Outcomes analysis of daptomycin use in a community hospital.

Abstract:

:This study was conducted to assess clinical and cost outcomes associated with the use of daptomycin. This objective was addressed through a consecutive patient chart review of the first 50 inpatients treated with daptomycin. Type of infection, identity of isolated pathogens, prior therapy, duration of therapy, length of hospitalization, cost of antibiotics, adverse events, and outcomes were evaluated. The analysis showed that mean patient age was 64 y, and mean length of hospitalization was 9.2 d. A total of 62% of patients had confirmed methicillin-resistant Staphylococcus aureus infection. The mean duration of daptomycin therapy was 7.5 d; however, in patients given treatment for complicated skin and skin structure infections, the mean duration of therapy was 6.1 d (n=15) and 7.1 d (n=16) for first- and second-line daptomycin therapy, respectively. The average course of daptomycin cost $727 (n=38) and $390 (n=11), respectively, in the subset of patients with renal insufficiency. In patients who did not respond to prior antibiotic treatment for a Gram-positive bacterial infection (n=26), the mean duration of prior therapy with antibiotics was 6.0 d and the cost was $287. For patients who were transitioned to outpatient daptomycin therapy (n=14), hospital charges were reduced by an estimated $102,340. In 48 patients (96%), infection was resolved with daptomycin therapy. Daptomycin was effective in resolving Grampositive infection in this aged patient population. Earlier identification of antibiotic failure, first-line use of daptomycin in patients with complicated skin and skin structure infections, and outpatient daptomycin therapy provided cost savings and improved clinical outcomes at this facility.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Fossaceca C

doi

10.1007/BF02848774

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

517-28

issue

3

eissn

0741-238X

issn

1865-8652

pii

629

journal_volume

24

pub_type

杂志文章,多中心研究
  • Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.

    abstract::Chronic constipation (CC) and irritable bowel syndrome with constipation (IBS-C) are common gastrointestinal (GI) disorders. Current treatment options, either prescription or nonprescription medications, have limited efficacy in a subset of patients. There is significant demand for more efficacious medications for the...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-013-0012-9

    authors: Vazquez-Roque MI,Bouras EP

    更新日期:2013-03-01 00:00:00

  • Enhanced Safety Surveillance of Seasonal Quadrivalent Influenza Vaccines in English Primary Care: Interim Analysis.

    abstract:INTRODUCTION:The European Medicines Agency (EMA) requires vaccine manufacturers to conduct enhanced safety surveillance (ESS) of seasonal influenza vaccines including a near real-time evaluation of collected data. The objective was to identify whether the use of passive surveillance or active surveillance provides diff...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0747-4

    authors: de Lusignan S,Dos Santos G,Byford R,Schuind A,Damaso S,Shende V,McGee C,Yonova I,Ferreira F

    更新日期:2018-08-01 00:00:00

  • Evaluation of Physicochemical and Biological Stability of 36-Months-Aged SB5 (Adalimumab Biosimilar) for 4 Weeks at Room Temperature.

    abstract:INTRODUCTION:Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the finan...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0851-5

    authors: Park D,Yun J,Hwang SJ,Park SJ

    更新日期:2019-02-01 00:00:00

  • Real-life dosage and clinical efficacy of biphasic insulin preparations in patients with type 2 diabetes.

    abstract:INTRODUCTION:This retrospective study used data from a primary care database to compare two insulin products in routine clinical practice for the treatment of type 2 diabetes in the UK. PATIENTS AND METHODS:Records were analyzed for patients with type 2 diabetes who had been initiated on biphasic insulin aspart 30 (BI...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-010-0079-5

    authors: Fakhoury WK,Richter H,Christensen TE

    更新日期:2010-11-01 00:00:00

  • Long-Term Efficacy of Tumor Necrosis Factor Inhibitors for the Treatment of Methotrexate-Naïve Rheumatoid Arthritis: Systematic Literature Review and Meta-Analysis.

    abstract:INTRODUCTION:Synthesis of evidence on the long-term use of first-line biologic therapy in patients with early rheumatoid arthritis (RA) is required. We compared the efficacy of up to 5 years' treatment with first-line tumor necrosis factor inhibitors (TNFis) versus other treatment strategies in this population. METHOD...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-018-0869-8

    authors: Gulácsi L,Zrubka Z,Brodszky V,Rencz F,Alten R,Szekanecz Z,Péntek M

    更新日期:2019-03-01 00:00:00

  • Assessing thrombosis risk in patients with idiopathic, diabetic, and postsurgical gastroparesis.

    abstract::Patients with severe gastrointestinal motility disorders are often found to have intravenous access clots or deep venous thrombosis. It has previously been reported that many patients who have intravenous access thrombosis have concomitant thrombotic risk factors. In this study, the goal was to determine the underlyin...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850315

    authors: Lobrano A,Blanchard K,Rock W,Johnson W,Schmieg B,Borman K,Araghizadeh F,Minocha A,Abell TL

