abstract：PURPOSE OF REVIEW:This article will review recent changes in the standard of care for olaparib, niraparib, and rucaparib, as well as ongoing trials evaluating this class of drugs in combination with antiangiogenic agents and PD-1/PD-L1 inhibitors. RECENT FINDINGS:Niraparib received FDA approval for use in patients wit...

journal_title：Current opinion in obstetrics & gynecology

authors： Washington CR,Moore KN

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight relevant strategies to overcome poly(ADP-ribose) polymerase (PARP) inhibitor resistance and present key clinical trials. RECENT FINDINGS:The use of PARP inhibition (PARPi) for frontline maintenance offers substantial clinical benefit in patients with homologous recombination-deficient tu...

journal_title：Current opinion in obstetrics & gynecology

authors： Hinchcliff E,Chelariu-Raicu A,Westin SN

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Amidst the worldwide coronavirus disease 2019 pandemic, a new medical landscape revolving around telemedicine has arisen. The purpose of this review is to describe and analyze current urogynecologic guidelines for optimizing usage of telemedicine when treating women with pelvic floor disorders. RECEN...

journal_title：Current opinion in obstetrics & gynecology

authors： Serna-Gallegos T,Ninivaggio CS

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:With over 50 million abortions annually and 25% of pregnancies ending in abortion worldwide, abortion is one of the most common medical procedures. Yet abortion-related topics are glaringly absent from medical school curricula in the USA with half of medical schools including no formal training or onl...

journal_title：Current opinion in obstetrics & gynecology

authors： Burns RM,Shaw KA

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Examine recent evidence of randomized controlled trials and meta-analyses regarding the effect of maternal vitamin D status and supplementation over obstetrical and offspring outcomes. RECENT FINDINGS:Maternal serum 25-hydroxyvitamin [25(OH)D] progressively declines during pregnancy because of fetal ...

journal_title：Current opinion in obstetrics & gynecology

authors： Pérez-López FR,Pilz S,Chedraui P

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence-based women's healthcare is underpinned by systematic reviews and guidelines. Generating an evidence synthesis to support guidance for clinical practice is a time-consuming and labour-intensive activity that delays transfer of research into practice. Artificial intelligence has the potential ...

journal_title：Current opinion in obstetrics & gynecology

authors： Amezcua-Prieto C,Fernández-Luna JM,Huete-Guadix JF,Bueno-Cavanillas A,Khan KS

更新日期：2020-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To avoid both overtreatment and undertreatment accurate risk assessment is mandatory. The present review gives an overview of recently published articles covering prognostic and predictive factors for adjuvant therapy in early breast cancer. RECENT FINDINGS:Gene expression signatures enhance prognost...

journal_title：Current opinion in obstetrics & gynecology

authors： Schmidt M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint blockade (ICB) is a promising area of cancer therapeutic research. Therapies targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) mechanism of tumor immune evasion have resulted in durable responses in many difficult-to-treat tumor types. While these...

journal_title：Current opinion in obstetrics & gynecology

authors： Chin CD,Fares CM,Konecny GE,Rao J

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To review minimally invasive modifications of traditional surgeries for female stress urinary incontinence (SUI) in light of increased demand. RECENT FINDINGS:Prior to the synthetic mid-urethral sling (MUS), traditional procedures were used to correct SUI. Often these were retropubic colposuspension ...

journal_title：Current opinion in obstetrics & gynecology

authors： Shaw JS

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an overview of recent research and guidelines regarding contraception and breastfeeding. RECENT FINDINGS:Recent studies assessed lactogenesis, breastfeeding rates, and milk supply concerns in patients starting postpartum hormonal contraception. One study showed a small but statistically si...

journal_title：Current opinion in obstetrics & gynecology

authors： Stanton TA,Blumenthal PD

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the complexity of caring for gynecologic patients who refuse blood transfusion and discusses the importance of early, targeted perioperative and intraoperative medical optimization. We review alternative interventions and the importance of medical management to minimize blood lo...

journal_title：Current opinion in obstetrics & gynecology

authors： Han ES,Arora C,Hur HC,Advincula AP,Kim JHJ

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To review important considerations in the counseling and management of women over the age of 40 desiring a myomectomy for symptomatic fibroids. RECENT FINDINGS:Women in the late reproductive and perimenopausal years may choose a myomectomy over a hysterectomy for reasons of fertility preservation or ...

journal_title：Current opinion in obstetrics & gynecology

authors： Pepin K,Reddy H,Clark NV

更新日期：2019-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The study of embryonic development through conventional microscopy has contributed significantly to the success of IVF. However, clinical pregnancy rates per transfer remain as low as 30% according to the latest records of European society if human reproduction and society if assisted reproduction. Co...

