Cost associated with D-Dimer screening for acute aortic dissection.


INTRODUCTION:D-Dimer (DD) has been described as a useful predictor of both morphologic changes in acute thoracic aortic dissection (TAD) and of TAD-associated mortality. This study analyzed the use of DD screening to screen patients with chest pain for acute (TAD) to determine if it improves diagnosis and cost effectiveness. This study also looked at the association of DD levels with diagnoses frequently seen in patients with dyspnea or chest pain. METHODS:At the Helios Hospital, Krefeld, the authors analyzed the data of all patients (n = 1053, age (mean, SD) 62 ± 19 years, 49% males) admitted for chest pain to the nonsurgical emergency department (ED) in February 2010. Chest pain was the second most frequent symptom causing 138 (13.1%) admissions, 102 of which had DD testing (Inniovance® D-Dimer Assay, Dade Behring/Siemens, Germany). To assess the diagnostic reliability of DD testing, the sensitivity, specificity, and odds ratio, including 95% confidence interval, were estimated. RESULTS:None of the patients admitted were found to have acute TAD. Had the authors used a computerized tomography (CT) scan to rule out TAD in every patient with chest pain, actual costs would have been euro 12,328. A restriction of CT scans to patients with elevated DD levels would have lowered costs to euro 5360. The actual costs were euro 670.30 for CT scans and euro 540.60 for DD tests. On analyzing the association with other diagnoses, both sensitivity and specificity were low, with the exception of pneumonia. CONCLUSION:Owing to the low incidence of TAD, DD screening increases diagnostic efforts and costs but it remains unclear whether it would actually speed up TAD diagnosis. In a clinical setting DD did not help to discriminate other relevant diagnoses. Despite the high sensitivity of DD for aortic dissection published in the literature, the physician's clinical judgment remains paramount.


Adv Ther


Advances in therapy


Moysidis T,Lohmann M,Lutkewitz S,Kemmeries G,Kröger K




Has Abstract


2011-11-01 00:00:00












  • Efficacy and safety of butterbur herbal extract Ze 339 in seasonal allergic rhinitis: postmarketing surveillance study.

    abstract::The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Käufeler R,Polasek W,Brattström A,Koetter U

    更新日期:2006-03-01 00:00:00

  • Chemotherapy with modified docetaxel, cisplatin, and 5-fluorouracil in patients with metastatic head and neck cancer.

    abstract:INTRODUCTION:This retrospective study evaluates the efficacy of palliative chemotherapy with a modified docetaxel, cisplatin, 5-fluorouracil (5-FU; "TPF" regimen) regimen (mTPF; reduced doses of docetaxel, cisplatin, and 5-FU with reduction of intravenous 5-FU from 4 days to 2 days) in Asian patients with recurrent and...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Lin JT,Lai GM,Chang TH,Liu MT,Bi CP,Wang JW,Chen MK

    更新日期:2012-01-01 00:00:00

  • Enhanced Safety Surveillance of Seasonal Quadrivalent Influenza Vaccines in English Primary Care: Interim Analysis.

    abstract:INTRODUCTION:The European Medicines Agency (EMA) requires vaccine manufacturers to conduct enhanced safety surveillance (ESS) of seasonal influenza vaccines including a near real-time evaluation of collected data. The objective was to identify whether the use of passive surveillance or active surveillance provides diff...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: de Lusignan S,Dos Santos G,Byford R,Schuind A,Damaso S,Shende V,McGee C,Yonova I,Ferreira F

    更新日期:2018-08-01 00:00:00

  • Treatment patterns following discontinuation of adalimumab, etanercept, and infliximab in a US managed care sample.

    abstract:OBJECTIVES:Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS:The IMS LifeLink Health Plan Claims database was use...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Yeaw J,Watson C,Fox KM,Schabert VF,Goodman S,Gandra SR

    更新日期:2014-04-01 00:00:00

  • Echinacea reduces the risk of recurrent respiratory tract infections and complications: a meta-analysis of randomized controlled trials.

