Abstract：
:This prospective study was performed to determine whether gentamicin can be prescribed routinely to patients with spinal cord injury undergoing urologic procedures, or whether antibiotic therapy must be selected on the basis of recent urine microbiologic test results. Between January 2004 and June 2005, procedures were performed on 38 patients, all of whom were prescribed antibiotics on the basis of a microbiology report. Sixteen patients who underwent urologic surgery during 2003 and received gentamicin empirically served as a control group. The patients' clinical course was monitored for postprocedure sepsis. Only 12 patients received gentamicin as the sole antibiotic; 10 patients required an additional antimicrobial for urine samples that grew more than 1 organism and contained bacteria resistant to gentamicin; 26 patients needed antibiotics other than gentamicin for gentamicin-resistant uropathogens. Three patients with organisms sensitive to gentamicin as well as another antibiotic received an agent considered less nephrotoxic than gentamicin. After the procedure, sepsis occurred in only 1 patient, a man with chronic lymphocytic leukemia and small cell carcinoma of the urinary bladder. Three control group patients developed a fever in excess of 39 degrees C. One of these patients did not require a change of antibiotic, another patient recovered after 3 changes of antibiotic, and the third patient recovered from septicemia after receiving ventilatory support. Antibiotics should be prescribed on the basis of recent urine microbiologic test results, and empiric therapy with gentamicin should be avoided in patients with spinal cord injury who are scheduled to undergo urologic procedures.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Vaidyanathan S,Soni BMdoi
10.1007/BF02850350subject
Has Abstractpub_date
2006-01-01 00:00:00pages
92-7issue
1eissn
0741-238Xissn
1865-8652pii
451journal_volume
23pub_type
临床试验,杂志文章abstract：:Nonketotic hyperosmolar coma (NHC) is characterized by severe hyperglycemia; absence of, or only slight ketosis; nonketotic acidosis; severe dehydration; depressed sensorium or frank coma; and various neurologic signs. This condition is uncommon in type 1 diabetes. Because of little or no osmotic diuresis in patients ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849861
更新日期：2005-09-01 00:00:00
abstract：INTRODUCTION:Fixed-combination intraocular pressure (IOP)-lowering medications simplify treatment regimens for patients requiring 2 ocular hypotensive agents to maintain sufficiently low IOP. The aim of this study was to evaluate the safety and efficacy of fixed-combination brinzolamide 1%/brimonidine 0.2% (BBFC) versu...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s12325-014-0168-y
更新日期：2014-12-01 00:00:00
abstract：:Recently, high levels of neurotrophic factors have been found in bronchial asthma; these factors include nerve growth factor, brain-derived neurotrophic factor, and leukemia inhibitory factor, among others. Neurotrophic factors are first synthesized in bronchial epithelial cells, immune cells, and other cells in the a...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02848784
更新日期：2007-05-01 00:00:00
abstract：:Combination therapies are a widely accepted approach to type 2 diabetes treatment, considering that monotherapies fail to provide adequate glycemic control in the majority of cases. The combination of oral antidiabetic agents into a single tablet would significantly simplify the therapeutic regimen and maximize patien...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0067-z
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is associated with poor prognosis despite significant recent advances in its treatment. An intravenous formulation of epoprostenol sodium containing glycine and mannitol (epoprostenol GM; GlaxoSmithKline, London, UK) is widely used to treat PAH. A new formulation of ep...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-013-0029-0
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s12325-008-0071-5
更新日期：2008-06-01 00:00:00
abstract：:Cardiovascular diseases (CVDs) are the leading cause of premature deaths globally and in Ukraine. Dyslipidemia is a recognized risk factor for the development of CVD. Therefore, early detection and appropriate management of dyslipidemia are essential for the primary prevention of CVDs. However, currently, there is a l...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01490-z
更新日期：2020-11-01 00:00:00
abstract：:Endophthalmitis is an intraocular inflammatory condition which may or may not be caused by infective agents. Noninfectious (sterile) endophthalmitis may be attributable to various causes including postoperative retained soft lens matter or toxicity following introduction of other agents into the eye. Infectious endoph...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-016-0307-8
更新日期：2016-05-01 00:00:00
abstract：:In a multicenter, open-label evaluation, 1098 patients with ocular itching and a history of perennial or seasonal allergic conjunctivitis instilled one drop of nedocromil sodium 2% twice daily in each eye. Ocular symptoms, signs, and global improvement were assessed at baseline and 1 month; satisfaction scores, qualit...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02850056
更新日期：2002-03-01 00:00:00
abstract：:Cases are presented to illustrate pitfalls in radiologic and histopathologic diagnosis in urology. In a 73-year-old woman, ultrasound revealed calcification in an irregular mass arising from the left wall of the bladder. Bladder biopsy reported the mass as papillary transitional cell carcinoma. Histologically, the spe...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850223
更新日期：2006-11-01 00:00:00
abstract：:The tolerability of brimonidine tartrate 0.15%--referred to as bromonidine-Purite 0.15% in this study--was compared with brimonidine tartrate 0.2% in irritated eyes of healthy volunteers as well as patients with glaucoma or ocular hypertension (N=20) in a 2-week, single-center, randomized, double-masked, crossover stu...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02849799
更新日期：2003-11-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control. METHODS:A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All pat...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0066-8
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:The 1100delC CHEK2 allele has been associated with a 1.4-to 4.7-fold increased risk of breast cancer in women carrying this mutation. Our study investigated the frequency of this allele in a Chinese population. METHODS:Using touchdown polymerase chain reaction, we sequenced the CHEK2.1100delC mutation in ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0057-3
