Mifepristone treatment of olanzapine-induced weight gain in healthy men.

abstract：INTRODUCTION:The traditional model of evaluating treatments based primarily on primary outcome measures has stumbled in its application to rare disease. Rare disease clinical trials face the methodological challenges of small, heterogeneous patient populations and relatively few validated, disease-specific outcome meas...

journal_title：Advances in therapy

authors： Contesse MG,Valentine JE,Wall TE,Leffler MG

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Although chronic opioid therapy is usually initiated using short-acting opioids, many patients with chronic pain are subsequently converted to long-acting and extended-release preparations. In clinical practice, optimal management requires careful individualization of dosage in order to achieve an appropri...

journal_title：Advances in therapy

authors： Nalamachu SR

更新日期：2012-10-01 00:00:00

abstract：INTRODUCTION:The healthcare sector contributes 5-8% of the global greenhouse gas emissions. Global and regional organizations and governments have started to design and implement measures to reduce global greenhouse gas emissions in the healthcare sector, e.g. by green public procurement policies and inclusion of ecolo...

journal_title：Advances in therapy

authors： Ortsäter G,Borgström F,Soulard S,Miltenburger C

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Adherence to diabetes medication has been linked to improved glycemic levels and lower costs, but previous research on adherence has typically involved oral antidiabetic medication or insulin. This study examines how adherence and persistence to once-daily liraglutide impact glycemic control and economic o...

journal_title：Advances in therapy

authors： Buysman EK,Liu F,Hammer M,Langer J

更新日期：2015-04-01 00:00:00

abstract：:Two patients with thalassemia minor and end-stage renal failure on hemodialysis were treated with epoetin zeta (Silapo, Retacrit; STADA, Germany), a medicinal product that was developed and registered as biosimilar to epoetin alfa. Dosing was titrated individually for two patients to achieve a stable hemoglobin (Hb) c...

journal_title：Advances in therapy

authors： Kumchev E,Koytchev R,Dimitrakov D,Stavrev P,Tsochev G,Siebert-Weigel M

更新日期：2008-12-01 00:00:00

abstract：:Despite more than a century of evolving federal legislation, there remain many unapproved drugs on the United States (US) market. This article reviews the history of drug approval in the US, beginning with the landmark Pure Food and Drug Act of 1906, through to the development of the US Food and Drug Administration (F...

journal_title：Advances in therapy

authors： Nasr A,Lauterio TJ,Davis MW

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016. METHODS:The authors revi...

journal_title：Advances in therapy

authors： Gray A,McQuillan C,Menown IBA

更新日期：2017-07-01 00:00:00

abstract：:Bacterial translocation is the passage of bacteria or endotoxins from the gastrointestinal tract to extraintestinal sites, such as mesenteric lymph nodes, liver, spleen, and bloodstream. In this study, the investigators examined the effects of various enteral nutrients on bacterial translocation and intestinal morphol...

journal_title：Advances in therapy

authors： Aydogan A,Kismet K,Kilicoglu B,Erel S,Ozcan AH,Gollu A,Yildiz E,Akkus MA

更新日期：2007-01-01 00:00:00

abstract：:This 6-month randomized study evaluated the safety and efficacy of sibutramine in 57 overweight Hispanic patients with hypertension. Following a 2-week washout to confirm the diagnosis of hypertension, antihypertensive medication was adjusted to achieve a blood pressure less than 140/90 mm Hg before institution of eit...

journal_title：Advances in therapy

authors： Fanghänel G,Cortinas L,Sánchez-Reyes L,Gómez-Santos R,Campos-Franco E,Berber A

更新日期：2003-03-01 00:00:00

abstract：INTRODUCTION:It is unclear whether patients and their loved ones appreciate that cardiovascular disease (CVD) is the major cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). The purpose of this survey was to evaluate the degree of awareness regarding the link between T2DM and CVD. METHODS:An online s...

