Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review.

abstract：:In this 2-week, randomized, crossover study, ophthalmic solutions of nedocromil sodium 2% and olopatadine hydrochloride 0.1% were compared for effectiveness and acceptability in 28 patients with perennial allergic conjunctivitis and previous olopatadine experience. Patients received nedocromil twice daily or olopatadi...

journal_title：Advances in therapy

authors： Alexander M,Allegro S,Hicks A

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the clinical outcomes of patients with anterior segment neovascularization treated with or without intravitreal bevacizumab. METHODS:This was a retrospective, comparative case series of 60 patients with anterior segment neovascularization: 30 consecutive patients ...

journal_title：Advances in therapy

authors： Lupinacci AP,Calzada JI,Rafieetery M,Charles S,Netland PA

更新日期：2009-02-01 00:00:00

abstract：:The prevalence of chronic airways diseases such as chronic obstructive pulmonary disease and asthma is increasing. They lead to symptoms such as a cough and shortness of breath, partially through bronchoconstriction. Inhaled anticholinergics are one of a number of treatments designed to treat bronchoconstriction in ai...

journal_title：Advances in therapy

authors： Flynn RA,Glynn DA,Kennedy MP

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Evidence suggests that elevated plasma levels of B-type natriuretic peptide (BNP) are found in patients with chronic obstructive pulmonary disease (COPD) and right ventricular dysfunction. We examined the effects of exercise on plasma BNP levels in patients with COPD who have normal right ventricular funct...

journal_title：Advances in therapy

authors： Gemici G,Erdim R,Celiker A,Tokay S,Ones T,Inanir S,Oktay A

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Repository corticotropin injection (RCI; H.P. Acthar® Gel; Mallinckrodt Pharmaceuticals Inc., Hampton, NJ) is a highly purified, prolonged-release porcine preparation of adrenocorticotropic hormone (ACTH) analogue that is FDA-approved for treatment of 19 autoimmune and inflammatory disorders. The diverse p...

journal_title：Advances in therapy

authors： Philbin M,Niewoehner J,Wan GJ

更新日期：2017-08-01 00:00:00

abstract：:In a randomized, controlled, double-blind trial, 70 patients (mean age, 49.7 years) suffering from mild to moderate depression received one tablet of either St. John's Wort (Hypericum perforatum) extract (Calmigen) or fluoxetine hydrochloride (Prozac) twice a day for 6 weeks. Efficacy was determined according to the 1...

journal_title：Advances in therapy

authors： Behnke K,Jensen GS,Graubaum HJ,Gruenwald J

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:High-dose intravenous esomeprazole is the only approved pharmacological treatment for the prevention of peptic ulcer rebleeding (currently approved in over 100 countries worldwide), but has not yet been approved in China. This study aimed to evaluate a high-dose esomeprazole intravenous regimen vs. an acti...

journal_title：Advances in therapy

authors： Bai Y,Chen DF,Wang RQ,Chen YX,Shi RH,Tian DA,Chen H,Eklund S,Li ZS,Chinese Peptic Ulcer Bleeding Research Group.

更新日期：2015-11-01 00:00:00

abstract：:Treating hyperglycemia is a critical aspect of managing type 2 diabetes mellitus (T2DM), but can be especially challenging in patients from vulnerable groups such as those with chronic kidney disease, African Americans, and older people. The dipeptidyl peptidase (DPP)-4 inhibitors are relatively new oral antidiabetes ...

journal_title：Advances in therapy

authors： Kountz D

更新日期：2013-12-01 00:00:00

abstract：:Propolis is a natural product produced by bees that was discovered through the study of traditional cures and knowledge of indigenous people throughout the world. It is rich in vitamins A, B, C, and E, and in amino acids, copper, iron, manganese, and zinc. The investigators studied the duration-dependent hepatoprotect...

