Abstract：
:Real-world studies have become increasingly important in providing evidence of treatment effectiveness in clinical practice. While randomized clinical trials (RCTs) are the "gold standard" for evaluating the safety and efficacy of new therapeutic agents, necessarily strict inclusion and exclusion criteria mean that trial populations are often not representative of the patient populations encountered in clinical practice. Real-world studies may use information from electronic health and claims databases, which provide large datasets from diverse patient populations, and/or may be observational, collecting prospective or retrospective data over a long period of time. They can therefore provide information on the long-term safety, particularly pertaining to rare events, and effectiveness of drugs in large heterogeneous populations, as well as information on utilization patterns and health and economic outcomes. This review focuses on how evidence from real-world studies can be utilized to complement data from RCTs to gain a more complete picture of the advantages and disadvantages of medications as they are used in practice.Funding: Sanofi US, Inc.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Blonde L,Khunti K,Harris SB,Meizinger C,Skolnik NSdoi
10.1007/s12325-018-0805-ysubject
Has Abstractpub_date
2018-11-01 00:00:00pages
1763-1774issue
11eissn
0741-238Xissn
1865-8652pii
10.1007/s12325-018-0805-yjournal_volume
35pub_type
杂志文章,评审abstract：:Patients with acute myeloid leukemia (AML) with the t(8;21) karyotype generally have a favorable clinical course, but key prognostic factors remain poorly defined. This study was conducted to determine the prognoses and treatment outcomes of patients with AML with this unique cytogenetic change. A total of 22 patients...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849984
更新日期：2007-07-01 00:00:00
abstract：:Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in adolescents. Such infection is associated with substantial health risks and is unpredictable in its resolution. Genital warts are the most common clinical manifestations of genital HPV infections. Most genital warts are c...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0827-5
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journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02849898
更新日期：2007-03-01 00:00:00
abstract：INTRODUCTION:Acute gastrointestinal bleeding (GIB) is a major cause of death in liver cirrhosis. This multicenter study aims to develop and validate a novel and easy-to-access model for predicting the prognosis of patients with cirrhosis and acute GIB. METHODS:Patients with cirrhosis and acute GIB were enrolled and ra...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-019-01083-5
更新日期：2019-11-01 00:00:00
abstract：INTRODUCTION:Functional and organic impairments of the singing voice are common career-threatening problems of singers presenting in phoniatric and laryngological departments. The objective was to evaluate the efficacy of phonosurgery, logopedic voice treatment and vocal pedagogy in common organic and functional voice ...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：10.1007/s12325-018-0725-x
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abstract：INTRODUCTION:Advanced renal cell carcinoma (RCC) shows a propensity for extending into the tributaries of the renal veins, which poses a notable surgical challenge. In this study we addressed the question as to whether patients with RCC and vein involvement can be identified as having a significant risk of immediate de...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0235-z
更新日期：2015-08-01 00:00:00
abstract：:Tumor necrosis factor (TNF) inhibitors are widely used biologics for the treatment of several chronic inflammatory diseases. The launch of anti-TNF biosimilars has introduced the possibility of non-medical switching between originator biologics and their biosimilars. However, the potential clinical and patient-reporte...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0742-9
更新日期：2018-09-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-009-0074-x
更新日期：2009-10-01 00:00:00
abstract：INTRODUCTION:Antipsychotic medications are associated with significant weight gain, type 2 diabetes mellitus, dyslipidemia, and increased cardiovascular risk. Suggested mechanisms of weight gain from antipsychotic medication include antagonism of histamine and serotonin receptors, and effects on the hypothalamic-pituit...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-009-0070-1
更新日期：2009-10-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control. METHODS:A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All pat...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0066-8
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS:The IMS LifeLink Health Plan Claims database was use...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-014-0110-3
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to determine prescribing trends in a specialist glaucoma clinic in the UK. Specifically, the aims were to determine which drugs were prescribed as first-, second-, and third-line treatment, the persistence of first-, second-, and third-line treatment regimens, and the proporti...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0593-9
更新日期：2017-08-01 00:00:00
