The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes in Asia.

Abstract:

:The improvement of glycemic control in patients with type 2 diabetes (T2D) is an urgent need in Asia. East Asian T2D patients have distinct characteristics, including relatively low body weight, early impairment of islet beta cell function with reduced insulin secretion and a marked increase in postprandial blood glucose levels. Control of postprandial hyperglycemia and beta cell preservation are key elements of the therapeutic strategy for these patients. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce HbA1c, fasting plasma glucose, and (in particular) postprandial glucose levels, and slow gastric emptying, while minimizing the risk of hypoglycemia and weight gain. Compared with long-acting GLP-1RAs, short-acting GLP-1RAs produce greater slowing of gastric emptying (which is a key factor driving the reduction of postprandial glycemia) and induce beta cell rest rather than promoting postprandial insulin secretion when used under physiological conditions. GLP-1RAs have greater efficacy in Asian than Caucasian patients. GLP-1RA add-on therapy provides clinically meaningful reductions in HbA1c and postprandial glucose in Asians with T2D inadequately controlled by oral antidiabetic drugs (OADs) or basal insulin ± OADs. Premixed insulin is often prescribed for T2D patients in China. A short-acting GLP-1RA plus basal insulin is an alternative to premixed insulin, resulting in better efficacy and a lower risk of hypoglycemia and weight gain. In conclusion, GLP-1RAs, especially short-acting GLP-1RAs, are a practical treatment option for East Asian patients with T2D inadequately controlled by OADs or basal insulin.Funding: Sanofi.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Lu JM

doi

10.1007/s12325-019-00914-9

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

798-805

issue

4

eissn

0741-238X

issn

1865-8652

pii

10.1007/s12325-019-00914-9

journal_volume

36

pub_type

杂志文章,评审
  • Effect of epoetin zeta for correction of renal anemia in hemodialysis patients with thalassemia minor.

    abstract::Two patients with thalassemia minor and end-stage renal failure on hemodialysis were treated with epoetin zeta (Silapo, Retacrit; STADA, Germany), a medicinal product that was developed and registered as biosimilar to epoetin alfa. Dosing was titrated individually for two patients to achieve a stable hemoglobin (Hb) c...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0119-6

    authors: Kumchev E,Koytchev R,Dimitrakov D,Stavrev P,Tsochev G,Siebert-Weigel M

    更新日期:2008-12-01 00:00:00

  • A Map of Racial and Ethnic Disparities in Influenza Vaccine Uptake in the Medicare Fee-for-Service Program.

    abstract:INTRODUCTION:Despite improved understanding of the risks of influenza and better vaccines for older patients, influenza vaccination rates remain subpar, including in high-risk groups such as older adults, and demonstrate significant racial and ethnic disparities. METHODS:This study considers demographic, clinical, and...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01324-y

    authors: Hall LL,Xu L,Mahmud SM,Puckrein GA,Thommes EW,Chit A

    更新日期:2020-05-01 00:00:00

  • Nonketotic hyperosmolar coma in a patient with type 1 diabetes-related diabetic nephropathy: case report.

    abstract::Nonketotic hyperosmolar coma (NHC) is characterized by severe hyperglycemia; absence of, or only slight ketosis; nonketotic acidosis; severe dehydration; depressed sensorium or frank coma; and various neurologic signs. This condition is uncommon in type 1 diabetes. Because of little or no osmotic diuresis in patients ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02849861

    authors: Dogan E,Erkoc R,Sayarlioglu H,Buyukbese A

    更新日期:2005-09-01 00:00:00

  • Direct Oral Anticoagulants in Patients with Liver Disease in the Era of Non-Alcoholic Fatty Liver Disease Global Epidemic: A Narrative Review.

    abstract::Atrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent and relevant healthcare issues. Direct oral anticoagulants (DOACs) are now the first-choice for anticoagulant treatment of these conditions displaying a better efficacy/safety profile than vitamin-K antagonists, mainly due to significantly ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01307-z

    authors: Ballestri S,Capitelli M,Fontana MC,Arioli D,Romagnoli E,Graziosi C,Lonardo A,Marietta M,Dentali F,Cioni G

    更新日期:2020-05-01 00:00:00

  • Safety and tolerability of tapentadol extended release in moderate to severe chronic osteoarthritis or low back pain management: pooled analysis of randomized controlled trials.

    abstract:INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-014-0128-6

    authors: Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

    更新日期:2014-06-01 00:00:00

  • Impulse magnetic-field therapy for insomnia: a double-blind, placebo-controlled study.

