X-Linked Hypophosphataemic Rickets and Growth.

Abstract:

:X-linked hypophosphataemia (XLH) is the most prevalent form of hereditary rickets characterized by an alteration of phosphate metabolism which frequently leads to the appearance of fractures, bone deformities and growth delay. Although the mechanism of growth impairment in patients with XLH still needs to be clarified, it is known that this alteration is not due to genetic or endocrine factors. A potential explanation for the impairment of growth in this disease is the alteration of the growth plate, a structure responsible for longitudinal growth of bones. Some of the findings in the growth plate of patients with XLH include atypical organization of chondrocytes due to low rates of proliferation and apoptosis and disturbance of chondrocyte hypertrophy, overactivation of the mitogen-activated protein kinase (MAPK) signalling pathway and upregulation of phosphorylated extracellular signal-regulated kinase (pERK). Conventional treatment of XLH (consisting of oral phosphate supplements and active vitamin D analogues) is often insufficient for the longitudinal growth of bone, but other strategies based on recombinant growth hormone or therapies targeting fibroblast growth factor 23 (FGF23) or its receptor, such as burosumab, have shown promising results. This article briefly describes the relationship between XLH and growth retardation, and how to address this alteration in patients with XLH.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Santos Rodríguez F

doi

10.1007/s12325-019-01178-z

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

55-61

issue

Suppl 2

eissn

0741-238X

issn

1865-8652

pii

10.1007/s12325-019-01178-z

journal_volume

37

pub_type

杂志文章,评审
  • The Most Severe Stage of Chronic Venous Disease: An Update on the Management of Patients with Venous Leg Ulcers.

    abstract::Venous leg ulcers (VLUs) are the most severe manifestation of chronic venous disease (CVD). Due to their chronic nature, high recurrence rate and slow healing time, VLUs account for 80% of all leg ulcers seen in patients with CVD. VLUs impose a heavy burden on patients that reduces their quality of life; VLUs also rep...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01219-y

    authors: Nicolaides AN

    更新日期:2020-02-01 00:00:00

  • Prognosis and treatment outcome in patients with acute myeloid leukemia with t(8;21)(q22;q22).

    abstract::Patients with acute myeloid leukemia (AML) with the t(8;21) karyotype generally have a favorable clinical course, but key prognostic factors remain poorly defined. This study was conducted to determine the prognoses and treatment outcomes of patients with AML with this unique cytogenetic change. A total of 22 patients...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02849984

    authors: Chen CC,Gau JP,Yu YB,Lu CH,Lee KD,You JY

    更新日期:2007-07-01 00:00:00

  • Short-Term Assessment of Intravitreal Dexamethasone Implant Using Enhanced-Depth Image Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients with Retinal Vascular Diseases.

    abstract:INTRODUCTION:To evaluate the short-term efficacy and safety of intravitreal dexamethasone implant (IDI) in patients with macular oedema associated with diabetic retinopathy (DR) and retinal vein occlusion (RVO) using enhanced-depth image optical coherence tomography (EDI-OCT) and to estimate the effect of dexamethasone...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0848-0

    authors: Minnella AM,Federici M,Pagliei V,Lanza A,Gambini G,Caputo CG,Falsini B,Caporossi A

    更新日期:2019-02-01 00:00:00

  • A Budget Impact Model to Estimate the Environmental Impact of Adopting RESPIMAT® Re-usable in the Nordics and Benelux.

    abstract:INTRODUCTION:The healthcare sector contributes 5-8% of the global greenhouse gas emissions. Global and regional organizations and governments have started to design and implement measures to reduce global greenhouse gas emissions in the healthcare sector, e.g. by green public procurement policies and inclusion of ecolo...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01114-1

    authors: Ortsäter G,Borgström F,Soulard S,Miltenburger C

    更新日期:2019-12-01 00:00:00

  • Antibiotic therapy for patients with spinal cord injury undergoing urologic procedures.

    abstract::This prospective study was performed to determine whether gentamicin can be prescribed routinely to patients with spinal cord injury undergoing urologic procedures, or whether antibiotic therapy must be selected on the basis of recent urine microbiologic test results. Between January 2004 and June 2005, procedures wer...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02850350

    authors: Vaidyanathan S,Soni BM

    更新日期:2006-01-01 00:00:00

  • Cost-effectiveness analysis of lopinavir/ritonavir and atazanavir+ritonavir regimens in the CASTLE study.

    abstract:INTRODUCTION:The purpose of the study was to conduct a cost-effectiveness analysis and budget impact analysis comparing lopinavir with ritonavir (LPV/r) and atazanavir plus ritonavir (ATV+RTV) for antiretroviral-naïve patients with a baseline CD4+ T-cell distribution and total cholesterol (TC) profile as reported in th...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0141-8

    authors: Simpson KN,Rajagopalan R,Dietz B

    更新日期:2009-02-01 00:00:00

  • Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better.

