Combination therapy in hypertension.

Abstract:

:Hypertension is recognized as a major risk factor for cardiovascular and renal diseases and represents the leading cause of mortality worldwide. In spite of proven benefits of hypertension treatment, blood pressure control rates are poor, even in high-income countries with virtually full-access to therapies. Nearly 75% of hypertensive patients do not achieve adequate control with monotherapy, thus needing combination treatment. Strategies to improve blood pressure control include the prompt shift from monotherapy to combination therapy, the initial treatment with a two-drug combination, and the use of fixed-dose combinations in a single pill. Currently, preferred combinations include a renin-angiotensin blocker, either an angiotensin-converting enzyme inhibitor or an angiotensin-receptor blocker plus a calcium channel blocker or a diuretic. Some patients will also require a triple combination to achieve blood pressure control.

journal_name

Adv Ther

journal_title

Advances in therapy

authors

Gorostidi M,de la Sierra A

doi

10.1007/s12325-013-0020-9

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

320-36

issue

4

eissn

0741-238X

issn

1865-8652

journal_volume

30

pub_type

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