journal_title：Advances in therapy

authors： Bhadauria M,Nirala SK,Shukla S

更新日期：2007-09-01 00:00:00

abstract：:Duodenal self-expandable metal stents (SEMS) are designed for palliation and prompt relief of malignant gastric outlet obstruction (GOO). This mini-invasive endoscopic treatment is preferable to surgery due to its lower morbidity and mortality, shorter hospitalization, and earlier symptoms relief; furthermore endoscop...

journal_title：Advances in therapy

authors： Boškoski I,Tringali A,Familiari P,Mutignani M,Costamagna G

更新日期：2010-10-01 00:00:00

abstract：:Angio-immunoblastic T-cell lymphoma (AITL), a rare disease that constitutes 1% to 2% of non-Hodgkin's lymphomas, presents in middle-aged and elderly individuals. This report describes a patient with high-grade fever and lymphadenopathy. An extensive in-hospital work-up that included lymph node biopsy yielded negative ...

journal_title：Advances in therapy

authors： Usmani SZ,Sahay T,Eisenberg L

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Previous studies showed the relation of mental distress such as anxiety and depression to coronary vasoconstriction and myocardial ischemia. However, the mental health status of patients suspected to have vasospastic angina is unclear. METHODS:A total of 99 patients underwent intracoronary acetylcholine (AC...

journal_title：Advances in therapy

authors： Saito Y,Shoji T,Tateishi K,Kitahara H,Fujimoto Y,Kobayashi Y

更新日期：2020-09-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which can induce multisystem disease. Human angiotensin-converting enzyme 2 (ACE2) widely expressing in arterial and venous endothelial cells and arterial smooth muscle cells has been identified as a functional rec...

journal_title：Advances in therapy

authors： Wang J,Saguner AM,An J,Ning Y,Yan Y,Li G

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Spinal muscular atrophy (SMA) is a neurodegenerative disease of the motor neurons that results in progressive muscle weakness. It is also the leading hereditary cause of infant mortality. Homozygous loss of the survival motor neuron (SMN1) gene causes SMA, and the number of copies of the SMN2 gene modulate...

journal_title：Advances in therapy

authors： Dayangaç-Erden D,Topaloğlu H,Erdem-Yurter H

更新日期：2008-03-01 00:00:00

abstract：:The present study, which was designed as a prospective, double-masked, randomized, controlled, single-site study, was conducted to compare the effects of 3 approved ophthalmic nonsteroidal anti-inflammatory drugs-nepafenac ophthalmic suspension 0.1% (Nevanac; Alcon Laboratories, Inc., Fort Worth, Tex), ketorolac trome...

journal_title：Advances in therapy

authors： Durrie DS,Kennard MG,Boghossian AJ

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS:A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general inf...

journal_title：Advances in therapy

authors： Wang XW,Niu XG,Li JX,Zhang SS,Jiao XF

更新日期：2019-03-01 00:00:00

abstract：:Data from the Framingham Heart Study and risk-appraisal models were used to develop a Coronary Heart Disease (CHD) Risk Factor Calculator for early identification of high-risk individuals. The Calculator was tested at an employee health fair for a large northeastern US corporation. Of the 590 employees who registered ...

journal_title：Advances in therapy

authors： Day D

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Tiotropium, a long-acting muscarinic antagonist, is approved for maintenance treatment of asthma in patients at least 6 years of age in the USA. We systematically reviewed published evidence on the efficacy and safety of 2.5 µg tiotropium Respimat® add-on therapy to inhaled corticosteroid (ICS) with or wit...

journal_title：Advances in therapy

authors： Mansfield L,Duong-Quy S,Craig T

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:An 8-week trial of amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) for moderate or severe hypertension demonstrated more-pronounced blood pressure (BP)-lowering effects compared with dual-component therapies. To elucidate the effects of time and baseline BP on the observed responses, exploratory an...

journal_title：Advances in therapy

authors： Calhoun DA,Crikelair NA,Yen J,Glazer RD

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Diuretic responsiveness in patients with chronic heart failure (CHF) is better assessed by urine production per unit diuretic dose than by the absolute urine output or diuretic dose. Diuretic resistance arises over time when the plateau rate of sodium and water excretion is reached prior to optimal fluid e...

