Abstract：
:In an open-label 12-week study, the safety and efficacy of bimatoprost 0.03% was evaluated in 55 patients with open-angle glaucoma or ocular hypertension inadequately controlled by topical beta-blocker monotherapy. Patients discontinued their topical beta-blocker therapy at the baseline visit and began bimatoprost monotherapy that evening. Study visits were at 6 and 12 weeks postbaseline. Bimatoprost reduced intraocular pressure (IOP) 4.5 mm Hg (21.5%; P < .001) from baseline at week 6 and 4.2 mm Hg (19.6%; P < .001) at week 12. Patients were more likely to achieve low target pressures with bimatoprost than with topical beta-blockers. Conjunctival hyperemia was the most commonly reported adverse event. The findings from this study indicate bimatoprost monotherapy provides a substantially greater IOP reduction than topical beta-blocker therapy and allows more patients to achieve a low target pressure. Bimatoprost is an effective alternative to topical beta-blockers for the treatment of glaucoma and ocular hypertension.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Quinones R,Earl MLdoi
10.1007/BF02850101subject
Has Abstractpub_date
2004-11-01 00:00:00pages
370-9issue
6eissn
0741-238Xissn
1865-8652pii
367journal_volume
21pub_type
临床试验,杂志文章abstract：INTRODUCTION:Subsequent lines of subcutaneous tumor necrosis factor alpha inhibitor (SC-TNFi) treatment may be well motivated in the management of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)-collectively named inflammatory arthritis (IA). However, the costs associated with swit...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01425-8
更新日期：2020-09-01 00:00:00
abstract：:Resistance to first- and second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) and development and progression of central nervous system metastases remain significant issues in the treatment of ALK-positive non-small-cell lung cancer. Lorlatinib is a novel third-generation ALK TKI that i...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01365-3
更新日期：2020-06-01 00:00:00
abstract：INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a complex disease in which multiple organs and hormones contribute to the pathogenesis of disease. The intestinal hormone, glucagon-like peptide-1 (GLP-1), secreted in response to nutrient ingestion, increases insulin secretion from pancreatic β-cells and reduces glucagon...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-015-0262-9
更新日期：2015-11-01 00:00:00
abstract：:Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in adolescents. Such infection is associated with substantial health risks and is unpredictable in its resolution. Genital warts are the most common clinical manifestations of genital HPV infections. Most genital warts are c...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02849928
更新日期：2005-05-01 00:00:00
abstract：INTRODUCTION:There is limited information published on switching erythropoiesis-stimulating agent (ESA) treatment for anemia associated with chronic kidney disease (CKD) from darbepoetin alfa (DA) to methoxy polyethylene glycol-epoetin beta (PEG-Epo) outside the protocol of interventional clinical studies. AFFIRM (Aran...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-013-0063-y
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin-17A, has demonstrated robust efficacy in the treatment of moderate to severe psoriasis (PsO), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), with a rapid onset of action, sustained long-term clinical responses and...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01352-8
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Adherence to disease-modifying therapies (DMTs) is essential for the reduction of multiple sclerosis (MS) progression and relapse. However, only limited data currently exist on the impact of treatment adherence on MS-related clinical and economic outcomes in the real world setting. OBJECTIVE:To assess the i...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-010-0093-7
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:The OPTIMA© (MSD, Courbevoie, France) questionnaire was developed to promote shared decisions and the set-up of specific micro-objectives in clinical practice by optimizing communication between type 2 diabetes (T2DM) patients and their physicians. The present study aimed to assess OPTIMA in clinical practic...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-016-0341-6
更新日期：2016-06-01 00:00:00
abstract：:Venous leg ulcers (VLUs) are the most severe manifestation of chronic venous disease (CVD). Due to their chronic nature, high recurrence rate and slow healing time, VLUs account for 80% of all leg ulcers seen in patients with CVD. VLUs impose a heavy burden on patients that reduces their quality of life; VLUs also rep...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01219-y
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Evidence suggests that elevated plasma levels of B-type natriuretic peptide (BNP) are found in patients with chronic obstructive pulmonary disease (COPD) and right ventricular dysfunction. We examined the effects of exercise on plasma BNP levels in patients with COPD who have normal right ventricular funct...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：10.1007/s12325-008-0067-1
更新日期：2008-07-01 00:00:00
abstract：:Subretinal hemorrhage secondary to age-related macular degeneration (AMD) has a poor visual prognosis. Surgical drainage of the blood improves visual acuity only in selected patients. We report on two elderly patients with spontaneous subretinal hemorrhage from AMD. In one eye, recombinant tissue plasminogen activator...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:With the increasing availability of biosimilars, the practice of switching therapies for non-medical reasons between an originator biologic and an analogous biosimilar has become more common. The evidence to support this practice mostly comes from single-switch randomized controlled trials (RCTs) and real-world (RW) e...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01472-1
更新日期：2020-11-01 00:00:00
abstract：:The improvement of glycemic control in patients with type 2 diabetes (T2D) is an urgent need in Asia. East Asian T2D patients have distinct characteristics, including relatively low body weight, early impairment of islet beta cell function with reduced insulin secretion and a marked increase in postprandial blood gluc...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-019-00914-9