    abstract:INTRODUCTION:Respiratory tract infections are common, and these infections occur frequently in children, susceptible adults, and older persons. The risk for recurrences and complications relates not only to the presence of viruses but also to immune function. Therefore, modulation of the immune system and antiviral int...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究


    authors: Schapowal A,Klein P,Johnston SL

    更新日期:2015-03-01 00:00:00

  • Plume Characteristics of Two HFA-Driven Inhaled Corticosteroid/Long-Acting Beta2-Agonist Combination Pressurized Metered-Dose Inhalers.

    abstract:INTRODUCTION:New inhalers propelled by hydrofluoroalkanes (HFAs) have improved plume characteristics: higher fine particle fraction, and warmer plumes with reduced force and velocity. Together, this may avoid reflex interruption of inhalation and improve lung deposition of the inhaled drugs. However, even with HFA-prop...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Johal B,Murphy S,Tuohy J,Marshall J

    更新日期:2015-06-01 00:00:00

  • Self-expandable metallic stents for malignant gastric outlet obstruction.

    abstract::Duodenal self-expandable metal stents (SEMS) are designed for palliation and prompt relief of malignant gastric outlet obstruction (GOO). This mini-invasive endoscopic treatment is preferable to surgery due to its lower morbidity and mortality, shorter hospitalization, and earlier symptoms relief; furthermore endoscop...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Boškoski I,Tringali A,Familiari P,Mutignani M,Costamagna G

    更新日期:2010-10-01 00:00:00

  • Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs.

    abstract::Traveling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss of appetite, reduced cognitive skills, and disruption of the sleep/wake cycle. In susceptible air travel passengers, jet lag may exacerbate affective illness and result i...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Srinivasan V,Singh J,Pandi-Perumal SR,Brown GM,Spence DW,Cardinali DP

    更新日期:2010-11-01 00:00:00

  • Persistence, Dose Titration, and Health Care Resource Utilization Among Crohn's Disease Patients Treated With Ustekinumab: A Real-World Analysis in the United States.

    abstract:INTRODUCTION:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. This real-world study evaluated persistence, dose titration, health care resource utilization (HCRU) and associated costs, and medication use among CD patients treated with ustekinumab (UST) in several pooled US commercia...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Obando C,Ding Z,Muser E,Vaidya N,Qiang W,Sun X,Wang H,Mallampati R,Xie L

    更新日期:2020-05-01 00:00:00

  • An Economic Evaluation of Iron Isomaltoside 1000 Versus Ferric Carboxymaltose in Patients with Inflammatory Bowel Disease and Iron Deficiency Anemia in Denmark.

    abstract:INTRODUCTION:The incidence of inflammatory bowel disease (IBD) in Denmark is among the highest in the world, with Crohn's disease and ulcerative colitis occurring at rates of 9.1 and 18.6 per 100,000 person-years respectively in 2010-2013. Anemia is the most prevalent extraintestinal complication of IBD, most commonly ...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Pollock RF,Muduma G

    更新日期:2018-12-01 00:00:00

  • Two innovative pharmaceutical forms of leuprorelin: results from 818 patients with advanced prostate cancer.

    abstract:OBJECTIVES:This study set out to examine the efficacy and tolerability of two innovative implant forms of leuprorelin acetate in men with advanced hormone-dependent prostate cancer in everyday clinical practice. METHODS:Data were collected from 818 patients (from 273 centers across Germany) who were pretreated with sl...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Gravel P,Samland D,Löffler M,Maier S,Panozzo M,Muenzberg M

    更新日期:2013-03-01 00:00:00

  • Relationships between markers of inflammation, severity of injury, and clinical outcomes in hemorrhagic shock.

    abstract::This study was performed to investigate the relationships between markers of inflammation in serum (interleukin-6 [IL-6], interleukin-10 [IL-10], and granulocyte elastase [GE]), severity of injury, and clinical outcomes, and to evaluate the predictive value of these markers for major complications and mortality. This ...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Akkose S,Ozgurer A,Bulut M,Koksal O,Ozdemír F,Ozguç H

    更新日期:2007-09-01 00:00:00

  • Real-life dosage and clinical efficacy of biphasic insulin preparations in patients with type 2 diabetes.

