Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.

abstract：:Despite more than a century of evolving federal legislation, there remain many unapproved drugs on the United States (US) market. This article reviews the history of drug approval in the US, beginning with the landmark Pure Food and Drug Act of 1906, through to the development of the US Food and Drug Administration (F...

journal_title：Advances in therapy

authors： Nasr A,Lauterio TJ,Davis MW

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:The long-term safety of dimethyl fumarate (DMF) in patients with relapsing-remitting multiple sclerosis (RRMS) has been studied in mainly Caucasian patients. The present interim analysis aimed to evaluate the 72-week safety of DMF in Japanese patients with RRMS. METHODS:Safety data of Japanese subjects en...

journal_title：Advances in therapy

authors： Ochi H,Niino M,Onizuka Y,Hiramatsu K,Hase M,Yun J,Matta A,Torii S

更新日期：2018-10-01 00:00:00

abstract：:Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are common gastrointestinal (GI) disorders. Current treatment options, either prescription or nonprescription medications, have limited efficacy in a subset of patients. There is significant demand for more efficacious medications for the...

journal_title：Advances in therapy

authors： Vazquez-Roque MI,Bouras EP

更新日期：2013-03-01 00:00:00

abstract：:Hyperthyroidism is associated with increased bone turnover. Besides the hormones of calcium metabolism, locally produced factors are important in maintaining normal bone metabolism. Interleukin-6 (IL-6), in particular, has a major influence on bone turnover. In this study, serum IL-6 and tumor necrosis factor-alpha (T...

journal_title：Advances in therapy

authors： Sekeroglu MR,Altun ZB,Algün E,Dülger H,Noyan T,Balaharoglu R,Oztürk M

更新日期：2006-05-01 00:00:00

abstract：:Patients with reversible bronchospasm benefit from the use of inhaled beta-adrenergic agents. In this retrospective study of 24 older patients with a variety of conditions associated with reversible bronchospasm--asthma, asthma with emphysema, chronic bronchitis, and asthmatic bronchitis--symptomatic improvement was n...

journal_title：Advances in therapy

authors： Messina MS

更新日期：1995-05-01 00:00:00

abstract：:In this 2-week, randomized, crossover study, ophthalmic solutions of nedocromil sodium 2% and olopatadine hydrochloride 0.1% were compared for effectiveness and acceptability in 28 patients with perennial allergic conjunctivitis and previous olopatadine experience. Patients received nedocromil twice daily or olopatadi...

journal_title：Advances in therapy

authors： Alexander M,Allegro S,Hicks A

更新日期：2000-05-01 00:00:00

abstract：:In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina. ...

journal_title：Advances in therapy

authors： Oddone F,Tanga L,Kóthy P,Holló G,VISIONARY Study Group.

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a serious health concern. Repurposing of existing drugs indicated for other conditions seems to be the first choice for immediate therapeutic management. The quality of early evidence favoring the different treatment options needs t...

journal_title：Advances in therapy

authors： Subramanian K,Nalli A,Senthil V,Jain S,Nayak A,Bhat A

更新日期：2020-10-01 00:00:00

abstract：:Shock is a serious acute circulatory failure leading to inadequate oxygen delivery to the cells. Its treatment is mainly based on circulating fluid optimization, and vasopressors to provide an adequate mean arterial pressure and microcirculatory flow. Norepinephrine is the drug of choice, but high dosages may be respo...

journal_title：Advances in therapy

authors： Puntillo F,Giglio M,Pasqualucci A,Brienza N,Paladini A,Varrassi G

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:High-dose intravenous esomeprazole is the only approved pharmacological treatment for the prevention of peptic ulcer rebleeding (currently approved in over 100 countries worldwide), but has not yet been approved in China. This study aimed to evaluate a high-dose esomeprazole intravenous regimen vs. an acti...

journal_title：Advances in therapy

authors： Bai Y,Chen DF,Wang RQ,Chen YX,Shi RH,Tian DA,Chen H,Eklund S,Li ZS,Chinese Peptic Ulcer Bleeding Research Group.

