Correlation of anal cytology with follow-up histology and Human Papillomavirus genotyping: A 10-year experience from an academic medical center.

Abstract:

BACKGROUND:Anal cytology (AC) is accepted as a practical screening modality for anal cancer. However, studies suggest that AC and anal biopsy dysplasia correlation is less robust than in cervicovaginal specimens. The current study goals were to look at our institutional experience in a subset of ACs and correlate with surgical pathology (SP), as well as evaluate their Human Papillomavirus (HPV) status. METHODS:377 ACs from 169 patients (151 males and 18 females) from 2008 to 2017 were included. HPV genotyping (n = 47) and SP within one year of AC (n = 58) were reviewed. RESULTS:AC/SP was discrepant in 22 cases (37.9%), with a tendency towards AC underestimating the degree of dysplasia. Specifically, any abnormality on AC was 93.8% sensitive for detecting high-grade dysplasia (HGD). However, when requiring a high-grade AC diagnosis, the sensitivity decreases to 12.5%. "Other high-risk HPV" was the most common genotype (57.4%). When considered with all AC with a high-grade diagnosis, co-testing with HPV improved the sensitivity for HGD to 56.3%. Sensitivity improved further to 87.5% when only considering cases with both AC and HPV testing, and were high-risk HPV positive. Furthermore, following review and consensus diagnosis, 8 cases changed from "Discrepant" to "Agreed", reducing the discrepancy rate to 24.1%. Remaining discrepancies were explained by sampling error. CONCLUSION:Given the enhanced sensitivity of AC and HPV testing together, and sampling error seen with AC leading to underestimating dysplasia, we recommend AC and HPV co-testing, as well as describing confounding factors in AC reports and obtaining consensus opinion in equivocal cases.

journal_name

Ann Diagn Pathol

authors

Hopp AM,Pant M,Sniedze S,Parsons LN,Hunt B,Giorgadze T

doi

10.1016/j.anndiagpath.2020.151670

subject

Has Abstract

pub_date

2020-11-20 00:00:00

pages

151670

eissn

1092-9134

issn

1532-8198

pii

S1092-9134(20)30216-1

journal_volume

50

pub_type

杂志文章
  • Bilateral renal tumors; conventional clear cell carcinoma and contralateral t(6;11)/t(X;17)-like tumor Histomorphologic, immunohistochemical, ultrastructural and molecular genetic studies including the report of a novel mutation in the VHL gene.

    abstract::A 34-year-old pregnant woman with bilateral kidney tumors 9.5 and 2.5 cm in maximum diameter is presented. The larger tumor was clear renal cell carcinoma. The smaller contralateral tumor was focally HMB45 positive and had unusual histomorphology, including features resembling clear renal cell carcinoma with features ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2010.05.004

    authors: Petersson F,Michal M,Vaněček T,Hora M,Trivunic S,Halbhuber Z,Hes O

    更新日期:2011-10-01 00:00:00

  • Invasive ductal carcinoma of the breast with a microglandular adenosis pattern.

    abstract::Invasive breast carcinomas of special type are composed of up to 35% of all cases, such as tubular carcinoma, mucinous carcinoma, invasive cribriform carcinoma, lobular carcinoma, metaplastic carcinoma, medullary carcinoma, and other rare variants. They are recognized by their specific growth and morphologic patterns,...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2003.11.009

    authors: Shen SS,Sahin AA

    更新日期:2004-02-01 00:00:00

  • Measuring the dimension of invasive component in pT1 urothelial carcinoma in transurethral resection specimens can predict time to recurrence.

    abstract::Recurrences of nonmuscle-invasive urothelial bladder cancer are very common following resection. Predictive histopathologic variables in transurethral resection of bladder tumor (TURBT) specimens are of particular importance especially in determining the behavior of lamina propria-invasive tumors (high grade T1 stage)...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.11.002

    authors: Hu Z,Mudaliar K,Quek ML,Paner GP,Barkan GA

    更新日期:2014-04-01 00:00:00

  • Lipomatous supratentorial primitive neuroectodermal tumor with glioblastomatous differentiation.

    abstract::Cases of cerebral neuroblastoma or supratentorial primitive neuroectodermal tumor with malignant gliomatous components are relatively uncommon. Less frequent is the combination of these 2 elements with a mesenchymal component. This is a case report of a lipomatous supratentorial primitive neuroectodermal tumor with gl...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.04.009

    authors: Prayson RA

    更新日期:2009-02-01 00:00:00

  • The cribriform features of adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma: cytokeratin and integrin expression.

