听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览JOURNAL OF PINEAL RESEARCH期刊下所有文献
  • Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia.

    abstract::Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration. During this study, we used the oxygen-induced retinopathy mice model to mimic retinal hypoxia-ischemia phenotypes to investigate further the ne...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12716

    authors: Huang R,Xu Y,Lu X,Tang X,Lin J,Cui K,Yu S,Shi Y,Ye D,Liu Y,Liang X

    更新日期:2021-01-11 00:00:00

  • Photoperiod integration in C3H rd1 mice.

    abstract::In mammals, the suprachiasmatic nuclei (SCN) constitute the main circadian clock, receiving input from the retina which allows synchronization of endogenous biological rhythms with the daily light/dark cycle. Over the year, the SCN encodes photoperiodic variations through duration of melatonin secretion, with abundant...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12711

    authors: Leclercq B,Hicks D,Laurent V

    更新日期:2020-12-16 00:00:00

  • Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling.

    abstract::Seasonal day length has been linked to the prevalence of mood disorders, and however, the mechanisms underlying this relationship remain unknown. Previous work in our laboratory has shown that developmental exposure to seasonal photoperiods has enduring effects on the activity of mouse dorsal raphe serotonergic neuron...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12705

    authors: Giannoni-Guzmán MA,Kamitakahara A,Magalong V,Levitt P,McMahon DG

    更新日期:2020-11-19 00:00:00

  • The interplay between mast cells, pineal gland, and circadian rhythm: Links between histamine, melatonin, and inflammatory mediators.

    abstract::Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells that play a protective role against pathogens and inflammation. MC distribution and activation are associated with the circadian rh...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审

    doi:10.1111/jpi.12699

    authors: Pham L,Baiocchi L,Kennedy L,Sato K,Meadows V,Meng F,Huang CK,Kundu D,Zhou T,Chen L,Alpini G,Francis H

    更新日期:2020-10-05 00:00:00

  • Modeling melanopsin-mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness.

    abstract::A physiologically based model of arousal dynamics is improved to incorporate the effects of the light spectrum on circadian phase resetting, melatonin suppression, and subjective sleepiness. To account for these nonvisual effects of light, melanopic irradiance replaces photopic illuminance that was used previously in ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12681

    authors: Tekieh T,Lockley SW,Robinson PA,McCloskey S,Zobaer MS,Postnova S

    更新日期:2020-10-01 00:00:00

  • Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice.

    abstract::Melatonin, a neurohormone that binds to two G protein-coupled receptors MT1 and MT2, is involved in pain regulation, but the distinct role of each receptor has yet to be defined. We characterized the nociceptive responses of mice with genetic inactivation of melatonin MT1 (MT1-/- ), or MT2 (MT2-/- ), or both MT1 /MT2 ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12671

    authors: Posa L,Lopez-Canul M,Rullo L,De Gregorio D,Dominguez-Lopez S,Kaba Aboud M,Caputi FF,Candeletti S,Romualdi P,Gobbi G

    更新日期:2020-10-01 00:00:00

  • Melatonin improves uterine-conceptus interaction via regulation of SIRT1 during early pregnancy.

    abstract::Melatonin has been shown to improve in vitro fertilization and offspring survival after bacterial infection, but its role in regulating maternal-fetal communication during early pregnancy has not been investigated. Results of this study demonstrated expression of abundant melatonin receptors in conceptus and endometri...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12670

    authors: Bae H,Yang C,Lee JY,Park S,Bazer FW,Song G,Lim W

    更新日期:2020-09-01 00:00:00

  • Decreased melatonin secretion in patients with glaucoma: Quantitative association with glaucoma severity in the LIGHT study.

    abstract::Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large-scale studies have been performed. The purpose of this cross-...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12662

    authors: Yoshikawa T,Obayashi K,Miyata K,Saeki K,Ogata N

    更新日期:2020-09-01 00:00:00

  • The dual roles of melatonin biosynthesis enzymes in the coordination of melatonin biosynthesis and autophagy in cassava.

