Abstract：
INTRODUCTION:D-Dimer (DD) has been described as a useful predictor of both morphologic changes in acute thoracic aortic dissection (TAD) and of TAD-associated mortality. This study analyzed the use of DD screening to screen patients with chest pain for acute (TAD) to determine if it improves diagnosis and cost effectiveness. This study also looked at the association of DD levels with diagnoses frequently seen in patients with dyspnea or chest pain. METHODS:At the Helios Hospital, Krefeld, the authors analyzed the data of all patients (n = 1053, age (mean, SD) 62 ± 19 years, 49% males) admitted for chest pain to the nonsurgical emergency department (ED) in February 2010. Chest pain was the second most frequent symptom causing 138 (13.1%) admissions, 102 of which had DD testing (Inniovance® D-Dimer Assay, Dade Behring/Siemens, Germany). To assess the diagnostic reliability of DD testing, the sensitivity, specificity, and odds ratio, including 95% confidence interval, were estimated. RESULTS:None of the patients admitted were found to have acute TAD. Had the authors used a computerized tomography (CT) scan to rule out TAD in every patient with chest pain, actual costs would have been euro 12,328. A restriction of CT scans to patients with elevated DD levels would have lowered costs to euro 5360. The actual costs were euro 670.30 for CT scans and euro 540.60 for DD tests. On analyzing the association with other diagnoses, both sensitivity and specificity were low, with the exception of pneumonia. CONCLUSION:Owing to the low incidence of TAD, DD screening increases diagnostic efforts and costs but it remains unclear whether it would actually speed up TAD diagnosis. In a clinical setting DD did not help to discriminate other relevant diagnoses. Despite the high sensitivity of DD for aortic dissection published in the literature, the physician's clinical judgment remains paramount.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Moysidis T,Lohmann M,Lutkewitz S,Kemmeries G,Kröger Kdoi
10.1007/s12325-011-0069-2subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1038-44issue
11eissn
0741-238Xissn
1865-8652journal_volume
28pub_type
杂志文章abstract：:A 54-y-old patient with rheumatoid arthritis (RA) and bilateral lower-limb lymphoedema is presented. Complete decongestive physical therapy (CDP) is the cornerstone of the management programme in all patients suffering from lymphoedema associated with RA, but it is not clear which therapy is the most effective in decr...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0006-1
更新日期：2008-01-01 00:00:00
abstract：:In an open-label 12-week study, the safety and efficacy of bimatoprost 0.03% was evaluated in 55 patients with open-angle glaucoma or ocular hypertension inadequately controlled by topical beta-blocker monotherapy. Patients discontinued their topical beta-blocker therapy at the baseline visit and began bimatoprost mon...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF02850101
更新日期：2004-11-01 00:00:00
abstract：INTRODUCTION:This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS:A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general inf...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-0889-z
更新日期：2019-03-01 00:00:00
abstract：:Many doubts surround the numerous forms of nonsurgical treatment of nonresectable hepatocellular carcinoma (HCC). Our study aimed to reach reliable conclusions on the actual efficacy of these treatments. We examined 85 studies involving a total of 6746 patients: 6113 were treated; the remaining 633 were not. We applie...
journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
doi：
更新日期：1994-11-01 00:00:00
abstract：:This study was conducted to determine the reasons for the choice of self-prescribed laxatives and to acquire information on how they were used and tolerated. From November 1999 to February 2000, 70 pharmacies, uniformly located throughout the Campania region of southern Italy, distributed a questionnaire to purchasers...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850360
更新日期：2002-09-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
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pub_type： 杂志文章,随机对照试验
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journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-014-0125-9
更新日期：2014-06-01 00:00:00
abstract：:Intensive postremission chemotherapy has produced disease-free survival comparable to that of bone marrow transplantation in patients with acute myelogenous leukemia (AML), but its efficacy was unknown in Taiwan. We assessed the efficacy of intensive postremission chemotherapy, consisting of high-dose arabinoside-C (H...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02852390
更新日期：2001-03-01 00:00:00
abstract：:X-linked hypophosphataemia (XLH) is the most prevalent form of hereditary rickets characterized by an alteration of phosphate metabolism which frequently leads to the appearance of fractures, bone deformities and growth delay. Although the mechanism of growth impairment in patients with XLH still needs to be clarified...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-014-0141-9
更新日期：2014-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：10.1007/s12325-015-0253-x
更新日期：2015-10-01 00:00:00
abstract：INTRODUCTION:Acute gastrointestinal bleeding (GIB) is a major cause of death in liver cirrhosis. This multicenter study aims to develop and validate a novel and easy-to-access model for predicting the prognosis of patients with cirrhosis and acute GIB. METHODS:Patients with cirrhosis and acute GIB were enrolled and ra...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-019-01083-5
