abstract：:Triple negative breast cancer (TNBC) represents a small subtype of breast cancer yet it has the worst outcome. Immunotherapy using immune checkpoint inhibitors combined with chemotherapy was recently approved by the FDA raising the hope for an improved outcome. The approval was based on demonstration of a positive PD-...

journal_title：Annals of diagnostic pathology

authors： Al-Jussani GN,Dabbagh TZ,Al-Rimawi D,Sughayer MA

更新日期：2021-01-09 00:00:00

abstract：:Malignant vascular neoplasms such as epithelioid hemangioendothelioma (EHE) and angiosarcoma (AS) can arise within the liver. The aim of this study was to study the expression of keratins CK7, AE1/AE3 and OSCAR in primary hepatic EHE and AS. 9 cases of hepatic EHE and 13 cases of hepatic AS were stained with ERG, CK7,...

journal_title：Annals of diagnostic pathology

authors： Lee HE,Torbenson MS,Wu TT,Chandan VS

更新日期：2020-12-01 00:00:00

abstract：:Papillary thyroid microcarcinoma (PTMC) has the highest incidence among all thyroid carcinomas. Although surgery is the primary treatment for PTMC, it inevitably leads to trauma and some complications. To formulate an optimal treatment strategy, we aim to clarify the risk factors for lymph node metastasis (LNM) in PTM...

journal_title：Annals of diagnostic pathology

authors： Zhao L,Sun X,Luo Y,Wang F,Lyu Z

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Anal cytology (AC) is accepted as a practical screening modality for anal cancer. However, studies suggest that AC and anal biopsy dysplasia correlation is less robust than in cervicovaginal specimens. The current study goals were to look at our institutional experience in a subset of ACs and correlate with ...

journal_title：Annals of diagnostic pathology

authors： Hopp AM,Pant M,Sniedze S,Parsons LN,Hunt B,Giorgadze T

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Estrogen receptors (ER), progesterone receptors (PR) and the human epidermal growth factor receptor-2 (HER2) are basic breast cancer molecular markers that are also best recognized prognostic factors and predictors of type of targeted therapy to be given. The objectives are to study the correlation of expres...

journal_title：Annals of diagnostic pathology

authors： Mohanty SS

更新日期：2020-11-05 00:00:00

abstract：:Infection by SARS-CoV-2 commonly begins in the nasopharynx, and the cytologic and molecular correlates are not characterized. Fifty-eight cytologic preps (20 oral and 38 from the nasopharynx) were obtained from ten patients and analyzed in a blinded fashion for SARS-CoV-2 spike and envelope protein by immunohistochemi...

journal_title：Annals of diagnostic pathology

authors： Nuovo GJ,Magro C,Mikhail A

更新日期：2020-10-01 00:00:00

abstract：:Folate receptor alpha (FRα) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases. It has been shown to be a potential prognostic and therapeutic target, primarily in lung and ovarian cancer, as well as in breast cancer. The aim of this...

journal_title：Annals of diagnostic pathology

authors： Zagorac I,Lončar B,Dmitrović B,Kralik K,Kovačević A

更新日期：2020-10-01 00:00:00

abstract：:The urinary bladder may be involved by a variety of secondary tumors that originate from other organs. Bladder secondary tumors are rare and may be mistaken as bladder primary tumors because of their overlapping morphologic features. To avoid the diagnostic pitfalls, we analyzed the clinicopathologic features of bladd...

journal_title：Annals of diagnostic pathology

authors： Hamza A,Hwang MJ,Czerniak BA,Guo CC

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Epithelioid angiomyolipoma (EAML) is a rare potentially malignant variant of renal angiomyolipoma (RAML). This study aims to determine whether RAML clinico-pathologic and molecular features (i.e. p53 gene abnormalities) differ significantly with regards to its histologic variant or to the presence of an epit...

journal_title：Annals of diagnostic pathology

authors： Boudaouara O,Kallel R,Dhieb D,Smaoui W,Ayed HB,Keskes L,Sellami Boudawara T

更新日期：2020-08-01 00:00:00

abstract：:The hematoxylin and eosin slides of 100 consecutive cases diagnosed as CIN 1-2 were combined with 25 CIN 1 and 25 negative for CIN as documented by in situ HPV testing. The 150 cases were then reviewed blinded and scored as "CIN" or "negative for CIN". Each of the 50 controls was correctly scored. Of the 100 cases, 62...