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:New biosimilars of monoclonal antibodies are anticipated to bring significant cost savings and increase access to treatment. The rituximab biosimilar CT-P10 has recently been approved in Europe in all indications held by reference rituximab (RTX), including rheumatoid arthritis, non-Hodgkin's lymphoma, and...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-017-0522-y
更新日期：2017-05-01 00:00:00
abstract：:Designed to provide information about patients with schizophrenia who switch from depot neuroleptics to the oral, atypical antipsychotic risperidone, this multicenter observational study enrolled patients who wished to stop the depot, had an unsatisfactory response, or experienced unacceptable side effects. Individual...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1999-03-01 00:00:00
abstract：:Retinal vein occlusions are common retinal vascular disorders with the potential for significant vision-related morbidity. Retinal vein occlusions are classified as either branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO), or hemiretinal vein occlusion (HRVO) based on the specific occlusion s...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-010-0088-4
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Rhegmatogenous retinal detachment (RRD) with extensive choroidal detachment (CD), suprachoroidal fluid (SCF), and lower intraocular pressure (IOP) markedly increase the difficulty of pars plana vitrectomy (PPV) because it makes the insertion and placement of the trocar cannulas for PPV time-consuming and t...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0801-2
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s12325-008-0071-5
更新日期：2008-06-01 00:00:00
abstract：:Bacterial translocation is the passage of bacteria or endotoxins from the gastrointestinal tract to extraintestinal sites, such as mesenteric lymph nodes, liver, spleen, and bloodstream. In this study, the investigators examined the effects of various enteral nutrients on bacterial translocation and intestinal morphol...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849991
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:This analysis of pooled data from four randomized, controlled-dose adjustment, phase 3 studies (three 15-week, double-blind, placebo- and active-controlled studies and a 1-year, open-label, active-controlled safety study) in patients with chronic osteoarthritis hip or knee pain or low back pain evaluated t...
journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
doi：10.1007/s12325-014-0128-6
更新日期：2014-06-01 00:00:00
abstract：:In the past 15 years, improvements in the treatment of HIV infection have dramatically reduced morbidity and mortality. Nucleoside reverse transcriptase inhibitors are the backbone of combination antiretroviral therapy for the treatment of HIV. One of the recommended and commonly used therapies in this class is the on...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-010-0006-9
更新日期：2010-01-01 00:00:00
abstract：:Real-world studies have become increasingly important in providing evidence of treatment effectiveness in clinical practice. While randomized clinical trials (RCTs) are the "gold standard" for evaluating the safety and efficacy of new therapeutic agents, necessarily strict inclusion and exclusion criteria mean that tr...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-018-0805-y
更新日期：2018-11-01 00:00:00
abstract：:Cardiovascular diseases (CVDs) are the leading cause of premature deaths globally and in Ukraine. Dyslipidemia is a recognized risk factor for the development of CVD. Therefore, early detection and appropriate management of dyslipidemia are essential for the primary prevention of CVDs. However, currently, there is a l...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01490-z
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Previous studies showed the relation of mental distress such as anxiety and depression to coronary vasoconstriction and myocardial ischemia. However, the mental health status of patients suspected to have vasospastic angina is unclear. METHODS:A total of 99 patients underwent intracoronary acetylcholine (AC...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01424-9
更新日期：2020-09-01 00:00:00
abstract：:In the original article. The third author name is incorrect. The correct name is Nicholas J. Leeper. ...
journal_title：Advances in therapy
pub_type： 已发布勘误
doi：10.1007/s12325-020-01220-5
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:P-wave dispersion (PWD) has been shown to be a non-invasive electrocardiographic predictor for development of atrial fibrillation (AF). Thus, it may be possible to attenuate AF risk through improvement of PWD. In this study, we compared the effects of an angiotensin-converting enzyme (ACE) inhibitor, quina...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-008-0083-1
更新日期：2008-08-01 00:00:00
abstract：INTRODUCTION:The healthcare sector contributes 5-8% of the global greenhouse gas emissions. Global and regional organizations and governments have started to design and implement measures to reduce global greenhouse gas emissions in the healthcare sector, e.g. by green public procurement policies and inclusion of ecolo...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-019-01114-1
更新日期：2019-12-01 00:00:00
abstract：:Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-016-0311-z
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION:The 21-gene breast cancer assay (Oncotype DX(®); Genomic Health, Inc.) is a validated diagnostic test that predicts the likelihood of adjuvant chemotherapy benefit and 10-year risk of distant recurrence in patients with hormone-receptor-positive, human epidermal growth receptor 2-negative, early-stage brea...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0190-8
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:Video-assisted thoracic surgery (VATS) lung resections are complex procedures with a critical role played by endoscopic staplers in the transection of vessels, bronchi, and lung tissue. This retrospective, observational study compared hospital resource use, costs, and complications of VATS lobectomy proced...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0679-z
更新日期：2018-05-01 00:00:00