    abstract::Both autophagy and melatonin play important roles in plant development and stress response. However, the direct correlation between autophagy and melatonin as well as the underlying mechanism remains elusive in plants. In this study, we discovered that the expression of three autophagy-associated genes (MeATG8b, 8c, a...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12652

    authors: Wei Y,Bai Y,Cheng X,Zhu B,Reiter RJ,Shi H

    更新日期:2020-08-01 00:00:00

  • Melatonin rhythm and other outputs of the master circadian clock in the desert goat (Capra hircus) are entrained by daily cycles of ambient temperature.

    abstract::In desert areas, mammals such as camel and goat are exposed to harsh environmental conditions. The ambient temperature (Ta) cycles have been shown to entrain the circadian clock in the camel. In the present work, we assumed that, in the goat living in a desert biotope, Ta cycles would have the same synchronizing effec...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12634

    authors: Farsi H,Harti D,Achaâban MR,Piro M,Raverot V,Bothorel B,Ouassat M,Challet E,Pévet P,El Allali K

    更新日期:2020-04-01 00:00:00

  • Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.

    abstract::Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhyth...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审

    doi:10.1111/jpi.12639

    authors: Sato K,Meng F,Francis H,Wu N,Chen L,Kennedy L,Zhou T,Franchitto A,Onori P,Gaudio E,Glaser S,Alpini G

    更新日期:2020-04-01 00:00:00

  • Immune-pineal axis protects rat lungs exposed to polluted air.

    abstract::Environmental pollution in the form of particulate matter <2.5 μm (PM2.5 ) is a major risk factor for diseases such as lung cancer, chronic respiratory infections, and major cardiovascular diseases. Our goal was to show that PM2.5 eliciting a proinflammatory response activates the immune-pineal axis, reducing the pine...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12636

    authors: Carvalho-Sousa CE,Pereira EP,Kinker GS,Veras M,Ferreira ZS,Barbosa-Nunes FP,Martins JO,Saldiva PHN,Reiter RJ,Fernandes PA,da Silveira Cruz-Machado S,Markus RP

    更新日期:2020-04-01 00:00:00

  • Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides.

    abstract::Melatonin (MT), endogenously secreted by the pineal gland, is closely related to multiple biological processes; however, its effect on thrombopoiesis is still not well illustrated. Here, we demonstrate that MT administration can elevate peripheral platelet levels. Analysis of different stages in thrombopoiesis reveals...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12637

    authors: Chen S,Qi Y,Wang S,Xu Y,Shen M,Hu M,Du C,Chen F,Chen M,Lu Y,Zhang Z,Quan Y,Wang C,Wang F,Wang J

    更新日期:2020-04-01 00:00:00

  • Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy.

    abstract::Abnormal proliferation and motility of retinal pigment epithelial cells leads to proliferative vitreoretinopathy (PVR). Melatonin is a known effective antitumour and anti-invasive agent, but whether it affects the formation and underlying mechanisms of PVR remains unclear. In this study, the results of the MTT assay, ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12615

    authors: Yang SF,Chen YS,Chien HW,Wang K,Lin CL,Chiou HL,Lee CY,Chen PN,Hsieh YH

    更新日期:2020-01-01 00:00:00

  • Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways.

    abstract::Optic atrophy 1 (OPA1)-related mitochondrial fusion and mitophagy are vital to sustain mitochondrial homeostasis under stress conditions. However, no study has confirmed whether OPA1-related mitochondrial fusion/mitophagy is activated by melatonin and, consequently, attenuates cardiomyocyte death and mitochondrial str...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12542

    authors: Zhang Y,Wang Y,Xu J,Tian F,Hu S,Chen Y,Fu Z

    更新日期:2019-03-01 00:00:00

  • Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain.

    abstract::Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24-hour sleep-wake disorders, and major depressive disorders. In mammal...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12540

    authors: Cecon E,Ivanova A,Luka M,Gbahou F,Friederich A,Guillaume JL,Keller P,Knoch K,Ahmad R,Delagrange P,Solimena M,Jockers R

    更新日期:2019-03-01 00:00:00

  • Melatonin-mediated downregulation of ZNF746 suppresses bladder tumorigenesis mainly through inhibiting the AKT-MMP-9 signaling pathway.

