Abstract:
INTRODUCTION:Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. This real-world study evaluated persistence, dose titration, health care resource utilization (HCRU) and associated costs, and medication use among CD patients treated with ustekinumab (UST) in several pooled US commercial database populations. METHODS:CD patients aged ≥ 18 years with medical or pharmacy claims for UST were selected from pooled data from 3 large, national commercial databases. The first observed medical or pharmacy claim for UST was the index date. Patients were required to have had ≥ 1 medical claim with a CD diagnosis during the 12 months prior to the index date and continuous health plan enrollment for a minimum of 12 months prior to and 12 months after the index date. Comparisons of outcomes during the baseline and follow-up periods were conducted using inferential statistical tests. RESULTS:A total of 214 eligible UST patients were selected. The majority (74.8%) were biologic experienced (mean age: 41 years), and 83.6% remained treatment persistent during the 12-month post-index period. Among discontinuers, 25.7% restarted UST, and 8.6% switched from UST in the 12-month observation period. The mean treatment duration was 329 days. Most patients (77%) used the recommended UST dose, as defined as being within a 20% dose variation from label (90 mg/8 weeks ± 20%), 17.9% experienced dose escalation, and 5.1% experienced dose reduction. Post-index immunomodulator and corticosteroid use reduced by 20% and 28%, respectively, as compared with pre-index use among CD patients using UST. Annual all-cause ER visits and inpatient stays decreased by 20.5% and 30.3%, respectively, with similar downward trends for annual CD-related HCRU. CONCLUSIONS:The majority of CD patients prescribed UST were biologic experienced, and persistence was high over the 1-year follow-up. UST treatment initiation was associated with reductions in ER visits, inpatient stays, and steroid and other medication use.
journal_name
Adv Therjournal_title
Advances in therapyauthors
Obando C,Ding Z,Muser E,Vaidya N,Qiang W,Sun X,Wang H,Mallampati R,Xie Ldoi
10.1007/s12325-020-01276-3subject
Has Abstractpub_date
2020-05-01 00:00:00pages
2127-2143issue
5eissn
0741-238Xissn
1865-8652pii
10.1007/s12325-020-01276-3journal_volume
37pub_type
杂志文章abstract::As head and neck squamous cell carcinoma (HNSCC) patients with distant metastases (DM) were generally treated only palliatively, the value of screening for DM was usually limited to attempts to avoid extensive locoregional treatment when DM were present pretreatment. Recently, the concept of treating oligometastases, ...
journal_title:Advances in therapy
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journal_title:Advances in therapy
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journal_title:Advances in therapy
pub_type: 杂志文章,meta分析
doi:
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Advances in therapy
pub_type: 杂志文章,评审
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journal_title:Advances in therapy
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Advances in therapy
pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,已发布勘误
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journal_title:Advances in therapy
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journal_title:Advances in therapy
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更新日期:2017-05-01 00:00:00
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journal_title:Advances in therapy
pub_type: 杂志文章,meta分析
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