    abstract::This 4-week double-blind, placebo-controlled study assessed the efficacy of impulse magnetic-field therapy for insomnia. One hundred one patients were randomly assigned to either active treatment (n = 50) or placebo (n = 51) and allocated to one of three diagnostic groups: (1) sleep latency; (2) interrupted sleep; or ...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02850111

    authors: Pelka RB,Jaenicke C,Gruenwald J

    更新日期:2001-07-01 00:00:00

  • Physical Activity in Liver Transplantation: A Patient's and Physicians' Experience.

    abstract::Liver transplantation has become a highly standardized, acceptable option for selected patients with end-stage liver disease and/or hepatocellular carcinoma in the setting of cirrhosis. Both conditions are associated with loss of skeletal muscle mass (sarcopenia) and physical deconditioning. Both conditions result in ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0797-7

    authors: Beekman L,Berzigotti A,Banz V

    更新日期:2018-11-01 00:00:00

  • Comparative Efficacy of JAK Inhibitors for Moderate-To-Severe Rheumatoid Arthritis: A Network Meta-Analysis.

    abstract:INTRODUCTION:Janus kinase (JAK) inhibitors are a class of targeted therapies for rheumatoid arthritis (RA) with established clinical efficacy. However, little is known about their efficacy compared with each other. This network meta-analysis (NMA) estimated the comparative efficacy of JAK inhibitors currently approved ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-020-01303-3

    authors: Pope J,Sawant R,Tundia N,Du EX,Qi CZ,Song Y,Tang P,Betts KA

    更新日期:2020-05-01 00:00:00

  • Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors.

    abstract::In the last few years, immunotherapy has transformed the way we treat solid tumors, including melanoma, lung, head neck, breast, renal, and bladder cancers. Durable responses and long-term survival benefit has been experienced by many cancer patients, with favorable toxicity profiles of immunotherapeutic agents relati...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-019-01051-z

    authors: Arora S,Velichinskii R,Lesh RW,Ali U,Kubiak M,Bansal P,Borghaei H,Edelman MJ,Boumber Y

    更新日期:2019-10-01 00:00:00

  • Reduction of cardiovascular risk and mortality: a population-based approach.

    abstract::The purpose of this study was to evaluate risk pattern and mortality in a general population epidemiologic study performed by a staff of hypertension specialists working as the "good father of a family," with lifestyle and therapeutic advice and instrumental measurements. Mortality among the study population (n=856) d...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850213

    authors: Casiglia E,Saugo M,Schiavon L,Tikhonoff V,Rigoni G,Basso G,Mazza A,Rizzato E,Guglielmi F,Martini B,Bascelli A,Caffi S,Pessina AC

    更新日期:2006-11-01 00:00:00

  • Effectiveness of Perindopril/Indapamide Single-Pill Combination in Uncontrolled Patients with Hypertension: A Pooled Analysis of the FORTISSIMO, FORSAGE, ACES and PICASSO Observational Studies.

    abstract:INTRODUCTION:Our objective was to determine the effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in a broad range of patient profiles, including subgroups with varying hypertension severity, age and cardiovascular risk profiles. METHODS:Patient data from four large prospective observat...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01527-3

    authors: Dézsi CA,Glezer M,Karpov Y,Brzozowska-Villatte R,Farsang C

    更新日期:2020-11-05 00:00:00

  • Retrospective estimate of the nursing cost of autonomy impairment and cost benefit in clinical trials: feasibility and application of piracetam in demented elderly patients.

    abstract::The aims of this study were to determine whether the nursing costs of functional disability could be assessed retrospectively and, if so, whether this method was sensitive enough to show the influence of a treatment on economic costs. Four studies were available for this purpose: three randomized, double-blind, place...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:

    authors: Vlietinck R,Van Loon H,Van de Broele H,Tormans G

    更新日期:1993-09-01 00:00:00

  • Population-based screening with the Coronary Heart Disease Risk Factor Calculator.

    abstract::Data from the Framingham Heart Study and risk-appraisal models were used to develop a Coronary Heart Disease (CHD) Risk Factor Calculator for early identification of high-risk individuals. The Calculator was tested at an employee health fair for a large northeastern US corporation. Of the 590 employees who registered ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850248

    authors: Day D

    更新日期:2001-01-01 00:00:00

  • Multislice Computed Tomographic Manifestation of Transient Hepatic Attenuation Difference in the Left Lobe of the Liver: A Retrospective Study.