    abstract::There still lacking effective treatment for bladder cancer. This study investigated whether melatonin (Mel) can suppress the growth and invasion of bladder cancer cells. Male C57B/L6 mice were categorized into control group (ie, subcutaneous injection of HT1197 bladder cancer cell line at the back] and treatment group...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12536

    authors: Chen YT,Yang CC,Shao PL,Huang CR,Yip HK

    更新日期:2019-01-01 00:00:00

  • Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation.

    abstract::Melatonin has been proposed as a possible treatment for the deleterious effects of hypoxia/reoxygenation (H/R), such as autophagy, inflammation, and apoptosis. Pathological pregnancies, such as preeclampsia, are associated with placental H/R, and decreased placental melatonin synthesis as well as lower melatonin level...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12520

    authors: Sagrillo-Fagundes L,Assunção Salustiano EM,Ruano R,Markus RP,Vaillancourt C

    更新日期:2018-11-01 00:00:00

  • Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia.

    abstract::Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. There have been no material advances in the treatment of preeclampsia for nearly 50 years. Combining in vitro studies and a clinical trial, we aimed to determine whether melatonin could be a useful adjuvant therapy. In a xanthine/x...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12508

    authors: Hobson SR,Gurusinghe S,Lim R,Alers NO,Miller SL,Kingdom JC,Wallace EM

    更新日期:2018-10-01 00:00:00

  • Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.

    abstract::Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be asso...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12493

    authors: Heo JI,Yoon DW,Yu JH,Kim NH,Yoo HJ,Seo JA,Kim SG,Choi KM,Baik SH,Choi DS,Kim NH

    更新日期:2018-09-01 00:00:00

  • Distribution and density of melatonin receptors in human main pancreatic islet cell types.

    abstract::Recent investigations of our group established that melatonin modulates hormone secretion of pancreatic islets via melatonin receptor types MT1 and MT2. Expression of MT1 and MT2 has been shown in mouse, rat, and human pancreatic islets as well as in the β-, α-, and δ-cell lines INS-1, αTC1.9, and QGP-1. In view of th...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12480

    authors: Zibolka J,Bazwinsky-Wutschke I,Mühlbauer E,Peschke E

    更新日期:2018-08-01 00:00:00

  • Melatonin-mediated inhibition of Cav3.2 T-type Ca2+ channels induces sensory neuronal hypoexcitability through the novel protein kinase C-eta isoform.

    abstract::Recent studies implicate melatonin in the antinociceptive activity of sensory neurons. However, the underlying mechanisms are still largely unknown. Here, we identify a critical role of melatonin in functionally regulating Cav3.2 T-type Ca2+ channels (T-type channel) in trigeminal ganglion (TG) neurons. Melatonin inhi...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12476

    authors: Zhang Y,Ji H,Wang J,Sun Y,Qian Z,Jiang X,Snutch TP,Sun Y,Tao J

    更新日期:2018-05-01 00:00:00

  • Melatonin prevents hypochlorous acid-mediated cyanocobalamin destruction and cyanogen chloride generation.

    abstract::Hypochlorous acid (HOCl) is a potent cytotoxic oxidant generated by the enzyme myeloperoxidase (MPO) in the presence of hydrogen peroxide (H2 O2 ) and chloride (Cl- ). Elevated levels of HOCl play an important role in various pathological conditions through oxidative modification of several biomolecules. Recently, we ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12463

    authors: Jeelani R,Maitra D,Chatzicharalampous C,Najeemuddin S,Morris RT,Abu-Soud HM

    更新日期:2018-04-01 00:00:00

  • Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis.

    abstract::Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis con...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12449

    authors: Zhang Y,Liu X,Bai X,Lin Y,Li Z,Fu J,Li M,Zhao T,Yang H,Xu R,Li J,Ju J,Cai B,Xu C,Yang B

    更新日期:2018-03-01 00:00:00

  • The role of melatonin in the neurodevelopmental etiology of schizophrenia: A study in human olfactory neuronal precursors.