journal_title：Advances in therapy

authors： Perreault L,Boardman MK,Pak J

更新日期：2019-03-01 00:00:00

abstract：:Angio-immunoblastic T-cell lymphoma (AITL), a rare disease that constitutes 1% to 2% of non-Hodgkin's lymphomas, presents in middle-aged and elderly individuals. This report describes a patient with high-grade fever and lymphadenopathy. An extensive in-hospital work-up that included lymph node biopsy yielded negative ...

journal_title：Advances in therapy

authors： Usmani SZ,Sahay T,Eisenberg L

更新日期：2007-07-01 00:00:00

abstract：:Patients with acute myeloid leukemia (AML) with the t(8;21) karyotype generally have a favorable clinical course, but key prognostic factors remain poorly defined. This study was conducted to determine the prognoses and treatment outcomes of patients with AML with this unique cytogenetic change. A total of 22 patients...

journal_title：Advances in therapy

authors： Chen CC,Gau JP,Yu YB,Lu CH,Lee KD,You JY

更新日期：2007-07-01 00:00:00

abstract：:Totally implantable catheters and totally implantable venous access devices (TIVADs) represent a valid method of administering long-term chemotherapy. TIVADs have several advantages over other methods of venous access: they are easy to implant under local anesthesia, they cause less discomfort for patients, and they c...

journal_title：Advances in therapy

authors： Ozyuvaci E,Kutlu F

更新日期：2006-07-01 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors are widely used biologics for the treatment of several chronic inflammatory diseases. The launch of anti-TNF biosimilars has introduced the possibility of non-medical switching between originator biologics and their biosimilars. However, the potential clinical and patient-reporte...

journal_title：Advances in therapy

authors： Numan S,Faccin F

更新日期：2018-09-01 00:00:00

abstract：:This study was performed to investigate the relationships between markers of inflammation in serum (interleukin-6 [IL-6], interleukin-10 [IL-10], and granulocyte elastase [GE]), severity of injury, and clinical outcomes, and to evaluate the predictive value of these markers for major complications and mortality. This ...

journal_title：Advances in therapy

authors： Akkose S,Ozgurer A,Bulut M,Koksal O,Ozdemír F,Ozguç H

更新日期：2007-09-01 00:00:00

abstract：:Life expectancy has increased substantially over the last few decades, leading to a worldwide increase in the prevalence and burden of aging-associated diseases. Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. Cellular senescence is a state of cell c...

journal_title：Advances in therapy

authors： Amaya-Montoya M,Pérez-Londoño A,Guatibonza-García V,Vargas-Villanueva A,Mendivil CO

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:New inhalers propelled by hydrofluoroalkanes (HFAs) have improved plume characteristics: higher fine particle fraction, and warmer plumes with reduced force and velocity. Together, this may avoid reflex interruption of inhalation and improve lung deposition of the inhaled drugs. However, even with HFA-prop...

journal_title：Advances in therapy

authors： Johal B,Murphy S,Tuohy J,Marshall J

更新日期：2015-06-01 00:00:00

abstract：:In an open, controlled study, 44 patients complaining of vertigo, dizziness, or both, caused by vascular vestibular disorders were randomly treated with extract of Ginkgo biloba (EGb 761) 80 mg twice daily or with betahistine dihydrochloride (BI) 16 mg twice daily for 3 months. A complete neuro-otologic and equilibrim...

journal_title：Advances in therapy

authors： Cesarani A,Meloni F,Alpini D,Barozzi S,Verderio L,Boscani PF

更新日期：1998-09-01 00:00:00

abstract：:Retinal vein occlusions are common retinal vascular disorders with the potential for significant vision-related morbidity. Retinal vein occlusions are classified as either branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), or hemiretinal vein occlusion (HRVO) based on the specific occlusion s...

journal_title：Advances in therapy

authors： Aref AA,Scott IU

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading cause of mortality in diabetes. As asymptomatic myocardial ischemia (MI) is frequent in diabetes, we hypothesized that DPN may be associated with MI in p...