    abstract::Cribriform areas are common features of both adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Both are malignant salivary gland tumors that share similar histologic patterns, but with marked distinct clinical behavior. This study was undertaken to improve the accuracy of the histopathology diagnosti...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2001.29339

    authors: Araújo VC,Loducca SV,Sousa SO,Williams DM,Araújo NS

    更新日期:2001-12-01 00:00:00

  • Reflections on the use of controls in immunohistochemistry and proposal for application of a multitissue spring-roll control block.

    abstract::The conventional positive control in immunohistochemistry consists of a separately immunostained slide containing tissue known to show positive reaction with the antibody. Although it can indicate that the reagents are sound, it cannot guarantee that the appropriate reagents have indeed been dispensed in the correct o...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2000.17892

    authors: Chan JK,Wong CS,Ku WT,Kwan MY

    更新日期:2000-10-01 00:00:00

  • Gonadal tumor with granulosa cell tumor features in an adult testis.

    abstract::Granulosa cell tumor is almost exclusively an ovarian tumor. Rare cases of granulosa cell tumor have been reported involving the testes. We report a testicular gonadal stromal tumor with granulosa cell differentiation in a 54-year-old white man. The tumor was discovered by an ultrasound evaluation for left hydrocele. ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2002.30607

    authors: Wang BY,Rabinowitz DS,Granato RC Sr,Unger PD

    更新日期:2002-02-01 00:00:00

  • Carcinoid tumor of the gall bladder.

    abstract::Carcinoid of the gall bladder and bile duct is a rare tumor. Primary gall bladder and biliary duct system carcinoids constitute less than 1% of all carcinoid tumors arising from different parts of the body. We describe a case of carcinoid tumor of the gall bladder in a 53-year-old woman. The rarity of this entity prom...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2005.12.003

    authors: Anjaneyulu V,Shankar-Swarnalatha G,Rao SC

    更新日期:2007-04-01 00:00:00

  • Pathologic approach to pulmonary hemorrhage.

    abstract::The pathologist's approach to pulmonary hemorrhage is outlined. Most cases fall into those examples of pulmonary hemorrhage caused by localized sites of bleeding, and those examples that fall within the spectrum of diffuse alveolar hemorrhage. The histologic evaluation of pulmonary hemorrhage is outlined including ass...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2001.27923

    authors: Colby TV,Fukuoka J,Ewaskow SP,Helmers R,Leslie KO

    更新日期:2001-10-01 00:00:00

  • Lymphoglandular bodies in malignant tumors: with special reference to histologic specimens.

    abstract::Lymphoglandular bodies (LGBs) have been described as cytoplasmic fragments of lymphocytes and a specific feature of organized lymphoid tissue. The recognition of LGBs is useful in distinguishing malignant lymphomas from carcinomas and sarcomas in cytology specimens, especially in Giemsa-stained tissues. So far, there ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.10.001

    authors: Murakami T,Kayano H,Itoh T,Shimizu Y,Ban S,Ogawa F,Sannohe S,Kondo S,Shimizu M

    更新日期:2008-08-01 00:00:00

  • Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features.

    abstract::Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-te...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2010.07.008

    authors: Kuroda N,Tamura M,Hamaguchi N,Mikami S,Pan CC,Brunelli M,Martignoni G,Hes O,Michal M,Lee GH

    更新日期:2011-12-01 00:00:00

  • A patient with prostate cancer and multiple myeloma-diagnostics and possible association of both diseases.

    abstract::In this report, we describe a case of a patient with prostate cancer and multiple myeloma as the second metachronous malignant disease. To our knowledge, synchronous occurrence of bone marrow prostate cancer metastases and multiple myeloma-as it was found in the clinical disease course of our patient-has not been docu...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2011.04.010

    authors: Sučić M,Bišof V,Cačić M,Kinda SB,Kolenc D,Ljubić N,Sučić T,Potočki K

    更新日期:2012-12-01 00:00:00

  • Ki-1 anaplastic large-cell lymphoma occurring at the site of ileocolonic anastomosis in a patient treated surgically for colonic adenocarcinoma: case report and review of the literature.

