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Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature.

Abstract：

:DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the abdominal cavity. This paper reports on immnohistochemical expression of DOG1 in 19 LGFMSs using two different monoclonal antibodies: K9 (Leica, Novocastra Laboratories, Newcastle upon Tyne, UK) and SP31 (Thermo Scientific, Freemont, USA). All LGFMSs displayed the standard histological pattern of alternating myxoid and fibrous areas, low cellularity and bland spindle-cell morphology. Positive staining for MUC4 was observed in 18/19 cases (94.7%), while there was rearrangement of the FUS gene in 14/19 (73.7%) cases and of the EWR1 gene in 2/19 (10.5%). The sarcoma staining negative for MUC4 displayed FUS gene rearrangement. Whole-section immunohistochemistry revealed positive staining for DOG1 in 8/19 cases (42.1%), though only with clone K9. Cytoplasmic as well as membrane staining was observed in all cases; staining was focal (10-30%) and of varying intensity (1+ to 2+). In conclusion, DOG1 clone K9 exhibited low sensitivity (42.1%) for the diagnosis of LGFMS, although higher than clone SP31. Since the two clones display similar sensitivity and specificity for GIST diagnosis, SP31 would appear to be more specific for this purpose, since no reaction was observed here with LGFMS, a GIST-mimicking lesion.

journal_name

Ann Diagn Pathol

journal_title

Annals of diagnostic pathology

authors

Vallejo-Benítez A,Rodríguez-Zarco E,Carrasco SP,Pereira-Gallardo S,Brugal Molina J,García-Escudero A,Robles Frías A,Marcilla D,González-Cámpora R

doi

10.1016/j.anndiagpath.2017.05.002

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

8-11

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(16)30190-3

journal_volume

30

pub_type

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