abstract：:Uveitis is a group of diseases characterized by intraocular inflammation, of which some are driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada disease, Behçet's disease, uveitis associated with spondyloarthritis, ocular sarcoidosis, sympathetic ophthalmia and birdshot chorioretinopathy. T...

journal_title：Progress in retinal and eye research

authors： Zhong Z,Su G,Kijlstra A,Yang P

更新日期：2021-01-01 00:00:00

abstract：:Gene expression provides valuable insight into cell function. As such, vision researchers have frequently employed gene expression studies to better understand retinal physiology and disease. With the advent of single-cell RNA sequencing, expression experiments provide an unparalleled resolution of information. Instea...

journal_title：Progress in retinal and eye research

authors： Voigt AP,Mullin NK,Stone EM,Tucker BA,Scheetz TE,Mullins RF

更新日期：2020-12-28 00:00:00

abstract：:Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO regulates the contractility of vascular smooth muscle cells and permeability of endothelial cells in response to either biochemical or biomecha...

journal_title：Progress in retinal and eye research

authors： Reina-Torres E,De Ieso ML,Pasquale LR,Madekurozwaa M,van Batenburg-Sherwooda J,Overby DR,Stamer WD

更新日期：2020-11-28 00:00:00

abstract：:Recombinant adeno-associated virus (AAV) is the leading vector for gene therapy in the retina. As non-pathogenic, non-integrating, replication deficient vector, the recombinant virus efficiently transduces all key retinal cell populations. Successful testing of AAV vectors in clinical trials of inherited retinal disea...

journal_title：Progress in retinal and eye research

authors： Bucher K,Rodríguez-Bocanegra E,Dauletbekov D,Fischer MD

更新日期：2020-10-15 00:00:00

abstract：:Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a marked impact on the wellbeing and productivity of individuals and has a major economic impact on healthcare providers. The only means of treating cataract is by surgical intervention. A modern cataract operation generates a...

journal_title：Progress in retinal and eye research

authors： Wormstone IM,Wormstone YM,Smith AJO,Eldred JA

更新日期：2020-09-22 00:00:00

abstract：:Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the second most abundant protein in the corneal stroma. In this review, we summarize the current knowledge concerning the expression, molecular structure, binding partners, and functions of human TGFBIp. To date, 74 mutations in...

journal_title：Progress in retinal and eye research

authors： Nielsen NS,Poulsen ET,Lukassen MV,Chao Shern C,Mogensen EH,Weberskov CE,DeDionisio L,Schauser L,Moore TCB,Otzen DE,Hjortdal J,Enghild JJ

更新日期：2020-07-01 00:00:00

abstract：:Age-related diseases, including age-related macular degeneration (AMD), are of growing importance in a world where population ageing has become a dominant global trend. Although a wide variety of risk factors for AMD have been identified, age itself remains by far the most important risk factor, making it an urgent pr...

journal_title：Progress in retinal and eye research

authors： Rozing MP,Durhuus JA,Krogh Nielsen M,Subhi Y,Kirkwood TB,Westendorp RG,Sørensen TL

更新日期：2020-05-01 00:00:00

abstract：:Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by th...

journal_title：Progress in retinal and eye research

authors： Munier FL,Beck-Popovic M,Chantada GL,Cobrinik D,Kivelä TT,Lohmann D,Maeder P,Moll AC,Carcaboso AM,Moulin A,Schaiquevich P,Bergin C,Dyson PJ,Houghton S,Puccinelli F,Vial Y,Gaillard MC,Stathopoulos C

更新日期：2019-11-01 00:00:00

abstract：:Compression of the optic chiasm causes an optic neuropathy that may be associated with reversible visual loss often immediately following surgical decompression. While the precise pathogenesis of retinal ganglion cell impairment and eventual death remains poorly understood, a number of putative mechanisms may play a r...

journal_title：Progress in retinal and eye research

authors： Danesh-Meyer HV,Yoon JJ,Lawlor M,Savino PJ

更新日期：2019-11-01 00:00:00

abstract：:Axonal degeneration is an active, highly controlled process that contributes to beneficial processes, such as developmental pruning, but also to neurodegeneration. In glaucoma, ocular hypertension leads to vision loss by killing the output neurons of the retina, the retinal ganglion cells (RGCs). Multiple processes ha...