    abstract:INTRODUCTION:This retrospective study used data from a primary care database to compare two insulin products in routine clinical practice for the treatment of type 2 diabetes in the UK. PATIENTS AND METHODS:Records were analyzed for patients with type 2 diabetes who had been initiated on biphasic insulin aspart 30 (BI...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Fakhoury WK,Richter H,Christensen TE

    更新日期:2010-11-01 00:00:00

  • Assessing the Therapeutic Utility of Professional Continuous Glucose Monitoring in Type 2 Diabetes Across Various Therapies: A Retrospective Evaluation.

    abstract:BACKGROUND:There have been few large studies that have analyzed the effect of professional (masked) continuous glucose monitoring (P-CGM) on glycemic control in patients with type 2 diabetes (T2DM) who were on a broad spectrum of baseline therapies. METHODS:We performed a retrospective, blinded evaluation of glycemic ...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Kesavadev J,Vigersky R,Shin J,Pillai PBS,Shankar A,Sanal G,Krishnan G,Jothydev S

    更新日期:2017-08-01 00:00:00

  • Linagliptin/Metformin fixed-dose combination treatment: a dual attack to type 2 diabetes pathophysiology.

    abstract::Combination therapies are a widely accepted approach to type 2 diabetes treatment, considering that monotherapies fail to provide adequate glycemic control in the majority of cases. The combination of oral antidiabetic agents into a single tablet would significantly simplify the therapeutic regimen and maximize patien...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Koliaki C,Doupis J

    更新日期:2012-12-01 00:00:00

  • Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain.

    abstract:INTRODUCTION:This pooled analysis of data from three phase 3 studies in patients with chronic osteoarthritis knee or low back pain evaluated the efficacy and tolerability of tapentadol prolonged release (PR; 100-250 mg twice daily) compared with placebo and oxycodone hydrochloride (HCl) controlled release (CR; 20-50 mg...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析


    authors: Lange B,Kuperwasser B,Okamoto A,Steup A,Häufel T,Ashworth J,Etropolski M

    更新日期:2010-06-01 00:00:00

  • Dose conversion ratio in hemodialysis patients switched from darbepoetin alfa to PEG-epoetin beta: AFFIRM study.

    abstract:INTRODUCTION:There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. AFFIRM (Aran...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究


    authors: Choi P,Farouk M,Manamley N,Addison J

    更新日期:2013-11-01 00:00:00

  • Safety and tolerability of tapentadol extended release in moderate to severe chronic osteoarthritis or low back pain management: pooled analysis of randomized controlled trials.

    abstract:INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析


    authors: Etropolski M,Kuperwasser B,Flügel M,Häufel T,Lange B,Rauschkolb C,Laschewski F

    更新日期:2014-06-01 00:00:00

  • The Impact of a Single Nucleotide Polymorphism in SIGMAR1 on Depressive Symptoms in Major Depressive Disorder and Bipolar Disorder.

    abstract:INTRODUCTION:Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive diso...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Mandelli L,Wang SM,Han C,Lee SJ,Patkar AA,Masand PS,Pae CU,Serretti A

    更新日期:2017-03-01 00:00:00

  • Reduced Hypoglycemia Risk in Type 2 Diabetes Patients Switched to/Initiating Insulin Glargine 300 vs 100 U/ml: A European Real-World Study.

    abstract:INTRODUCTION:Randomized controlled trials and real-world data from the USA have shown similar glycemic control with insulin glargine 300 U/ml (Gla-300) and insulin glargine 100 U/ml (Gla-100) and reduced hypoglycemia risk with Gla-300. This real-world study describes the efficacy and safety of Gla-300 and Gla-100 in pa...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Escalada J,Bonnet F,Wu J,Bonnemaire M,Gupta S,Cambron-Mellott JM,Nicholls C,Müller-Wieland D

    更新日期:2020-09-01 00:00:00

  • Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.

    abstract::Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are common gastrointestinal (GI) disorders. Current treatment options, either prescription or nonprescription medications, have limited efficacy in a subset of patients. There is significant demand for more efficacious medications for the...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Vazquez-Roque MI,Bouras EP

