Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related diabetic nephropathy: case report.

Abstract:

:Nonketotic hyperosmolar coma (NHC) is characterized by severe hyperglycemia; absence of, or only slight ketosis; nonketotic acidosis; severe dehydration; depressed sensorium or frank coma; and various neurologic signs. This condition is uncommon in type 1 diabetes. Because of little or no osmotic diuresis in patients with diabetic nephropathy, increases in plasma osmolality and therefore the likelihood of neurologic symptoms are limited. A 20-year-old male patient with type 1 diabetes with chronic kidney disease on conservative treatment (glomerular filtration rate [GFR], 18 mL/dk) presented with acute nonketotic hyperosmolar syndrome. The patient was admitted presenting with thirst, fatigue, and drowsiness. Blood biochemistry levels were urea 87 mg/dL, creatinine 5.09 mg/dL, glucose 830 mg/dL, glycosylated hemoglobin (HbA1c) 8%, C peptide <0.3 ng/mL, sodium 131 mmol/L, chloride 93 mmol/L, potassium 5.2 mmol/L, and calculated serum osmolality 385 mOsm/kg. The presumptive diagnosis on admission was nonketotic hyperosmolar syndrome precipitated by urinary infection. This is the first case report of hyperosmolar coma in a patient with type 1 diabetes with chronic kidney disease.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Dogan E,Erkoc R,Sayarlioglu H,Buyukbese A

doi

10.1007/BF02849861

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

429-32

issue

5

eissn

0741-238X

issn

1865-8652

pii

416

journal_volume

22

pub_type

杂志文章
  • Effect of acute and long-term administration of ramipril on circadian rhythm of blood pressure in essential hypertension.

    abstract::Ambulatory monitoring was used to evaluate the antihypertensive efficacy and effect on circadian rhythms of blood pressure and heart rate of a single dose and long-term administration of ramipril in 20 patients with mild to moderate essential hypertension. Patients initially were randomized to receive either placebo o...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Cavazzini D,Amadei G,Manfredini R,Musacci G,Mele D,Longhini C

    更新日期:1995-01-01 00:00:00

  • Adalimumab Reduces Extraintestinal Manifestations in Patients with Crohn's Disease: A Pooled Analysis of 11 Clinical Studies.

    abstract:INTRODUCTION:Extraintestinal manifestations (EIMs) in patients with Crohn's disease (CD) are common and associated with additional morbidity. This study aimed to evaluate the effect of adalimumab therapy on EIM resolution and identify potential predictors of EIM resolution in adult and pediatric patients with moderate ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0678-0

    authors: Louis EJ,Reinisch W,Schwartz DA,Löfberg R,Robinson AM,Berg S,Wang AW,Maa JF,Huang B,Pappalardo B

    更新日期:2018-04-01 00:00:00

  • Utility of Saxagliptin in the Treatment of Type 2 Diabetes: Review of Efficacy and Safety.

    abstract:INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a complex disease in which multiple organs and hormones contribute to the pathogenesis of disease. The intestinal hormone, glucagon-like peptide-1 (GLP-1), secreted in response to nutrient ingestion, increases insulin secretion from pancreatic β-cells and reduces glucagon...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-015-0262-9

    authors: Jain R

    更新日期:2015-11-01 00:00:00

  • Ulipristal acetate: a novel option for the medical management of symptomatic uterine fibroids.

    abstract::Fibroids, the most common tumor in women of reproductive age, impact negatively on women's health and quality of life, and have significant cost implications for their management. The current mainstay treatments are surgical (myomectomy and hysterectomy) and more recently radiological (UAE and focused ultrasound surge...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-012-0042-8

    authors: Talaulikar VS,Manyonda IT

    更新日期:2012-08-01 00:00:00

  • Prevalence of diagnosed adult immune thrombocytopenia in the United Kingdom.

    abstract:INTRODUCTION:Data regarding the prevalence of immune thrombocytopenia (ITP) is limited, and is derived from North American population-based analyses. Therefore, the authors conducted the first study outside the United States (US) using the United Kingdom (UK) General Practice Research Database (GPRD) to estimate the ad...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-011-0084-3

    authors: Bennett D,Hodgson ME,Shukla A,Logie JW

    更新日期:2011-12-01 00:00:00

  • Clinical Utility of Cxbladder for the Diagnosis of Urothelial Carcinoma.

    abstract:INTRODUCTION:This study aimed to demonstrate the clinical utility of non-invasive multigene Cxbladder urine tests in reducing the overall number of diagnostic tests and invasive procedures used in the clinical evaluation of patients presenting with microhematuria, a key symptom of urothelial carcinoma (UC). There is a ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-017-0518-7

    authors: Darling D,Luxmanan C,O'Sullivan P,Lough T,Suttie J

    更新日期:2017-05-01 00:00:00

  • Survival, Chemotherapy Treatments, and Health Care Utilization Among Patients with Advanced Small Cell Lung Cancer: An Observational Study.

