abstract：BACKGROUND:Tailored Antiplatelet Initiation to Lessen Outcomes Due to Decreased Clopidogrel Response after Percutaneous Coronary Intervention (TAILOR-PCI) is the largest cardiovascular genotype-based randomized pragmatic trial (NCT#01742117) to evaluate the role of genotype-guided selection of oral P2Y12 inhibitor ther...

journal_title：American heart journal

authors： Pereira NL,Avram R,So DY,Iturriaga E,Byrne J,Lennon RJ,Murthy V,Geller N,Goodman SG,Rihal C,Rosenberg Y,Bailey K,Pletcher MJ,Marcus GM,Farkouh ME,Olgin JE

更新日期：2021-02-01 00:00:00

abstract：:Sodium-glucose cotransporter 2 inhibitor (SGLT2i) use is associated with improved cardiovascular and kidney outcomes. However, the magnitude and potential heterogeneity of effect across patients with varying types of cardiometabolic and kidney disease is unclear. To examine the effect of SGLT2i on cardiovascular and k...

journal_title：American heart journal

authors： Salah HM,Al'Aref SJ,Khan MS,Al-Hawwas M,Vallurupalli S,Mehta JL,Mounsey JP,Greene SJ,McGuire DK,Lopes RD,Fudim M

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Ideal cardiovascular health (ICH) aims at primordial prevention of cardiovascular diseases in the population. However, there is a lack of research describing ICH in youth from middle-income countries. The aims of this study were to describe the prevalence of ICH at 18 and 22-years old and to investigate the ...

journal_title：American heart journal

authors： Oliveira RS,Schneider BC,Callo-Quinte G,Oliveira IO,Gonçalves H,Wehrmeister F,Menezes AMB

更新日期：2021-01-25 00:00:00

abstract：BACKGROUND:Few data are available on the temporal patterns of health resource utilization (HRU) and expenditures around paroxysmal supraventricular tachycardia (PSVT) diagnosis. This study assessed the longitudinal trends in HRU and expenditures in the 3 years preceding and subsequent to PSVT diagnosis. METHODS:Adult ...

journal_title：American heart journal

authors： Chew DS,Sacks NC,Emden MR,Preib MT,Cyr PL,Wood D,Pokorney SD

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:In patients with atrial fibrillation, incomplete adherence to anticoagulants increases risk of stroke. Non-warfarin oral anticoagulants (NOACs) are expensive; we evaluated whether higher copayments are associated with lower NOAC adherence. METHODS:Using a national claims database of commercially-insured pat...

journal_title：American heart journal

authors： Rome BN,Gagne JJ,Avorn J,Kesselheim AS

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes. However, TMAO is the final product of a complex metabolic pathway (ie, choline/carnitine) that has never been entirely investigated in HF. The present study investigates a panel of metabolites involved in...

journal_title：American heart journal

authors： Israr MZ,Bernieh D,Salzano A,Cassambai S,Yazaki Y,Heaney LM,Jones DJL,Ng LL,Suzuki T

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:In patients with coronary heart disease (CHD), atrial fibrillation (AF) is associated with increased morbidity and mortality. We investigated the associations between clinical risk factors and biomarkers with incident AF in patients with CHD. METHODS AND RESULTS:Around 13,153 patients with optimally treated...

journal_title：American heart journal

authors： Tomasdottir M MD,Held C MD, PhD,Hadziosmanovic N,Westerbergh J,Lindbäck J,Aylward PE,Budaj A,Cannon CP,Engdahl J,Granger CB,Koenig W,Manolis AJ,Oldgren J,Stewart RAH,Svennberg E,Vinereanu D,White HD,Siegbahn A,Wallent

更新日期：2021-01-02 00:00:00

abstract：:High blood pressure is the leading cause of preventable morbidity and mortality globally. Many patients remain on single-drug treatment with poor control, although guidelines recognize that most require combination therapy for blood pressure control. Our hypothesis is that a single-pill combination of 4 blood pressure...

