Risk markers of incident atrial fibrillation in patients with coronary heart disease.

Abstract:

BACKGROUND:In patients with coronary heart disease (CHD), atrial fibrillation (AF) is associated with increased morbidity and mortality. We investigated the associations between clinical risk factors and biomarkers with incident AF in patients with CHD. METHODS AND RESULTS:Around 13,153 patients with optimally treated CHD included in the STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY (STABILITY) trial with plasma samples obtained at randomization. Mean follow-up time was 3.5 years. The association between clinical risk factors and biomarkers with incident AF was estimated with Cox-regression models. Validation was performed in 1,894 patients with non-ST-elevation acute coronary syndrome included in the FRISC-II trial. The median (min-max) age was 64 years (range 26-92) and 2,514 (19.1%) were women. A total of 541 patients, annual incidence rate of 1.2%, developed AF during follow-up. In multivariable models, older age, higher levels of NT-proBNP, higher body mass index (BMI), male sex, geographic regions, low physical activity, and heart failure were independently associated with increased risk of incident AF with hazard ratios ranging from 1.04 to 1.79 (P ≤ .05). NT-proBNP improved the C-index from 0.70 to 0.71. In the validation cohort, age, BMI, and NT-proBNP were associated with increased risk of incident AF with similar hazard ratios. CONCLUSIONS:In patients with optimally treated CHD, the incidence of new AF was 1.2% per year. Age, NT-proBNP as a marker of impaired cardiac function, and BMI were the strongest factors, independently and consistently associated with incident AF. Male sex and low physical activity may also contribute to the risk of AF in patients with CHD.

journal_name

Am Heart J

journal_title

American heart journal

authors

Tomasdottir M MD,Held C MD, PhD,Hadziosmanovic N,Westerbergh J,Lindbäck J,Aylward PE,Budaj A,Cannon CP,Engdahl J,Granger CB,Koenig W,Manolis AJ,Oldgren J,Stewart RAH,Svennberg E,Vinereanu D,White HD,Siegbahn A,Wallent

doi

10.1016/j.ahj.2020.12.016

subject

Has Abstract

pub_date

2021-01-02 00:00:00

pages

92-101

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(20)30425-7

journal_volume

233

pub_type

杂志文章
  • Metabolic considerations in the choice of therapy for the patient with hypertension.

    abstract::The objective of treating patients with hypertension is not simply to reduce blood pressure but rather to prevent the associated morbidity and mortality. Recent assessments of clinical trials have shown that while the risk of stroke is consistently lower with antihypertensive therapy, the same degree of success has no...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(91)90451-m

    authors: Black HR

    更新日期:1991-02-01 00:00:00

  • Report of the National Heart, Lung and Blood Institute-National Institute of Allergy and Infectious Diseases working group on antimicrobial strategies and cardiothoracic surgery.

    abstract::Infections related to cardiac surgery increase morbidity and mortality, and increase cost and use of health resources. With the widespread use of synthetic materials, whether in prosthetic valves or vascular conduits, bacterial infection and, more rarely, fungal complications can be devastating, requiring prolonged an...

    journal_title:American heart journal

    pub_type: 评论

    doi:10.1016/j.ahj.2003.08.016

    authors: Lowy FD,Waldhausen JA,Miller M,Sopko G,Rosenberg Y,Skarlatos SI,National Heart, Lung and Blood Institute-National Institute of Allergy and Infectious Diseases working group on antimicrobial strategies and cardiothoracic surgery.