    abstract::Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. Howeve...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12421

    authors: Galván-Arrieta T,Trueta C,Cercós MG,Valdés-Tovar M,Alarcón S,Oikawa J,Zamudio-Meza H,Benítez-King G

    更新日期:2017-10-01 00:00:00

  • An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep.

    abstract::Melatonin as a potent antioxidant exhibits important nutritional and medicinal values. To produce melatonin-enriched milk will benefit the consumers. In this study, a sheep bioreactor which generates melatonin-enriched milk has been successfully developed by the technology that combined CRISPR/Cas9 system and microinj...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12406

    authors: Ma T,Tao J,Yang M,He C,Tian X,Zhang X,Zhang J,Deng S,Feng J,Zhang Z,Wang J,Ji P,Song Y,He P,Han H,Fu J,Lian Z,Liu G

    更新日期:2017-08-01 00:00:00

  • Overexpression of rice serotonin N-acetyltransferase 1 in transgenic rice plants confers resistance to cadmium and senescence and increases grain yield.

    abstract::While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated. Because the plant SNAT protein differs from that of animals in its subcellular localization and enzyme kinetics, ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12392

    authors: Lee K,Back K

    更新日期:2017-04-01 00:00:00

  • Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings.

    abstract::Melatonin has demonstrated a potential protective effect in central nervous system. Thus, it is interesting to determine whether pre-ischemia melatonin administration could protect against cerebral ischemia/reperfusion (IR)-related injury and the underlying molecular mechanisms. In this study, we revealed that IR inju...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12395

    authors: Feng D,Wang B,Wang L,Abraham N,Tao K,Huang L,Shi W,Dong Y,Qu Y

    更新日期:2017-04-01 00:00:00

  • Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse.

    abstract::Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocy...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12396

    authors: Zhang M,Dai X,Lu Y,Miao Y,Zhou C,Cui Z,Liu H,Xiong B

    更新日期:2017-04-01 00:00:00

  • Melatonin is required for H2 O2 - and NO-mediated defense signaling through MAPKKK3 and OXI1 in Arabidopsis thaliana.

    abstract::Melatonin influences plant innate immunity through the mitogen-activated protein kinase (MAPK) pathway. However, the most upstream MAPK component in melatonin signaling and the dependence of generation of a reactive oxygen species (ROS) burst on melatonin synthesis and signaling remain unclear. In this study, treatmen...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12379

    authors: Lee HY,Back K

    更新日期:2017-03-01 00:00:00

  • Melatonin enhances survival and preserves functional integrity of stem cells: A review.

    abstract::Despite state-of-the-art pharmaceutical regimens, continuous improvements in diagnostic techniques as well as refinements in equipment and interventional procedures, many diseases remain refractory to conventional therapies. Recent advances in stem cell (SC) biology have opened an avenue to exploring its therapeutic p...

    journal_title:Journal of pineal research

    pub_type: 杂志文章,评审

    doi:10.1111/jpi.12372

    authors: Lee MS,Yin TC,Sung PH,Chiang JY,Sun CK,Yip HK

    更新日期:2017-03-01 00:00:00

  • Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC), a disease common in the South-East Asian population, has high lymph node metastatic ability. Melatonin, an endogenously produced substance present in animals, plants, fungi, and bacteria, has oncostatic activity via several mechanisms. The molecular mechanisms involved in melatonin-medi...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12365

    authors: Ho HY,Lin CW,Chien MH,Reiter RJ,Su SC,Hsieh YH,Yang SF

    更新日期:2016-11-01 00:00:00

  • Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis.

    abstract::Glioblastoma stem-like cells (GSCs) displaying self-renewing and tumor-propagating capacity play a particularly important role in maintaining tumor growth, therapeutic resistance, and tumor recurrence. Therefore, new therapeutic strategies focusing on impairing GSC maintenance are urgently needed. Here, we used GSCs i...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12341

    authors: Chen X,Hao A,Li X,Du Z,Li H,Wang H,Yang H,Fang Z

    更新日期:2016-09-01 00:00:00

  • Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition.

