Core needle biopsy of benign, borderline and in-situ problematic lesions of the breast: Diagnosis, differential diagnosis and immunohistochemistry.


:Core needle biopsy (CNB) is the most common sampling technique for the histologic evaluation of breast abnormalities. Diagnosing benign proliferative, borderline and some in-situ lesions in CNB is challenging and subject to a significant degree of interobserver variability. In addition, due to the inherent limitations of CNB, "upgrading" to a more significant pathology at excision is an important consideration for some lesions. Pathologists carry a major responsibility in patient diagnosis, risk stratification and management. Familiarity with the histologic features and the clinical significance of these common and problematic lesions encountered in CNB is necessary for adequate treatment and patient follow-up. This review will focus on benign, atypical and in-situ epithelial proliferations, papillary lesions, radial sclerosing lesions, adenosis and cellular fibroepithelial lesions. Highlights of histologic features, useful strategies for accurate diagnosis, basic immunohistochemistry and management will be presented.


Ann Diagn Pathol


Rosa M,Agosto-Arroyo E




Has Abstract


2019-12-01 00:00:00












  • Intraductal tubular neoplasms of the pancreas: an overview.

    abstract::Intraductal lesions of the pancreas are an uncommon but increasingly recognized group of entities mainly because of advances in imaging technology. In the past, precise categorization and understanding of true pancreatic intraduct neoplasms were hampered not only by their relative rarity but also because of the pletho...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Chelliah A,Kalimuthu S,Chetty R

    更新日期:2016-10-01 00:00:00

  • Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder.

    abstract::The sequence of molecular changes leading to neoplastic transformation in the gallbladder remains elusive. The aim of this study is to characterize the spectrum of nuclear p16 protein product immunohistochemical expression in tissue microarray cores taken from resected gallbladders, comprising histologically normal ga...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Lynch BC,Lathrop SL,Ye D,Ma TY,Cerilli LA

    更新日期:2008-06-01 00:00:00

  • Secondary tumors of the bladder: A survival outcome study.

    abstract::The urinary bladder may be involved by a variety of secondary tumors that originate from other organs. Bladder secondary tumors are rare and may be mistaken as bladder primary tumors because of their overlapping morphologic features. To avoid the diagnostic pitfalls, we analyzed the clinicopathologic features of bladd...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Hamza A,Hwang MJ,Czerniak BA,Guo CC

    更新日期:2020-10-01 00:00:00

  • Brain in the middle ear or nasal cavity: heterotopia or encephalocele?

    abstract::Brain in the middle ear or nasal cavity: heterotopia or encephalocele? The answer to this question is greatly influenced by clinical information. Sometimes, however, this information is insufficient and the pathologist's opinion may influence patient management. It seems that most pathologists tend to get the answer w...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Heffner DK

    更新日期:2004-08-01 00:00:00

  • Plexiform leiomyoma of the esophagus: a complex radiographic, pathologic and endoscopic diagnosis.

    abstract::Radiographic identification of an abnormal lesion in the esophagus routinely occurs during workup of patients with symptomatic dysphagia. Leiomyoma is the most common benign finding; however, plexiform leiomyoma, a distinctive but rare variant, follows an unusual pattern of growth which can be a challenging surgical r...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Jaroszewski DE,Lam-Himlin D,Gruden J,Lidner TK,Etxebarria AA,De Petris G

    更新日期:2011-10-01 00:00:00

  • Clear cell sarcoma of the mediastinum.

    abstract::A 59-year-old woman presented with a large mediastinal mass. At thoracotomy, the mass was found tightly adherent to the esophageal wall and right lower lobe of the lung. Histological examination showed a solid tumor composed of closely packed nests of cells with clear and eosinophilic cytoplasm, which were strongly an...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Tirabosco R,Lang-Lazdunski L,Diss TC,Amary MF,Rodriguez-Justo M,Landau D,Lorenzi W,Flanagan AM

    更新日期:2009-06-01 00:00:00

  • Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center.

    abstract::A granular cell tumor (GCT) is relatively uncommon and objectively diagnosed with neural markers on immunohistochemistry (IHC). Recent studies have described additional markers for a GCT. Herein, we present morphologic spectrum of 12 GCTs of soft tissues and skin, including 10 benign and 2 malignant subtypes with an o...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Rekhi B,Jambhekar NA

    更新日期:2010-06-01 00:00:00

  • Histopathological diagnosis of acral lentiginous melanoma in early stages.

    abstract::Acral lentiginous melanoma is a rare variant of melanoma that is associated with a relatively low survival rate. The latter is partly due to the advanced stage in which the tumor is usually diagnosed. The diagnostic delay is mainly due to difficulties in identifying the very early histopathological signs of acral mela...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Fernandez-Flores A,Cassarino DS

    更新日期:2017-02-01 00:00:00

  • Primary cutaneous Rosai-Dorfman disease; a case-based review of a diagnostically and therapeutically challenging rare variant.

