Abstract：
INTRODUCTION:Infantile hemangiomas (IH) are the most common benign vascular tumors of childhood, with an incidence of 5-10% during the first year of age. Propranolol is considered the first-line treatment for this condition. Potentially there is a high probability of negative results to therapy, because in many countries there are no treatment protocols or propranolol formulations appropriate for the pediatric population. The objective of the present study was to evaluate the impact of pharmacist interventions such as detecting, analyzing, and solving problems presented during treatment with propranolol in patients with IH. METHODS:An open observational prospective study was performed over 25 months in a group of pediatric patients diagnosed with infantile hemangioma treated with propranolol. Pharmacist participation consisted of development of an extemporaneous formulation and counseling the child's parents. At each visit to the pharmacy service, family members were interviewed, detecting and classifying problems related to treatment. RESULTS:Sixty-three children with IH were treated during the period under review. Patient ages ranged from 3 to 11 months old; 64% were female and 36% were male. Forty-nine problems in 30 patients were detected, principally inadequate dose (18.4%), non-adherence to treatment (16.3%), side effects (14.3%), and wrong administration (14.3%). Of the problems detected, 81.6% were resolved. Interventions by the pharmacist in 27 patients were intensive counseling on adherence to therapy (20%), detection of adverse effects (11.4%), and adjustment of the dose (22.9%). In 95.2% of patients a good response to treatment was obtained compared with 77.2% reported in European studies without pharmacist intervention. CONCLUSION:It seems that pharmacist participation increases adherence to treatment and reduces the likelihood of adverse effects, allowing for safe and effective therapy in patients with IH.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Castaneda S,Melendez-Lopez S,Garcia E,De la Cruz H,Sanchez-Palacio Jdoi
10.1007/s12325-016-0391-9subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1831-1839issue
10eissn
0741-238Xissn
1865-8652pii
10.1007/s12325-016-0391-9journal_volume
33pub_type
杂志文章abstract：INTRODUCTION:To compare the 24-h intraocular pressure (IOP) control and tolerability of travoprost/timolol benzalkonium chloride (BAK)-free (TTFC) vs. latanoprost/timolol fixed combination preserved with BAK (LTFC) in open-angle glaucoma patients insufficiently controlled with latanoprost 0.005% monotherapy given once ...
journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s12325-014-0125-9
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:The incidence of inflammatory bowel disease (IBD) in Denmark is among the highest in the world, with Crohn's disease and ulcerative colitis occurring at rates of 9.1 and 18.6 per 100,000 person-years respectively in 2010-2013. Anemia is the most prevalent extraintestinal complication of IBD, most commonly ...
journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0827-5
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journal_title：Advances in therapy
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2009-10-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
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更新日期：2014-08-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,评审
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更新日期：2012-12-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s12325-019-0871-9
更新日期：2019-03-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02850257
更新日期：2003-03-01 00:00:00
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doi：10.1007/s12325-018-0801-2
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pub_type： 杂志文章,meta分析
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2008-01-01 00:00:00
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pub_type： 已发布勘误
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更新日期：2020-11-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章
doi：10.1007/s12325-018-0784-z
更新日期：2018-10-01 00:00:00
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journal_title：Advances in therapy
pub_type： 杂志文章,随机对照试验
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更新日期：2018-10-01 00:00:00
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更新日期：2019-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Advances in therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-01-01 00:00:00
