Sclerosing extramedullary hematopoietic tumor.

Abstract:

:A 73-year-old woman presented with abdominal pain, weakness, and weight loss. Pertinent medical history included myelofibrosis, severe anemia, and lumpectomy for breast cancer. Computed tomography showed marked splenomegaly and numerous soft tissue masses in the mesentery. Excisional biopsy of the mass showed an encapsulated tumor with yellow-tan nodular growth pattern. Microscopically, the tumor was characterized by the presence of bizarre giant cells in background of prominent dense fibrous stroma. The atypical giant cells were positive for FVIII antibody staining. Many other cells were positive for CD43 antibody staining, indicating that the tumor was hematopoietic in nature, so-called sclerosing extramedullary hematopoietic tumor. Extramedullary hematopoiesis is a common phenomenon associated with severe anemia of any cause. When associated with myelofibrosis, however, it has different morphology from extramedullary hematopoiesis of the other causes. The significance of recognizing sclerosing extramedullary hematopoietic tumor is that it is often mistaken for sarcomas and other malignant neoplasms, especially when the clinical history is unknown.

journal_name

Ann Diagn Pathol

authors

Yang X,Bhuiya T,Esposito M

doi

10.1053/adpa.2002.34574

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

183-7

issue

3

eissn

1092-9134

issn

1532-8198

pii

aadpa0060183

journal_volume

6

pub_type

杂志文章
  • Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature.

    abstract::DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2017.05.002

    authors: Vallejo-Benítez A,Rodríguez-Zarco E,Carrasco SP,Pereira-Gallardo S,Brugal Molina J,García-Escudero A,Robles Frías A,Marcilla D,González-Cámpora R

    更新日期:2017-10-01 00:00:00

  • A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology.

    abstract::In the recent years, basaloid squamous cell carcinomas (BSCCs) have gained attention because of (1) observation of a relative increase in the number of tumors arising particularly in head and neck sites, (2) identification of human papillomavirus (HPV) in BSCCs arising predominantly in the oropharynx, and (3) controve...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2013.09.001

    authors: Jayasooriya PR,Tilakaratne WM,Mendis BR,Lombardi T

    更新日期:2013-12-01 00:00:00

  • Cytologic and molecular correlates of SARS-CoV-2 infection of the nasopharynx.

    abstract::Infection by SARS-CoV-2 commonly begins in the nasopharynx, and the cytologic and molecular correlates are not characterized. Fifty-eight cytologic preps (20 oral and 38 from the nasopharynx) were obtained from ten patients and analyzed in a blinded fashion for SARS-CoV-2 spike and envelope protein by immunohistochemi...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2020.151565

    authors: Nuovo GJ,Magro C,Mikhail A

    更新日期:2020-10-01 00:00:00

  • Unusual locations of hydatid disease: A 10-year experience from a tertiary reference center in Western Turkey.

    abstract:INTRODUCTION:Hydatid disease is an endemic parasitic infection caused by Echinococcus granulosus mostly seen in the Mediterranean countries. The most affected organ is the liver, however hydatidosis can be found anywhere in the human body. METHODS:The records of patients who were diagnosed with hydatid disease in our ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2017.01.011

    authors: Gun E,Etit D,Buyuktalanci DO,Cakalagaoglu F

    更新日期:2017-08-01 00:00:00

  • Measuring the dimension of invasive component in pT1 urothelial carcinoma in transurethral resection specimens can predict time to recurrence.

    abstract::Recurrences of nonmuscle-invasive urothelial bladder cancer are very common following resection. Predictive histopathologic variables in transurethral resection of bladder tumor (TURBT) specimens are of particular importance especially in determining the behavior of lamina propria-invasive tumors (high grade T1 stage)...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.11.002

    authors: Hu Z,Mudaliar K,Quek ML,Paner GP,Barkan GA

    更新日期:2014-04-01 00:00:00

  • Frozen section discrepancy in the evaluation of nonneoplastic central nervous system samples.