    abstract::Primary cutaneous Rosai-Dorfman disease is a rare form of Rosai-Dorfman disease limited to the skin. The diagnosis of primary cutaneous disease is based on a combination of clinical presentation, histopathology, and the detection of S100+, CD68+, and CD1a- histiocytic immunophenotyping. However, the diagnosis of prima...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Fayne R,Rengifo SS,Gonzalez I,Solorzano JL,Gonzalez D,Vega F,Cho-Vega JH

    更新日期:2020-04-01 00:00:00

  • Immunohistochemical expression of p16 protein in oral squamous cell carcinoma and lichen planus.

    abstract::Epithelial carcinogenesis is a multistep process. Specific genetic events lead to malignant transformation of oral epithelium. Oral squamous cell carcinoma (OSCC) may be preceded by potentially malignant lesions such as oral lichen planus (OLP). The p16 protein functions as a negative regulator of the cell cycle progr...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Salehinejad J,Sharifi N,Amirchaghmaghi M,Ghazi N,Shakeri MT,Ghazi A

    更新日期:2014-08-01 00:00:00

  • Differentiated squamous intraepithelial lesion (dSIL)-like changes in the epidermis overlying anogenital melanocytic nevi: A diagnostic pitfall.

    abstract:BACKGROUND:Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of th...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Michalova K,Kazakov DV,Michal M,Hadravsky L,Kacerovska D,Rychly B,Miesbauerova M,Michal M

    更新日期:2017-02-01 00:00:00

  • Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic study of 11 cases.

    abstract::Mammary analogue secretory carcinoma (MASC) is a recently described tumor sharing the histologic, immunohistochemical, and molecular profile of secretory carcinoma of breast. We aimed to evaluate the morphologic and histochemical features needed/required for the diagnosis of MASC without adjunct of molecular analysis....

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Din NU,Fatima S,Kayani N

    更新日期:2016-06-01 00:00:00

  • Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma.

    abstract::Although several lines of evidence existed suggesting that Mortalin was linked with survival in malignant tumors; it has been barely described regarding the prognostic involvement of its expression in hepatocellular carcinoma (HCC). Herein, to understand the prognostic meaning of Mortalin expression, Immunohistochemis...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Cheng W,Zhang B,Zikeliyar M,Wang J,Jian H,Wu K,Zhang Y,Ding J

    更新日期:2019-10-01 00:00:00

  • Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management.

    abstract::The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to m...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Calhoun BC,Collie AM,Lott-Limbach AA,Udoji EN,Sieck LR,Booth CN,Downs-Kelly E

    更新日期:2016-12-01 00:00:00

  • The cribriform features of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma: cytokeratin and integrin expression.

    abstract::Cribriform areas are common features of both adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Both are malignant salivary gland tumors that share similar histologic patterns, but with marked distinct clinical behavior. This study was undertaken to improve the accuracy of the histopathology diagnosti...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Araújo VC,Loducca SV,Sousa SO,Williams DM,Araújo NS

    更新日期:2001-12-01 00:00:00

  • Pleural body cavity-based lymphoma.

    abstract::We report a case of recurrent body cavity-based non-Hodgkin's lymphoma in a patient with advanced acquired immunodeficiency syndrome who presented with bilateral pleural effusions, without evidence of an associated tumor mass. The lymphoma cells were large and pleomorphic, lacking pan-T- and pan-B-cell markers, but ex...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Perez MT,Cabello-Inchausti B,Viamonte M Jr,Nixon D

    更新日期:1998-04-01 00:00:00

  • Fatal amebic encephalitis caused by Balamuthia mandrillaris in an immunocompetent host: a clinicopathological review of pathogenic free-living amebae in human hosts.

    abstract::Encephalitis caused by Balamuthia amebic species is an increasingly recognized chronic granulomatous infectious process that may affect both immunocompetent and immunocompromised individuals. The course of the disease is insidious but fatal in most cases, mainly because of delayed diagnosis, difficulty in isolation an...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Perez MT,Bush LM

    更新日期:2007-12-01 00:00:00

  • Correlation of anal cytology with follow-up histology and Human Papillomavirus genotyping: A 10-year experience from an academic medical center.

    abstract:BACKGROUND:Anal cytology (AC) is accepted as a practical screening modality for anal cancer. However, studies suggest that AC and anal biopsy dysplasia correlation is less robust than in cervicovaginal specimens. The current study goals were to look at our institutional experience in a subset of ACs and correlate with ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Hopp AM,Pant M,Sniedze S,Parsons LN,Hunt B,Giorgadze T

    更新日期:2020-11-20 00:00:00

  • Processing the entire capsule in thyroid follicular lesions improves diagnostic accuracy.

    abstract:BACKGROUND:There is contradictory evidence in literature with respect to diagnosis and management of follicular lesions of the thyroid gland. From surgical pathology stand point, pathologists require submission and processing of entire capsule for microscopic evaluation. This can be extremely challenging especially in ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Hamza A,Khawar S,Alrajjal A,Salehi S

    更新日期:2019-04-01 00:00:00

  • Anaplastic large cell lymphoma: another entity in the differential diagnosis of small round blue cell tumors.

