Liraglutide for the treatment of type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials.

Abstract:

INTRODUCTION:Liraglutide has been widely used in the treatment of type 2 diabetes mellitus (T2DM), however, the results of a number of randomized placebo-controlled trials on the effects of liraglutide for the treatment of T2DM have varied. The purpose of this study was to assess the effects of liraglutide versus placebo for the treatment of T2DM. METHODS:We searched randomized controlled trials comparing liraglutide and placebo for the treatment of T2DM in the following databases: MEDLINE; EMBASE; Cochrane Library Central Register of Controlled Trials; and Clinical Trials Gov (through August 2014). The standard mean difference (SMD) was calculated for the continuous data and a χ (2) test was used to evaluate heterogeneity. RESULTS:Initially, 103 articles were retrieved through the literature search and 11 studies met the requirements for the meta-analysis. The effects of liraglutide on lowering glycosylated hemoglobin, fasting plasma glucose, reducing weight, lowering blood pressure, and the prevalence of adverse events were significantly different from placebo (P < 0.0001, SMD = -0.96, 95% CI = [-1.20, -0.73]; P < 0.0001, SMD = -0.72, 95% CI = [-0.99, -0.45]; P = 0.004, SMD = -0.24, 95% CI = [-0.40, -0.07]; P = 0.021, SMD = -0.15, 95% CI = [-0.27, -0.02], and P = 0.007, respectively). CONCLUSION:Liraglutide had greater hypoglycemic, weight-reducing and systolic blood pressure-lowering effects than placebo. However, there were more adverse events in the treatment with liraglutide. It is suggested that additional well-designed, large, studies be conducted to further support the use of liraglutide and provide objective guidance for clinical application of liraglutide.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Du Q,Wang YJ,Yang S,Zhao YY,Han P

doi

10.1007/s12325-014-0164-2

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1182-95

issue

11

eissn

0741-238X

issn

1865-8652

journal_volume

31

pub_type

杂志文章,meta分析
  • Angiotensin Receptor Blockers Versus Angiotensin Converting Enzyme Inhibitors for the Treatment of Arterial Hypertension and the Role of Olmesartan.

    abstract::Blood pressure lowering by all classes of antihypertensive drugs is accompanied by significant reductions of stroke and major cardiovascular (CV) events. Drugs acting on the renin-angiotensin-aldosterone system, such as angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), showed s...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-018-0859-x

    authors: Omboni S,Volpe M

    更新日期:2019-02-01 00:00:00

  • Combination therapy in hypertension.

    abstract::Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-013-0020-9

    authors: Gorostidi M,de la Sierra A

    更新日期:2013-04-01 00:00:00

  • Best Practice Approach to Successful Conversion of Fosaprepitant to Aprepitant IV in a Large Multisite Community Oncology Infusion Center: A Retrospective Analysis.

    abstract:PURPOSE:To evaluate the impact on cost, time, resource use, and clinic workflow of converting the route of drug administration from a neurokinin-1 receptor antagonist (NK-1 RA) 30-min intravenous (IV) infusion to aprepitant IV, and more specifically to IV push, within a multicenter community oncology practice. METHODS...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01377-z

    authors: Burns D,Kula J,Marshall S,Ashworth E,Ornelas M

    更新日期:2020-07-01 00:00:00

  • How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?

    abstract::Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific sympt...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-017-0494-y

    authors: López F,Williams MD,Skálová A,Hellquist H,Suárez C,Nixon IJ,Rodrigo JP,Cardesa A,Strojan P,Quer M,Hunt JL,Rinaldo A,Ferlito A

    更新日期:2017-04-01 00:00:00

  • Iron chelation therapy: clinical effectiveness, economic burden and quality of life in patients with iron overload.

    abstract:INTRODUCTION:This study of UK patients examines clinical, health-related quality of life (HRQOL) and economic outcomes associated with iron chelation therapy (ICT). Desferrioxamine (DFO) (Desferal; Novartis, Switzerland) and Deferiprone (Ferriprox; Apotex, Canada) are ICTs used to treat iron overload. DFO requires 8-to...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0085-z

    authors: Payne KA,Rofail D,Baladi JF,Viala M,Abetz L,Desrosiers MP,Lordan N,Ishak K,Proskorovsky I

    更新日期:2008-08-01 00:00:00

  • Survival, Chemotherapy Treatments, and Health Care Utilization Among Patients with Advanced Small Cell Lung Cancer: An Observational Study.