    abstract:INTRODUCTION:Transient hepatic attenuation differences (THAD) are areas of high parenchymal enhancement observed during the hepatic arterial phase on computed tomography (CT). THAD in the left lobe of the liver can lead to surgical complications. METHODS:A retrospective study was conducted on patients who underwent mu...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01428-5

    authors: Yang B,Si G,He Q,Liu S,Wang S,Xian R,Zhang J,Yu F,Guan J

    更新日期:2020-09-01 00:00:00

  • Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician.

    abstract::Real-world studies have become increasingly important in providing evidence of treatment effectiveness in clinical practice. While randomized clinical trials (RCTs) are the "gold standard" for evaluating the safety and efficacy of new therapeutic agents, necessarily strict inclusion and exclusion criteria mean that tr...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-018-0805-y

    authors: Blonde L,Khunti K,Harris SB,Meizinger C,Skolnik NS

    更新日期:2018-11-01 00:00:00

  • Effect of Ivabradine on Endothelial Function in Patients with Stable Angina Pectoris: Assessment with the Endo-PAT 2000 Device.

    abstract:INTRODUCTION:Ivabradine has opened up new possibilities for treating stable angina and chronic heart failure by lowering heart rate. Ivabradine lowers heart rate by selectively inhibiting the I f current in the sinoatrial node. This study aimed to determine whether the decrease in heart rate achieved with ivabradine wa...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12325-015-0253-x

    authors: Jedlickova L,Merkovska L,Jackova L,Janicko M,Fedacko J,Novakova B,Chmelarova A,Majernik J,Pella D

    更新日期:2015-10-01 00:00:00

  • Ocular hypotensive efficacy of brimonidine 0.15% as adjunctive therapy with latanoprost 0.005% in patients with open-angle glaucoma or ocular hypertension.

    abstract::This study was undertaken to evaluate the ocular hypotensive efficacy of brimonidine Purite 0.15% (Alphagan P 0.15%; Allergan, Inc., Irvine, Calif) given as adjunctive therapy with latanoprost 0.005% (Xalatan; Pfizer Inc., New York, NY( to patients with open-angle glaucoma or ocular hypertension. In this multicenter, ...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF02849898

    authors: Mundorf T,Noecker RJ,Earl M

    更新日期:2007-03-01 00:00:00

  • Effects of fluvastatin slow-release (XL 80 mg) versus simvastatin (20 mg) on the lipid triad in patients with type 2 diabetes.

    abstract::The lipid triad is the association of small, dense (sd) low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and hypertriglyceridemia, all of which play a role in coronary artery disease in patients with type 2 diabetes. Although statins have demonstrated clear positive effects on cardiovascular morbidit...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/BF02849947

    authors: Bevilacqua M,Righini V,Barrella M,Vago T,Chebat E,Dominguez LJ

    更新日期:2005-11-01 00:00:00

  • Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients.

    abstract:INTRODUCTION:Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHO...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-013-0030-7

    authors: Arai T

    更新日期:2013-05-01 00:00:00

  • Angio-immunoblastic T-cell lymphoma in evolution: a case report.

    abstract::Angio-immunoblastic T-cell lymphoma (AITL), a rare disease that constitutes 1% to 2% of non-Hodgkin's lymphomas, presents in middle-aged and elderly individuals. This report describes a patient with high-grade fever and lymphadenopathy. An extensive in-hospital work-up that included lymph node biopsy yielded negative ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02849974

    authors: Usmani SZ,Sahay T,Eisenberg L

    更新日期:2007-07-01 00:00:00

  • Melatonin and tryptophan circadian profiles in patients with advanced non-small cell lung cancer.

    abstract:INTRODUCTION:Accumulating studies indicate that melatonin is a natural oncostatic agent capable of mediating the influence of the psychoneuroendocrine system on cancer growth. Although there is increasing evidence to show that the pineal gland may play a role in human non-small cell lung cancer (NSCLC), there is uncert...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-009-0068-8

    authors: Hu S,Shen G,Yin S,Xu W,Hu B

    更新日期:2009-09-01 00:00:00

  • Duration-dependent hepatoprotective effects of propolis extract against carbon tetrachloride-induced acute liver damage in rats.

