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Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS).

Abstract：

:The Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural China. Intermediate risk markers were measured in a random subsample of villages every 12 months over 3 years to track progress against key assumptions underlying study design. Measures of 24-hour urinary sodium, 24-hour urinary potassium, blood pressure and participants' use of salt substitute were recorded, with differences between intervention and control groups estimated using generalized linear mixed models. The primary outcome of annual event rate in the two groups combined was determined by dividing confirmed fatal and non-fatal strokes by total follow-up time in the first 2 years. The mean differences (95% CI) were -0.32 g (-0.68 to 0.05) for 24-hour urinary sodium, +0.77 g (+0.60 to +0.93) for 24-hour urinary potassium, -2.65 mmHg (-4.32 to -0.97) for systolic blood pressure and +0.30 mmHg (-0.72 to +1.32) for diastolic blood pressure. Use of salt substitute was reported by 97.5% in the intervention group versus 4.2% in the control group (P<.0001). The overall estimated annual event rate for fatal and non-fatal stroke was 3.2%. The systolic blood pressure difference and the annual stroke rate were both in line with the statistical assumptions underlying study design. The trial should be well placed to address the primary hypothesis at completion of follow-up.

journal_name

Am Heart J

journal_title

American heart journal

authors

Huang L,Tian M,Yu J,Li Q,Liu Y,Yin X,Wu JH,Marklund M,Wu Y,Li N,Elliott P,Yan LL,Labarthe DR,Hao Z,Shi J,Feng X,Zhang J,Zhang Y,Zhang R,Zhou B,Li Z,Sun J,Zhao Y,Yu Y,Neal B

doi

10.1016/j.ahj.2019.12.020

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

136-145

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(20)30005-3

journal_volume

221

pub_type

杂志文章,随机对照试验

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