journal_title：American heart journal

authors： Chow CK,Atkins ER,Billot L,Chalmers J,Hillis GS,Hay P,Neal B,Nelson M,Patel A,Reid CM,Schlaich M,Usherwood T,Webster R,Rodgers A

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:The DANHEART trial is a multicenter, randomized (1:1), parallel-group, double-blind, placebo-controlled study in chronic heart failure patients with reduced ejection fraction (HFrEF). This investigator driven study will include 1500 HFrEF patients and test in a 2 × 2 factorial design: 1) if hydralazine-isoso...

journal_title：American heart journal

authors： Wiggers H,Køber L,Gislason G,Schou M,Poulsen MK,Vraa S,Nielsen OW,Bruun NE,Nørrelund H,Hollingdal M,Barasa A,Bøttcher M,Dodt K,Hansen VB,Nielsen G,Knudsen AS,Lomholdt J,Mikkelsen KV,Jonczy B,Brønnum-Schou J,Poenar

更新日期：2021-01-01 00:00:00

abstract：:Acute myocardial infarction (MI) patients remain at high risk for recurrent events. Cholesterol efflux, mediated by apolipoprotein A-I, removes excess cholesterol from atherosclerotic plaque and transports it to the liver for excretion. Impaired cholesterol efflux is associated with higher cardiovascular (CV) event ra...

journal_title：American heart journal

authors： Gibson CM,Kastelein JJP,Phillips AT,Aylward PE,Yee MK,Tendera M,Nicholls SJ,Pocock S,Goodman SG,Alexander JH,Lincoff AM,Bode C,Duffy D,Heise M,Berman G,Mears SJ,Tricoci P,Deckelbaum LI,Steg PG,Ridker P,Mehran R

更新日期：2021-01-01 00:00:00

abstract：:Congenitally corrected transposition of the great arteries (ccTGA) is associated with various types of arrhythmia, including supraventricular tachycardia (SVT) and complete atrioventricular block (cAVB). Our study aims to characterize the arrhythmia burden, associated risk factors, arrhythmia mechanisms, and the long-...

journal_title：American heart journal

authors： Tseng WC,Huang CN,Chiu SN,Lu CW,Wang JK,Lin MT,Chen CA,Wu MH

更新日期：2021-01-01 00:00:00

abstract：:Myocarditis Disease Unit (MDU) is a functional multidisciplinary network designed to offer multidisciplinary assistance to patients with myocarditis. More than 300 patients coming from the whole Country are currently followed up at a specialized multidisciplinary outpatient clinic. Following the pandemic outbreak of t...

journal_title：American heart journal

authors： Peretto G,De Luca G,Campochiaro C,Palmisano A,Busnardo E,Sartorelli S,Barzaghi F,Cicalese MP,Esposito A,Sala S

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Less than half of patients with cardiometabolic disease consistently take prescribed medications. While health insurers and some delivery organizations use claims to measure adherence, most clinicians do not have access during routine interactions. Self-reported scales exist, but their practical utility is o...

journal_title：American heart journal

authors： Lauffenburger JC,Fontanet CP,Isaac T,Gopalakrishnan C,Sequist TD,Gagne JJ,Jackevicius CA,Fischer MA,Solomon DH,Choudhry NK

更新日期：2020-10-01 00:00:00

abstract：:We aimed to investigate long-term (≥5 years) outcomes of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) using a meta-analysis from updated published randomized trials. Our data showed that the risk of all-cause death as well as cardi...

journal_title：American heart journal

authors： Kuno T,Ueyama H,Rao SV,Cohen MG,Tamis-Holland JE,Thompson C,Takagi H,Bangalore S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend anticoagulation therapy during primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI). However, whether anticoagulation should be continued after pPCI has not been well investigated. METHODS/DESIGN:The RIGHT trial is a prospectiv...

journal_title：American heart journal

authors： Yan Y,Wang X,Guo J,Li Y,Ai H,Gong W,Que B,Zhen L,Lu J,Ma C,Montalescot G,Nie S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:The optimal antibiotic treatment length for infective endocarditis (IE) is uncertain. International guidelines recommend treatment duration of up to 6 weeks for patients with left-sided IE but are primarily based on historical data and expert opinion. Efficacies of modern therapies, fast recovery seen in man...