    abstract:INTRODUCTION:Most cases of small cell lung cancer (SCLC) are diagnosed at an advanced stage. The objective of this study was to investigate patient characteristics, survival, chemotherapy treatments, and health care use after a diagnosis of advanced SCLC in subjects enrolled in a health system network. METHODS:This wa...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01161-8

    authors: He J,Shao C,Hui SL,Zhang Z,Baker J,Dexter PR,Kachroo S,Jin F

    更新日期:2020-01-01 00:00:00

  • Denosumab Versus Zoledronic Acid in Bone Disease Treatment of Newly Diagnosed Multiple Myeloma: An International, Double-Blind, Randomized Controlled Phase 3 Study-Asian Subgroup Analysis.

    abstract:INTRODUCTION:The primary analysis of a global phase 3 study that evaluated the efficacy and safety of denosumab versus zoledronic acid for preventing skeletal-related events (SREs) in adults with newly diagnosed multiple myeloma (MM) indicated that denosumab was noninferior to zoledronic acid for time to first on-study...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12325-020-01395-x

    authors: Huang SY,Yoon SS,Shimizu K,Chng WJ,Chang CS,Wong RS,Gao S,Wang Y,Gordon SW,Glennane A,Min CK

    更新日期:2020-07-01 00:00:00

  • Current Perspectives of Prophylaxis and Management of Acute Infective Endophthalmitis.

    abstract::Endophthalmitis is an intraocular inflammatory condition which may or may not be caused by infective agents. Noninfectious (sterile) endophthalmitis may be attributable to various causes including postoperative retained soft lens matter or toxicity following introduction of other agents into the eye. Infectious endoph...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-016-0307-8

    authors: Tranos P,Dervenis N,Vakalis AN,Asteriadis S,Stavrakas P,Konstas AG

    更新日期:2016-05-01 00:00:00

  • Self-Care in the Twenty First Century: A Vital Role for the Pharmacist.

    abstract::In order for the global healthcare system to remain sustainable, healthcare spending needs to be reduced, and self-treating certain conditions under the guidance of a pharmacist provides a means of accomplishing this goal. This article was developed to describe global healthcare trends affecting self-care with a speci...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-016-0395-5

    authors: Bell J,Dziekan G,Pollack C,Mahachai V

    更新日期:2016-10-01 00:00:00

  • Nedocromil sodium ophthalmic solution 2% twice daily in patients with allergic conjunctivitis.

    abstract::In a multicenter, open-label evaluation, 1098 patients with ocular itching and a history of perennial or seasonal allergic conjunctivitis instilled one drop of nedocromil sodium 2% twice daily in each eye. Ocular symptoms, signs, and global improvement were assessed at baseline and 1 month; satisfaction scores, qualit...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF02850056

    authors: Tauber J,Alocril Community Allergy Trial Study Group.

    更新日期:2002-03-01 00:00:00

  • Comparison of the effects of quinapril and irbesartan on P-wave dispersion in hypertensive patients.

    abstract:INTRODUCTION:P-wave dispersion (PWD) has been shown to be a non-invasive electrocardiographic predictor for development of atrial fibrillation (AF). Thus, it may be possible to attenuate AF risk through improvement of PWD. In this study, we compared the effects of an angiotensin-converting enzyme (ACE) inhibitor, quina...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12325-008-0083-1

    authors: Guntekin U,Gunes Y,Tuncer M,Simsek H,Gunes A

    更新日期:2008-08-01 00:00:00

  • Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.

    abstract::Neuroinflammation is a process involved in the pathogenesis of different disorders, both autoimmune, such as neuropsychiatric systemic lupus erythematosus, and degenerative, such as Alzheimer's and Parkinson's disease. In the central nervous system, the local milieu is tightly regulated by different mediators, among w...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-016-0474-7

    authors: Gualtierotti R,Guarnaccia L,Beretta M,Navone SE,Campanella R,Riboni L,Rampini P,Marfia G

    更新日期:2017-02-01 00:00:00

  • Treatment of hypertension and adherence to treatment guidelines in clinical practice: an Italian study.

    abstract::Despite the results from clinical trials in patients with hypertension and the development of a long list of guidelines for the management of hypertension, many physicians and other healthcare professionals still manage hypertension using approaches that clearly diverge at least partially from the recommendations of t...

    journal_title:Advances in therapy

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1007/BF02849881

    authors: Malacco E,Ferri C,Grandi AM,Kilama MO,Soglian AG,Vigna L

    更新日期:2005-03-01 00:00:00

  • Hypertonic Saline in Conjunction with High-Dose Furosemide Improves Dose-Response Curves in Worsening Refractory Congestive Heart Failure.