journal_title：Progress in retinal and eye research

authors： Syc-Mazurek SB,Libby RT

更新日期：2019-11-01 00:00:00

abstract：:The ability of the human lens to accommodate is mediated by the ciliary muscle and zonule; the manifest optical power changes depend on the shape and material properties of the lens. The latter are difficult to measure with accuracy and, given the dynamic aspects of accommodation and the ageing of cells and tissues, t...

journal_title：Progress in retinal and eye research

authors： Wang K,Pierscionek BK

更新日期：2019-07-01 00:00:00

abstract：:Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the degeneration of one or two retinal cell types that cannot r...

journal_title：Progress in retinal and eye research

authors： Jin ZB,Gao ML,Deng WL,Wu KC,Sugita S,Mandai M,Takahashi M

更新日期：2019-03-01 00:00:00

abstract：:The timecourse and extent of changes in pupil area in response to light are reviewed in all classes of vertebrate and cephalopods. Although the speed and extent of these responses vary, most species, except the majority of teleost fish, show extensive changes in pupil area related to light exposure. The neuromuscular ...

journal_title：Progress in retinal and eye research

authors： Douglas RH

更新日期：2018-09-01 00:00:00

abstract：:Autoimmune diseases usually follow a relapsing-remitting or a chronic progressive course. To understand the underlying immunopathogenesis we investigated experimental Lewis rat models displaying both disease types, which were only dependent on the autoantigen peptide used for immunization. Retinal S-Antigen-peptide PD...

journal_title：Progress in retinal and eye research

authors： Diedrichs-Möhring M,Kaufmann U,Wildner G

更新日期：2018-07-01 00:00:00

abstract：:Age related macular degeneration (AMD) is a complex multifactorial disease caused by the interplay of age and genetic and environmental risk factors. A common feature observed in early and both forms of late AMD is the breakdown of the physiologically immunosuppressive subretinal environment and the protracted accumul...

journal_title：Progress in retinal and eye research

authors： Guillonneau X,Eandi CM,Paques M,Sahel JA,Sapieha P,Sennlaub F

更新日期：2017-11-01 00:00:00

abstract：:Imaging techniques based on retinal autofluorescence have found broad applications in ophthalmology because they are extremely sensitive and noninvasive. Conventional fundus autofluorescence imaging measures fluorescence intensity of endogenous retinal fluorophores. It mainly derives its signal from lipofuscin at the ...

journal_title：Progress in retinal and eye research

authors： Dysli C,Wolf S,Berezin MY,Sauer L,Hammer M,Zinkernagel MS

更新日期：2017-09-01 00:00:00

abstract：:The thickness of tear film has been investigated under both invasive and non-invasive methods. While invasive methods are largely historical, more recent noninvasive methods are generally based on optical approaches that provide accurate, precise, and rapid measures. Optical microscopy, interferometry, and optical coh...

journal_title：Progress in retinal and eye research

authors： Bai Y,Nichols JJ

更新日期：2017-05-01 00:00:00

abstract：:Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve. For several decades, we have understood that the RGC death process was executed by apoptosis, suggesting that there may be ways to therapeutically intervene in this cell death program and provide a more direct treatment to the...

journal_title：Progress in retinal and eye research

authors： Maes ME,Schlamp CL,Nickells RW

更新日期：2017-03-01 00:00:00

abstract：:Autophagy is a catabolic pathway that promotes the degradation and recycling of cellular components. Proteins, lipids, and even whole organelles are engulfed in autophagosomes and delivered to the lysosome for elimination. In response to stress, autophagy mediates the degradation of cell components, which are recycled...

journal_title：Progress in retinal and eye research

authors： Boya P,Esteban-Martínez L,Serrano-Puebla A,Gómez-Sintes R,Villarejo-Zori B

更新日期：2016-11-01 00:00:00

abstract：:Diabetes mellitus (DM) is a major health problem with devastating effects on ocular health in both industrialized and developing countries. The control of hyperglycemia is critical to minimizing the impact of DM on ocular tissues because inadequate glycemic control leads to ocular tissue changes that range from a temp...