    更新日期:2004-04-01 00:00:00

  • Beneficial effects of the alpha-adrenergic antagonist nicergoline during acute myocardial ischemia and reperfusion in the dog.

    abstract::Recent experimental and clinical data have stimulated interest in the use of alpha-adrenergic antagonists in acute myocardial infarction. We evaluated nicergoline, a new relatively selective alpha 1-antagonist which uniquely lowers heart rate. Open-chest dogs, randomized to control (n = 25) or intravenously treated gr...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(83)90646-4

    authors: Bolli R,Brandon TA,Fisher DJ,Fernandez GC,Miller RR

    更新日期:1983-11-01 00:00:00

  • Effects of carvedilol therapy on restrictive diastolic filling pattern in chronic heart failure.

    abstract:BACKGROUND:Carvedilol therapy during congestive heart failure demonstrated a good efficacy in mortality rate reduction and in improvement of left ventricular (LV) systolic performance. However, currently there is not any finding about the drug's effect on diastolic filling. The aim of this study was to evaluate the eff...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0002-8703(03)00525-8

    authors: Palazzuoli A,Carrera A,Calabria P,Puccetti L,Pastrorelli M,Pasqui AL,Auteri A,Bruni F

    更新日期:2004-01-01 00:00:00

  • Prehospital statin use and low-density lipoprotein cholesterol levels at admission in acute coronary syndrome patients with history of myocardial infarction or revascularization: Findings from the Improving Care for Cardiovascular Disease in China (CCC) p

    abstract:BACKGROUND:Lowering low-density lipoprotein cholesterol (LDL-C) by statins is a key strategy for secondary prevention of acute coronary syndrome (ACS). However, few studies have examined prehospital statin use and admission LDL-C levels in ACS patients with history of myocardial infarction (MI) or revascularization. Th...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2019.02.019

    authors: Xing Y,Liu J,Hao Y,Liu J,Huo Y,Smith SC Jr,Ge J,Ma C,Han Y,Fonarow GC,Taubert KA,Morgan L,Yang N,Zhou M,Zhao D,CCC-ACS Investigators.

    更新日期:2019-06-01 00:00:00

  • Efficacy of early invasive management post-fibrinolysis in men versus women with ST-elevation myocardial infarction: a subgroup analysis from Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarctio

    abstract:BACKGROUND:The TRANSFER-AMI study demonstrated that early routine percutaneous coronary intervention post-fibrinolysis (pharmacoinvasive strategy) is superior to conservative management for ST-elevation myocardial infarction. However, it is not clear whether treatment efficacy differs between men and women. METHODS:In...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2012.05.022

    authors: Bhan V,Cantor WJ,Yan RT,Mehta SR,Morrison LJ,Heffernan M,Fitchett D,Džavík V,Ducas J,Borgundvaag B,Cohen EA,Goodman SG,Yan AT

    更新日期:2012-09-01 00:00:00

  • Doppler echocardiographic evaluation of the spectrum of left ventricular diastolic dysfunction in essential hypertension.

    abstract::Left ventricular topography and diastolic and systolic functions were studied in 41 patients with essential hypertension (group 1) and 33 age-matched normal adults (group 2) by Doppler echocardiography. In group 1 54% had LV concentric hypertrophy, 19% had combined concentric hypertrophy and eccentric remodeling, and ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90560-6

    authors: Ren JF,Pancholy SB,Iskandrian AS,Lighty GW Jr,Mallavarapu C,Segal BL

    更新日期:1994-04-01 00:00:00

  • Neurohumoral activation in congestive heart failure.

    abstract::This article reviews the evidence that congestive heart failure is accompanied by an increased plasma norepinephrine concentration and that this is due not only to a reduced tissue clearance of the substance but also to a marked increase in sympathetic nerve activity. It also reports data that indicate that the sympat...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(90)90054-2

    authors: Mancia G

    更新日期:1990-12-01 00:00:00

  • Acute positive inotropic intervention: the phosphodiesterase inhibitors.

    abstract::Phosphodiesterase inhibitors that are selective for cAMP-specific cardiac and vascular PDE III comprise a new group of agents for the treatment of heart failure, which at present are limited to clinical shortterm intravenous use and research uses only. Although both intravenous amrinone and milrinone are FDA approved,...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90078-v

    authors: DiBianco R

    更新日期:1991-06-01 00:00:00

  • Prevention of no-reflow/slow-flow phenomenon during rotational atherectomy--a prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil.