    abstract::Frozen section (FS) for intraoperative evaluation of central nervous system (CNS) lesions provides the neurosurgeon with a rapid preliminary pathologic diagnosis. Diagnosis of nonneoplastic lesions is particularly challenging in this venue. To highlight common diagnostic pitfalls, we sought to identify discrepancies b...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2009.05.006

    authors: Plesec TP,Prayson RA

    更新日期:2009-12-01 00:00:00

  • Gastrointestinal stromal tumor of the ampulla of Vater with osteoclastic giant cells, osteoid-like matrix deposition, and aneurysmal bone cyst-like features.

    abstract::Gastrointestinal stromal tumors are a heterogeneous group with a wide spectrum of histologic features. We describe the first case of 61-year-old woman who presented gastrointestinal stromal tumors of the ampulla of Vater with osteoclast-like giant cells surrounding osteoid-like material and aneurismal bone cyst-like a...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2012.08.003

    authors: Candanedo-Gonzalez F,Camacho-Rebollar L,Uscanga CC,Utrilla AR,Bucio ME,Rodriguez SS,Hernandez LM

    更新日期:2013-08-01 00:00:00

  • Angiosarcoma of the uterus: report of 2 new cases with deviant clinicopathologic features and review of the literature.

    abstract::A few cases of uterine angiosarcoma have been detailed in the literature: 2 new cases are herein described featuring some unusual clinical or phenotypic differences compared with previously published cases, such as occurrence in premenopausal age or a poorly differentiated histology. The patients were 35 and 81 years ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.08.001

    authors: Cardinale L,Mirra M,Galli C,Goldblum JR,Pizzolitto S,Falconieri G

    更新日期:2008-06-01 00:00:00

  • Dedifferentiated chordoma of the thoracic spine with rhabdomyosarcomatous differentiation. Report of a case and review of the literature.

    abstract::A case of spinal thoracic chordoma involving the T9 vertebra in a 70-year-old male patient, destroying the vertebral body and invading the vertebral canal with compression of the spinal cord, is presented. The patient was referred to our neurosurgical unit with a history of an irradiated metastatic adenocarcinoma to t...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2006.09.002

    authors: Bisceglia M,D'Angelo VA,Guglielmi G,Dor DB,Pasquinelli G

    更新日期:2007-08-01 00:00:00

  • Correlation of folate receptor alpha expression with clinicopathological parameters and outcome in triple negative breast cancer.

    abstract::Folate receptor alpha (FRα) is a membrane-bound protein with a high affinity for folate, which is necessary for the biosynthesis of amino acids and nucleotide bases. It has been shown to be a potential prognostic and therapeutic target, primarily in lung and ovarian cancer, as well as in breast cancer. The aim of this...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2020.151596

    authors: Zagorac I,Lončar B,Dmitrović B,Kralik K,Kovačević A

    更新日期:2020-10-01 00:00:00

  • Brain in the middle ear or nasal cavity: heterotopia or encephalocele?

    abstract::Brain in the middle ear or nasal cavity: heterotopia or encephalocele? The answer to this question is greatly influenced by clinical information. Sometimes, however, this information is insufficient and the pathologist's opinion may influence patient management. It seems that most pathologists tend to get the answer w...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/j.anndiagpath.2004.04.009

    authors: Heffner DK

    更新日期:2004-08-01 00:00:00

  • Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features.

    abstract::Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-te...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2010.07.008

    authors: Kuroda N,Tamura M,Hamaguchi N,Mikami S,Pan CC,Brunelli M,Martignoni G,Hes O,Michal M,Lee GH

    更新日期:2011-12-01 00:00:00

  • Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is rare, benign lesion using modified stringent diagnostic criteria: Reclassification and outcome study.

    abstract:BACKGROUND:Rigid diagnostic criteria for NIFTP have been recently proposed. The frequency of NIFTP using the new criteria is unknown, and whether abortive papillae are associated with BRAFV600E mutation has not been studied. The aim of this study is to identify NIFTP by a retrospective review of Follicular Variant of P...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.151439

    authors: Cubero Rego D,Lee H,Boguniewicz A,Jennings TA

    更新日期:2020-02-01 00:00:00

  • Prevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia: A reference laboratory experience.

    abstract::Hypereosinophilia (HE) is defined as persistently elevated absolute eosinophil count (AEC) ≥ 1.5 × 109/L, which can be due to a variety of underlying causes. In this study, we investigated the prevalence and spectrum of T-cell lymphoproliferative disorders in 124 consecutive patients with HE by flow cytometric immunop...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2019.151412

    authors: Shi M,Rech KL,Otteson GE,Horna P,Olteanu H,Pardanani A,Chen D,Jevremovic D

