当前位置： SCI文献检索 > ADVANCES IN THERAPY期刊下所有文献 > Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.

Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids.

Abstract：

:Neuroinflammation is a process involved in the pathogenesis of different disorders, both autoimmune, such as neuropsychiatric systemic lupus erythematosus, and degenerative, such as Alzheimer's and Parkinson's disease. In the central nervous system, the local milieu is tightly regulated by different mediators, among which are chemoattractant cytokines, also known as chemokines. These small molecules are able to modulate trafficking of immune cells in the course of nervous system development or in response to tissue damage, and different patterns of chemokine molecule and receptor expression have been described in several neuroinflammatory disorders. In recent years, a number of studies have highlighted a pivotal role of sphingolipids in regulating neuroinflammation. Sphingolipids have different functions, among which are the control of leukocyte egress from lymphonodes into inflamed tissues, the expression of various mediators of inflammation and a direct effect on the cells of the central nervous system as regulators of neuroinflammation. In the future, a better knowledge of these two groups of mediators could provide insight into the pathogenesis of neuroinflammatory disorders and could help develop novel diagnostic tools and therapeutic strategies.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Gualtierotti R,Guarnaccia L,Beretta M,Navone SE,Campanella R,Riboni L,Rampini P,Marfia G

doi

10.1007/s12325-016-0474-7

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

396-420

issue

2

eissn

0741-238X

issn

1865-8652

pii

10.1007/s12325-016-0474-7

journal_volume

34

pub_type

杂志文章,评审

相关文献

ADVANCES IN THERAPY文献大全