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:nab-Paclitaxel plus gemcitabine (nab-P + G) and FOLFIRINOX (FFX) are among the most common first-line (1L) therapies for metastatic adenocarcinoma of the pancreas (MPAC), but real-world data on their comparative effectiveness are limited. METHODS:This retrospective cohort study compared the efficacy and s...

journal_title：Advances in therapy

authors： Kim S,Signorovitch JE,Yang H,Patterson-Lomba O,Xiang CQ,Ung B,Parisi M,Marshall JL

更新日期：2018-10-01 00:00:00

abstract：:This 4-week double-blind, placebo-controlled study assessed the efficacy of impulse magnetic-field therapy for insomnia. One hundred one patients were randomly assigned to either active treatment (n = 50) or placebo (n = 51) and allocated to one of three diagnostic groups: (1) sleep latency; (2) interrupted sleep; or ...

journal_title：Advances in therapy

authors： Pelka RB,Jaenicke C,Gruenwald J

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:This study aimed to demonstrate the clinical utility of non-invasive multigene Cxbladder urine tests in reducing the overall number of diagnostic tests and invasive procedures used in the clinical evaluation of patients presenting with microhematuria, a key symptom of urothelial carcinoma (UC). There is a ...

journal_title：Advances in therapy

authors： Darling D,Luxmanan C,O'Sullivan P,Lough T,Suttie J

更新日期：2017-05-01 00:00:00

abstract：:Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific sympt...

journal_title：Advances in therapy

authors： López F,Williams MD,Skálová A,Hellquist H,Suárez C,Nixon IJ,Rodrigo JP,Cardesa A,Strojan P,Quer M,Hunt JL,Rinaldo A,Ferlito A

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:P-wave dispersion (PWD) has been shown to be a non-invasive electrocardiographic predictor for development of atrial fibrillation (AF). Thus, it may be possible to attenuate AF risk through improvement of PWD. In this study, we compared the effects of an angiotensin-converting enzyme (ACE) inhibitor, quina...

journal_title：Advances in therapy

authors： Guntekin U,Gunes Y,Tuncer M,Simsek H,Gunes A

更新日期：2008-08-01 00:00:00

abstract：:Knee osteoarthritis (KOA) is the most common musculoskeletal disorder, especially in middle up to old age. KOA also results in many complications like changes in gait. Nowadays, changes in lifestyle and the reduced physical activity make people more vulnerable to KOA. Therefore, considering the increasing prevalence o...

journal_title：Advances in therapy

authors： Ganjeh S,Rezaeian ZS,Mostamand J

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:New biosimilars of monoclonal antibodies are anticipated to bring significant cost savings and increase access to treatment. The rituximab biosimilar CT-P10 has recently been approved in Europe in all indications held by reference rituximab (RTX), including rheumatoid arthritis, non-Hodgkin's lymphoma, and...

journal_title：Advances in therapy

authors： Gulácsi L,Brodszky V,Baji P,Rencz F,Péntek M

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:To assess the impact of certolizumab pegol (CZP) treatment on clinical, patient-reported, and musculoskeletal ultrasound outcomes and to determine the treatment response time point most predictive of long-term outcomes in Italian patients with rheumatoid arthritis (RA). METHODS:CZP-SPEED (NCT01443364) was...

journal_title：Advances in therapy

authors： Sarzi-Puttini P,Filippucci E,Adami S,Meroni PL,Batticciotto A,Idolazzi L,De Lucia O,Talavera P,Kumke T,Grassi W

更新日期：2018-08-01 00:00:00

abstract：:Cases are presented to illustrate pitfalls in radiologic and histopathologic diagnosis in urology. In a 73-year-old woman, ultrasound revealed calcification in an irregular mass arising from the left wall of the bladder. Bladder biopsy reported the mass as papillary transitional cell carcinoma. Histologically, the spe...