    abstract:BACKGROUND:The potential exists for microcirculatory impairment during rotational coronary atherectomy (RA) due to embolization of plaque debris, platelet aggregation, or vasospasm. This prospective randomized pilot study aimed to confirm favorable effects of nicorandil during RA compared with verapamil. METHODS:We ra...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2007.07.036

    authors: Matsuo H,Watanabe S,Watanabe T,Warita S,Kojima T,Hirose T,Iwama M,Ono K,Takahashi H,Segawa T,Minatoguchi S,Fujiwara H

    更新日期:2007-11-01 00:00:00

  • Susceptibility to atrial fibrillation and ventricular tachyarrhythmia in the Wolff-Parkinson-White syndrome: role of the accessory pathway.

    abstract::Clinical and electrophysiologic characteristics associated with spontaneous and inducible atrial fibrillation and ventricular tachyarrhythmia were assessed in 20 consecutive patients with Wolff-Parkinson-White (WPW) syndrome undergoing surgical division (n = 12) or transcatheter electrical ablation (n = 8) of accessor...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90342-x

    authors: Waspe LE,Brodman R,Kim SG,Fisher JD

    更新日期:1986-12-01 00:00:00

  • Imaging and diagnostic testing: diastolic dysfunction after coronary artery bypass grafting: a frequent finding of clinical significance not influenced by intravenous calcium.

    abstract:BACKGROUND:Diastolic dysfunction is common immediately after coronary artery bypass surgery (CABG). The duration of this phenomenon is unknown. Intravenous calcium is frequently administered during separation from cardiopulmonary bypass (CPB). We sought to determine whether intravenous calcium influences perioperative ...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/S0002-8703(02)94786-1

    authors: Ekery DL,Davidoff R,Orlandi QG,Apstein CS,Hesselvik JF,Shemin RJ,Shapira OM

    更新日期:2003-05-01 00:00:00

  • Persistent depressive symptoms lower aspirin adherence after acute coronary syndromes.

    abstract:BACKGROUND:Even mild depressive symptoms during hospitalization are an independent risk factor for mortality after acute coronary syndromes (ACS). The mortality risk is highest for patients whose depressive symptoms persist after ACS. Low adherence to medications that reduce the risk of subsequent cardiac events may be...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.05.014

    authors: Rieckmann N,Kronish IM,Haas D,Gerin W,Chaplin WF,Burg MM,Vorchheimer D,Davidson KW

    更新日期:2006-11-01 00:00:00

  • Current concepts in the pathogenesis of atrial fibrillation.

    abstract::Current evidence suggests that the pathogenesis of atrial fibrillation (AF) is multifactorial. The observation that AF, once present, alters the electrophysiologic properties of the atrial myocardium causing self-perpetuation of the arrhythmia raised the importance of electrical remodeling in its pathogenesis. Althoug...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/j.ahj.2008.10.009

    authors: Kourliouros A,Savelieva I,Kiotsekoglou A,Jahangiri M,Camm J

    更新日期:2009-02-01 00:00:00

  • Calcification of the tricuspid anulus diagnosed by two-dimensional echocardiography.

    abstract::An 84-year-old female who previously underwent repair of an atrial septal defect had evidence of increased reflectiveness of the posterior tricuspid anulus in the apical four-chamber view and the right ventricular two-chamber view. In addition, the inferior vena cava was dilated and during contrast echocardiography, c...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90839-1

    authors: Mattleman S,Panidis I,Kotler MN,Mintz GS,Morganroth J,Ross J,Victor M

    更新日期:1984-05-01 00:00:00

  • Acute and chronic effects of ketanserin on the electrophysiologic properties of isolated rabbit ventricular myocardium: particular reference to repolarization.

    abstract::The acute and chronic cellular electrophysiologic actions of ketanserin, a selective blocker of 5-hydroxytriptamine (5-HT2) receptor, were examined in the isolated rabbit ventricular muscle. This work was prompted by the recent observations that small numbers of patients treated with hypertension develop QTc prolongat...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90012-9

    authors: Kamiya K,Venkatesh N,Singh BN

    更新日期:1988-06-01 00:00:00

  • M-mode echocardiography in left bundle branch block: significance of frontal plane QRS axis.