    abstract::Systemic anaplastic large-cell lymphoma is an uncommon type of non-Hodgkin lymphoma characterized by strong expression of the Ki-1 (CD30) antigen. Gastrointestinal involvement typically is less common than in other types of non-Hodgkin's lymphoma. We report a case of CD30-positive anaplastic large-cell lymphoma occurr...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2001.25408

    authors: Cooperberg MR,Fiedler PN

    更新日期:2001-06-01 00:00:00

  • Cholesteryl Ester Storage Disease: An underdiagnosed cause of cirrhosis in adults.

    abstract::Cholesteryl Ester Storage Disease (CESD), is a rare multisystem autosomal recessive disorder and belongs to the broad family of lysosomal storage disorders. It can present anytime from infancy and childhood to even adulthood. The clinical manifestations are generally severe in infants and with milder forms in adults. ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2017.02.005

    authors: Pant M,Oshima K

    更新日期:2017-12-01 00:00:00

  • Osteoclastlike giant cell tumor of the salivary gland.

    abstract::Giant cell tumor of the salivary gland is extremely rare, with only 15 cases published in the English literature. The tumor characteristically contains a mixture of multinucleated giant cells, resembling osteoclasts of bone, and neoplastic mononuclear cells. In about half of the reported cases, there is an associated ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.06.009

    authors: Fang X,Hicks DG,Hicks W Jr,Zhang S

    更新日期:2009-04-01 00:00:00

  • Neuropathology associated with ventricular assist devices: an autopsy series of 33 patients.

    abstract::The ventricular assist device (VAD) is a mechanical pump that has been shown to be an effective modality of cardiac support in patients with heart failure refractory to pharmacologic intervention and who are awaiting cardiac allograft transplantation. Neuropathologic findings in these patients have not been well descr...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2001.23019

    authors: Heverly DN,Prayson RA

    更新日期:2001-04-01 00:00:00

  • Serrated lesions of the colon A window on a more clear classification.

    abstract::Serrated polyps evaluation represents a challenge for pathologists for lacking of univocal criteria that leads to different inter -individual interpretation. The aim of our review is to offer an alternative simpler histologic and endoscopic approach to these lesions for a more correct relationship between endoscopists...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2019.05.006

    authors: Villanacci V,Baronchelli C,Manenti S,Bassotti G,Salviato T

    更新日期:2019-08-01 00:00:00

  • Chromophobe renal cell carcinoma: a morphologic and immunohistochemical study of 45 cases.

    abstract::The aim of this study was to evaluate the morphological spectrum of chromophobe renal cell carcinoma (CRCC) and diagnostic utility of a panel of three immunohistochemical stains. All cases of CRCC reported between 2002 and 2012 in the Section of Histopathology, Aga Khan University Hospital, were retrieved. A total of ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2013.06.005

    authors: Din NU,Fatima S,Ahmad Z

    更新日期:2013-12-01 00:00:00

  • Pleomorphic myofibrosarcoma of the tibia with aneuploid DNA content.

    abstract::Myofibrosarcomas of the tibia are exceedingly rare, with only one case reported in the literature. We describe DNA ploidy of high-grade myofibrosarcoma of the tibia in correlation with clinicomorphologic and ultrastructural features in a 16-year-old adolescent girl. Radiological studies revealed an expanding osteolyti...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2007.04.002

    authors: Gonzalez FA,Vazquez AC,Uscanga CC,Cortes IJ,Malagon D

    更新日期:2007-10-01 00:00:00

  • Inflammatory pseudotumor (myofibroblastic tumor) of the heart.

    abstract::Inflammatory pseudotumor (IPT) (also known as inflammatory myofibroblastic tumor) is an uncommon spindle cell lesion that was initially recognized in the lung and is now known to occur in virtually every major organ of the body. Its precise biological nature and clinical characteristics are still relatively uncertain....

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2002.32380

    authors: Li L,Cerilli LA,Wick MR

    更新日期:2002-04-01 00:00:00

  • Life-threatening hemoptysis caused by chronic idiopathic pulmonary hilar fibrosis with unilateral pulmonary vein occlusion.

    abstract::We present the case of a patient who has a life-threatening hemoptysis caused by occlusion of the right pulmonary vein owing to external compression by excessive fibrous tissue. Because the patient's lung was essentially nonfunctional and hemoptysis persisted, we performed a pneumonectomy on her. Pathological analysis...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2005.07.006

    authors: den Bakker MA,Thomeer M,Maat AP,Groeninx van Zoelen CE

    更新日期:2005-12-01 00:00:00

  • Observer reliability in assessment of mitotic activity and MIB-1-determined proliferation rate in pediatric sarcomas.