journal_title：American heart journal

authors： Østergaard L,Pries-Heje MM,Hasselbalch RB,Rasmussen M,Åkesson P,Horvath R,Povlsen J,Gill S,Bruun NE,Müllertz K,Tuxen CD,Ihlemann N,Helweg-Larsen J,Moser C,Fosbøl EL,Bundgaard H,Iversen K

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) complicated by cardiogenic shock (CS) is associated with high mortality. Early coronary revascularization improves survival, but the optimal mode of revascularization remains uncertain. We sought to characterize practice patterns and outcomes of coronary artery bypass grafting (CAB...

journal_title：American heart journal

authors： Smilowitz NR,Alviar CL,Katz SD,Hochman JS

更新日期：2020-08-01 00:00:00

abstract：:Little is known about the impact of accountable care organizations (ACO) on hospitalized heart failure (HF) patients, a high-cost and high-risk population. OBJECTIVE:We linked Medicare fee-for-service claims from 2013 to 2015 with data from American Heart Association Get With The Guidelines-HF registry to compare HF ...

journal_title：American heart journal

authors： Luo N,Hammill BG,DeVore AD,Xu H,Fonarow GC,Albert NM,Matsouaka RA,Hernandez AF,Yancy C,Mentz RJ

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The prevalence of renal disease in cardiac intensive care units (CICUs) is increasing, but little is known about the utilization, concurrent therapies, and outcomes of patients requiring acute renal replacement therapy (RRT) in this specialized environment. METHODS:In the Critical Care Cardiology Trials Net...

journal_title：American heart journal

authors： van Diepen S,Tymchak W,Bohula EA,Park JG,Daniels LB,Phreaner N,Barnett CF,Kenigsberg BB,DeFilippis A,Singam NS,Barsness GW,Jentzer JC,Ternus B,Morrow DA,Katz JN,Critical Care Cardiology Trials Network Investigators.

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The American Heart Association recommends women with congenital heart defects (CHD) receive contraceptive counseling early in their reproductive years, but little is known about contraceptive method use among women with CHD. We describe recent female sterilization and reversible prescription contraceptive me...

journal_title：American heart journal

authors： Anderson KN,Tepper NK,Downing K,Ailes EC,Abarbanell G,Farr SL

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:In adults, the most common cause of out-of-hospital cardiac arrests (OHCA) is acute coronary artery occlusion. If an immediate coronary angiogram (CAG) is recommended for survivors presenting a ST segment elevation on the electrocardiogram (ECG) performed after resuscitation, there is still a debate regardin...

journal_title：American heart journal

authors： Hauw-Berlemont C,Lamhaut L,Diehl JL,Andreotti C,Varenne O,Leroux P,Lascarrou JB,Guerin P,Loeb T,Roupie E,Daubin C,Beygui F,Vilfaillot A,Glippa S,Djadi-Prat J,Chatellier G,Cariou A,Spaulding C,EMERGE investigators.

更新日期：2020-04-01 00:00:00

abstract：:The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in ...

journal_title：American heart journal

authors： Huang L,Tian M,Yu J,Li Q,Liu Y,Yin X,Wu JH,Marklund M,Wu Y,Li N,Elliott P,Yan LL,Labarthe DR,Hao Z,Shi J,Feng X,Zhang J,Zhang Y,Zhang R,Zhou B,Li Z,Sun J,Zhao Y,Yu Y,Neal B

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Despite a higher prevalence of sudden cardiac death (SCD), black individuals are less likely than whites to have an implantable cardioverter defibrillator (ICD) implanted. Racial differences in ICD utilization is in part explained by higher refusal rates in black individuals. Decision support can assist with...

journal_title：American heart journal

authors： Thomas KL,Sullivan LT 2nd,Al-Khatib SM,LaPointe NA,Sears S,Kosinski AS,Jackson LR 2nd,Kutyifa V,Peterson ED