journal_title：Annals of diagnostic pathology

authors： Nuovo G

更新日期：2020-06-01 00:00:00

abstract：:Beta-catenin, encoded by the CTNNB1 gene, plays an important role in cell proliferation. Mutations of CTNNB1 are oncogenic in several tumor types and are often associated with a nuclear abnormal expression. However, such mutations have only rarely been reported in non-small cell lung carcinomas and their clinical sign...

journal_title：Annals of diagnostic pathology

authors： Thomas de Montpréville V,Lacroix L,Rouleau E,Mamodaly M,Leclerc J,Tutuianu L,Planchard D,Boulate D,Mercier O,Besse B,Fadel É,Ghigna MR

更新日期：2020-06-01 00:00:00

abstract：:Primary cutaneous Rosai-Dorfman disease is a rare form of Rosai-Dorfman disease limited to the skin. The diagnosis of primary cutaneous disease is based on a combination of clinical presentation, histopathology, and the detection of S100+, CD68+, and CD1a- histiocytic immunophenotyping. However, the diagnosis of prima...

journal_title：Annals of diagnostic pathology

authors： Fayne R,Rengifo SS,Gonzalez I,Solorzano JL,Gonzalez D,Vega F,Cho-Vega JH

更新日期：2020-04-01 00:00:00

abstract：:Hypereosinophilia (HE) is defined as persistently elevated absolute eosinophil count (AEC) ≥ 1.5 × 109/L, which can be due to a variety of underlying causes. In this study, we investigated the prevalence and spectrum of T-cell lymphoproliferative disorders in 124 consecutive patients with HE by flow cytometric immunop...

journal_title：Annals of diagnostic pathology

authors： Shi M,Rech KL,Otteson GE,Horna P,Olteanu H,Pardanani A,Chen D,Jevremovic D

更新日期：2020-02-01 00:00:00

abstract：:Papillary renal cell carcinoma (PRCC) is currently a well-studied type of RCC. In addition to PRCC type 1, there are a number of other subtypes and variants of PRCCs which have been reported. We describe a series of 6 PRCCs with papillary, micropapillary and/or tubulopapillary architecture and prominent spindle cell s...

journal_title：Annals of diagnostic pathology

authors： Rogala J,Kojima F,Alaghehbandan R,Agaimy A,Martinek P,Ondic O,Ulamec M,Sperga M,Michalova K,Pivovarcikova K,Pitra T,Hora M,Ferak I,Marečková J,Michal M,Hes O

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Rigid diagnostic criteria for NIFTP have been recently proposed. The frequency of NIFTP using the new criteria is unknown, and whether abortive papillae are associated with BRAFV600E mutation has not been studied. The aim of this study is to identify NIFTP by a retrospective review of Follicular Variant of P...

journal_title：Annals of diagnostic pathology

authors： Cubero Rego D,Lee H,Boguniewicz A,Jennings TA

更新日期：2020-02-01 00:00:00

abstract：:Core needle biopsy (CNB) is the most common sampling technique for the histologic evaluation of breast abnormalities. Diagnosing benign proliferative, borderline and some in-situ lesions in CNB is challenging and subject to a significant degree of interobserver variability. In addition, due to the inherent limitations...

journal_title：Annals of diagnostic pathology

authors： Rosa M,Agosto-Arroyo E

更新日期：2019-12-01 00:00:00

abstract：AIMS:BK polyomavirus nephropathy (BKPyVN) is an important cause of allograft failure after renal transplantation. Despite early screening for the virus, allograft loss from BKPyVN is still experienced in up to 14% of all renal transplant recipients. The aim of this study was to investigate the association between BKPyV...

journal_title：Annals of diagnostic pathology

authors： Sanders ML,Swee M,Fraer M,Kuppachi S,Ten Eyck P,Rastogi P

更新日期：2019-10-01 00:00:00

abstract：:Although several lines of evidence existed suggesting that Mortalin was linked with survival in malignant tumors; it has been barely described regarding the prognostic involvement of its expression in hepatocellular carcinoma (HCC). Herein, to understand the prognostic meaning of Mortalin expression, Immunohistochemis...

journal_title：Annals of diagnostic pathology

authors： Cheng W,Zhang B,Zikeliyar M,Wang J,Jian H,Wu K,Zhang Y,Ding J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Hodgkin's Lymphoma (HL) is a peculiar subtype of lymphoid malignancies. The etiology of HL is still unknown. Insulin-like growth factor II mRNA-binding Protein 3 (IMP3) is a member of IMP family. In HL, IMP3 is expressed in the cytoplasmic compartment of the tumor cells (in both HRS cells & LP cells) against...

