Abstract：
:Folate receptor alpha (FRα) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases. It has been shown to be a potential prognostic and therapeutic target, primarily in lung and ovarian cancer, as well as in breast cancer. The aim of this study was to examine FRα expression in a cohort of patients with triple negative breast cancer (TNBC), in correlation with clinicopathological parameters and prognostic factors. By using polyclonal FRα antibody on archival paraffin blocks immunohistochemistry was performed. To evaluate the expression of FRα, H-score was used, which marks both the proportion of stained cells and the intensity of staining. Statistical analysis correlating FRα expression with clinicopathologic parameters and clinical outcome were performed. FRα was expressed in most of the patients (85%). Significant correlation of expression and histologic grade (Mann Whitney U test, P = 0,03) and type of tumor (P = 0,02), was found. It was noticed that with higher Ki-67 proliferation index values, H-score has lower values (r = -0,284, P = 0,006). Multivariant regression analysis (Cox regression, Stepwise method) showed H-score as a significant predictor for the risk of disease recurrence (OR = 1,005, P = 0,04). No correlation between FRα expression and overall survival (OS) and disease-free survival (DFS) was found. In conclusion, FRα is highly expressed in TNBC, and, given the correlation with clinicopathological parameters, subpopulation of patients could be identified that could be potential targets for new therapeutic perspectives in the treatment of this breast cancer subtype.
journal_name
Ann Diagn Patholjournal_title
Annals of diagnostic pathologyauthors
Zagorac I,Lončar B,Dmitrović B,Kralik K,Kovačević Adoi
10.1016/j.anndiagpath.2020.151596subject
Has Abstractpub_date
2020-10-01 00:00:00pages
151596eissn
1092-9134issn
1532-8198pii
S1092-9134(20)30139-8journal_volume
48pub_type
杂志文章abstract：:Recurrences of nonmuscle-invasive urothelial bladder cancer are very common following resection. Predictive histopathologic variables in transurethral resection of bladder tumor (TURBT) specimens are of particular importance especially in determining the behavior of lamina propria-invasive tumors (high grade T1 stage)...
journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1053/adpa.2002.36654
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2009.02.002
更新日期：2009-10-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1053/adpa.2002.34574
更新日期：2002-06-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1053/adpa.2003.50011
更新日期：2003-04-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1053/adpa.2001.25408
更新日期：2001-06-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.05.005
更新日期：2008-04-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2016.11.002
更新日期：2017-02-01 00:00:00
abstract：:Myoid angioendothelioma of the spleen is an uncommon, benign vascular tumor that is morphologically characterized by a composite of vascular spaces and stromal cells with myoid feature. Herein, we report a case of the myoid angioendothelioma of the spleen, concurrent with rectal adenocarcinoma. A 41-year-old woman pre...
journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2012.03.001
更新日期：2013-02-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2007.01.006
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/s1092-9134(98)80050-6
更新日期：1998-04-01 00:00:00
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journal_title：Annals of diagnostic pathology
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2014.04.003
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2005.03.006
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
doi：10.1016/j.anndiagpath.2010.08.003
更新日期：2011-12-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章,评审
doi：10.1016/j.anndiagpath.2007.04.001
更新日期：2007-06-01 00:00:00
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journal_title：Annals of diagnostic pathology
pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
