Abstract：
INTRODUCTION:Evidence suggests that elevated plasma levels of B-type natriuretic peptide (BNP) are found in patients with chronic obstructive pulmonary disease (COPD) and right ventricular dysfunction. We examined the effects of exercise on plasma BNP levels in patients with COPD who have normal right ventricular function METHODS:Seventeen patients with a diagnosis of COPD and normal right ventricular function demonstrated by radionuclide ventriculography, and 17 age-and sex-matched healthy subjects underwent a treadmill exercise test. Plasma BNP levels were measured sequentially before, immediately after, and 1 hour after the exercise test RESULTS:The mean plasma BNP+/-standard deviation levels of the COPD and control groups before exercise were 21.3+/-16 pg/ml and 13.4+/-11 pg/ml, respectively (P>0.05). Mean plasma BNP level measured immediately after exercise was 37.9+/-31 pg/ml in the COPD group, reflecting a statistically significant increase when compared with the initial value (P<0.05). The control group did not show any significant change in plasma BNP levels after the exercise test CONCLUSIONS:Exercise induces an increase in plasma BNP levels in patients with COPD who do not have right ventricular dysfunction at rest. Measurement of exercise-induced BNP levels may be a useful alternative to pulmonary artery catheterisation in identifying the patients who are likely to benefit from long-term oxygen therapy.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Gemici G,Erdim R,Celiker A,Tokay S,Ones T,Inanir S,Oktay Adoi
10.1007/s12325-008-0067-1subject
Has Abstractpub_date
2008-07-01 00:00:00pages
674-80issue
7eissn
0741-238Xissn
1865-8652journal_volume
25pub_type
临床试验,杂志文章abstract：:The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...
journal_title：Advances in therapy
pub_type： 杂志文章
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journal_title：Advances in therapy
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journal_title：Advances in therapy
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journal_title：Advances in therapy
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journal_title：Advances in therapy
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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journal_title：Advances in therapy
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journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
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更新日期：2008-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
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journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-07-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
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journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
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pub_type： 已发布勘误
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pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章,评审
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