更新日期：2019-11-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/BF02848774
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:To evaluate, from the patient's perspective, the burden of pain associated with hip/knee osteoarthritis (OA) in the USA and selected European Union (EU) countries. METHODS:Data were drawn from the 2017 global Adelphi OA Disease Specific Programme™ (DSP). Patients with hip/knee OA were stratified based on ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01445-4
更新日期：2020-09-01 00:00:00
abstract：:This multicenter, randomized, double-blind clinical trial was undertaken to compare the intraocular pressure (IOP)-lowering efficacy and safety of topical bimatoprost 0.03% with that of latanoprost 0.005% for the treatment of patients with normal-tension glaucoma. After washout of all ocular hypotensive medications, p...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02850159
更新日期：2006-05-01 00:00:00
abstract：:Combination therapies are a widely accepted approach to type 2 diabetes treatment, considering that monotherapies fail to provide adequate glycemic control in the majority of cases. The combination of oral antidiabetic agents into a single tablet would significantly simplify the therapeutic regimen and maximize patien...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0067-z
更新日期：2012-12-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
doi：10.1007/s12325-018-0869-8
更新日期：2019-03-01 00:00:00
abstract：INTRODUCTION:The purpose of this study was to evaluate the clinical outcomes of patients with anterior segment neovascularization treated with or without intravitreal bevacizumab. METHODS:This was a retrospective, comparative case series of 60 patients with anterior segment neovascularization: 30 consecutive patients ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0001-1
更新日期：2009-02-01 00:00:00
abstract：INTRODUCTION:Wet age-related macular degeneration (AMD) is a chronic eye condition that causes severe deterioration of vision and even blindness. Current wet AMD treatment in the UK involves the vascular endothelial growth factor inhibitors ranibizumab and aflibercept. Patients with wet AMD require frequent and long-te...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-016-0367-9
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:The Medicare Part D prescription plan has a coverage gap from $2250 to $5100 per year (2006 thresholds) in which patients pay full drug costs (the "donut hole"). We examined prescription costs in patients aged >or=65 years with atrial fibrillation (AF), and the proportions entering/exiting the donut hole i...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-009-0054-1
更新日期：2009-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0827-5
更新日期：2018-12-01 00:00:00
abstract：INTRODUCTION:The anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) alectinib was approved in Japan in 2014 for the treatment of ALK fusion gene-positive advanced non-small cell lung cancer (NSCLC). With the approvals of crizotinib in 2012 and ceritinib in 2017, Japan became the first country with multipl...
journal_title：Advances in therapy
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
abstract：INTRODUCTION:Recent research has suggested that serum tumor markers can give valuable prognostic information in gastric cancer. In this study, we examined the relationship between preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA 72-4, and alfa fetoprotein (AFP) levels on clinicopath...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0100-4
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is the classic progressive fibrosing interstitial lung disease (ILD), but some patients with ILDs other than IPF also develop a progressive fibrosing phenotype (PF-ILD). Information on use and cost of healthcare resources in patients with PF-ILD is limited. METHODS:We u...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01380-4
更新日期：2020-07-01 00:00:00
abstract：:Clarithromycin, an advanced-generation macrolide antibiotic, has demonstrated excellent in vitro activity against group A beta-hemolytic streptococcus (GABHS). Potent activity against Streptococcus pyogenes and a favorable pharmacokinetic profile have made it a reasonable alternative for treatment of patients with str...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02868027
更新日期：2000-01-01 00:00:00
abstract：:This study compared technetium-99m-hexakis-2-methoxyisobutyl-isonitrile (Tc-99m MIBI) with technetium-99m methylene iphosphonate (Tc-99m MDP) to determine whether Tc-99m MIBI could distinguish vertebral metastases from traumatic vertebral fractures. Twenty patients with traumatic vertebral fracture (and no malignant d...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850344
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:A combination of magnetic resonance imaging (MRI) with real-time high-resolution ultrasound (US) known as fusion imaging may improve visualization of musculoskeletal (MSK) sports medicine injuries. The aim of this study was to evaluate the applicability of MRI-US fusion technology in MSK sports medicine. ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0217-1
更新日期：2015-06-01 00:00:00
abstract：INTRODUCTION:Increasing dialysate magnesium (D-Mg2+) appears to be an intriguing strategy to obtain cardiovascular benefits in subjects with end-stage kidney disease (ESKD) on hemodialysis. To date, however, hemodialysis guidelines do not suggest to increase D-Mg2+ routinely set at 0.50 mmol/L. METHODS:A randomized 4-...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01505-9
更新日期：2020-12-01 00:00:00