    更新日期:2006-09-01 00:00:00

  • Treatment of hypertension and adherence to treatment guidelines in clinical practice: an Italian study.

    abstract::Despite the results from clinical trials in patients with hypertension and the development of a long list of guidelines for the management of hypertension, many physicians and other healthcare professionals still manage hypertension using approaches that clearly diverge at least partially from the recommendations of t...

    journal_title:Advances in therapy

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1007/BF02849881

    authors: Malacco E,Ferri C,Grandi AM,Kilama MO,Soglian AG,Vigna L

    更新日期:2005-03-01 00:00:00

  • Acceptance of Intanza® 9 μg intradermal influenza vaccine in routine clinical practice in Australia and Argentina.

    abstract:INTRODUCTION:Intanza® 9 μg (Sanofi Pasteur SA, Lyon, France), a split virion trivalent influenza vaccine delivered by intradermal injection with a microinjection system, became available as a vaccination for adults aged 18 to 59 years old, as of the 2010 southern hemisphere influenza season. METHODS:This study was des...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-011-0042-0

    authors: Eizenberg P,Booy R,Naser N,Mason G,Stamboulian D,Weber F

    更新日期:2011-08-01 00:00:00

  • Dyspnea in COPD: New Mechanistic Insights and Management Implications.

    abstract::Dyspnea is the most common symptom experienced by patients with chronic obstructive pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt a sedentary lifestyle which predictably leads to extensive skeletal muscle deconditioning, social isolation, and its negative psychological sequalae. This "dysp...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-019-01128-9

    authors: O'Donnell DE,Milne KM,James MD,de Torres JP,Neder JA

    更新日期:2020-01-01 00:00:00

  • Review of the If selective channel inhibitor ivabradine in the treatment of chronic stable angina.

    abstract::Coronary heart disease is the major cause of morbidity and mortality in industrialized countries, and its prevalence is predicted to grow as the population ages. Current drugs for chronic stable angina (such as beta-blockers, calcium-channel blockers, long- and short-acting nitrates, and potassium-channel activators) ...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-009-0005-x

    authors: Prasad UK,Gray D,Purcell H

    更新日期:2009-02-01 00:00:00

  • Reduced Hypoglycemia Risk in Type 2 Diabetes Patients Switched to/Initiating Insulin Glargine 300 vs 100 U/ml: A European Real-World Study.

    abstract:INTRODUCTION:Randomized controlled trials and real-world data from the USA have shown similar glycemic control with insulin glargine 300 U/ml (Gla-300) and insulin glargine 100 U/ml (Gla-100) and reduced hypoglycemia risk with Gla-300. This real-world study describes the efficacy and safety of Gla-300 and Gla-100 in pa...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01436-5

    authors: Escalada J,Bonnet F,Wu J,Bonnemaire M,Gupta S,Cambron-Mellott JM,Nicholls C,Müller-Wieland D

    更新日期:2020-09-01 00:00:00

  • Development of a Framework Based on Reflective MCDA to Support Patient-Clinician Shared Decision-Making: The Case of the Management of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) in the United States.

    abstract:INTRODUCTION:Well- or moderately differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are often slow-growing, and some patients with unresectable, asymptomatic, non-functioning tumors may face the choice between watchful waiting (WW), or somatostatin analogues (SSA) to delay progression. We developed ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-017-0653-1

    authors: Wagner M,Samaha D,Khoury H,O'Neil WM,Lavoie L,Bennetts L,Badgley D,Gabriel S,Berthon A,Dolan J,Kulke MH,Goetghebeur M

    更新日期:2018-01-01 00:00:00

  • Reduction of cardiovascular risk and mortality: a population-based approach.

    abstract::The purpose of this study was to evaluate risk pattern and mortality in a general population epidemiologic study performed by a staff of hypertension specialists working as the "good father of a family," with lifestyle and therapeutic advice and instrumental measurements. Mortality among the study population (n=856) d...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850213

    authors: Casiglia E,Saugo M,Schiavon L,Tikhonoff V,Rigoni G,Basso G,Mazza A,Rizzato E,Guglielmi F,Martini B,Bascelli A,Caffi S,Pessina AC

    更新日期:2006-11-01 00:00:00

  • Dorsal root ganglion: the target of acupuncture in the treatment of asthma.

    abstract::Recently, high levels of neurotrophic factors have been found in bronchial asthma; these factors include nerve growth factor, brain-derived neurotrophic factor, and leukemia inhibitory factor, among others. Neurotrophic factors are first synthesized in bronchial epithelial cells, immune cells, and other cells in the a...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/BF02848784

    authors: Feng JT,Hu CP,Li XZ

    更新日期:2007-05-01 00:00:00

  • Duration-dependent hepatoprotective effects of propolis extract against carbon tetrachloride-induced acute liver damage in rats.