    abstract::M-mode echocardiograms were obtained in 48 patients with complete left bundle branch block (LBBB). Of these 48 patients, 28 had LBBB with normal frontal plane QRS axis (-20 degrees to +90 degrees, mean +/- SD 18 degrees +/- 34 degrees), and 20 had LBBB with a left axis deviation (LAD) (-30 degrees to -60 degrees, mean...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(82)90010-2

    authors: Strasberg B,Rich S,Lam W,Swiryn S,Bauernfeind R,Rosen KM

    更新日期:1982-10-01 00:00:00

  • Phenylephrine plus propranolol improves the balance between myocardial oxygen supply and demand during experimental cardiopulmonary resuscitation.

    abstract::Epinephrine increases coronary blood flow but may not improve the balance between myocardial oxygen supply and demand during cardiopulmonary resuscitation (CPR). The objective of this study was to determine whether this balance can be improved by administering a relatively pure alpha-adrenergic vasoconstrictor, alone ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90120-1

    authors: Ditchey RV,Slinker BK

    更新日期:1994-02-01 00:00:00

  • Hemodynamic, electrocardiographic, and metabolic effects of fructose diphosphate on acute myocardial ischemia.

    abstract::The hemodynamic, electrocardiographic, and metabolic responses of dogs with acute myocardial ischemia to intravenous administration of fructose-1,6-diphosphate (FDP) were assessed. Analysis of the results (compared to dextrose control) revealed evidence of major improvement of LVEDP and cardiac output, significant dec...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(80)90228-8

    authors: Markov AK,Oglethorpe NC,Blake TM,Lehan PH,Hellems HK

    更新日期:1980-11-01 00:00:00

  • Coronary flow reserve abnormalities in patients with diabetes mellitus who have end-stage renal disease and normal epicardial coronary arteries.

    abstract:BACKGROUND:Diabetic nephropathy is associated with increased cardiovascular events. Coronary atherosclerosis is responsible for many of these events, but other mechanisms such as impaired flow reserve may be involved. The purpose of this study was to define the prevalence and mechanism of abnormal coronary velocity res...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2003.07.029

    authors: Ragosta M,Samady H,Isaacs RB,Gimple LW,Sarembock IJ,Powers ER

    更新日期:2004-06-01 00:00:00

  • Perioperative outcomes in reoperative cardiac surgery guided by cardiac multidetector computed tomographic angiography.

    abstract:BACKGROUND:Preoperative evaluation with contrast-enhanced multidetector computed tomographic angiography (MDCTA) is considered an "appropriate" indication based on expert consensus. We aimed to evaluate how the presurgical evaluation with MDCTA impacts the outcomes after reoperative cardiac surgery (RCS). METHODS:We r...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2009.11.005

    authors: Maluenda G,Goldstein MA,Lemesle G,Weissman G,Weigold G,Landsman MJ,Hill PC,Pita F,Corso PJ,Boyce SW,Pichard AD,Waksman R,Taylor AJ

    更新日期:2010-02-01 00:00:00

  • Quantitative assessment of temporal and spatial ventricular wall motion in normal and infarcted human left ventricles.

    abstract::A new integrated method for quantitating temporal and spatial systolic wall motion heterogeneity was developed and applied in 15 normal subjects and 26 patients with previous myocardial infarction (MI). After frame by frame digitizing, right anterior oblique left cineventriculograms (LV) were analyzed with 90 spaced r...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90465-5

    authors: Chen CG,Bonzel T,Just H,Seiffert G,Zeiher A,Kasper W,Wollschlaeger H

    更新日期:1986-10-01 00:00:00

  • What is a "save"?: Outcome measures in clinical evaluations of automatic external defibrillators.

    abstract::Automatic external defibrillators (AEDs) represent an important technologic innovation in the management of out-of-hospital cardiac arrest. We propose the following concept: AEDs are machines with the limited task of ventricular fibrillation (VF) identification, countershock delivery, and defibrillation. They cannot b...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(85)90002-x

    authors: Cummins RO,Eisenberg MS,Hallstrom AP,Hearne TR,Graves JR,Litwin PE

    更新日期:1985-12-01 00:00:00

  • The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients.

