Abstract：
INTRODUCTION:Advances in cystic fibrosis (CF) therapy have resulted in improved survival and increasing treatment burden and costs. The economic impact of current treatment strategies for CF is poorly defined. METHODS:The authors prospectively assessed direct medical costs (including hospitalizations, outpatient interventions, drugs, devices, dietetic products) in 165 consecutive CF patients (aged 5-39 years) seen between March and July 2009. RESULTS:The mean annual cost/patient increased with age and lung disease severity from yy4,164 in children aged ≤5 years to yy30,123 in patients aged >5 years with severe lung disease (forced expiratory volume in 1 second [FEV1] <40% of predicted). The increase in costs involved all items, with a progressive increase in cost attributed to hospitalizations. CONCLUSION:Treatment of CF is associated with relevant cost for the Italian National Healthcare Service. Costs of illness tend to increase progressively with age, suggesting that increasing economic resources should be allocated to the treatment of CF, given the increasing number of patients surviving into adulthood.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Colombo C,Daccò V,Alicandro G,Loi S,Mazzi S,Lucioni C,Ravasio Rdoi
10.1007/s12325-013-0008-5subject
Has Abstractpub_date
2013-02-01 00:00:00pages
165-75issue
2eissn
0741-238Xissn
1865-8652journal_volume
30pub_type
杂志文章abstract：:Shock is a serious acute circulatory failure leading to inadequate oxygen delivery to the cells. Its treatment is mainly based on circulating fluid optimization, and vasopressors to provide an adequate mean arterial pressure and microcirculatory flow. Norepinephrine is the drug of choice, but high dosages may be respo...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01422-x
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abstract：INTRODUCTION:ARTOS was an international, prospective, non-interventional, non-controlled observational study designed to determine the effectiveness, safety, and tolerability of moxifloxacin under daily-life conditions in patients with complicated skin and skin structure infections (cSSSIs) treated in Europe, the Middl...
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journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-011-0068-3
更新日期：2011-10-01 00:00:00
abstract：:This double-blind, randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department. Seventy consecutive adult patients with fractures or dislocations suitable for re...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:Subretinal hemorrhage secondary to age-related macular degeneration (AMD) has a poor visual prognosis. Surgical drainage of the blood improves visual acuity only in selected patients. We report on two elderly patients with spontaneous subretinal hemorrhage from AMD. In one eye, recombinant tissue plasminogen activator...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:This multicenter, randomized, double-blind clinical trial was undertaken to compare the intraocular pressure (IOP)-lowering efficacy and safety of topical bimatoprost 0.03% with that of latanoprost 0.005% for the treatment of patients with normal-tension glaucoma. After washout of all ocular hypotensive medications, p...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02850159
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Studies assessing the effect of high dose tigecycline on severe infections are limited and remain controversial. OBJECTIVES:To assess systematically the effectiveness and safety of high dose tigecycline in the treatment of severe infections. METHODS:Pubmed, Web of Science, Embase, MEDLINE, Cochrane Library...
journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
doi：10.1007/s12325-020-01235-y
更新日期：2020-03-01 00:00:00
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journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-11-01 00:00:00
abstract：INTRODUCTION:The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016. METHODS:The authors revi...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-017-0560-5
更新日期：2017-07-01 00:00:00
abstract：INTRODUCTION:Prostate cancer (PC) is the second leading cause of cancer death among US men and accounts for considerable healthcare expenditures. We evaluated economic outcomes in men with chemotherapy-naïve metastatic castration-resistant PC (mCRPC) treated with enzalutamide or abiraterone acetate plus prednisone (abi...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01260-x
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:The European Medicines Agency (EMA) requires vaccine manufacturers to conduct enhanced safety surveillance (ESS) of seasonal influenza vaccines including a near real-time evaluation of collected data. The objective was to identify whether the use of passive surveillance or active surveillance provides diff...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0747-4
更新日期：2018-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02849898
更新日期：2007-03-01 00:00:00
abstract：INTRODUCTION:Data regarding the prevalence of immune thrombocytopenia (ITP) is limited, and is derived from North American population-based analyses. Therefore, the authors conducted the first study outside the United States (US) using the United Kingdom (UK) General Practice Research Database (GPRD) to estimate the ad...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-011-0084-3
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Janus kinase (JAK) inhibitors are a class of targeted therapies for rheumatoid arthritis (RA) with established clinical efficacy. However, little is known about their efficacy compared with each other. This network meta-analysis (NMA) estimated the comparative efficacy of JAK inhibitors currently approved ...