    abstract:INTRODUCTION:Most cases of small cell lung cancer (SCLC) are diagnosed at an advanced stage. The objective of this study was to investigate patient characteristics, survival, chemotherapy treatments, and health care use after a diagnosis of advanced SCLC in subjects enrolled in a health system network. METHODS:This wa...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01161-8

    authors: He J,Shao C,Hui SL,Zhang Z,Baker J,Dexter PR,Kachroo S,Jin F

    更新日期:2020-01-01 00:00:00

  • Acceptance of Intanza® 9 μg intradermal influenza vaccine in routine clinical practice in Australia and Argentina.

    abstract:INTRODUCTION:Intanza® 9 μg (Sanofi Pasteur SA, Lyon, France), a split virion trivalent influenza vaccine delivered by intradermal injection with a microinjection system, became available as a vaccination for adults aged 18 to 59 years old, as of the 2010 southern hemisphere influenza season. METHODS:This study was des...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-011-0042-0

    authors: Eizenberg P,Booy R,Naser N,Mason G,Stamboulian D,Weber F

    更新日期:2011-08-01 00:00:00

  • Systemic Approach to Prevent Inadvertent Perfusion in Eyes with Extensive Choroidal Detachment, Suprachoroidal Fluid, and Hypotony During Pars Plana Vitrectomy.

    abstract:INTRODUCTION:Rhegmatogenous retinal detachment (RRD) with extensive choroidal detachment (CD), suprachoroidal fluid (SCF), and lower intraocular pressure (IOP) markedly increase the difficulty of pars plana vitrectomy (PPV) because it makes the insertion and placement of the trocar cannulas for PPV time-consuming and t...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0801-2

    authors: Zhang Z,Fang D,Peng M,Wei Y,Wang L,Fan S,Zhang S

    更新日期:2019-01-01 00:00:00

  • Successful treatment of acute subretinal hemorrhage in age-related macular degeneration by combined intravitreal injection of recombinant tissue plasminogen activator and gas.

    abstract::Subretinal hemorrhage secondary to age-related macular degeneration (AMD) has a poor visual prognosis. Surgical drainage of the blood improves visual acuity only in selected patients. We report on two elderly patients with spontaneous subretinal hemorrhage from AMD. In one eye, recombinant tissue plasminogen activator...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:

    authors: Hesse L,Kroll P

    更新日期:1997-09-01 00:00:00

  • A Budget Impact Model to Estimate the Environmental Impact of Adopting RESPIMAT® Re-usable in the Nordics and Benelux.

    abstract:INTRODUCTION:The healthcare sector contributes 5-8% of the global greenhouse gas emissions. Global and regional organizations and governments have started to design and implement measures to reduce global greenhouse gas emissions in the healthcare sector, e.g. by green public procurement policies and inclusion of ecolo...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01114-1

    authors: Ortsäter G,Borgström F,Soulard S,Miltenburger C

    更新日期:2019-12-01 00:00:00

  • Angio-immunoblastic T-cell lymphoma in evolution: a case report.

    abstract::Angio-immunoblastic T-cell lymphoma (AITL), a rare disease that constitutes 1% to 2% of non-Hodgkin's lymphomas, presents in middle-aged and elderly individuals. This report describes a patient with high-grade fever and lymphadenopathy. An extensive in-hospital work-up that included lymph node biopsy yielded negative ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02849974

    authors: Usmani SZ,Sahay T,Eisenberg L

    更新日期:2007-07-01 00:00:00

  • Comparative Efficacy of JAK Inhibitors for Moderate-To-Severe Rheumatoid Arthritis: A Network Meta-Analysis.

    abstract:INTRODUCTION:Janus kinase (JAK) inhibitors are a class of targeted therapies for rheumatoid arthritis (RA) with established clinical efficacy. However, little is known about their efficacy compared with each other. This network meta-analysis (NMA) estimated the comparative efficacy of JAK inhibitors currently approved ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-020-01303-3

    authors: Pope J,Sawant R,Tundia N,Du EX,Qi CZ,Song Y,Tang P,Betts KA

    更新日期:2020-05-01 00:00:00

  • Outcomes analysis of daptomycin use in a community hospital.

    abstract::This study was conducted to assess clinical and cost outcomes associated with the use of daptomycin. This objective was addressed through a consecutive patient chart review of the first 50 inpatients treated with daptomycin. Type of infection, identity of isolated pathogens, prior therapy, duration of therapy, length ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/BF02848774

    authors: Fossaceca C

    更新日期:2007-05-01 00:00:00

  • Cost of cystic fibrosis: analysis of treatment costs in a specialized center in northern Italy.