journal_title：Current opinion in obstetrics & gynecology

authors： Basile N,Elkhatib I,Meseguer M

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We review the techniques recently tested in both animal models and humans to provide a state-of-the-art on adult stem cell ovarian transplant to achieve ovarian rejuvenation in patients with diminished ovarian reserves. RECENT FINDINGS:As the firsts reports of spontaneous pregnancies achieved after b...

journal_title：Current opinion in obstetrics & gynecology

authors： Herraiz S,Pellicer N,Romeu M,Pellicer A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Maternal mental health disorders, including anxiety and depression, are one of the most common obstetric complications, presenting in pregnancy and postpartum. RECENT FINDINGS:Maternal mental health disorders are associated with adverse maternal and neonatal outcomes. Screening women in pregnancy and...

journal_title：Current opinion in obstetrics & gynecology

authors： Yeaton-Massey A,Herrero T

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Abortion services are essential in sexual and reproductive health and should be held to the same standards as other health services. Patient (or person)-centeredness is a key dimension of healthcare quality that incorporates the perspectives of patients in care provision. The purpose of this review is...

journal_title：Current opinion in obstetrics & gynecology

authors： Altshuler AL,Whaley NS

更新日期：2018-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The present article provides an overview of the molecular mechanisms underlying adolescent endometriosis and advances in both medical and surgical management. RECENT FINDINGS:Molecular and cellular features of endometriotic lesions differ from eutopic endometrium. There is altered estrogen-mediated c...

journal_title：Current opinion in obstetrics & gynecology

authors： Mama ST

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to outline ovarian conservation and fertility sparing surgery (FSS) in the management of the most common pediatric gynecology malignancies. RECENT FINDINGS:Management of gynecologic malignancies has evolved to have a greater appreciation for adverse late effects from rad...

journal_title：Current opinion in obstetrics & gynecology

authors： Stambough K,Childress KJ

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent findings related to possible causes of recurrent implantation failure of endometrial origin in normal uterus. RECENT FINDINGS:Recent evidences suggest that in apparently normal endometria, RIF may associate with molecular and functional changes in the uterus such as abnormal endometr...

journal_title：Current opinion in obstetrics & gynecology

authors： Bellver J,Simón C

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Telomere attrition and dysfunction has become a well established pathway involved in organismal aging, not only because it imposes a limitation to cell division and therefore, tissue regeneration but also because telomere homeostasis influences other pathways involved in aging. However, the implicatio...

journal_title：Current opinion in obstetrics & gynecology

authors： Varela E,Sánchez-de-Puerta I,García-Velasco JA

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Gonadotrophin in IVF increases the number of oocytes retrieved, and many doctors regard a high number of oocytes as a measurement of success in IVF. Thus, the dogma of more oocytes provides better IVF success has been broadly accepted. However, some European fertility specialists have argued against t...

journal_title：Current opinion in obstetrics & gynecology

authors： Lindenberg S,Almind GJ,Lindenberg FB

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. RECENT FINDINGS:Cells in germ series, including spe...

journal_title：Current opinion in obstetrics & gynecology

authors： Balmori C,Varela E

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiphospholipid syndrome (APS) is defined as the association of thrombotic events and/or obstetric morbidity in patients persistently positive for antiphospholipid antibodies (aPL). In this review, we will highlight the most important clinical presentations of APS with a focus on the obstetric morbid...

journal_title：Current opinion in obstetrics & gynecology

authors： Schreiber K,Radin M,Sciascia S

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The management of benign ovarian lesions in girls is currently a controversial topic in the pediatric surgical literature. The purpose of this review is to highlight the epidemiology of benign ovarian masses, outline preoperative risk stratification strategies, review the indications and importance of...

journal_title：Current opinion in obstetrics & gynecology

authors： Gonzalez DO,Minneci PC,Deans KJ

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D deficiency has been associated with a wide range of human disease states and the global epidemic, particularly in reproductive aged women, has led to a focus on this complex hormones role in human reproduction. Indeed vitamin D receptors are found throughout the reproductive tract in the ova...

journal_title：Current opinion in obstetrics & gynecology

authors： Franasiak JM,Lara EE,Pellicer A

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Growth hormone (GH) has been used as an adjunct in ovulation induction and IVF for 25 years, particularly as an adjunct to ovarian stimulation for women who had a previous poor response to stimulation in an IVF cycle. It does not have US Food and Drug Administration approval for this use. Unfortunatel...

journal_title：Current opinion in obstetrics & gynecology

authors： Hart RJ,Rombauts L,Norman RJ

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Traditionally, ovarian stimulation for IVF/intracytoplasmic sperm injection is performed by healthcare professionals, requiring the patient to make frequent visits to these centres. We describe the rationale, research findings and early clinical experience with home-based sonography for IVF patients. ...