    abstract::We saw in consultation a biopsy specimen from a 6-year old girl with anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL). The tumor arose in soft tissue of the neck, and diagnostic tissue was obtained by core needle biopsy. Histologically, the neoplasm was cellular without pattern. Immunohi...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Gustafson S,Medeiros LJ,Kalhor N,Bueso-Ramos CE

    更新日期:2009-12-01 00:00:00

  • Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement.

    abstract::Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Flucke U,Shepard SJ,Bekers EM,Tirabosco R,van Diest PJ,Creytens D,van Gorp JM

    更新日期:2018-08-01 00:00:00

  • Distinctive immunohistochemical staining in littoral cell angioma using ERG and WT-1.

    abstract::Littoral cell angioma (LCA) is a rare vascular tumor of the spleen. It has an immunohistochemical staining pattern that is somewhat distinctive but can still be occasionally confused with other vascular and stromal proliferations in the spleen. In this study, LCA was evaluated using Ets-related gene (ERG) and Wilms tu...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: O'Malley DP,Kim YS,Weiss LM

    更新日期:2015-06-01 00:00:00

  • Cutaneous pseudosarcomatous polyp: a recently described lesion.

    abstract::Three cases of cutaneous pseudosarcomatous polyp, a lesion recently described in the dermatopathology literature, are reported here. These benign proliferations display dramatic cytologic pleomorphism, but despite their disquieting morphological features, they have behaved in a benign fashion to date. All 3 lesions in...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Cathro HP,Patterson JW,Wick MR

    更新日期:2008-12-01 00:00:00

  • Cell turnover in apocrine metaplasia and apocrine adenosis of the breast.

    abstract::Apocrine metaplasia (APM) is a common finding in the breast of postmenopausal women and is seen in a broad spectrum of lesions ranging from microscopic cysts to invasive apocrine carcinoma. Apocrine metaplasia within sclerosing adenosis is known as apocrine adenosis (AA) and is considered a benign lesion of the breast...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Elayat G,Selim AG,Wells CA

    更新日期:2010-02-01 00:00:00

  • A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology.

    abstract::In the recent years, basaloid squamous cell carcinomas (BSCCs) have gained attention because of (1) observation of a relative increase in the number of tumors arising particularly in head and neck sites, (2) identification of human papillomavirus (HPV) in BSCCs arising predominantly in the oropharynx, and (3) controve...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审


    authors: Jayasooriya PR,Tilakaratne WM,Mendis BR,Lombardi T

    更新日期:2013-12-01 00:00:00

  • Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is rare, benign lesion using modified stringent diagnostic criteria: Reclassification and outcome study.

    abstract:BACKGROUND:Rigid diagnostic criteria for NIFTP have been recently proposed. The frequency of NIFTP using the new criteria is unknown, and whether abortive papillae are associated with BRAFV600E mutation has not been studied. The aim of this study is to identify NIFTP by a retrospective review of Follicular Variant of P...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Cubero Rego D,Lee H,Boguniewicz A,Jennings TA

    更新日期:2020-02-01 00:00:00

  • Clinicopathological spectrum of a series of Merkel cell carcinomas diagnosed at a tertiary cancer referral center in India, with current concepts.

    abstract::Merkel cell carcinoma (MCC) is a rare, clinically aggressive primary cutaneous neuroendocrine carcinoma. The present series describes clinicopathological features of 16 MCCs diagnosed at a tertiary cancer referral center. Sixteen MCCs occurred in 10 men and 6 women (M/F = 1.6:1), between the ages 37 and 74 years (mean...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Rekhi B,Kane SV,Jambhekar NA

    更新日期:2015-10-01 00:00:00

  • Hepatoid adenocarcinoma of the stomach.

    abstract::A 54-year-old man presented to his doctor with hematemesis and was found at endoscopy to have an ulcerated lesion in his stomach. A computed tomography scan was performed and revealed a mass in the fundus of the stomach. Multiple other lesions were identified in the liver, lungs, retroperitoneal space, and mesentery. ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Plaza JA,Vitellas K,Frankel WL

    更新日期:2004-06-01 00:00:00

  • Frozen section discrepancy in the evaluation of nonneoplastic central nervous system samples.

    abstract::Frozen section (FS) for intraoperative evaluation of central nervous system (CNS) lesions provides the neurosurgeon with a rapid preliminary pathologic diagnosis. Diagnosis of nonneoplastic lesions is particularly challenging in this venue. To highlight common diagnostic pitfalls, we sought to identify discrepancies b...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Plesec TP,Prayson RA

    更新日期:2009-12-01 00:00:00

  • The role of routine immunohistochemistry for Helicobacter pylori in gastric biopsy.

    abstract::Helicobacter pylori infection is associated with gastritis, gastric ulcer, gastric adenocarcinoma, and mucosal associated lymphoid tissue lymphoma. Documenting the presence of H pylori in a gastric biopsy is essential for appropriate patient care. Several special stains and immunohistochemistry (IHC) stain for H pylor...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章


    authors: Wang XI,Zhang S,Abreo F,Thomas J

    更新日期:2010-08-01 00:00:00