    abstract:INTRODUCTION:Diuretic responsiveness in patients with chronic heart failure (CHF) is better assessed by urine production per unit diuretic dose than by the absolute urine output or diuretic dose. Diuretic resistance arises over time when the plateau rate of sodium and water excretion is reached prior to optimal fluid e...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12325-015-0254-9

    authors: Paterna S,Di Gaudio F,La Rocca V,Balistreri F,Greco M,Torres D,Lupo U,Rizzo G,di Pasquale P,Indelicato S,Cuttitta F,Butler J,Parrinello G

    更新日期:2015-10-01 00:00:00

  • Dorsal root ganglion: the target of acupuncture in the treatment of asthma.

    abstract::Recently, high levels of neurotrophic factors have been found in bronchial asthma; these factors include nerve growth factor, brain-derived neurotrophic factor, and leukemia inhibitory factor, among others. Neurotrophic factors are first synthesized in bronchial epithelial cells, immune cells, and other cells in the a...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/BF02848784

    authors: Feng JT,Hu CP,Li XZ

    更新日期:2007-05-01 00:00:00

  • Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression.

    abstract::In a randomized, controlled, double-blind trial, 70 patients (mean age, 49.7 years) suffering from mild to moderate depression received one tablet of either St. John's Wort (Hypericum perforatum) extract (Calmigen) or fluoxetine hydrochloride (Prozac) twice a day for 6 weeks. Efficacy was determined according to the 1...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02850017

    authors: Behnke K,Jensen GS,Graubaum HJ,Gruenwald J

    更新日期:2002-01-01 00:00:00

  • B-type natriuretic peptide levels in patients with COPD and normal right ventricular function.

    abstract:INTRODUCTION:Evidence suggests that elevated plasma levels of B-type natriuretic peptide (BNP) are found in patients with chronic obstructive pulmonary disease (COPD) and right ventricular dysfunction. We examined the effects of exercise on plasma BNP levels in patients with COPD who have normal right ventricular funct...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12325-008-0067-1

    authors: Gemici G,Erdim R,Celiker A,Tokay S,Ones T,Inanir S,Oktay A

    更新日期:2008-07-01 00:00:00

  • Haptoglobin Genotype and Vitamin E Versus Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis in China: A Multicenter, Randomized, Placebo-Controlled Trial Design.

    abstract:INTRODUCTION:Vitamin E is one of the most promising agents for nonalcoholic steatohepatitis (NASH) treatment, and its drug responsiveness may be closely associated with haptoglobin (Hp) genotype. However, its efficacy and safety remain unknown in China. This clinical trial of vitamin E versus placebo for the treatment ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s12325-018-0670-8

    authors: Zang S,Chen J,Song Y,Bai L,Chen J,Chi X,He F,Sheng H,Wang J,Xie S,Xie W,Yang Y,Zhang J,Zheng M,Zou Z,Wang B,Shi J,Chinese NAFLD Clinical Research Network (CNAFLD CRN).

    更新日期:2018-02-01 00:00:00

  • Efficacy of etanercept and complete decongestive physical therapy in bilateral lower-limb lymphoedema associated with rheumatoid arthritis: a case report.

    abstract::A 54-y-old patient with rheumatoid arthritis (RA) and bilateral lower-limb lymphoedema is presented. Complete decongestive physical therapy (CDP) is the cornerstone of the management programme in all patients suffering from lymphoedema associated with RA, but it is not clear which therapy is the most effective in decr...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0006-1

    authors: Eyigor S,Karapolat H,Kirazli Y

    更新日期:2008-01-01 00:00:00

  • Correction to: Real-World Predictors of Major Adverse Cardiovascular Events and Major Adverse Limb Events Among Patients with Chronic Coronary Artery Disease and/or Peripheral Arterial Disease.

    abstract::In the original article. The third author name is incorrect. The correct name is Nicholas J. Leeper. ...

    journal_title:Advances in therapy

    pub_type: 已发布勘误

    doi:10.1007/s12325-020-01220-5

    authors: Berger A,Simpson A,Leeper NJ,Murphy B,Nordstrom B,Ting W,Zhao Q,Berger J

    更新日期:2020-02-01 00:00:00

  • Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques-A Literature Review.

    abstract::Polycystic ovary syndrome (PCOS) affects 6-10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin resistance and hyperandrogenism, which play a severe detrimental role...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-018-0810-1

    authors: Reyes-Muñoz E,Sathyapalan T,Rossetti P,Shah M,Long M,Buscema M,Valenti G,La Rosa VL,Cianci S,Vitale SG

    更新日期:2018-11-01 00:00:00

  • The Case for the Use of Patient and Caregiver Perception of Change Assessments in Rare Disease Clinical Trials: A Methodologic Overview.

    abstract:INTRODUCTION:The traditional model of evaluating treatments based primarily on primary outcome measures has stumbled in its application to rare disease. Rare disease clinical trials face the methodological challenges of small, heterogeneous patient populations and relatively few validated, disease-specific outcome meas...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-019-00920-x

    authors: Contesse MG,Valentine JE,Wall TE,Leffler MG

    更新日期:2019-05-01 00:00:00

  • Correction to: Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study.

    abstract::In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina. ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12325-020-01407-w

    authors: Oddone F,Tanga L,Kóthy P,Holló G,VISIONARY Study Group.