    abstract::Propolis is a natural product produced by bees that was discovered through the study of traditional cures and knowledge of indigenous people throughout the world. It is rich in vitamins A, B, C, and E, and in amino acids, copper, iron, manganese, and zinc. The investigators studied the duration-dependent hepatoprotect...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02877719

    authors: Bhadauria M,Nirala SK,Shukla S

    更新日期:2007-09-01 00:00:00

  • Assessing the Therapeutic Utility of Professional Continuous Glucose Monitoring in Type 2 Diabetes Across Various Therapies: A Retrospective Evaluation.

    abstract:BACKGROUND:There have been few large studies that have analyzed the effect of professional (masked) continuous glucose monitoring (P-CGM) on glycemic control in patients with type 2 diabetes (T2DM) who were on a broad spectrum of baseline therapies. METHODS:We performed a retrospective, blinded evaluation of glycemic ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-017-0576-x

    authors: Kesavadev J,Vigersky R,Shin J,Pillai PBS,Shankar A,Sanal G,Krishnan G,Jothydev S

    更新日期:2017-08-01 00:00:00

  • Prognostic Role of Ki-67 in Adrenocortical Carcinoma After Primary Resection: A Retrospective Mono-Institutional Study.

    abstract:INTRODUCTION:Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. It is vitally important to predict prognosis and restrict unnecessary adjuvant treatments for patients with ACC. This study aims to confirm the prognostic value of Ki-67 and provide a prognostic evaluation on ACC after primary surgery...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-01050-0

    authors: Zhang F,Zhang F,Liu Z,Wu K,Zhu Y,Lu Y

    更新日期:2019-10-01 00:00:00

  • Self-Care in the Twenty First Century: A Vital Role for the Pharmacist.

    abstract::In order for the global healthcare system to remain sustainable, healthcare spending needs to be reduced, and self-treating certain conditions under the guidance of a pharmacist provides a means of accomplishing this goal. This article was developed to describe global healthcare trends affecting self-care with a speci...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-016-0395-5

    authors: Bell J,Dziekan G,Pollack C,Mahachai V

    更新日期:2016-10-01 00:00:00

  • SOFA Score Can Effectively Predict the Incidence of Sepsis and 30-Day Mortality in Liver Transplant Patients: A Retrospective Study.

    abstract:INTRODUCTION:This study aims to evaluate the early predictive value for postoperative sepsis and 30-day mortality in liver transplant patients using sequential organ failure assessment (SOFA). METHODS:A total of 96 liver transplant patients were enrolled into this study from February 2015 to June 2018. The general inf...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-0889-z

    authors: Wang XW,Niu XG,Li JX,Zhang SS,Jiao XF

    更新日期:2019-03-01 00:00:00

  • Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study.

    abstract:INTRODUCTION:To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG). METHODS:Twelve OAG patients (mean age ± standard deviation 52.58 ± 11.39 years, intraocular pres...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-019-0897-z

    authors: Parisi V,Oddone F,Roberti G,Tanga L,Carnevale C,Ziccardi L,Manni G

    更新日期:2019-04-01 00:00:00

  • Switching from depot antipsychotics to risperidone: results of a study of chronic schizophrenia. The Schizophrenia Treatment & Assessment Group.

    abstract::Designed to provide information about patients with schizophrenia who switch from depot neuroleptics to the oral, atypical antipsychotic risperidone, this multicenter observational study enrolled patients who wished to stop the depot, had an unsatisfactory response, or experienced unacceptable side effects. Individual...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Desai NM,Huq Z,Martin SD,McDonald G

    更新日期:1999-03-01 00:00:00

  • Preference for Oral and Injectable GLP-1 RA Therapy Profiles in Japanese Patients with Type 2 Diabetes: A Discrete Choice Experiment.

    abstract:INTRODUCTION:Glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) approved to date are administered by injection; therefore, patient perceptions of an oral GLP-1 RA are unknown. This discrete choice experiment explored preferences for (unbranded) oral and injectable GLP-1 RA profiles among Japanese patients with typ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-020-01561-1

    authors: Igarashi A,Bekker Hansen B,Langer J,Tavella F,Collings H,Davies N,Wyn R

    更新日期:2020-11-27 00:00:00

  • Effectiveness and Persistence with Liraglutide Among Patients with Type 2 Diabetes in Routine Clinical Practice--EVIDENCE: A Prospective, 2-Year Follow-Up, Observational, Post-Marketing Study.