abstract：:Data from the Framingham Heart Study and risk-appraisal models were used to develop a Coronary Heart Disease (CHD) Risk Factor Calculator for early identification of high-risk individuals. The Calculator was tested at an employee health fair for a large northeastern US corporation. Of the 590 employees who registered ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850248
更新日期：2001-01-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01377-z
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:This study set out to examine the efficacy and tolerability of two innovative implant forms of leuprorelin acetate in men with advanced hormone-dependent prostate cancer in everyday clinical practice. METHODS:Data were collected from 818 patients (from 273 centers across Germany) who were pretreated with sl...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0010-y
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:This study aimed to demonstrate the clinical utility of non-invasive multigene Cxbladder urine tests in reducing the overall number of diagnostic tests and invasive procedures used in the clinical evaluation of patients presenting with microhematuria, a key symptom of urothelial carcinoma (UC). There is a ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0518-7
更新日期：2017-05-01 00:00:00
abstract：INTRODUCTION:To assess the impact of certolizumab pegol (CZP) treatment on clinical, patient-reported, and musculoskeletal ultrasound outcomes and to determine the treatment response time point most predictive of long-term outcomes in Italian patients with rheumatoid arthritis (RA). METHODS:CZP-SPEED (NCT01443364) was...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2018-08-01 00:00:00
abstract：INTRODUCTION:To assess the risk factors associated with regorafenib-related adverse events (AEs) in metastatic colorectal cancer (mCRC) and gastrointestinal stromal tumors (GIST). We also evaluated different measures of combatting AEs and their success rate to aid physicians in early identification and management of re...
journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
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更新日期：2019-08-01 00:00:00
abstract：:Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific sympt...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0223-3
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:Accumulating studies indicate that melatonin is a natural oncostatic agent capable of mediating the influence of the psychoneuroendocrine system on cancer growth. Although there is increasing evidence to show that the pineal gland may play a role in human non-small cell lung cancer (NSCLC), there is uncert...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0068-8
更新日期：2009-09-01 00:00:00
abstract：:The lipid-lowering effect of a carob pulp preparation rich in insoluble dietary fiber and polyphenols was investigated in a noncomparative, open-label pilot study. Over 8 weeks, 47 volunteers with moderate hypercholesterolemia (total cholesterol 232-302 mg/dL) consumed 15 g of carob per day in three products (breakfas...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02853169
更新日期：2001-09-01 00:00:00
abstract：:Permixon, the lipidosterolic extract of Serenoa repens, is widely used for the treatment of symptoms associated with benign prostatic hyperplasia (BPH). This open study assessed the efficacy and tolerability of Permixon 160 mg twice daily administered for 2 years. One hundred fifty-five men with clinically diagnosed B...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02853175
更新日期：2002-11-01 00:00:00
abstract：INTRODUCTION:The Medicare Part D prescription plan has a coverage gap from $2250 to $5100 per year (2006 thresholds) in which patients pay full drug costs (the "donut hole"). We examined prescription costs in patients aged >or=65 years with atrial fibrillation (AF), and the proportions entering/exiting the donut hole i...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0054-1
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:There have been few large studies that have analyzed the effect of professional (masked) continuous glucose monitoring (P-CGM) on glycemic control in patients with type 2 diabetes (T2DM) who were on a broad spectrum of baseline therapies. METHODS:We performed a retrospective, blinded evaluation of glycemic ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0576-x
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:Extraintestinal manifestations (EIMs) in patients with Crohn's disease (CD) are common and associated with additional morbidity. This study aimed to evaluate the effect of adalimumab therapy on EIM resolution and identify potential predictors of EIM resolution in adult and pediatric patients with moderate ...
journal_title：Advances in therapy
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-015-0194-4
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Real-world data are sparse on longitudinal associations of opioid use with pain interference with activities (PIA) and daily function with osteoarthritis (OA) in the USA. METHODS:Data from the 2010-2015 Medical Expenditure Panel Surveys were analyzed for community-dwelling adults with OA. Opioid use patte...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01200-4
更新日期：2020-02-01 00:00:00