journal_title：Advances in therapy

authors： Vaidyanathan S,Soni BM,Hughes PL,Mansour P,Singh G

更新日期：2006-11-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to report outcome measures with third-generation pre-attached scrotal port adjustable transobturator male system (ATOMS) for male stress urinary incontinence (SUI) after radical prostatectomy. METHODS:A prospective open study was conducted on consecutive patients. Evaluatio...

journal_title：Advances in therapy

authors： Angulo JC,Arance I,Esquinas C,Dorado JF,Marcelino JP,Martins FE

更新日期：2017-05-01 00:00:00

abstract：:In an open, controlled study, 44 patients complaining of vertigo, dizziness, or both, caused by vascular vestibular disorders were randomly treated with extract of Ginkgo biloba (EGb 761) 80 mg twice daily or with betahistine dihydrochloride (BI) 16 mg twice daily for 3 months. A complete neuro-otologic and equilibrim...

journal_title：Advances in therapy

authors： Cesarani A,Meloni F,Alpini D,Barozzi S,Verderio L,Boscani PF

更新日期：1998-09-01 00:00:00

abstract：:In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients, with favorable toxicity profiles of immunotherapeutic agents relati...

journal_title：Advances in therapy

authors： Arora S,Velichinskii R,Lesh RW,Ali U,Kubiak M,Bansal P,Borghaei H,Edelman MJ,Boumber Y

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Benefit and risk of anticoagulation in cirrhotic patients with portal vein thrombosis (PVT) remain controversial, especially in those with asymptomatic PVT and in non-liver transplant candidates. Furthermore, the predictors of portal vein recanalization and bleeding events after anticoagulation are critica...

journal_title：Advances in therapy

authors： Wang L,Guo X,Xu X,De Stefano V,Plessier A,Noronha Ferreira C,Qi X

更新日期：2020-11-05 00:00:00

abstract：:The corneal toxicity of 2 intraocular pressure-lowering agents was compared in a rabbit cornea model with New Zealand White rabbits. Corneal epithelial morphology and cell size were assessed by in vivo confocal microscopy. Baseline microscopic examinations were performed on 1 eye of each animal. Two weeks later, the e...

journal_title：Advances in therapy

authors： Whitson JT,Cavanagh HD,Lakshman N,Petroll WM

更新日期：2006-09-01 00:00:00

abstract：INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...

journal_title：Advances in therapy

authors： Kiltz U,Sfikakis PP,Gaffney K,Sator PG,von Kiedrowski R,Bounas A,Gullick N,Conrad C,Rigopoulos D,Lespessailles E,Romanelli M,Ghislain PD,Brandt-Jürgens J,Rashkov R,Aassi M,Orsenigo R,Perella C,Pournara E,Gathmann S,

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive diso...

journal_title：Advances in therapy

authors： Mandelli L,Wang SM,Han C,Lee SJ,Patkar AA,Masand PS,Pae CU,Serretti A

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...

journal_title：Advances in therapy

authors： Atug O,Giral A,Kalayci C,Dolar E,Isitan F,Oguz D,Ovunc O,Ozgur O,Soykan I,Simsek I,Unal S,Yenice N,Turkish HEMANEX Study Group.

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016. METHODS:The authors revi...

journal_title：Advances in therapy

authors： Gray A,McQuillan C,Menown IBA

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:New inhalers propelled by hydrofluoroalkanes (HFAs) have improved plume characteristics: higher fine particle fraction, and warmer plumes with reduced force and velocity. Together, this may avoid reflex interruption of inhalation and improve lung deposition of the inhaled drugs. However, even with HFA-prop...

journal_title：Advances in therapy

authors： Johal B,Murphy S,Tuohy J,Marshall J

更新日期：2015-06-01 00:00:00

abstract：:Clarithromycin, an advanced-generation macrolide antibiotic, has demonstrated excellent in vitro activity against group A beta-hemolytic streptococcus (GABHS). Potent activity against Streptococcus pyogenes and a favorable pharmacokinetic profile have made it a reasonable alternative for treatment of patients with str...

journal_title：Advances in therapy

authors： McCarty J,Hedrick JA,Gooch WM

更新日期：2000-01-01 00:00:00