    abstract:INTRODUCTION:Advances in cystic fibrosis (CF) therapy have resulted in improved survival and increasing treatment burden and costs. The economic impact of current treatment strategies for CF is poorly defined. METHODS:The authors prospectively assessed direct medical costs (including hospitalizations, outpatient inter...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-013-0008-5

    authors: Colombo C,Daccò V,Alicandro G,Loi S,Mazzi S,Lucioni C,Ravasio R

    更新日期:2013-02-01 00:00:00

  • Evaluation of a new formulation of epoprostenol sodium in Japanese patients with pulmonary arterial hypertension (EPITOME4).

    abstract:INTRODUCTION:Pulmonary arterial hypertension (PAH) is associated with poor prognosis despite significant recent advances in its treatment. An intravenous formulation of epoprostenol sodium containing glycine and mannitol (epoprostenol GM; GlaxoSmithKline, London, UK) is widely used to treat PAH. A new formulation of ep...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12325-013-0029-0

    authors: Tamura Y,Ono T,Fukuda K,Satoh T,Sasayama S

    更新日期:2013-05-01 00:00:00

  • Switching from depot antipsychotics to risperidone: results of a study of chronic schizophrenia. The Schizophrenia Treatment & Assessment Group.

    abstract::Designed to provide information about patients with schizophrenia who switch from depot neuroleptics to the oral, atypical antipsychotic risperidone, this multicenter observational study enrolled patients who wished to stop the depot, had an unsatisfactory response, or experienced unacceptable side effects. Individual...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Desai NM,Huq Z,Martin SD,McDonald G

    更新日期:1999-03-01 00:00:00

  • Dysfunctional Coagulation in COVID-19: From Cell to Bedside.

    abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which can induce multisystem disease. Human angiotensin-converting enzyme 2 (ACE2) widely expressing in arterial and venous endothelial cells and arterial smooth muscle cells has been identified as a functional rec...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01399-7

    authors: Wang J,Saguner AM,An J,Ning Y,Yan Y,Li G

    更新日期:2020-07-01 00:00:00

  • Self-Care in the Twenty First Century: A Vital Role for the Pharmacist.

    abstract::In order for the global healthcare system to remain sustainable, healthcare spending needs to be reduced, and self-treating certain conditions under the guidance of a pharmacist provides a means of accomplishing this goal. This article was developed to describe global healthcare trends affecting self-care with a speci...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-016-0395-5

    authors: Bell J,Dziekan G,Pollack C,Mahachai V

    更新日期:2016-10-01 00:00:00

  • Relationships between markers of inflammation, severity of injury, and clinical outcomes in hemorrhagic shock.

    abstract::This study was performed to investigate the relationships between markers of inflammation in serum (interleukin-6 [IL-6], interleukin-10 [IL-10], and granulocyte elastase [GE]), severity of injury, and clinical outcomes, and to evaluate the predictive value of these markers for major complications and mortality. This ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02877699

    authors: Akkose S,Ozgurer A,Bulut M,Koksal O,Ozdemír F,Ozguç H

    更新日期:2007-09-01 00:00:00

  • Cost associated with D-Dimer screening for acute aortic dissection.

    abstract:INTRODUCTION:D-Dimer (DD) has been described as a useful predictor of both morphologic changes in acute thoracic aortic dissection (TAD) and of TAD-associated mortality. This study analyzed the use of DD screening to screen patients with chest pain for acute (TAD) to determine if it improves diagnosis and cost effectiv...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-011-0069-2

    authors: Moysidis T,Lohmann M,Lutkewitz S,Kemmeries G,Kröger K

    更新日期:2011-11-01 00:00:00

  • Drug evaluation: vildagliptin-metformin single-tablet combination.

    abstract::The single-tablet combination of vildagliptin and metformin addresses key defects of type 2 diabetes for improved glycemic control. By inhibiting the dipeptidyl peptidase-4 (DPP-4) enzyme, vildagliptin raises the levels of the active incretin hormones, glucagon-like peptide 1 and glucose-dependent insulinotropic pepti...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-009-0010-0

    authors: Tahrani AA,Piya MK,Barnett AH

    更新日期:2009-02-01 00:00:00

  • Clinical and Economic Evaluation of Repository Corticotropin Injection: A Narrative Literature Review of Treatment Efficacy and Healthcare Resource Utilization for Seven Key Indications.