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:The extent to which individual knowledge, preferences, and priorities explain lower use of invasive cardiac care among older vs. younger adults presenting with acute coronary syndrome (ACS) is unknown. We directly surveyed a group of patients to ascertain their preferences and priorities for invas...

journal_title：American heart journal

authors： Nanna MG,Peterson ED,Wu A,Harding T,Galanos AN,Wruck L,Alexander KP

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Analyses of country or regional differences in cardiovascular (CV) trials are based on geographical subgroup analyses. However, apart from map location and related racial, ethnic, and genetic variations, identified differences may also depend on social structure and provision and access to health care, for w...

journal_title：American heart journal

authors： Ferreira JP,Rossignol P,Dewan P,Lamiral Z,White WB,Pitt B,McMurray JJV,Zannad F

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) improves outcomes, functional capacity and quality of life in patients with heart failure. Despite two decades of experience with CRT, the rate of non-response remains approximately 30%. CRT efficacy is impacted by pacing location, which is anatomically limited in conv...

journal_title：American heart journal

authors： Singh JP,Abraham WT,Auricchio A,Delnoy PP,Gold M,Reddy VY,Sanders P,Lindenfeld J,Rinaldi CA

更新日期：2019-11-01 00:00:00

abstract：:Given the preventable morbidity and mortality associated with atrial fibrillation (AF), increased awareness of undiagnosed AF, and advances in mobile electrocardiogram (ECG) technology, there is a critical need to assess the effectiveness of using such technology to routinely screen for AF in clinical practice. VITAL-...

journal_title：American heart journal

authors： Ashburner JM,Atlas SJ,McManus DD,Chang Y,Trisini Lipsanopoulos AT,Borowsky LH,Guan W,He W,Ellinor PT,Singer DE,Lubitz SA

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. METHODS:In this open-label, m...

journal_title：American heart journal

authors： Weber B,Bersch-Ferreira ÂC,Torreglosa CR,Marcadenti A,Lara ES,da Silva JT,Costa RP,Santos RHN,Berwanger O,Bosquetti R,Pagano R,Mota LGS,de Oliveira JD,Soares RM,Galante AP,da Silva SA,Zampieri FG,Kovacs C,Amparo FC,

更新日期：2019-09-01 00:00:00

abstract：:Critical limb ischemia is associated with excessively high risk for cardiovascular events, including myocardial infarction and death. Additionally, in this patient population non-invasive evaluation of coronary artery disease is limited due to (1) inability of exercise testing, (2) frequent occurrence of balanced isch...

journal_title：American heart journal

authors： Toth G,Brodmann M,Barbato E,Mangiacapra F,Schneller L,Orias V,Gil R,Bil J,Bartus S,Ruzsa Z

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:False positive rate (FPR) of the current basic life support (BLS) termination of resuscitation (TOR) rule in out-of-hospital cardiac arrest (OHCA) patients (not witnessed; no return of spontaneous circulation prior to transport; and no shocks were delivered) has been ethically challenging. We validated the c...

journal_title：American heart journal

authors： Yoon JC,Kim YJ,Ahn S,Jin YH,Lee SW,Song KJ,Shin SD,Hwang SO,Kim WY,Korean Cardiac Arrest Research Consortium KoCARC.

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Lowering low-density lipoprotein cholesterol (LDL-C) by statins is a key strategy for secondary prevention of acute coronary syndrome (ACS). However, few studies have examined prehospital statin use and admission LDL-C levels in ACS patients with history of myocardial infarction (MI) or revascularization. Th...

journal_title：American heart journal

authors： Xing Y,Liu J,Hao Y,Liu J,Huo Y,Smith SC Jr,Ge J,Ma C,Han Y,Fonarow GC,Taubert KA,Morgan L,Yang N,Zhou M,Zhao D,CCC-ACS Investigators.