    abstract::Propolis is a natural product produced by bees that was discovered through the study of traditional cures and knowledge of indigenous people throughout the world. It is rich in vitamins A, B, C, and E, and in amino acids, copper, iron, manganese, and zinc. The investigators studied the duration-dependent hepatoprotect...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02877719

    authors: Bhadauria M,Nirala SK,Shukla S

    更新日期:2007-09-01 00:00:00

  • The Cost-Effectiveness of Ranibizumab Treat and Extend Regimen Versus Aflibercept in the UK.

    abstract:INTRODUCTION:Wet age-related macular degeneration (AMD) is a chronic eye condition that causes severe deterioration of vision and even blindness. Current wet AMD treatment in the UK involves the vascular endothelial growth factor inhibitors ranibizumab and aflibercept. Patients with wet AMD require frequent and long-te...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-016-0367-9

    authors: Ghosh W,Wickstead R,Claxton L,Kusel J,Taylor M,Fleetwood K,Pulikottil-Jacob R

    更新日期:2016-09-01 00:00:00

  • Long-term allergen-specific immunotherapy correlates with long-term allergen-specific immunological tolerance.

    abstract:INTRODUCTION:One method of treatment for allergic diseases is allergen-specific immunotherapy (SIT). The clinical efficacy of SIT in pollen-induced allergic rhinitis has been demonstrated in several controlled clinical trials. There is no consensus about the protective effect of SIT. In this study, we evaluated the cor...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0004-3

    authors: Ali I,Goksal K,Ozan B,Gulsen D

    更新日期:2008-01-01 00:00:00

  • Correction to: Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study.

    abstract::In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina. ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12325-020-01407-w

    authors: Oddone F,Tanga L,Kóthy P,Holló G,VISIONARY Study Group.

    更新日期:2020-08-01 00:00:00

  • The Case for the Use of Patient and Caregiver Perception of Change Assessments in Rare Disease Clinical Trials: A Methodologic Overview.

    abstract:INTRODUCTION:The traditional model of evaluating treatments based primarily on primary outcome measures has stumbled in its application to rare disease. Rare disease clinical trials face the methodological challenges of small, heterogeneous patient populations and relatively few validated, disease-specific outcome meas...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-019-00920-x

    authors: Contesse MG,Valentine JE,Wall TE,Leffler MG

    更新日期:2019-05-01 00:00:00

  • Correction to: Patterns of Bicalutamide Use in Prostate Cancer Treatment: A U.S. Real-World Analysis Using the SEER-Medicare Database.

    abstract::The original article can be found online. ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12325-018-0767-0

    authors: Beebe-Dimmer JL,Ruterbusch JJ,Bylsma LC,Gillezeau C,Fryzek J,Schultz NM,Flanders SC,Barlev A,Heath E,Quek RGW

    更新日期:2018-09-01 00:00:00

  • Estimation of the Prevalence of Progressive Fibrosing Interstitial Lung Diseases: Systematic Literature Review and Data from a Physician Survey.

    abstract::Some patients with interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis exhibit a progressive clinical phenotype. These chronic progressive fibrosing ILDs have a variety of underlying diseases, and their prevalence is currently unknown. Here we carry out the first systematic review of literature ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01578-6

    authors: Olson A,Hartmann N,Patnaik P,Wallace L,Schlenker-Herceg R,Nasser M,Richeldi L,Hoffmann-Vold AM,Cottin V

    更新日期:2020-12-14 00:00:00

  • Pharmacokinetics and Safety of DS-8500a, an Antidiabetic Drug, in Japanese Subjects with Hepatic or Renal Impairment: A Single-Center, Open-Label, Single-Dose Study.

    abstract:INTRODUCTION:The pharmacokinetics, safety, and tolerability of DS-8500a (a G protein receptor 119 agonist) up to 100 mg have been investigated in healthy Japanese adults. The objective of this study was to evaluate the effects of hepatic or renal impairment on the pharmacokinetics of a single 25-mg oral dose of DS-8500...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0739-4

    authors: Kato M,Ishizuka H,Taguchi T,Shiosakai K,Kamiyama E,Sata M,Yoshida T

    更新日期:2018-08-01 00:00:00

  • Prophylactic intranasal mupirocin ointment in the treatment of peritonitis in continuous ambulatory peritoneal dialysis patients.

    abstract::This study was undertaken to evaluate the effectiveness of prophylactic intranasal mupirocin for peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD). A total of 49 patients undergoing CAPD for at least 6 mo were followed for 1 year. A nasal smear was obtained from each patient at the beginning ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/BF02849908

    authors: Sit D,Kadiroglu AK,Kayabasi H,Yilmaz ME

    更新日期:2007-03-01 00:00:00