    更新日期:2020-02-01 00:00:00

  • Immunoexpression of p53 in cutaneous and subcutaneous leiomyosarcomas.

    abstract::The diagnosis of malignancy in cutaneous and subcutaneous smooth muscle tumors is based on subtle criteria. Therefore, any ancillary technique useful in this differential diagnosis is always welcome. In this report, we study the immunoexpression of p53 in 19 malignant smooth muscle tumors of the skin (15 cutaneous lei...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2016.05.008

    authors: Fernandez-Flores A,Monteagudo C

    更新日期:2016-10-01 00:00:00

  • Significance of isolated vasculitis in the gynecological tract: what clinicians do with the pathologic diagnosis of vasculitis?

    abstract::Vasculitides includes a heterogeneous group of disorders with the common histologic findings of vascular wall inflammation. Systemic or localized disease (eg, renal vasculitis) has serious consequences. The incidence of isolated gynecologic vasculitis diagnosed on pathology specimens and its significance is little kno...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2014.03.008

    authors: Roma AA,Amador-Ortiz C,Liapis H

    更新日期:2014-08-01 00:00:00

  • Primitive neuroectodermal tumor of the cervix: a clinicopathologic and immunohistochemical study of two cases.

    abstract::Two cases of primary primitive neuroectodermal tumors of the cervix are presented. The two female patients are 35 and 51 years of age who presented with abnormal uterine bleeding of several weeks' duration. On gynecologic examination, a mass in the cervical area was palpated and a biopsy was obtained. The initial biop...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2002.35739

    authors: Malpica A,Moran CA

    更新日期:2002-10-01 00:00:00

  • Ki-1 anaplastic large-cell lymphoma occurring at the site of ileocolonic anastomosis in a patient treated surgically for colonic adenocarcinoma: case report and review of the literature.

    abstract::Systemic anaplastic large-cell lymphoma is an uncommon type of non-Hodgkin lymphoma characterized by strong expression of the Ki-1 (CD30) antigen. Gastrointestinal involvement typically is less common than in other types of non-Hodgkin's lymphoma. We report a case of CD30-positive anaplastic large-cell lymphoma occurr...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2001.25408

    authors: Cooperberg MR,Fiedler PN

    更新日期:2001-06-01 00:00:00

  • Adenolipomas of the head and neck: analysis of 6 cases.

    abstract::Adenolipomas are rare benign neoplasms composed of mature adipose tissue and glandular elements. We report 6 patients with adenolipomas of the head and neck region: 3 in the parathyroid, 2 in the thyroid, and 1 in the parotid gland. The patients were 4 women and 2 men, ranging in age from 21 to 70 years (mean, 62.5 ye...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2005.07.012

    authors: Daboin KP,Ochoa-Perez V,Luna MA

    更新日期:2006-04-01 00:00:00

  • CD133 expression in oral lichen planus correlated with the risk for progression to oral squamous cell carcinoma.

    abstract::Oral lichen planus (OLP) is a potentially malignant disorder associated with an increased risk for progression to oral squamous cell carcinoma (OSCC). The objective of this study to determine protein expression of cancer stem cell marker CD133 in tissue samples of patients with OLP and evaluate the correlation between...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.06.004

    authors: Sun L,Feng J,Ma L,Liu W,Zhou Z

    更新日期:2013-12-01 00:00:00

  • FTO mRNA expression in the lower quartile is associated with bad prognosis in clear cell renal cell carcinoma based on TCGA data mining.

    abstract::Fat mass and obesity associated (FTO) is a protein-coding gene, also known as the obesity gene. It has been reported previously to be associated with a variety of malignant cancers, such as breast, thyroid and acute myeloid leukemia. The aim of the present study was to investigate the FTO mRNA expression in human clea...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2018.10.009

    authors: Wen L,Yu Y,Lv H,He Y,Yang B

    更新日期:2019-02-01 00:00:00

  • Primary chondrosarcoma of ethmoid bone in a 6-year-old child.