journal_title：Advances in therapy

authors： Baltzis D,Roustit M,Grammatikopoulou MG,Katsaboukas D,Athanasiou V,Iakovou I,Veves A,Manes C,Trakatelli MC

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

journal_title：Advances in therapy

authors： Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

更新日期：2014-06-01 00:00:00

abstract：:Neuroinflammation is a process involved in the pathogenesis of different disorders, both autoimmune, such as neuropsychiatric systemic lupus erythematosus, and degenerative, such as Alzheimer's and Parkinson's disease. In the central nervous system, the local milieu is tightly regulated by different mediators, among w...

journal_title：Advances in therapy

authors： Gualtierotti R,Guarnaccia L,Beretta M,Navone SE,Campanella R,Riboni L,Rampini P,Marfia G

更新日期：2017-02-01 00:00:00

abstract：:Brucellosis remains an important public health problem in Turkey, just as it is in other regions of the world. This study was conducted to determine the types and rates of cutaneous lesions that occur in patients with brucellosis. Brucellosis was diagnosed by standard tube agglutination testing for Brucella antibodies...

journal_title：Advances in therapy

authors： Akcali C,Savas L,Baba M,Turunc T,Seckin D

更新日期：2007-07-01 00:00:00

abstract：:Resistance to first- and second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and development and progression of central nervous system metastases remain significant issues in the treatment of ALK-positive non-small-cell lung cancer. Lorlatinib is a novel third-generation ALK TKI that i...

journal_title：Advances in therapy

authors： Reed M,Rosales AS,Chioda MD,Parker L,Devgan G,Kettle J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Adherence to disease-modifying therapies (DMTs) is essential for the reduction of multiple sclerosis (MS) progression and relapse. However, only limited data currently exist on the impact of treatment adherence on MS-related clinical and economic outcomes in the real world setting. OBJECTIVE:To assess the i...

journal_title：Advances in therapy

authors： Tan H,Cai Q,Agarwal S,Stephenson JJ,Kamat S

更新日期：2011-01-01 00:00:00

abstract：:The extensive use of angiotensin-converting enzyme inhibitors (ACEIs) as antihypertensive agents and the huge amount of data collected in clinical trials and post-marketing studies has allowed the extending of the indication of ACEIs beyond blood pressure control. Current guidelines recommend ACEIs in symptomatic pati...

journal_title：Advances in therapy

authors： Borghi C,Omboni S

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is the classic progressive fibrosing interstitial lung disease (ILD), but some patients with ILDs other than IPF also develop a progressive fibrosing phenotype (PF-ILD). Information on use and cost of healthcare resources in patients with PF-ILD is limited. METHODS:We u...

journal_title：Advances in therapy

authors： Olson AL,Maher TM,Acciai V,Mounir B,Quaresma M,Zouad-Lejour L,Wells CD,De Loureiro L

更新日期：2020-07-01 00:00:00

abstract：:The aims of this study were to determine whether the nursing costs of functional disability could be assessed retrospectively and, if so, whether this method was sensitive enough to show the influence of a treatment on economic costs. Four studies were available for this purpose: three randomized, double-blind, place...

journal_title：Advances in therapy

authors： Vlietinck R,Van Loon H,Van de Broele H,Tormans G

更新日期：1993-09-01 00:00:00

abstract：INTRODUCTION:Pulmonary arterial hypertension (PAH) is associated with poor prognosis despite significant recent advances in its treatment. An intravenous formulation of epoprostenol sodium containing glycine and mannitol (epoprostenol GM; GlaxoSmithKline, London, UK) is widely used to treat PAH. A new formulation of ep...

journal_title：Advances in therapy

authors： Tamura Y,Ono T,Fukuda K,Satoh T,Sasayama S

更新日期：2013-05-01 00:00:00

abstract：:The original article can be found online. ...

journal_title：Advances in therapy

authors： Beebe-Dimmer JL,Ruterbusch JJ,Bylsma LC,Gillezeau C,Fryzek J,Schultz NM,Flanders SC,Barlev A,Heath E,Quek RGW

更新日期：2018-09-01 00:00:00