    abstract::In hematoxylin-eosin-stained sections of 20 pediatric sarcomas the mitotic index was assessed by four experienced pathologists and four less-experienced observers without prior instructions. In adjacent sections immunolabeled for MIB-1, the proliferation index was assessed as the estimated percentage of labeled cells ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2000.8126

    authors: Molenaar WM,Plaat BE,Berends ER,te Meerman GJ

    更新日期:2000-08-01 00:00:00

  • So-called sclerosing hemangioma of lung: current concept.

    abstract::Sclerosing hemangioma of the lung is a rare neoplasm with polymorphic histologic features. Despite various patterns, there are 2 unifying cellular components: "surface cells" and "round cells." Although histogenesis has been debated for decades, most ultrastructural, immunocytochemical, and molecular studies strongly ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1016/j.anndiagpath.2009.07.002

    authors: Kalhor N,Staerkel GA,Moran CA

    更新日期:2010-02-01 00:00:00

  • Primitive neuroectodermal tumor of the cervix: a clinicopathologic and immunohistochemical study of two cases.

    abstract::Two cases of primary primitive neuroectodermal tumors of the cervix are presented. The two female patients are 35 and 51 years of age who presented with abnormal uterine bleeding of several weeks' duration. On gynecologic examination, a mass in the cervical area was palpated and a biopsy was obtained. The initial biop...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1053/adpa.2002.35739

    authors: Malpica A,Moran CA

    更新日期:2002-10-01 00:00:00

  • Functioning adrenocortical oncocytoma: a case report and review of the literature.

    abstract::Adrenocortical oncocytoma is exceptionally rare. Most of these tumors are benign and nonfunctioning. We report a case of functioning adrenocortical oncocytoma located in the right adrenal gland in a 53-year-old woman who presented with Cushing's syndrome. The tumor was small, with exclusively oncocytic histologic feat...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2005.05.005

    authors: Xiao GQ,Pertsemlidis DS,Unger PD

    更新日期:2005-10-01 00:00:00

  • Acute respiratory distress syndrome and blastomycosis: presentation of nine cases and review of the literature.

    abstract::Mississippi has the highest prevalence of blastomycosis in the country. In 20 years and 5 months there were 123 patients treated for blastomycosis at the University of Mississippi Medical Center. Among these, 107 patients had lung involvement and nine patients (8.4%) developed acute respiratory distress syndrome. Seve...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章,评审

    doi:10.1053/adpa.2001.21473

    authors: Lemos LB,Baliga M,Guo M

    更新日期:2001-02-01 00:00:00

  • Expression of vitamin D receptor in clear cell papillary renal cell carcinoma.

    abstract::Clear cell papillary renal cell carcinoma (ccpRCC) is a recently recognized subtype of renal cell carcinoma. In this study, we investigated the clinicopathological and immunohistochemical features in a group of 26 cases of ccpRCC, with a special emphasis on the expression of vitamin D receptor (VDR). The mean age of p...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2018.06.007

    authors: Wang Y,Ding Y,Qin C,Gu M,Wang Z,Han C,Liu X,Li H,Hua H

    更新日期:2018-10-01 00:00:00

  • Aggressive (malignant) epithelial odontogenic ghost cell tumor.

    abstract::A 57-year-old man had an expanding cystic lesion of the anterior maxilla that demonstrated destruction and disruption of local structures. A cystic odontogenic neoplasm as well as various forms of odontogenic carcinoma was suspected. Incisional biopsy and microscopic examination revealed an aggressive epithelial odont...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/s1092-9134(99)80056-2

    authors: Castle JT,Arendt DM

    更新日期:1999-08-01 00:00:00

  • Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement.

    abstract::Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2018.05.003

    authors: Flucke U,Shepard SJ,Bekers EM,Tirabosco R,van Diest PJ,Creytens D,van Gorp JM

    更新日期:2018-08-01 00:00:00

  • Hepatoid adenocarcinoma of the stomach.

    abstract::A 54-year-old man presented to his doctor with hematemesis and was found at endoscopy to have an ulcerated lesion in his stomach. A computed tomography scan was performed and revealed a mass in the fundus of the stomach. Multiple other lesions were identified in the liver, lungs, retroperitoneal space, and mesentery. ...

    journal_title:Annals of diagnostic pathology

    pub_type: 杂志文章

    doi:10.1016/j.anndiagpath.2004.03.005

    authors: Plaza JA,Vitellas K,Frankel WL

    更新日期:2004-06-01 00:00:00