    abstract:INTRODUCTION:The aim of this study was to investigate whether the efficacy of liraglutide observed in randomized controlled trials translates into therapeutic benefits in the French population during routine clinical practice. METHODS:This observational, prospective, multicenter study included 3152 adults with type 2 ...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-015-0245-x

    authors: Gautier JF,Martinez L,Penfornis A,Eschwège E,Charpentier G,Huret B,Madani S,Gourdy P

    更新日期:2015-09-01 00:00:00

  • Effects of Brinzolamide, a Topical Carbonic Anhydrase Inhibitor, on Corneal Endothelial Cells.

    abstract:INTRODUCTION:This clinical study aimed to investigate the effect of brinzolamide, a topical carbonic anhydrase inhibitor, on corneal endothelial cells (CECs) in patients with glaucoma using a follow-up clinical study design. METHODS:Patients with primary open-angle glaucoma or ocular hypertension were administrated an...

    journal_title:Advances in therapy

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12325-016-0373-y

    authors: Nakano T,Inoue R,Kimura T,Suzumura H,Tanino T,Yamazaki Y,Yoshikawa K,Tatemichi M

    更新日期:2016-08-01 00:00:00

  • Pitfalls in radiologic and histopathologic diagnosis of urologic disease--report of 4 cases.

    abstract::Cases are presented to illustrate pitfalls in radiologic and histopathologic diagnosis in urology. In a 73-year-old woman, ultrasound revealed calcification in an irregular mass arising from the left wall of the bladder. Bladder biopsy reported the mass as papillary transitional cell carcinoma. Histologically, the spe...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02850223

    authors: Vaidyanathan S,Soni BM,Hughes PL,Mansour P,Singh G

    更新日期:2006-11-01 00:00:00

  • Intensive postremission chemotherapy in Taiwanese adults with acute myelogenous leukemia.

    abstract::Intensive postremission chemotherapy has produced disease-free survival comparable to that of bone marrow transplantation in patients with acute myelogenous leukemia (AML), but its efficacy was unknown in Taiwan. We assessed the efficacy of intensive postremission chemotherapy, consisting of high-dose arabinoside-C (H...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/BF02852390

    authors: Hsu HC,Gau JP,Liu JM,Chau WK,Ho CH

    更新日期:2001-03-01 00:00:00

  • Cannabis Use in Hospitalized Patients with Chronic Pain.

    abstract:INTRODUCTION:To date, no study has reported the prevalence of cannabis use in chronic pain patients. The aim of this study is to investigate the trends in cannabis use among chronic pain in-patients from 2011 to 2015 in the USA. METHODS:Patients were identified from the National Inpatient Sample (NIS) database using t...

    journal_title:Advances in therapy

    pub_type: 杂志文章,评审

    doi:10.1007/s12325-020-01416-9

    authors: Orhurhu V,Urits I,Olusunmade M,Olayinka A,Salisu Orhurhu M,Uwandu C,Aner M,Ogunsola S,Akpala L,Hirji S,Viswanath O,Karri J,Simopoulos T,Gill J

    更新日期:2020-08-01 00:00:00

  • Short-Term Assessment of Intravitreal Dexamethasone Implant Using Enhanced-Depth Image Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients with Retinal Vascular Diseases.

    abstract:INTRODUCTION:To evaluate the short-term efficacy and safety of intravitreal dexamethasone implant (IDI) in patients with macular oedema associated with diabetic retinopathy (DR) and retinal vein occlusion (RVO) using enhanced-depth image optical coherence tomography (EDI-OCT) and to estimate the effect of dexamethasone...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-018-0848-0

    authors: Minnella AM,Federici M,Pagliei V,Lanza A,Gambini G,Caputo CG,Falsini B,Caporossi A

    更新日期:2019-02-01 00:00:00

  • Liraglutide for the treatment of type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials.

    abstract:INTRODUCTION:Liraglutide has been widely used in the treatment of type 2 diabetes mellitus (T2DM), however, the results of a number of randomized placebo-controlled trials on the effects of liraglutide for the treatment of T2DM have varied. The purpose of this study was to assess the effects of liraglutide versus place...

    journal_title:Advances in therapy

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12325-014-0164-2

    authors: Du Q,Wang YJ,Yang S,Zhao YY,Han P

    更新日期:2014-11-01 00:00:00

  • Pregabalin for alcohol dependence: a critical review of the literature.

    abstract:INTRODUCTION:Alcohol dependence represents a severe pathological disorder associated with a significant rate of morbidity and mortality. To date, limited pharmacological agents exist to treat this disorder, and there is a growing interest for new therapies. In this context, pregabalin represents a promising strategy. P...

    journal_title:Advances in therapy

    pub_type: 杂志文章

    doi:10.1007/s12325-012-0061-5

    authors: Guglielmo R,Martinotti G,Clerici M,Janiri L

    更新日期:2012-11-01 00:00:00