journal_title：Progress in retinal and eye research

authors： Kador PF,Wyman M,Oates PJ

更新日期：2016-09-01 00:00:00

abstract：:The rationale behind hyperacute fibrinolytic therapy for cerebral and retinal arterial occlusion is to rescue ischaemic cells from irreversible damage through timely restitution of tissue perfusion. In cerebral stroke, an anoxic tissue compartment (the "infarct core") is surrounded by a hypoxic compartment (the "ischa...

journal_title：Progress in retinal and eye research

authors： McLeod D,Beatty S

更新日期：2015-11-01 00:00:00

abstract：:Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two cell types, trabecular meshwork (TM) and Schlemm's canal (SC) endothelia, interact in the juxtacanalicular tissue (JCT) region of the conve...

journal_title：Progress in retinal and eye research

authors： Stamer WD,Braakman ST,Zhou EH,Ethier CR,Fredberg JJ,Overby DR,Johnson M

更新日期：2015-01-01 00:00:00

abstract：:The dedicator of cytokinesis (Dock) family is composed of atypical guanine exchange factors (GEFs) that activate the Rho GTPases Rac1 and Cdc42. Rho GTPases are best documented for their roles in actin polymerization and they regulate important cellular functions, including morphogenesis, migration, neuronal developme...

journal_title：Progress in retinal and eye research

authors： Namekata K,Kimura A,Kawamura K,Harada C,Harada T

更新日期：2014-11-01 00:00:00

abstract：:Neuroprotection is an emerging challenge in ophthalmology due to the particularly exposed location of retinal neurons and to the steadily increasing rate of intraocular surgical and pharmacological treatments applied to various eye diseases. Within few decades neuroprotection has developed from strongly contested appr...

journal_title：Progress in retinal and eye research

authors： Thanos S,Böhm MR,Meyer zu Hörste M,Prokosch-Willing V,Hennig M,Bauer D,Heiligenhaus A

更新日期：2014-09-01 00:00:00

abstract：:Historically understudied, cholesterol in the retina is receiving more attention now because of genetic studies showing that several cholesterol-related genes are risk factors for age-related macular degeneration (AMD) and because of eye pathology studies showing high cholesterol content of drusen, aging Bruch's membr...

journal_title：Progress in retinal and eye research

authors： Pikuleva IA,Curcio CA

更新日期：2014-07-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a common cause of irreversible visual loss and the disease burden is rising world-wide as the population ages. Both environmental and genetic factors contribute to the development of this disease. Among environmental factors, smoking, obesity and dietary factors including anti...

journal_title：Progress in retinal and eye research

authors： Sobrin L,Seddon JM

更新日期：2014-05-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world. AMD is a clinically heterogeneous disease presenting with drusen, pigmentary changes, geographic atrophy and/or choroidal neovascularization. Due to its heterogeneous presentation, it c...

journal_title：Progress in retinal and eye research

authors： Saksens NT,Fleckenstein M,Schmitz-Valckenberg S,Holz FG,den Hollander AI,Keunen JE,Boon CJ,Hoyng CB

更新日期：2014-03-01 00:00:00

abstract：:The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discover...

journal_title：Progress in retinal and eye research

authors： Borooah S,Phillips MJ,Bilican B,Wright AF,Wilmut I,Chandran S,Gamm D,Dhillon B

更新日期：2013-11-01 00:00:00

abstract：:Disturbances in the retinal vascular supply are involved in the pathophysiology of the most frequent diseases causing visual impairment and blindness in the Western World. These diseases are diagnosed by noting how morphological lesions in the retina vary in shape, size, location and dynamics, and subsequently conclud...

journal_title：Progress in retinal and eye research

authors： Bek T

更新日期：2013-09-01 00:00:00

abstract：:In a typical fish eye, the crystalline lens is the only refractive element. It is spherical in shape and has high refractive power. Most fish species have elaborate color vision and spectral sensitivity may range from the near-infrared to the near-ultraviolet. Longitudinal chromatic aberration exceeds depth of focus a...

journal_title：Progress in retinal and eye research

authors： Kröger RH

更新日期：2013-05-01 00:00:00

abstract：:Vision is the most important sense for humans and it is irreversibly impaired by axonal damage of retinal ganglion cells (RGCs) in the optic nerve due to the lack of axonal regeneration. The failure of regeneration is partially attributable to factors located in the inhibitory environment of the forming glial scar and...