journal_title：Annals of diagnostic pathology

authors： Masoud R,Ibrahiem A,Tantawy D,Eldosoky I

更新日期：2019-10-01 00:00:00

abstract：:We present clinicopathological and molecular cytogenetic features of five rare cases of Ewing sarcomas, occurring in the female genital tract. A 40 year-old lady presented with a 5.4 cm-sized vaginal mass of 3 months duration, which was histopathologically diagnosed as ES. She defaulted chemotherapy and 8 months later...

journal_title：Annals of diagnostic pathology

authors： Rekhi B,Agrawal R,Shetty O,Deodhar KK,Menon S,Ghosh J,Kerkar R,Maheshwari A

更新日期：2019-08-01 00:00:00

abstract：:Serrated polyps evaluation represents a challenge for pathologists for lacking of univocal criteria that leads to different inter -individual interpretation. The aim of our review is to offer an alternative simpler histologic and endoscopic approach to these lesions for a more correct relationship between endoscopists...

journal_title：Annals of diagnostic pathology

authors： Villanacci V,Baronchelli C,Manenti S,Bassotti G,Salviato T

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm, but clinically indolent subtypes are also recognized. Data on the utility of mutation profiling in the context of routine workup and its role in risk-stratification of MCL patients are limited. In this study, we describe the mutational landscape ...

journal_title：Annals of diagnostic pathology

authors： Sakhdari A,Ok CY,Patel KP,Kanagal-Shamanna R,Yin CC,Zuo Z,Hu S,Routbort MJ,Luthra R,Medeiros LJ,Khoury JD,Loghavi S

更新日期：2019-08-01 00:00:00

abstract：AIM:Tumour-infiltrating T lymphocytes (TIL) are considered to be a reliable prognostic marker in CC, but the use in daily practice is unclear. We investigated the survival effect of TIL methodologically in a highly homogeneous population. METHODS:Seventy-two stage IIA (T3N0) CC patients who underwent surgical resectio...

journal_title：Annals of diagnostic pathology

authors： Zengin M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:There is contradictory evidence in literature with respect to diagnosis and management of follicular lesions of the thyroid gland. From surgical pathology stand point, pathologists require submission and processing of entire capsule for microscopic evaluation. This can be extremely challenging especially in ...

journal_title：Annals of diagnostic pathology

authors： Hamza A,Khawar S,Alrajjal A,Salehi S

更新日期：2019-04-01 00:00:00

abstract：:This review is part of a collaboration between the American Registry of Pathology (the publisher of the Armed Forces Institute of Pathology Fascicles) and Annals of Diagnostic Pathology. It is in a series of expert recommendations on topics encountered in daily practice. The authors, two pathologists and a gastroenter...

journal_title：Annals of diagnostic pathology

authors： Montgomery EA,Canto MI,Srivastava A

更新日期：2019-04-01 00:00:00

abstract：:Fat mass and obesity associated (FTO) is a protein-coding gene, also known as the obesity gene. It has been reported previously to be associated with a variety of malignant cancers, such as breast, thyroid and acute myeloid leukemia. The aim of the present study was to investigate the FTO mRNA expression in human clea...

journal_title：Annals of diagnostic pathology

authors： Wen L,Yu Y,Lv H,He Y,Yang B

更新日期：2019-02-01 00:00:00

abstract：:Clear cell papillary renal cell carcinoma (ccpRCC) is a recently recognized subtype of renal cell carcinoma. In this study, we investigated the clinicopathological and immunohistochemical features in a group of 26 cases of ccpRCC, with a special emphasis on the expression of vitamin D receptor (VDR). The mean age of p...

journal_title：Annals of diagnostic pathology

authors： Wang Y,Ding Y,Qin C,Gu M,Wang Z,Han C,Liu X,Li H,Hua H

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Comparison of analytical and immunohistochemical performance of progesterone receptor (PR) antibodies with correlation to recurrence of invasive breast cancer treated with endocrine therapy. METHODS:The binding-affinity kinetics of PR clones 1E2, 1A6, 16 and 636 were compared using synthetic peptides derived...

journal_title：Annals of diagnostic pathology

authors： Calhoun BC,Mosteller B,Warren D,Smith M,Jordi Rowe J,Lanigan CP,Mrazeck KC,Walker E,Newell AH,Jones R

更新日期：2018-08-01 00:00:00

abstract：:Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the ...

journal_title：Annals of diagnostic pathology

authors： Flucke U,Shepard SJ,Bekers EM,Tirabosco R,van Diest PJ,Creytens D,van Gorp JM