journal_title：Advances in therapy
pub_type： 杂志文章,meta分析
doi：10.1007/s12325-020-01303-3
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control. METHODS:A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All pat...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0066-8
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:Despite improved understanding of the risks of influenza and better vaccines for older patients, influenza vaccination rates remain subpar, including in high-risk groups such as older adults, and demonstrate significant racial and ethnic disparities. METHODS:This study considers demographic, clinical, and...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-020-01324-y
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION:Rivastigmine is a cholinesterase inhibitor, approved for the treatment of mild-to-moderate dementia of Alzheimer's type. This study assessed the short- and long-term effectiveness and safety of rivastigmine in patients with mild-to-moderate Alzheimer's disease (AD) in a real-world clinical setting in Taiwa...
journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究
doi：10.1007/s12325-019-00939-0
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Antipsychotic medications are associated with significant weight gain, type 2 diabetes mellitus, dyslipidemia, and increased cardiovascular risk. Suggested mechanisms of weight gain from antipsychotic medication include antagonism of histamine and serotonin receptors, and effects on the hypothalamic-pituit...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-009-0070-1
更新日期：2009-10-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0739-4
更新日期：2018-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/BF02849964
更新日期：2007-07-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-012-0042-8
更新日期：2012-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01490-z
更新日期：2020-11-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0827-5
更新日期：2018-12-01 00:00:00
abstract：:Diabetes mellitus is one of the most serious heterogeneous endocrinologic diseases; more than 90% of those given this diagnosis have type 2 diabetes mellitus, usually accompanied by macrovascular and microvascular complications. Because most cases include a 7- to 10-y latency period before disease onset, however, it i...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02877709
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-015-0245-x
更新日期：2015-09-01 00:00:00
abstract：:To avoid the side effects associated with long-term administration of high doses of inhaled glucocorticosteroids, they should be used at the lowest effective dose. This study compared the clinical efficacy of budesonide given via a dry-powder, inspiratory flow-driven device (Turbuhaler), at a daily dose of 800 microgr...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1996-01-01 00:00:00
abstract：:Multiple, potentially practice-changing cardiology trials have been presented or published over the past year. In this paper, we summarize and place in clinical context, new data regarding management of acute coronary syndrome and ST-elevation myocardial infarction (copeptin assessment, otamixaban, cangrelor, prasugre...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-014-0141-9
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:To date, no study has reported the prevalence of cannabis use in chronic pain patients. The aim of this study is to investigate the trends in cannabis use among chronic pain in-patients from 2011 to 2015 in the USA. METHODS:Patients were identified from the National Inpatient Sample (NIS) database using t...
journal_title：Advances in therapy
pub_type： 杂志文章,评审
doi：10.1007/s12325-020-01416-9
更新日期：2020-08-01 00:00:00
abstract：:Eupatorium laevigatum Lam. is a plant common to the central region of Brazil, where it is a widely used remedy for lesions such as buccal aphthae. These painful inflammatory ulcers affect 50% of the general population. For the first part of this two-part study, a phytotherapeutic preparation from E. laevigatum extract...
journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850010
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVES:This study set out to examine the efficacy and tolerability of two innovative implant forms of leuprorelin acetate in men with advanced hormone-dependent prostate cancer in everyday clinical practice. METHODS:Data were collected from 818 patients (from 273 centers across Germany) who were pretreated with sl...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-013-0010-y
更新日期：2013-03-01 00:00:00