    abstract:INTRODUCTION:Repository corticotropin injection (RCI; H.P. Acthar® Gel; Mallinckrodt Pharmaceuticals Inc., Hampton, NJ) is a highly purified, prolonged-release porcine preparation of adrenocorticotropic hormone (ACTH) analogue that is FDA-approved for treatment of 19 autoimmune and inflammatory disorders. The diverse p...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-017-0569-9

    authors: Philbin M,Niewoehner J,Wan GJ

    更新日期:2017-08-01 00:00:00

  • The Role of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes in Asia.

    abstract::The improvement of glycemic control in patients with type 2 diabetes (T2D) is an urgent need in Asia. East Asian T2D patients have distinct characteristics, including relatively low body weight, early impairment of islet beta cell function with reduced insulin secretion and a marked increase in postprandial blood gluc...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-019-00914-9

    authors: Lu JM

    更新日期:2019-04-01 00:00:00

  • Safety and efficacy of Eupatorium laevigatum paste as therapy for buccal aphthae: randomized, double-blind comparison with triamcinolone 0.1% orabase.

    abstract::Eupatorium laevigatum Lam. is a plant common to the central region of Brazil, where it is a widely used remedy for lesions such as buccal aphthae. These painful inflammatory ulcers affect 50% of the general population. For the first part of this two-part study, a phytotherapeutic preparation from E. laevigatum extract...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02850010

    authors: Paulo Filho W,Ribeiro JE,Pinto DS

    更新日期:2000-11-01 00:00:00

  • Evaluation of MRI-US Fusion Technology in Sports-Related Musculoskeletal Injuries.

    abstract:INTRODUCTION:A combination of magnetic resonance imaging (MRI) with real-time high-resolution ultrasound (US) known as fusion imaging may improve visualization of musculoskeletal (MSK) sports medicine injuries. The aim of this study was to evaluate the applicability of MRI-US fusion technology in MSK sports medicine. ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-015-0217-1

    authors: Wong-On M,Til-Pérez L,Balius R

    更新日期:2015-06-01 00:00:00

  • Prophylactic intranasal mupirocin ointment in the treatment of peritonitis in continuous ambulatory peritoneal dialysis patients.

    abstract::This study was undertaken to evaluate the effectiveness of prophylactic intranasal mupirocin for peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD). A total of 49 patients undergoing CAPD for at least 6 mo were followed for 1 year. A nasal smear was obtained from each patient at the beginning ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/BF02849908

    authors: Sit D,Kadiroglu AK,Kayabasi H,Yilmaz ME

    更新日期:2007-03-01 00:00:00

  • Breaking Barriers to Effective Type 2 Diabetes Management: Findings from the use of the OPTIMA© Questionnaire in Clinical Practice.

    abstract:BACKGROUND:The OPTIMA© (MSD, Courbevoie, France) questionnaire was developed to promote shared decisions and the set-up of specific micro-objectives in clinical practice by optimizing communication between type 2 diabetes (T2DM) patients and their physicians. The present study aimed to assess OPTIMA in clinical practic...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12325-016-0341-6

    authors: Grimaldi A,Penfornis A,Consoli S,Falissard B,Eymard E,Williams P,Dejager S

    更新日期:2016-06-01 00:00:00

  • Prognostic Role of Ki-67 in Adrenocortical Carcinoma After Primary Resection: A Retrospective Mono-Institutional Study.

    abstract:INTRODUCTION:Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. It is vitally important to predict prognosis and restrict unnecessary adjuvant treatments for patients with ACC. This study aims to confirm the prognostic value of Ki-67 and provide a prognostic evaluation on ACC after primary surgery...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01050-0

    authors: Zhang F,Zhang F,Liu Z,Wu K,Zhu Y,Lu Y

    更新日期:2019-10-01 00:00:00

  • Genital infection with human papillomavirus in adolescents.

    abstract::Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in adolescents. Such infection is associated with substantial health risks and is unpredictable in its resolution. Genital warts are the most common clinical manifestations of genital HPV infections. Most genital warts are c...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/BF02849928

    authors: Leung AK,Kellner JD,Davies HD

    更新日期:2005-05-01 00:00:00

  • Evaluation of the comfort of Alphagan P compared with Alphagan in irritated eyes.

    abstract::The tolerability of brimonidine tartrate 0.15%--referred to as bromonidine-Purite 0.15% in this study--was compared with brimonidine tartrate 0.2% in irritated eyes of healthy volunteers as well as patients with glaucoma or ocular hypertension (N=20) in a 2-week, single-center, randomized, double-masked, crossover stu...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02849799

    authors: Mundorf T,Wilcox KA,Ousler GW 3rd,Welch D,Abelson MB

    更新日期:2003-11-01 00:00:00