    abstract:INTRODUCTION:Oxycodone is one of the most commonly used opioid analgesics in the clinical management of pain. The present retrospective analysis aimed to determine the dose of oxycodone that could achieve effective control of moderate pain when combined with a fixed dose of acetaminophen, and the time required to reach...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-016-0339-0

    authors: Natoli S,Lazzari M,Carpenedo R,Palombo E,Silvi MB,Mammucari M,Dauri M

    更新日期:2016-06-01 00:00:00

  • Long-term allergen-specific immunotherapy correlates with long-term allergen-specific immunological tolerance.

    abstract:INTRODUCTION:One method of treatment for allergic diseases is allergen-specific immunotherapy (SIT). The clinical efficacy of SIT in pollen-induced allergic rhinitis has been demonstrated in several controlled clinical trials. There is no consensus about the protective effect of SIT. In this study, we evaluated the cor...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-008-0004-3

    authors: Ali I,Goksal K,Ozan B,Gulsen D

    更新日期:2008-01-01 00:00:00

  • Pooled Safety and Tolerability Analysis of Empagliflozin in Patients with Type 2 Diabetes Mellitus.

    abstract:INTRODUCTION:The aim of this analysis was to characterize the safety and tolerability of empagliflozin in patients with type 2 diabetes mellitus (T2DM) who were randomized to empagliflozin (10/25 mg) or placebo in clinical trials. METHODS:Pooled data from 20 trials were analyzed for patients with T2DM treated with emp...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01329-7

    authors: Kinduryte Schorling O,Clark D,Zwiener I,Kaspers S,Lee J,Iliev H

    更新日期:2020-08-01 00:00:00

  • Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study.

    abstract:INTRODUCTION:To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG). METHODS:Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pres...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-0897-z

    authors: Parisi V,Oddone F,Roberti G,Tanga L,Carnevale C,Ziccardi L,Manni G

    更新日期:2019-04-01 00:00:00

  • Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain.

    abstract:INTRODUCTION:This pooled analysis of data from three phase 3 studies in patients with chronic osteoarthritis knee or low back pain evaluated the efficacy and tolerability of tapentadol prolonged release (PR; 100-250 mg twice daily) compared with placebo and oxycodone hydrochloride (HCl) controlled release (CR; 20-50 mg...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-010-0036-3

    authors: Lange B,Kuperwasser B,Okamoto A,Steup A,Häufel T,Ashworth J,Etropolski M

    更新日期:2010-06-01 00:00:00

  • Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?

    abstract:INTRODUCTION:Oral supplementation of chondroitin sulfate (CS) and glucosamine (GlcN), symptomatic slow-acting molecules, is recommended by European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis and Musculoskeletal Diseases (ESCEO) and other European Union (EU) guidelines for the restorati...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01064-8

    authors: Stellavato A,Restaino OF,Vassallo V,Finamore R,Ruosi C,Cassese E,De Rosa M,Schiraldi C

    更新日期:2019-11-01 00:00:00

  • Prophylactic intranasal mupirocin ointment in the treatment of peritonitis in continuous ambulatory peritoneal dialysis patients.

    abstract::This study was undertaken to evaluate the effectiveness of prophylactic intranasal mupirocin for peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD). A total of 49 patients undergoing CAPD for at least 6 mo were followed for 1 year. A nasal smear was obtained from each patient at the beginning ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/BF02849908

    authors: Sit D,Kadiroglu AK,Kayabasi H,Yilmaz ME

    更新日期:2007-03-01 00:00:00

  • Anticholinergic treatment in airways diseases.

    abstract::The prevalence of chronic airways diseases such as chronic obstructive pulmonary disease and asthma is increasing. They lead to symptoms such as a cough and shortness of breath, partially through bronchoconstriction. Inhaled anticholinergics are one of a number of treatments designed to treat bronchoconstriction in ai...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-009-0074-x

    authors: Flynn RA,Glynn DA,Kennedy MP

    更新日期:2009-10-01 00:00:00

  • Reduction of cardiovascular risk and mortality: a population-based approach.

    abstract::The purpose of this study was to evaluate risk pattern and mortality in a general population epidemiologic study performed by a staff of hypertension specialists working as the "good father of a family," with lifestyle and therapeutic advice and instrumental measurements. Mortality among the study population (n=856) d...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850213

    authors: Casiglia E,Saugo M,Schiavon L,Tikhonoff V,Rigoni G,Basso G,Mazza A,Rizzato E,Guglielmi F,Martini B,Bascelli A,Caffi S,Pessina AC

