Abstract：
:Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the degeneration of one or two retinal cell types that cannot regenerate spontaneously in humans. Aberrant retinal pigment epithelial (RPE) cells can be observed through optical coherence tomography (OCT) in AMD patients. In RP patients, the morphological and functional abnormalities of RPE and photoreceptor layers are caused by a genetic abnormality. Stargardt's disease or juvenile macular degeneration, which is characterized by the loss of the RPE and photoreceptors in the macular area, causes central vision loss at an early age. Loss of retinal ganglion cells (RGCs) can be observed in patients with glaucoma. Once the retinal cell degeneration is triggered, no treatments can reverse it. Transplantation-based approaches have been proposed as a universal therapy to target patients with various concomitant diseases. Both the replacement of dead cells and neuroprotection are strategies used to rescue visual function in animal models of retinal degeneration. Diverse retinal cell types derived from pluripotent stem cells, including RPE cells, photoreceptors, RGCs and even retinal organoids with a layered structure, provide unlimited cell sources for transplantation. In addition, mesenchymal stem cells (MSCs) are multifunctional and protect degenerating retinal cells. The aim of this review is to summarize current findings from preclinical and clinical studies. We begin with a brief introduction to retinal degenerative diseases and cell death in diverse diseases, followed by methods for retinal cell generation. Preclinical and clinical studies are discussed, and future concerns about efficacy, safety and immunorejection are also addressed.
journal_name
Prog Retin Eye Resjournal_title
Progress in retinal and eye researchauthors
Jin ZB,Gao ML,Deng WL,Wu KC,Sugita S,Mandai M,Takahashi Mdoi
10.1016/j.preteyeres.2018.11.003subject
Has Abstractpub_date
2019-03-01 00:00:00pages
38-56eissn
1350-9462issn
1873-1635pii
S1350-9462(17)30123-4journal_volume
69pub_type
杂志文章,评审abstract：:This review considers the critical role of the conjunctiva in determining the success or failure of glaucoma filtration surgery. Glaucoma filtration surgery can be defined as an attempt to lower intraocular pressure (IOP) by the surgical formation of an artificial drainage pathway from the anterior chamber to the subc...
journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2017.01.002
更新日期：2017-03-01 00:00:00
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2017.06.005
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
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abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world. AMD is a clinically heterogeneous disease presenting with drusen, pigmentary changes, geographic atrophy and/or choroidal neovascularization. Due to its heterogeneous presentation, it c...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2013.11.001
更新日期：2014-03-01 00:00:00
abstract：:Compression of the optic chiasm causes an optic neuropathy that may be associated with reversible visual loss often immediately following surgical decompression. While the precise pathogenesis of retinal ganglion cell impairment and eventual death remains poorly understood, a number of putative mechanisms may play a r...
journal_title：Progress in retinal and eye research
pub_type： 杂志文章,评审
doi：10.1016/j.preteyeres.2019.06.001
更新日期：2019-11-01 00:00:00