journal_title：Current opinion in obstetrics & gynecology

authors： Gerris J

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Noninvasive prenatal diagnosis for single gene disorders is coming to fruition in its clinical utility. The presence of cell-free DNA in maternal plasma has been recognized for many years, and a number of applications have developed from this. Noninvasive prenatal diagnosis for single gene disorders h...

journal_title：Current opinion in obstetrics & gynecology

authors： Allen S,Young E,Bowns B

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Selective intrauterine growth restriction (sIUGR) in twin pregnancies presents a complex management problem for the fetal medicine specialist. This review summarizes what is currently known about sIUGR pathophysiology, particularly in monochorionic pregnancies and looks at the results of early trials ...

journal_title：Current opinion in obstetrics & gynecology

authors： Townsend R,Khalil A

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review current recommendations for the evaluation and management of delayed puberty in the female patient. RECENT FINDINGS:Kisspeptin activation has emerged as an important factor for initiation of pubertal development. Causes of delayed puberty can be considered in four main catego...

journal_title：Current opinion in obstetrics & gynecology

authors： Trotman GE

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article is to provide an update for the GP on selected common vulvar concerns in prepubertal girls. Presentation, diagnostic criteria, and management of common vulvar conditions will be described. The following conditions are frequently encountered and may pose diagnostic or manage...

journal_title：Current opinion in obstetrics & gynecology

authors： Vilano SE,Robbins CL

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to discuss the diagnosis, medical complications, and treatment of eating disorders as defined by the newly released Diagnostic and Statistical Manual, 5th edition. RECENT FINDINGS:With the introduction of the Diagnostic and Statistical Manual, 5th edition, the diagnostic...

journal_title：Current opinion in obstetrics & gynecology

authors： Sieke EH,Rome ES

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to understand the current use of minilaparoscopy in the field and how minilaparoscopy compares with traditional laparoscopy in terms of operative times, complications, pain, and cosmesis. RECENT FINDINGS:Although there are few randomized controlled trials comparing minil...

journal_title：Current opinion in obstetrics & gynecology

authors： Small Layne A,Pinkard L,Shepherd J

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Surgery can be an important treatment option for women with symptomatic endometriosis. This review summarizes the recommended preoperative work up and techniques in minimally invasive surgery for treatment of deeply infiltrating endometriosis (DIE) involving the obliterated posterior cul-de-sac, bowel...

journal_title：Current opinion in obstetrics & gynecology

authors： King CR,Lum D

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To review updated information on the influence of endometrial scratching on IVF. RECENT FINDINGS:Endometrial receptivity remains an important rate-limiting step affecting the success of IVF. The current evidence on the effect of endometrial scratching on IVF ranges from marked improvement, no differe...

journal_title：Current opinion in obstetrics & gynecology

authors： Ko JK,Ng EH

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The clinical utility of sperm DNA fragmentation tests needs to be revisited in light of increasing evidence of detrimental effect of sperm DNA damage on reproductive outcomes. RECENT FINDINGS:Current evidence supports the association between high sperm DNA fragmentation and poor outcomes with regards...

journal_title：Current opinion in obstetrics & gynecology

authors： Agarwal A,Cho CL,Esteves SC

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been increasing interest in developing assisted reproductive technologies to overcome failure at fertilization and early embryonic arrest. Some of the affected patients harbor too few copies of mitochondrial DNA (mtDNA) in their eggs at the time of fertilization, which results in development...

journal_title：Current opinion in obstetrics & gynecology

authors： St John JC,Tsai TS,Cagnone GL

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Noninvasive prenatal testing (NIPT) through the analysis of cell-free DNA in maternal plasma has rapidly changed screening for fetal chromosome abnormalities. We review practical and ethical challenges associated with the transition, progress in their resolution, and identify new emerging difficulties...

journal_title：Current opinion in obstetrics & gynecology

authors： Benn P,Chapman AR

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Expanded carrier screening, which detects carriers for a large number of autosomal recessive and X-linked diseases, is increasing in clinical utilization. A recent joint statement from multiple professional societies, in addition to a growing literature base, offers perspective on rationale, decision ...

journal_title：Current opinion in obstetrics & gynecology

authors： Lazarin GA,Goldberg JD

更新日期：2016-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Ductal carcinoma in situ (DCIS) accounts for approximately 20% of mammographically diagnosed breast cancers. Currently, there is a trend to consider DCIS as a lesion for which treatment deescalation is advocated to avoid overtreatment, that is, radiotherapy in addition to breast-conserving surgery or ...

journal_title：Current opinion in obstetrics & gynecology

authors： Lebeau A,Kühn T

更新日期：2016-02-01 00:00:00