    更新日期:2006-11-01 00:00:00

  • Ocular trauma in Turkey: a 2-year prospective study.

    abstract::This 2-year prospective study was conducted to identify those at risk for ophthalmologic emergencies, to define the risk factors and reasons for eye injuries, to analyze treatment options, and to compare findings with those of previous studies. A total of 203 patients (74% male, mean age 27.3+/-13.9 y, 51% right eye i...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850133

    authors: Oner A,Kekec Z,Karakucuk S,Ikizceli I,Sözüer EM

    更新日期:2006-03-01 00:00:00

  • Clinical, Ultrasound, and Predictability Outcomes Following Certolizumab Pegol Treatment (with Methotrexate) in Patients with Moderate-to-Severe Rheumatoid Arthritis: 52-Week Results from the CZP-SPEED Study.

    abstract:INTRODUCTION:To assess the impact of certolizumab pegol (CZP) treatment on clinical, patient-reported, and musculoskeletal ultrasound outcomes and to determine the treatment response time point most predictive of long-term outcomes in Italian patients with rheumatoid arthritis (RA). METHODS:CZP-SPEED (NCT01443364) was...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s12325-018-0751-8

    authors: Sarzi-Puttini P,Filippucci E,Adami S,Meroni PL,Batticciotto A,Idolazzi L,De Lucia O,Talavera P,Kumke T,Grassi W

    更新日期:2018-08-01 00:00:00

  • Estimation of the Prevalence of Progressive Fibrosing Interstitial Lung Diseases: Systematic Literature Review and Data from a Physician Survey.

    abstract::Some patients with interstitial lung diseases (ILDs) other than idiopathic pulmonary fibrosis exhibit a progressive clinical phenotype. These chronic progressive fibrosing ILDs have a variety of underlying diseases, and their prevalence is currently unknown. Here we carry out the first systematic review of literature ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01578-6

    authors: Olson A,Hartmann N,Patnaik P,Wallace L,Schlenker-Herceg R,Nasser M,Richeldi L,Hoffmann-Vold AM,Cottin V

    更新日期:2020-12-14 00:00:00

  • The dipeptidyl peptidase (DPP)-4 inhibitors for type 2 diabetes mellitus in challenging patient groups.

    abstract::Treating hyperglycemia is a critical aspect of managing type 2 diabetes mellitus (T2DM), but can be especially challenging in patients from vulnerable groups such as those with chronic kidney disease, African Americans, and older people. The dipeptidyl peptidase (DPP)-4 inhibitors are relatively new oral antidiabetes ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-013-0071-y

    authors: Kountz D

    更新日期:2013-12-01 00:00:00

  • Detection of Distant Metastases in Head and Neck Cancer: Changing Landscape.

    abstract::As head and neck squamous cell carcinoma (HNSCC) patients with distant metastases (DM) were generally treated only palliatively, the value of screening for DM was usually limited to attempts to avoid extensive locoregional treatment when DM were present pretreatment. Recently, the concept of treating oligometastases, ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-018-0662-8

    authors: de Bree R,Senft A,Coca-Pelaz A,Kowalski L,Lopez F,Mendenhall W,Quer M,Rinaldo A,Shaha AR,Strojan P,Takes RP,Silver CE,Leemans CR,Ferlito A

    更新日期:2018-02-01 00:00:00

  • Impact of adherence to disease-modifying therapies on clinical and economic outcomes among patients with multiple sclerosis.

    abstract:BACKGROUND:Adherence to disease-modifying therapies (DMTs) is essential for the reduction of multiple sclerosis (MS) progression and relapse. However, only limited data currently exist on the impact of treatment adherence on MS-related clinical and economic outcomes in the real world setting. OBJECTIVE:To assess the i...

    journal_title:Advances in therapy

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s12325-010-0093-7

    authors: Tan H,Cai Q,Agarwal S,Stephenson JJ,Kamat S

    更新日期:2011-01-01 00:00:00

  • Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study.

    abstract:INTRODUCTION:Phase IV post-marketing surveillance studies are needed to evaluate the real-world safety and effectiveness of drug products. This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01611-8

    authors: Gharibdoost F,Salari AH,Salesi M,Ebrahimi Chaharom F,Mottaghi P,Hosseini M,Sahebari M,Nazarinia M,Mirfeizi Z,Shakibi M,Moussavi H,Karimifar M,Mowla K,Karimzadeh H,Anjidani N,Jamshidi A

    更新日期:2021-01-11 00:00:00

  • Dyspnea in COPD: New Mechanistic Insights and Management Implications.