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an increasingly prevalent condition among heart failure (HF) patients. The long-term morbidity and mortality among patients with and without diabetes with HF with reduced (HFrEF), borderline (HFbEF), and preserved ejection fraction (HFpEF) are not well described. METHODS:Using the Get W...

journal_title：American heart journal

authors： Ziaeian B,Hernandez AF,DeVore AD,Wu J,Xu H,Heidenreich PA,Matsouaka RA,Bhatt DL,Yancy CW,Fonarow GC

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess one-year outcomes of invasive and non-invasive strategies in ST-elevation myocardial infarction (STEMI) among multimorbid older people with complex health needs. METHODS:We included patients, registered between 2006 and 2013 in the SWEDEHEART registry, who were 70 years o...

journal_title：American heart journal

authors： Gudnadottir GS,James SK,Andersen K,Lagerqvist B,Thrainsdottir IS,Ravn-Fischer A,Varenhorst C,Gudnason T

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Vein graft failure is a crucial challenge in coronary artery bypass graft (CABG) surgery. Previous studies have suggested a patency benefit of the No-Touch vein harvesting technique, but only with small sample sizes. MATERIALS AND METHODS:This study is a prospective, multicenter randomized clinical trial wi...

journal_title：American heart journal

authors： Wang X,Tian M,Zheng Z,Gao H,Wang Y,Wang L,Hu S

更新日期：2019-04-01 00:00:00

abstract：:Patients experiencing out-of-hospital cardiac arrest (OHCA) without ST-segment elevation are a heterogenic group with a variety of underlying causes. Up to one-third of patients display a significant coronary lesion compatible with myocardial infarction as OHCA trigger. There are no randomized data on patient selectio...

journal_title：American heart journal

authors： Desch S,Freund A,Graf T,Fichtlscherer S,Haake H,Preusch M,Hammer F,Akin I,Christ M,Liebetrau C,Skurk C,Steiner S,Voigt I,Schmitz R,Mudra H,Ledwoch J,Menck N,Horstkotte J,Pels K,Lahmann AL,Otto S,Lenk K,Ohlow M

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:We aimed to characterize the clinical and pathologic findings of aortic dissection (AD) over a nearly 60-year period. METHODS:The Jesse E. Edwards Registry of Cardiovascular Disease database was queried for cardiac specimens from autopsies with AD as a diagnosis and compared 2 cohorts: early (1956-1992) and...

journal_title：American heart journal

authors： Huynh N,Thordsen S,Thomas T,Mackey-Bojack SM,Duncanson ER,Nwuado D,Garberich RF,Harris KM

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS:We investigated sex-based differences in NIT results and subsequent cl...

journal_title：American heart journal

authors： Pagidipati NJ,Coles A,Hemal K,Lee KL,Dolor RJ,Pellikka PA,Mark DB,Patel MR,Litwin SE,Daubert MA,Shah SH,Hoffmann U,Douglas PS,PROMISE Investigators.

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure. METHODS AND RESULTS:The study was designed as a 2-armed partially blinded parallel...

journal_title：American heart journal

authors： SUPPORT-HF 2 Investigators and Committees. Electronic address: kazem.rahimi@georgeinstitute.ox.ac.uk.

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:CSL112 (apolipoprotein A-I [human]) is a plasma-derived apolipoprotein A-I developed for early reduction of cardiovascular risk following an acute myocardial infarction (AMI). The safety of CSL112 among AMI subjects with moderate, stage 3 chronic kidney disease (CKD) is unknown. METHODS:CSL112_2001, a multi...

journal_title：American heart journal

authors： Gibson CM,Kerneis M,Yee MK,Daaboul Y,Korjian S,Mehr AP,Tricoci P,Alexander JH,Kastelein JJP,Mehran R,Bode C,Lewis BS,Mehta R,Duffy D,Feaster J,Halabi M,Angiolillo DJ,Duerschmied D,Ophuis TO,Merkely B

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Subcortical small vessel disease, represented as white matter hyperintensity (WMH) on magnetic resonance images (MRI) is associated with functional decline in older people with hypertension. We evaluated the relationships of clinic and out-of-office blood pressures (BP) with WMH and functional status in olde...

journal_title：American heart journal

authors： White WB,Jalil F,Wakefield DB,Kaplan RF,Bohannon RW,Hall CB,Moscufo N,Fellows D,Guttmann CRG,Wolfson L

更新日期：2018-11-01 00:00:00