Abstract：
BACKGROUND:Previous studies showed the relation of mental distress such as anxiety and depression to coronary vasoconstriction and myocardial ischemia. However, the mental health status of patients suspected to have vasospastic angina is unclear. METHODS:A total of 99 patients underwent intracoronary acetylcholine (ACh) provocation tests for the diagnosis of vasospastic angina and mental health assessment using the 12-item General Health Questionnaire (GHQ-12) and State-Trait Anxiety Inventory Form Y (STAI Y-2). Patients with binary GHQ-12 ≥ 4 were defined as having poor mental health. RESULTS:Median GHQ-12 and STAI Y-2 were 3 [1, 6] and 44 [36, 50]. Forty-one (41%) patients had binary GHQ-12 ≥ 4, and 48 (48%) had positive ACh provocation tests. The number of provoked vasospasms and rate of electrocardiographic change and chest pain during ACh tests were not significantly different between patients with and without GHQ-12 ≥ 4. The incidence of positive ACh provocation test was similar between the two groups (49% vs. 48%, p = 1.00). The multivariable analysis indicated that younger age, no history of percutaneous coronary intervention and no diabetes mellitus were factors associated with higher GHQ-12 and/or STAI Y-2 scores. CONCLUSIONS:More than 40% of patients who underwent ACh provocation tests had poor mental condition. No impact of mental distress on positive ACh tests was found in this study.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Saito Y,Shoji T,Tateishi K,Kitahara H,Fujimoto Y,Kobayashi Ydoi
10.1007/s12325-020-01424-9subject
Has Abstractpub_date
2020-09-01 00:00:00pages
3807-3815issue
9eissn
0741-238Xissn
1865-8652pii
10.1007/s12325-020-01424-9journal_volume
37pub_type
杂志文章abstract：INTRODUCTION:ARTOS was an international, prospective, non-interventional, non-controlled observational study designed to determine the effectiveness, safety, and tolerability of moxifloxacin under daily-life conditions in patients with complicated skin and skin structure infections (cSSSIs) treated in Europe, the Middl...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0038-z
更新日期：2013-06-01 00:00:00
abstract：:Two patients with thalassemia minor and end-stage renal failure on hemodialysis were treated with epoetin zeta (Silapo, Retacrit; STADA, Germany), a medicinal product that was developed and registered as biosimilar to epoetin alfa. Dosing was titrated individually for two patients to achieve a stable hemoglobin (Hb) c...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-008-0119-6
更新日期：2008-12-01 00:00:00
abstract：:The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis. In an open postmarketing surveillance study, 580 patients were treated with an average of 2 tablets of Ze 33...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850143
更新日期：2006-03-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to assess the efficacy and safety of esomeprazole 40 mg once daily (q.d.) in healing reflux oesophagitis at 4 and 8 weeks, and the efficacy of esomeprazole 20 mg q.d. for 12 weeks in the maintenance of remission. METHODS:A total of 235 patients with endoscopically proven reflux o...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s12325-008-0071-5
更新日期：2008-06-01 00:00:00
abstract：INTRODUCTION:Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the finan...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0851-5
更新日期：2019-02-01 00:00:00
abstract：:Subretinal hemorrhage secondary to age-related macular degeneration (AMD) has a poor visual prognosis. Surgical drainage of the blood improves visual acuity only in selected patients. We report on two elderly patients with spontaneous subretinal hemorrhage from AMD. In one eye, recombinant tissue plasminogen activator...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Ambulatory monitoring was used to evaluate the antihypertensive efficacy and effect on circadian rhythms of blood pressure and heart rate of a single dose and long-term administration of ramipril in 20 patients with mild to moderate essential hypertension. Patients initially were randomized to receive either placebo o...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:A recent successful clinical trial demonstrated that a less invasive cell-injection procedure is a viable medical modality for treating corneal endothelial dystrophy. This medical advance still relies on human corneal endothelial cell (HCEC) sources derived from rare cornea donations. The progenitor of the corn...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01237-w
更新日期：2020-03-01 00:00:00
abstract：:This interventional study was undertaken to assess the impact of physiotherapy education on the knowledge and attitudes of physiotherapists (PTs) and physiotherapy students (PSs) toward euthanasia. The study, which was conducted during the period between 2004 and 2005, included a total of 494 participants (311 PTs; 18...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02850001
更新日期：2007-01-01 00:00:00
abstract：:Recently, high levels of neurotrophic factors have been found in bronchial asthma; these factors include nerve growth factor, brain-derived neurotrophic factor, and leukemia inhibitory factor, among others. Neurotrophic factors are first synthesized in bronchial epithelial cells, immune cells, and other cells in the a...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02848784
更新日期：2007-05-01 00:00:00
abstract：:In an open-label 12-week study, the safety and efficacy of bimatoprost 0.03% was evaluated in 55 patients with open-angle glaucoma or ocular hypertension inadequately controlled by topical beta-blocker monotherapy. Patients discontinued their topical beta-blocker therapy at the baseline visit and began bimatoprost mon...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF02850101
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVES:Because clinical guidelines do not offer clear recommendations for treatment options after discontinuing a tumor necrosis factor (TNF) blocker, this study evaluated treatment patterns within 360 days after discontinuation of TNF-blocker treatment. METHODS:The IMS LifeLink Health Plan Claims database was use...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-014-0110-3
更新日期：2014-04-01 00:00:00