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Programmed death ligand 1 (PD-L1), an immune check point inhibitor, is known to be expressed in several malignancies and is being considered as a prognostic factor and a potential immunotherapeutic target. The aim of this study was to characterize PD-L1 expression in thymomas and to determine correl...

journal_title：Annals of diagnostic pathology

authors： Guleria P,Husain N,Shukla S,Kumar S,Parshad R,Jain D

更新日期：2018-06-01 00:00:00

abstract：:To explore the distribution of lymphoid neoplasms in Northwest China, the clinical and pathological data of lymphoma patients from 2006 to 2014 were analyzed according to the WHO classification in Xijing Hospital. Of the 3244 cases, mature B-cell neoplasms occupied 60.7%, while mature T/NK-cell neoplasms and Hodgkin's...

journal_title：Annals of diagnostic pathology

authors： Cao C,Feng J,Gu H,Tang H,Xu L,Dong H,Dong B,Shu M,Bai Q,Liang R,Zhang T,Yang L,Wang Z,Chen X,Gao G

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Proteins p27 and c-Myc are both key players in the cell cycle. While p27, a tumor suppressor, inhibits progression from G1 to S phase, c-Myc, a proto-oncogene, plays a key role in cell cycle regulation and apoptosis. The objective of our study was to determine the association between expression of c-Myc and ...

journal_title：Annals of diagnostic pathology

authors： Khan F,Ricks-Santi LJ,Zafar R,Kanaan Y,Naab T

更新日期：2018-06-01 00:00:00

abstract：:Breast carcinoma with osteoclast-like giant cells (OGCs) is a rare disease characterized by the infiltration of OGCs in the tumor; however, cytological aspects of this tumor type remain elusive. We examined the cytological features in fine needle aspiration (FNA) biopsy smears obtained from 5 patients who were histolo...

journal_title：Annals of diagnostic pathology

authors： Ohashi R,Hayama A,Matsubara M,Watarai Y,Sakatani T,Naito Z,Shimizu A

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Biphenotypic sinonasal sarcoma (BSNS) is a recently described mesenchymal tumor exclusive to the sinonasal region. It is a low grade sarcoma, displaying evidence of myogenic and neural differentiation. Role of β-catenin immunohistochemistry in distinguishing it from its morphological mimics is not well-est...

journal_title：Annals of diagnostic pathology

authors： Kakkar A,Rajeshwari M,Sakthivel P,Sharma MC,Sharma SC

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Histiocytic sarcoma is an extremely rare hematologic malignancy of histiocytic origin. Five cases of primary cutaneous histiocytic sarcoma are presented. MATERIALS AND METHODS:Cases of primary cutaneous histiocytic sarcoma were identified using a natural language search from the dermatopathology data base...

journal_title：Annals of diagnostic pathology

authors： Magro CM,Kazi N,Sisinger AE

更新日期：2018-02-01 00:00:00

abstract：:Cholesteryl Ester Storage Disease (CESD), is a rare multisystem autosomal recessive disorder and belongs to the broad family of lysosomal storage disorders. It can present anytime from infancy and childhood to even adulthood. The clinical manifestations are generally severe in infants and with milder forms in adults. ...

journal_title：Annals of diagnostic pathology

authors： Pant M,Oshima K

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Increased expression of Programmed death ligand-1 (PD-L1) on cancer cells and immune cells predict response to PD-1/PDL1 inhibitors. Data regarding frequency and pattern of PD-L1 expression in NSCLC from India is not available. OBJECTIVES:To analyse PD-L1 expression on tumour cells (TC) and immune cells (...

journal_title：Annals of diagnostic pathology

authors： Vallonthaiel AG,Malik PS,Singh V,Kumar V,Kumar S,Sharma MC,Mathur S,Arava S,Guleria R,Jain D

更新日期：2017-12-01 00:00:00

abstract：:DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the...

journal_title：Annals of diagnostic pathology

authors： Vallejo-Benítez A,Rodríguez-Zarco E,Carrasco SP,Pereira-Gallardo S,Brugal Molina J,García-Escudero A,Robles Frías A,Marcilla D,González-Cámpora R

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Hydatid disease is an endemic parasitic infection caused by Echinococcus granulosus mostly seen in the Mediterranean countries. The most affected organ is the liver, however hydatidosis can be found anywhere in the human body. METHODS:The records of patients who were diagnosed with hydatid disease in our ...

journal_title：Annals of diagnostic pathology

authors： Gun E,Etit D,Buyuktalanci DO,Cakalagaoglu F

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but...

journal_title：Annals of diagnostic pathology

authors： Nguyen GH,Olson LC,Magro CM

更新日期：2017-06-01 00:00:00