    abstract::Chondrosarcoma (CS) is a distinctly uncommon tumor in young patients and tends to be located in the extremities. Cartilaginous tumors in young patients are benign tumors. We report a case of a childhood CS in a 6-year-old boy who presented with right-sided proptosis. Radiological examination revealed a large destructi...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2005.09.004

    authors: Mahesha V,Goyal R,Vaiphei K,Nada R,Gupta AK

    更新日期:2006-06-01 00:00:00

  • Low-grade fibromyxoid sarcoma metastatic to the prostate.

    abstract::Spindle cell tumors of the prostate are rare and mostly primary. We report a case of retroperitoneal sarcoma, which is a low-grade fibromyxoid sarcoma involving the prostate secondarily by metastasis. The patient was a 44-year-old man who presented with progressing abdominal pain. Computed tomography showed a large re...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2010.01.001

    authors: Baydar DE,Aki FT

    更新日期:2011-02-01 00:00:00

  • Primary extramedullary plasmacytoma of the esophagus.

    abstract::An uncommon manifestation of plasma cell neoplasia occurs outside the bone marrow and is designated "extramedullary plasmacytoma." These are usually encountered in mucosal sites of the head and neck region. The gastrointestinal tract may be secondarily involved in multiple myeloma or be the site of primary extramedull...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/s1092-9134(03)00017-0

    authors: Chetty R,Bramdev A,Reddy AD

    更新日期:2003-06-01 00:00:00

  • Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature.

    abstract::Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions. In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which wa...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2009.03.007

    authors: Huo L,Gilcrease MZ

    更新日期:2009-08-01 00:00:00

  • Lymphoglandular bodies in malignant tumors: with special reference to histologic specimens.

    abstract::Lymphoglandular bodies (LGBs) have been described as cytoplasmic fragments of lymphocytes and a specific feature of organized lymphoid tissue. The recognition of LGBs is useful in distinguishing malignant lymphomas from carcinomas and sarcomas in cytology specimens, especially in Giemsa-stained tissues. So far, there ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.10.001

    authors: Murakami T,Kayano H,Itoh T,Shimizu Y,Ban S,Ogawa F,Sannohe S,Kondo S,Shimizu M

    更新日期:2008-08-01 00:00:00

  • Perianal mammary-type myofibroblastoma.

    abstract::We report a unique case of an extramammary mammary-type myofibroblastoma of the perianal region. The patient was a 40-year old female with no significant past history, who presented with a right side painless perianal mass. Gross examination of the excised mass showed a well-circumscribed, apparently encapsulated, nod...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2009.08.005

    authors: Zhang Y,Jorda M,Goldblum JR

    更新日期:2010-10-01 00:00:00

  • Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas.

    abstract::The purpose of this study is to assess whether composite or coordinate immunoexpression patterns of estrogen receptor (ER), progesterone receptor (PR), and Wilms tumor 1 (WT1) gene can significantly distinguish between endometrial serous carcinoma (ESC) and ovarian serous carcinoma (OSC). Immunohistochemical analyses ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.04.011

    authors: Fadare O,James S,Desouki MM,Khabele D

    更新日期:2013-10-01 00:00:00

  • Loss of ELF3 immunoexpression is useful for detecting oral squamous cell carcinoma but not for distinguishing between grades of epithelial dysplasia.

    abstract::Early diagnosis and targeted therapy are crucial to mitigating the morbidity and mortality of oral squamous cell carcinoma. Among the potentially malignant oral disorders, epithelial dysplasia has known association with malignant transformation, but defensible gradation of dysplasia severity presents unmet challenges....

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.03.003

    authors: AbdulMajeed AA,Dalley AJ,Farah CS

    更新日期:2013-08-01 00:00:00

  • Pleomorphic myofibrosarcoma of the tibia with aneuploid DNA content.

    abstract::Myofibrosarcomas of the tibia are exceedingly rare, with only one case reported in the literature. We describe DNA ploidy of high-grade myofibrosarcoma of the tibia in correlation with clinicomorphologic and ultrastructural features in a 16-year-old adolescent girl. Radiological studies revealed an expanding osteolyti...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.04.002

    authors: Gonzalez FA,Vazquez AC,Uscanga CC,Cortes IJ,Malagon D

    更新日期:2007-10-01 00:00:00