    abstract::Dyspnea is the most common symptom experienced by patients with chronic obstructive pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt a sedentary lifestyle which predictably leads to extensive skeletal muscle deconditioning, social isolation, and its negative psychological sequalae. This "dysp...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-019-01128-9

    authors: O'Donnell DE,Milne KM,James MD,de Torres JP,Neder JA

    更新日期:2020-01-01 00:00:00

  • Real-World Impact of Cardiovascular Disease and Anemia on Quality of Life and Productivity in Patients with Non-Dialysis-Dependent Chronic Kidney Disease.

    abstract:INTRODUCTION:Patients with chronic kidney disease (CKD) have an increased risk of comorbid conditions, including cardiovascular disease (CVD). Anemia is prevalent in the CKD population and worsens as kidney function declines, resulting in a diminished quality of life and increased morbidity/mortality. The purpose of th...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-017-0566-z

    authors: Covic A,Jackson J,Hadfield A,Pike J,Siriopol D

    更新日期:2017-07-01 00:00:00

  • A Longitudinal Study of the Association of Opioid Use with Change in Pain Interference and Functional Limitations in a Nationally Representative Cohort of Adults with Osteoarthritis in the United States.

    abstract:INTRODUCTION:Real-world data are sparse on longitudinal associations of opioid use with pain interference with activities (PIA) and daily function with osteoarthritis (OA) in the USA. METHODS:Data from the 2010-2015 Medical Expenditure Panel Surveys were analyzed for community-dwelling adults with OA. Opioid use patte...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01200-4

    authors: Shah D,Zhao X,Wei W,Gandhi K,Dwibedi N,Webster L,Sambamoorthi U

    更新日期:2020-02-01 00:00:00

  • Relationships between markers of inflammation, severity of injury, and clinical outcomes in hemorrhagic shock.

    abstract::This study was performed to investigate the relationships between markers of inflammation in serum (interleukin-6 [IL-6], interleukin-10 [IL-10], and granulocyte elastase [GE]), severity of injury, and clinical outcomes, and to evaluate the predictive value of these markers for major complications and mortality. This ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02877699

    authors: Akkose S,Ozgurer A,Bulut M,Koksal O,Ozdemír F,Ozguç H

    更新日期:2007-09-01 00:00:00

  • Assessing thrombosis risk in patients with idiopathic, diabetic, and postsurgical gastroparesis.

    abstract::Patients with severe gastrointestinal motility disorders are often found to have intravenous access clots or deep venous thrombosis. It has previously been reported that many patients who have intravenous access thrombosis have concomitant thrombotic risk factors. In this study, the goal was to determine the underlyin...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850315

    authors: Lobrano A,Blanchard K,Rock W,Johnson W,Schmieg B,Borman K,Araghizadeh F,Minocha A,Abell TL

    更新日期:2006-09-01 00:00:00

  • Switching from depot antipsychotics to risperidone: results of a study of chronic schizophrenia. The Schizophrenia Treatment & Assessment Group.

    abstract::Designed to provide information about patients with schizophrenia who switch from depot neuroleptics to the oral, atypical antipsychotic risperidone, this multicenter observational study enrolled patients who wished to stop the depot, had an unsatisfactory response, or experienced unacceptable side effects. Individual...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Desai NM,Huq Z,Martin SD,McDonald G

    更新日期:1999-03-01 00:00:00

  • Second-Generation Trabecular Micro-Bypass Stents as Standalone Treatment for Glaucoma: A 36-Month Prospective Study.

    abstract:INTRODUCTION:To evaluate long-term outcomes following stand-alone implantation of two second-generation trabecular micro-bypass stents (iStent inject®, Glaukos Corp., San Clemente, CA, USA) in eyes with predominantly primary open-angle glaucoma (POAG) and considerable preoperative disease burden. METHODS:Eyes with POA...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-00984-9

    authors: Hengerer FH,Auffarth GU,Riffel C,Conrad-Hengerer I

    更新日期:2019-07-01 00:00:00

  • Benefit of Early Add-on of Linagliptin to Insulin in Japanese Patients With Type 2 Diabetes Mellitus: Randomized-Controlled Open-Label Trial (TRUST2).

    abstract:INTRODUCTION:This trial was conducted to assess the long-term safety, efficacy, and benefit of early add-on of linagliptin to insulin in patients with type 2 diabetes mellitus (T2DM). METHODS:This trial enrolled 246 subjects. The subjects were randomized to the linagliptin group or the control group and were observed ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-021-01631-y

    authors: Katsuno T,Shiraiwa T,Iwasaki S,Park H,Watanabe N,Kaneko S,Terasaki J,Hanafusa T,Imagawa A,Shimomura I,Ikegami H,Koyama H,Namba M,Miyagawa JI,TRUST2 study group.

    更新日期:2021-01-28 00:00:00