journal_title：Progress in retinal and eye research

authors： Fischer D,Leibinger M

更新日期：2012-11-01 00:00:00

abstract：:The refractive power of a lens is determined largely by its surface curvatures and the refractive index of its medium. These properties can also be used to control the sharpness of focus and hence the image quality. One of the most effective ways of doing this is with a gradient index. Eye lenses of all species, thus ...

journal_title：Progress in retinal and eye research

authors： Pierscionek BK,Regini JW

更新日期：2012-07-01 00:00:00

abstract：:Bacterial endophthalmitis is a sight threatening infection of the interior structures of the eye. Incidence in the US has increased in recent years, which appears to be related to procedures being performed on an aging population. The advent of outpatient intravitreal therapy for management of age-related macular dege...

journal_title：Progress in retinal and eye research

authors： Sadaka A,Durand ML,Gilmore MS

更新日期：2012-07-01 00:00:00

abstract：:The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the ocular surface. The integrity of this unit is necessary for the health and normal function of the eye and visual system. Nervous connec...

journal_title：Progress in retinal and eye research

authors： Barabino S,Chen Y,Chauhan S,Dana R

更新日期：2012-05-01 00:00:00

abstract：:In vertebrates, the innate and adaptive immune systems have evolved seamlessly to protect the host by rapidly responding to danger signals, eliminating pathogens and creating immunological memory as well as immunological tolerance to self. The innate immune system harnesses receptors that recognize conserved pathogen ...

journal_title：Progress in retinal and eye research

authors： Willermain F,Rosenbaum JT,Bodaghi B,Rosenzweig HL,Childers S,Behrend T,Wildner G,Dick AD

更新日期：2012-03-01 00:00:00

abstract：:Successful restoration of vision in human patients with gene therapy affirmed its promise to cure ocular diseases and disorders. The efficacy of gene therapy is contingent upon vector and mode of therapeutic DNA introduction into targeted cells/tissues. The cornea is an ideal tissue for gene therapy due to its ease of...

journal_title：Progress in retinal and eye research

authors： Mohan RR,Tovey JC,Sharma A,Tandon A

更新日期：2012-01-01 00:00:00

abstract：:Purines (in particular, ATP and adenosine) act as neuro- and gliotransmitters in the sensory retina where they are involved in bidirectional neuron-glia signaling. This review summarizes the present knowledge about the expression and functional importance of P1 (adenosine) and P2 (nucleotide) receptors in Müller glial...

journal_title：Progress in retinal and eye research

authors： Wurm A,Pannicke T,Iandiev I,Francke M,Hollborn M,Wiedemann P,Reichenbach A,Osborne NN,Bringmann A

更新日期：2011-09-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) forms the outer blood-retinal barrier by regulating the movement of solutes between the fenestrated capillaries of the choroid and the photoreceptor layer of the retina. Blood-tissue barriers use various mechanisms to accomplish their tasks including membrane pumps, transporters, a...

journal_title：Progress in retinal and eye research

authors： Rizzolo LJ,Peng S,Luo Y,Xiao W

更新日期：2011-09-01 00:00:00

abstract：:Light-emitting diodes (LEDs) are taking an increasing place in the market of domestic lighting because they produce light with low energy consumption. In the EU, by 2016, no traditional incandescent light sources will be available and LEDs may become the major domestic light sources. Due to specific spectral and energ...

journal_title：Progress in retinal and eye research

authors： Behar-Cohen F,Martinsons C,Viénot F,Zissis G,Barlier-Salsi A,Cesarini JP,Enouf O,Garcia M,Picaud S,Attia D

更新日期：2011-07-01 00:00:00

abstract：:Regeneration of visual pigments is essential for sustained visual function. Although the requirement for non-photochemical regeneration of the visual chromophore, 11-cis-retinal, was recognized early on, it was only recently that the trans to cis retinoid isomerase activity required for this process was assigned to a ...

journal_title：Progress in retinal and eye research

authors： Kiser PD,Palczewski K

更新日期：2010-09-01 00:00:00