    更新日期:2013-03-01 00:00:00

  • Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study.

    abstract:INTRODUCTION:To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG). METHODS:Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pres...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Parisi V,Oddone F,Roberti G,Tanga L,Carnevale C,Ziccardi L,Manni G

    更新日期:2019-04-01 00:00:00

  • A preliminary report on spinal muscular atrophy lymphoblastoid cell lines: are they an appropriate tool for drug screening?

    abstract:INTRODUCTION:Spinal muscular atrophy (SMA) is a neurodegenerative disease of the motor neurons that results in progressive muscle weakness. It is also the leading hereditary cause of infant mortality. Homozygous loss of the survival motor neuron (SMN1) gene causes SMA, and the number of copies of the SMN2 gene modulate...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Dayangaç-Erden D,Topaloğlu H,Erdem-Yurter H

    更新日期:2008-03-01 00:00:00

  • The Rituximab Biosimilar CT-P10 in Rheumatology and Cancer: A Budget Impact Analysis in 28 European Countries.

    abstract:INTRODUCTION:New biosimilars of monoclonal antibodies are anticipated to bring significant cost savings and increase access to treatment. The rituximab biosimilar CT-P10 has recently been approved in Europe in all indications held by reference rituximab (RTX), including rheumatoid arthritis, non-Hodgkin's lymphoma, and...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究


    authors: Gulácsi L,Brodszky V,Baji P,Rencz F,Péntek M

    更新日期:2017-05-01 00:00:00

  • The Challenges of Switching Therapies in an Evolving Multiple Biosimilars Landscape: A Narrative Review of Current Evidence.

    abstract::With the increasing availability of biosimilars, the practice of switching therapies for non-medical reasons between an originator biologic and an analogous biosimilar has become more common. The evidence to support this practice mostly comes from single-switch randomized controlled trials (RCTs) and real-world (RW) e...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Feagan BG,Marabani M,Wu JJ,Faccin F,Spronk C,Castañeda-Hernández G

    更新日期:2020-11-01 00:00:00

  • Assessing thrombosis risk in patients with idiopathic, diabetic, and postsurgical gastroparesis.

    abstract::Patients with severe gastrointestinal motility disorders are often found to have intravenous access clots or deep venous thrombosis. It has previously been reported that many patients who have intravenous access thrombosis have concomitant thrombotic risk factors. In this study, the goal was to determine the underlyin...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Lobrano A,Blanchard K,Rock W,Johnson W,Schmieg B,Borman K,Araghizadeh F,Minocha A,Abell TL

    更新日期:2006-09-01 00:00:00

  • Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina.

    abstract::Coronary heart disease is the major cause of morbidity and mortality in industrialized countries, and its prevalence is predicted to grow as the population ages. Current drugs for chronic stable angina (such as beta-blockers, calcium-channel blockers, long- and short-acting nitrates, and potassium-channel activators) ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审


    authors: Prasad UK,Gray D,Purcell H

    更新日期:2009-02-01 00:00:00

  • Prescribing Trends in a Glaucoma Clinic and Adherence to EGS Guidelines: A Retrospective, Non-Interventional, Single-Center UK Study.

    abstract:INTRODUCTION:The purpose of this study was to determine prescribing trends in a specialist glaucoma clinic in the UK. Specifically, the aims were to determine which drugs were prescribed as first-, second-, and third-line treatment, the persistence of first-, second-, and third-line treatment regimens, and the proporti...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Fajgenbaum M,Ansari E

    更新日期:2017-08-01 00:00:00

  • Correction to: Unlocking the Value of Anti-TNF Biosimilars: Reducing Disease Burden and Improving Outcomes in Chronic Immune-Mediated Inflammatory Diseases: A Narrative Review.

    abstract::In the original article, under the "Access to treatment" heading. ...

    journal_title:Advances in therapy

    pub_type: 已发布勘误


    authors: Rezk MF,Pieper B

    更新日期:2020-11-01 00:00:00

  • Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients.

    abstract:INTRODUCTION:Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHO...

    journal_title:Advances in therapy

    pub_type: 杂志文章


    authors: Arai T

    更新日期:2013-05-01 00:00:00