journal_title：Advances in therapy

authors： Paterna S,Di Gaudio F,La Rocca V,Balistreri F,Greco M,Torres D,Lupo U,Rizzo G,di Pasquale P,Indelicato S,Cuttitta F,Butler J,Parrinello G

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

journal_title：Advances in therapy

authors： Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:This retrospective study evaluates the efficacy of palliative chemotherapy with a modified docetaxel, cisplatin, 5-fluorouracil (5-FU; "TPF" regimen) regimen (mTPF; reduced doses of docetaxel, cisplatin, and 5-FU with reduction of intravenous 5-FU from 4 days to 2 days) in Asian patients with recurrent and...

journal_title：Advances in therapy

authors： Lin JT,Lai GM,Chang TH,Liu MT,Bi CP,Wang JW,Chen MK

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to determine prescribing trends in a specialist glaucoma clinic in the UK. Specifically, the aims were to determine which drugs were prescribed as first-, second-, and third-line treatment, the persistence of first-, second-, and third-line treatment regimens, and the proporti...

journal_title：Advances in therapy

authors： Fajgenbaum M,Ansari E

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Recent research has suggested that serum tumor markers can give valuable prognostic information in gastric cancer. In this study, we examined the relationship between preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA 72-4, and alfa fetoprotein (AFP) levels on clinicopath...

journal_title：Advances in therapy

authors： Ucar E,Semerci E,Ustun H,Yetim T,Huzmeli C,Gullu M

更新日期：2008-10-01 00:00:00

abstract：:Combination therapies are a widely accepted approach to type 2 diabetes treatment, considering that monotherapies fail to provide adequate glycemic control in the majority of cases. The combination of oral antidiabetic agents into a single tablet would significantly simplify the therapeutic regimen and maximize patien...

journal_title：Advances in therapy

authors： Koliaki C,Doupis J

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...

journal_title：Advances in therapy

authors： Atug O,Giral A,Kalayci C,Dolar E,Isitan F,Oguz D,Ovunc O,Ozgur O,Soykan I,Simsek I,Unal S,Yenice N,Turkish HEMANEX Study Group.

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Although chronic opioid therapy is usually initiated using short-acting opioids, many patients with chronic pain are subsequently converted to long-acting and extended-release preparations. In clinical practice, optimal management requires careful individualization of dosage in order to achieve an appropri...

journal_title：Advances in therapy

authors： Nalamachu SR

更新日期：2012-10-01 00:00:00

abstract：:To avoid the side effects associated with long-term administration of high doses of inhaled glucocorticosteroids, they should be used at the lowest effective dose. This study compared the clinical efficacy of budesonide given via a dry-powder, inspiratory flow-driven device (Turbuhaler), at a daily dose of 800 microgr...

journal_title：Advances in therapy

authors： Piquet J,Zuck P,Dennewald G,Dugue P,Grivaux M,Brun P,Severac JC,Ostinelli J,Cheeseman KH

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Our objective was to determine the effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in a broad range of patient profiles, including subgroups with varying hypertension severity, age and cardiovascular risk profiles. METHODS:Patient data from four large prospective observat...

journal_title：Advances in therapy

authors： Dézsi CA,Glezer M,Karpov Y,Brzozowska-Villatte R,Farsang C

更新日期：2020-11-05 00:00:00

abstract：INTRODUCTION:Prostate cancer (PC) is the second leading cause of cancer death among US men and accounts for considerable healthcare expenditures. We evaluated economic outcomes in men with chemotherapy-naïve metastatic castration-resistant PC (mCRPC) treated with enzalutamide or abiraterone acetate plus prednisone (abi...

journal_title：Advances in therapy

authors： Ramaswamy K,Lechpammer S,Mardekian J,Huang A,Schultz NM,Sandin R,Wang L,Baser O,George DJ

更新日期：2020-05-01 00:00:00