    abstract:BACKGROUND:Previous studies have demonstrated that the adenosine monophosphate deaminase 1 (AMPD1) C34T polymorphism may be associated with survival in cardiac populations with a protective effect of the T allele. However, these studies included limited number of patients with few cardiovascular events. METHODS:We pro...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.04.003

    authors: de Groote P,Lamblin N,Helbecque N,Mouquet F,Hermant X,Amouyel P,Dallongeville J,Bauters C

    更新日期:2006-10-01 00:00:00

  • Socioeconomic status, ethnic origin, and risk factors for coronary heart disease in children.

    abstract::The associations between socioeconomic status, ethnic origin, and risk factors for CHD were studied in 2,591 white and black children from two socioeconomically dissimilar populations in the New York City area. The study subjects were selected from all fourth graders in 44 elementary schools. Blood pressure, plasma li...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(87)90724-1

    authors: Walter HJ,Hofman A

    更新日期:1987-03-01 00:00:00

  • Neurohumoral and hemodynamic effects of lower body negative pressure in patients with congestive heart failure.

    abstract::Baroreflex modulation of forearm vascular resistance (FVR) has been reported to be abnormal in patients with congestive heart failure (CHF). However, the neurohumoral mechanisms for this impairment are not defined. We assessed the responses of arterial pressure, FVR, plasma norepinephrine, and plasma renin activity to...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(89)90075-6

    authors: Mohanty PK,Arrowood JA,Ellenbogen KA,Thames MD

    更新日期:1989-07-01 00:00:00

  • Cardiac abnormalities and cytosine-thymine-guanine trinucleotide repeats in myotonic dystrophy.

    abstract::This study investigated the correlation between cardiac abnormalities and cytosine-thymine-guanine (CTG) trinucleotide repeat expansion in patients with myotonic dystrophy (MD). We studied 18 patients with the adult form of classical MD and 18 age-matched control subjects. In patients with MD, left ventricular systoli...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(97)70137-6

    authors: Hayashi Y,Ikeda U,Kojo T,Nishinaga M,Miyashita H,Kuroda T,Inoue K,Nishizawa M,Shimada K

    更新日期:1997-08-01 00:00:00

  • Isolated T wave alternans.

    abstract::Two patients with isolated T wave alternans are reported, with their vectocardiograms, their response to carotid sinus stimulation, and the response to calcium infusion in one of them with documented severe hypocalcemia. Eleven cases of the literature are briefly reviewed. The alternans of the T wave appears with seve...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(78)90369-1

    authors: Navarro-Lopez F,Cinca J,Sanz G,Periz A,Magriña J,Betriu A

    更新日期:1978-03-01 00:00:00

  • Pre-excitation of the ventricle associated with total intra His bundle block.

    abstract::A case with total intra-His bundle block and intermittent pre-excitation syndrome is presented. During A-V conduction there was a P-delta interval of 130 msec. with a P-A interval of 20 msec., an A-H interval of 60 msec. and an H-V interval of 50 msec. During rapid atrial pacing the P-delta interval increased primaril...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(77)80350-5

    authors: Probst P,Pachinger O,Steinbach K,Kaindl F

    更新日期:1977-07-01 00:00:00

  • Abciximab improves 6-month clinical outcome after rescue coronary angioplasty.

    abstract:BACKGROUND:Few data are available concerning the effects on clinical outcome and left ventricular function of abciximab administration in patients undergoing rescue percutaneous transluminal coronary angioplasty (PTCA) after failed thrombolysis for acute myocardial infarction. The aim of the study was to investigate su...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mhj.2002.119762

    authors: Petronio AS,Musumeci G,Limbruno U,De Carlo M,Baglini R,Paterni G,Grazia Delle Donne M,Caravelli P,Nardi C,Mariani M

    更新日期:2002-02-01 00:00:00