    abstract::We tested the hypothesis that melatonin (Mel) enhances exogenous mitochondria (Mito) treatment against rodent hepatic ischemia-reperfusion (IR) injury. In vitro study utilized three groups of hepatocytes (i.e. nontreatment, menadione, and menadione-melatonin treatment, 4.0 × 10(5) each), while in vivo study used adult...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12326

    authors: Chen HH,Chen YT,Yang CC,Chen KH,Sung PH,Chiang HJ,Chen CH,Chua S,Chung SY,Chen YL,Huang TH,Kao GS,Chen SY,Lee MS,Yip HK

    更新日期:2016-08-01 00:00:00

  • Melatonin overcomes gemcitabine resistance in pancreatic ductal adenocarcinoma by abrogating nuclear factor-κB activation.

    abstract::Constitutive activation and gemcitabine induction of nuclear factor-κB (NF-κB) contribute to the aggressive behavior and chemotherapeutic resistance of pancreatic ductal adenocarcinoma (PDAC). Thus, targeting the NF-κB pathway has proven an insurmountable challenge for PDAC therapy. In this study, we investigated whet...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12285

    authors: Ju HQ,Li H,Tian T,Lu YX,Bai L,Chen LZ,Sheng H,Mo HY,Zeng JB,Deng W,Chiao PJ,Xu RH

    更新日期:2016-01-01 00:00:00

  • Melatonin nephroprotective action in Zucker diabetic fatty rats involves its inhibitory effect on NADPH oxidase.

    abstract::Excessive activity of NADPH oxidase (Nox) is considered to be of importance for the progress of diabetic nephropathy. The aim of the study was to elucidate the effect of melatonin, known for its nephroprotective properties, on Nox activity under diabetic conditions. The experiments were performed on three groups of an...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12296

    authors: Winiarska K,Dzik JM,Labudda M,Focht D,Sierakowski B,Owczarek A,Komorowski L,Bielecki W

    更新日期:2016-01-01 00:00:00

  • Melatonin prevents neural tube defects in the offspring of diabetic pregnancy.

    abstract::Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investigate the effects of melatonin on the incidence of NTDs (includ...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12282

    authors: Liu S,Guo Y,Yuan Q,Pan Y,Wang L,Liu Q,Wang F,Wang J,Hao A

    更新日期:2015-11-01 00:00:00

  • Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat.

    abstract::We tested whether combined melatonin (Mel) and exendin-4 (Ex4) treatment can better preserve glomerular structural integrity after ischemia-reperfusion (IR) injury compared with either alone. Adult male Sprague Dawley rats (n = 50) were equally divided into sham control (SC), IR, IR-Ex4 (10 μg/kg subcutaneously 30 min...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12273

    authors: Yip HK,Yang CC,Chen KH,Huang TH,Chen YL,Zhen YY,Sung PH,Chiang HJ,Sheu JJ,Chang CL,Chen CH,Chang HW,Chen YT

    更新日期:2015-11-01 00:00:00

  • Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.

    abstract::Melatonin is involved in the control of various physiological functions, such as sleep, cell growth and free radical scavenging. The ability of melatonin to behave as an antioxidant, together with the fact that the Alzheimer-related amyloid β-peptide (Aβ) triggers oxidative stress through hydroxyl radical-induced cell...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12260

    authors: Panmanee J,Nopparat C,Chavanich N,Shukla M,Mukda S,Song W,Vincent B,Govitrapong P

    更新日期:2015-10-01 00:00:00

  • Melatonin as a preventive and curative therapy against pulmonary hypertension.

    abstract::Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure, which leads to right ventricular (RV) hypertrophy and failure. The pathophysiological mechanisms of PH remain unclear but oxidative stress is believed to contribute to RV dysfunction. Melatonin is a powerful antioxidant and is cardio...

    journal_title:Journal of pineal research

    pub_type: 杂志文章

    doi:10.1111/jpi.12263

    authors: Maarman G,Blackhurst D,Thienemann F,Blauwet L,Butrous G,Davies N,Sliwa K,Lecour S

    更新日期:2015-10-01 00:00:00

260 条记录 1/7 页 « 1234567 »