abstract：INTRODUCTION:D-Dimer (DD) has been described as a useful predictor of both morphologic changes in acute thoracic aortic dissection (TAD) and of TAD-associated mortality. This study analyzed the use of DD screening to screen patients with chest pain for acute (TAD) to determine if it improves diagnosis and cost effectiv...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-011-0069-2
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:Clinical guidelines recommend levothyroxine as the standard of care for hypothyroidism and that patients should be treated with a consistent preparation of synthetic levothyroxine without switching among formulations. This study examines the likelihoods of negative clinical outcomes between continuous user...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01537-1
更新日期：2020-10-28 00:00:00
abstract：INTRODUCTION:The incidence of inflammatory bowel disease (IBD) in Denmark is among the highest in the world, with Crohn's disease and ulcerative colitis occurring at rates of 9.1 and 18.6 per 100,000 person-years respectively in 2010-2013. Anemia is the most prevalent extraintestinal complication of IBD, most commonly ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0827-5
更新日期：2018-12-01 00:00:00
abstract：:Complicated urinary tract infection (UTI), which often requires hospitalization or prolongs a hospital stay, presents numerous diagnostic and therapeutic challenges. Implementation of effective antimicrobial treatment is vital because of the risk of adverse sequelae due to persistence of infection, relapse, or reinfec...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：INTRODUCTION:Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inflammatory processes, but the efficacy of combined treatment with these substances in the treatment of arthr...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-011-0068-3
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:This study set out to examine the efficacy and tolerability of two innovative implant forms of leuprorelin acetate in men with advanced hormone-dependent prostate cancer in everyday clinical practice. METHODS:Data were collected from 818 patients (from 273 centers across Germany) who were pretreated with sl...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0010-y
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Phase IV post-marketing surveillance studies are needed to evaluate the real-world safety and effectiveness of drug products. This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01611-8
更新日期：2021-01-11 00:00:00
abstract：:This 6-month randomized study evaluated the safety and efficacy of sibutramine in 57 overweight Hispanic patients with hypertension. Following a 2-week washout to confirm the diagnosis of hypertension, antihypertensive medication was adjusted to achieve a blood pressure less than 140/90 mm Hg before institution of eit...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850257
更新日期：2003-03-01 00:00:00
abstract：INTRODUCTION:Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHO...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0030-7
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION:Oxycodone is one of the most commonly used opioid analgesics in the clinical management of pain. The present retrospective analysis aimed to determine the dose of oxycodone that could achieve effective control of moderate pain when combined with a fixed dose of acetaminophen, and the time required to reach...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-016-0339-0
更新日期：2016-06-01 00:00:00
abstract：:In this 2-week, randomized, crossover study, ophthalmic solutions of nedocromil sodium 2% and olopatadine hydrochloride 0.1% were compared for effectiveness and acceptability in 28 patients with perennial allergic conjunctivitis and previous olopatadine experience. Patients received nedocromil twice daily or olopatadi...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02853155
更新日期：2000-05-01 00:00:00
abstract：INTRODUCTION:Sevelamer hydrochloride (SH) and lanthanum carbonate (LC) are calcium-free phosphate binders used for the management of hyperphosphatemia in patients with end-stage renal disease (ESRD). The objective of this analysis was to evaluate the real-world dose-relativity between SH and LC monotherapy in US patien...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-013-0077-5
更新日期：2013-12-01 00:00:00
abstract：:The original article can be found online. ...
journal_title：Advances in therapy
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12325-018-0767-0
更新日期：2018-09-01 00:00:00
abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have an increased risk of comorbid conditions, including cardiovascular disease (CVD). Anemia is prevalent in the CKD population and worsens as kidney function declines, resulting in a diminished quality of life and increased morbidity/mortality. The purpose of th...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-017-0566-z
更新日期：2017-07-01 00:00:00
abstract：:In an open, controlled study, 44 patients complaining of vertigo, dizziness, or both, caused by vascular vestibular disorders were randomly treated with extract of Ginkgo biloba (EGb 761) 80 mg twice daily or with betahistine dihydrochloride (BI) 16 mg twice daily for 3 months. A complete neuro-otologic and equilibrim...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:The prognosis for patients with rheumatoid arthritis or spondyloarthritides has improved dramatically due to earlier diagnosis, recognition of the need to treat early with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), alone or in combinations, the establishment of treatment targets, and the ...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-014-0142-8
更新日期：2014-08-01 00:00:00
abstract：:X-linked hypophosphataemia (XLH) is the most prevalent form of hereditary rickets characterized by an alteration of phosphate metabolism which frequently leads to the appearance of fractures, bone deformities and growth delay. Although the mechanism of growth impairment in patients with XLH still needs to be clarified...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-019-01178-z
更新日期：2020-05-01 00:00:00
abstract：:Alpha-mannosidosis is a rare lysosomal storage disorder that generally presents in early childhood. It is a progressive, highly heterogeneous disease that is difficult to recognize, and a diagnosis is usually reached after referrals to multiple specialists. It is important to understand the challenges faced by patient...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01574-w
更新日期：2020-11-24 00:00:00