更新日期：2008-05-01 00:00:00
abstract：INTRODUCTION:To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG). METHODS:Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pres...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-0897-z
更新日期：2019-04-01 00:00:00
abstract：:Bacterial translocation is the passage of bacteria or endotoxins from the gastrointestinal tract to extraintestinal sites, such as mesenteric lymph nodes, liver, spleen, and bloodstream. In this study, the investigators examined the effects of various enteral nutrients on bacterial translocation and intestinal morphol...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849991
更新日期：2007-01-01 00:00:00
abstract：:Liver transplantation has become a highly standardized, acceptable option for selected patients with end-stage liver disease and/or hepatocellular carcinoma in the setting of cirrhosis. Both conditions are associated with loss of skeletal muscle mass (sarcopenia) and physical deconditioning. Both conditions result in ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0797-7
更新日期：2018-11-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) affects 6-10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin resistance and hyperandrogenism, which play a severe detrimental role...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-018-0810-1
更新日期：2018-11-01 00:00:00
abstract：:Low- and middle-income countries (LMICs) are challenged with a disproportionately high burden of noncommunicable diseases (NCDs) and limited healthcare resources at their disposal to tackle the NCD epidemic. Understanding the patient journey for NCDs from the patients' perspective can help healthcare systems in these ...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01519-3
更新日期：2020-12-01 00:00:00
abstract：:The aim of this prospective, randomized, open-label, blinded endpoint (PROBE) study was to compare the antihypertensive efficacy of 2 angiotensin II (AII) receptor antagonists with different pharmacologic profiles, valsartan and olmesartan, in patients with mild-to-moderate essential hypertension. After an initial 2-w...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850182
更新日期：2005-01-01 00:00:00
abstract：:This interventional study was undertaken to assess the impact of physiotherapy education on the knowledge and attitudes of physiotherapists (PTs) and physiotherapy students (PSs) toward euthanasia. The study, which was conducted during the period between 2004 and 2005, included a total of 494 participants (311 PTs; 18...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850001
更新日期：2007-01-01 00:00:00
abstract：:Diabetic foot ulcers (DFUs) are one of the most common and serious complications of diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a dynamic and complex biological process that can be divided into four partly overlapping phases: hemostasis, inflammation, proliferative and remode...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-014-0140-x
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:Tiotropium, a long-acting muscarinic antagonist, is approved for maintenance treatment of asthma in patients at least 6 years of age in the USA. We systematically reviewed published evidence on the efficacy and safety of 2.5 µg tiotropium Respimat® add-on therapy to inhaled corticosteroid (ICS) with or wit...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01062-w
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:To compare the efficacy and safety of combined cataract extraction and either excisional goniotomy performed with the Kahook Dual Blade (KDB; phaco-KDB group) or single iStent trabecular bypass implantation (phaco-iStent group) in eyes with mild to moderate glaucoma and visually significant cataract. METHODS:T...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01025-1
更新日期：2019-09-01 00:00:00
abstract：INTRODUCTION:This Phase 2 clinical trial assessed the efficacy and safety of the novel antioxidative, renewable compound SkQ1 for topical treatment of dry eye signs and symptoms. METHODS:In a single-center, randomized, double-masked, placebo-controlled, 29-day study, 91 subjects with mild to moderate dry eye instilled...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-015-0274-5
更新日期：2016-01-01 00:00:00
abstract：:Brucellosis remains an important public health problem in Turkey, just as it is in other regions of the world. This study was conducted to determine the types and rates of cutaneous lesions that occur in patients with brucellosis. Brucellosis was diagnosed by standard tube agglutination testing for Brucella antibodies...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849964
更新日期：2007-07-01 00:00:00
abstract：:This multicenter, double-masked, randomized, parallel-group study compared the efficacy and safety of ketorolac tromethamine 0.5% ophthalmic solution with levocabastine 0.05% and ketorolac tromethamine vehicle in patients with seasonal allergic conjunctivitis. One drop of ketorolac, levocabastine, or vehicle was insti...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02854842
更新日期：2000-03-01 00:00:00
abstract：INTRODUCTION:Diabetes-related healthcare costs are increasing in the United States, with inpatient hospitalization the largest component of medical expenditures. The aims of this study were to characterize hospitalized type 2 diabetes mellitus (T2DM) patients, understand the relationship between hospitalization and hea...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0223-3
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:A recent successful clinical trial demonstrated that a less invasive cell-injection procedure is a viable medical modality for treating corneal endothelial dystrophy. This medical advance still relies on human corneal endothelial cell (HCEC) sources derived from rare cornea donations. The progenitor of the corn...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01237-w
更新日期：2020-03-01 00:00:00
abstract：:Patients with reversible bronchospasm benefit from the use of inhaled beta-adrenergic agents. In this retrospective study of 24 older patients with a variety of conditions associated with reversible bronchospasm--asthma, asthma with emphysema, chronic bronchitis, and asthmatic bronchitis--symptomatic improvement was n...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:The single-tablet combination of vildagliptin and metformin addresses key defects of type 2 diabetes for improved glycemic control. By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, vildagliptin raises the levels of the active incretin hormones, glucagon-like peptide 1 and glucose-dependent insulinotropic pepti...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-009-0010-0
更新日期：2009-02-01 00:00:00
