.02 mg/kg). Vital signs and alertness scale scores of the patients were monitored. The Visual Analog Scale (VAS) was used to determine the degree of pain. There was no statistically significant difference between the VAS mean scores of the fentanyl and meperidine groups (t test, P = .772). The need for additional analgesic drugs was significantly more frequent in patients receiving meperidine (P = .018). No adverse events, such as hypotension or respiratory depression, were noted. Euphoria occurred in one patient in the fentanyl group. Although dose requirements differ, fentanyl and meperidine provide effective and reliable analgesia in closed reduction of fractures and dislocations.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Soysal S,Karcioglu O,Demircan A,Topacoglu H,Serinken M,Ozucelik N,Tirpan K,Gunerli A

doi

10.1007/BF02850035

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

312-21

issue

5

eissn

0741-238X

issn

1865-8652

pii

360

journal_volume

21

pub_type

临床试验,杂志文章,随机对照试验

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