    更新日期:2020-08-01 00:00:00

  • A 48-Week, Multicenter, Open-Label, Observational Study Evaluating Oral Rivastigmine in Patients with Mild-to-Moderate Alzheimer's Disease in Taiwan.

    abstract:INTRODUCTION:Rivastigmine is a cholinesterase inhibitor, approved for the treatment of mild-to-moderate dementia of Alzheimer's type. This study assessed the short- and long-term effectiveness and safety of rivastigmine in patients with mild-to-moderate Alzheimer's disease (AD) in a real-world clinical setting in Taiwa...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12325-019-00939-0

    authors: Chang CC,Peng GS,Lai TJ,Li CH,Liu CK

    更新日期:2019-06-01 00:00:00

  • Successful treatment of acute subretinal hemorrhage in age-related macular degeneration by combined intravitreal injection of recombinant tissue plasminogen activator and gas.

    abstract::Subretinal hemorrhage secondary to age-related macular degeneration (AMD) has a poor visual prognosis. Surgical drainage of the blood improves visual acuity only in selected patients. We report on two elderly patients with spontaneous subretinal hemorrhage from AMD. In one eye, recombinant tissue plasminogen activator...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:

    authors: Hesse L,Kroll P

    更新日期:1997-09-01 00:00:00

  • Impact of Powered and Tissue-Specific Endoscopic Stapling Technology on Clinical and Economic Outcomes of Video-Assisted Thoracic Surgery Lobectomy Procedures: A Retrospective, Observational Study.

    abstract:INTRODUCTION:Video-assisted thoracic surgery (VATS) lung resections are complex procedures with a critical role played by endoscopic staplers in the transection of vessels, bronchi, and lung tissue. This retrospective, observational study compared hospital resource use, costs, and complications of VATS lobectomy proced...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0679-z

    authors: Miller DL,Roy S,Kassis ES,Yadalam S,Ramisetti S,Johnston SS

    更新日期:2018-05-01 00:00:00

  • Safety Profile and Adverse Events of Special Interest for Fruquintinib in Chinese Patients with Previously Treated Metastatic Colorectal Cancer: Analysis of the Phase 3 FRESCO Trial.

    abstract:INTRODUCTION:In FRESCO (Fruquintinib Efficacy and Safety in 3+ Line Colorectal Cancer Patients) trial, fruquintinib demonstrated a statistically significant and clinically meaningful overall survival benefit in Chinese patients with metastatic colorectal cancer (mCRC). However, its safety profile, including adverse eve...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01477-w

    authors: Li J,Guo W,Bai Y,Deng Y,Yang L,Chen Z,Zhong H,Xu R,Pan H,Shu Y,Yuan Y,Zhou J,Xu N,Liu T,Ma D,Wu C,Cheng Y,Xu J,Chen D,Li W,Sun S,Yu Z,Cao P,Shen L,Chen H,Wang S,Wang H,Fan S,Guo X,Wang N,Han R

    更新日期:2020-11-01 00:00:00

  • Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.

    abstract:INTRODUCTION:Aripiprazole and olanzapine are atypical antipsychotics. Both drugs can induce metabolic changes; however, the metabolic side effects produced by aripiprazole are more benign. The aim of the study was to evaluate if aripiprazole and olanzapine alter prolactin levels, lipid and glucose metabolism and hepati...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01566-w

    authors: Koller D,Almenara S,Mejía G,Saiz-Rodríguez M,Zubiaur P,Román M,Ochoa D,Navares-Gómez M,Santos-Molina E,Pintos-Sánchez E,Abad-Santos F

    更新日期:2020-12-05 00:00:00

  • Efficacy and acceptability of nedocromil sodium 2% and olopatadine hydrochloride 0.1% in perennial allergic conjunctivitis.

    abstract::In this 2-week, randomized, crossover study, ophthalmic solutions of nedocromil sodium 2% and olopatadine hydrochloride 0.1% were compared for effectiveness and acceptability in 28 patients with perennial allergic conjunctivitis and previous olopatadine experience. Patients received nedocromil twice daily or olopatadi...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02853155

    authors: Alexander M,Allegro S,Hicks A

    更新日期:2000-05-01 00:00:00